Principles and applications of stereochemistry
- Michael North.
- Cheltenham, U.K. : Stanley Thornes Publishers, 1998.
- Physical description
- xii, 254 p. : ill. ; 24 cm.
- North, Michael, 1964-
- Includes bibliographical references and index.
- MOLECULAR STRUCTURE AND BONDING Isomerism Drawing Three Dimensional Chemical Stuctures VSEPR and the Shape of Molecules Structure and Bonding Clasification of Stereoisomers CIS-TRANS ISOMERISM Cis-Trans Isomerism in Alkenes Cis-Trans Isomerism in Other Systems Which Contain a double Bond Cis-Trans Isomerism in Cyclic Systems Cis-Trans Isomerism in Square Planar and Octohedral Metal Complexes Cis-Trans Isomerism about Single Bonds (Conformational Diastereomers) Methods for Distinguishing Cis-Trans Isomers ENANTIOMERS Structure of Enantiomers Nomenclature for Enantiomers (Speciation of Absolute Configuration) Chemical Properties of Enantiomers Physical Properties of Enantiomers Enantiomeric Excess Biological Properties of Enantiomers Chirality Due to Stereocentres at Atoms Other than Carbon Other Stereogenic Elements Which Can Produce Molecular Chirality COMPOUNDS WITH TWO OR MORE STEREOCENTRES Compounds with Two Stereocentres Compounds with More Than Two Stereocentres Polymer Stereochemistry Relative Stereochemistry Nomenclature Diastereomeric Excess INTERCONVERSION AND ANALYSIS OF STEREOISOMERS Racemization Epimerization Resolution Methods for Determining Enantiomeric Excess Determination of Absolute Configuration Determination of Relative Configuration MOLECULAR SYMMETRY Introduction Symmetry Elements and Symmetry Operations Symmetry of Molecules with Multiple Conformations Point Groups Symmetry and Chirality TOPISM AND PROSTEREOGENICITY Homotopic, Enantiopic and Diastereotopic Groups Homotopic, Enantiopic and Diastereotopic Faces Nomenclature for Heterotopic Groups and Faces CONFORMATION OF ACYLIC AND CYCLIC MOLECULES Introduction Conformations of Acyclic Molecules Conformations of Cyclic Alkanes and their Derivatives Cyclopropane Cyclobutane Cyclohexane Medium and Large Rings Conformation of Inorganic and Organometallic Compounds Conformation of Biopolymers Methods for Determining Molecular Conformation STEREOCHEMISTRY OF CHEMICAL REACTIONS Introduction Substitution Reactions Elimination Reactions Addition Reactions to Alkenes Addition of Nucleophiles to Aldehydes and Ketones Pericyclic Reactions ASYMMETRIC SYNTHESIS Introduction Use of Chiral Auxiliaries Use of Enantiomerically Pure Reagents Index.
- (source: Nielsen Book Data)
A thorough understanding of stereochemistry is essential for the comprehension of almost all aspects of modern organic chemistry. It is also of great significance in many biochemical and medicinal disciplines, since the stereoisomers of a compound can have dramatically different biological properties. This text explains how the different properties of stereoisomers of a compound arise, and what processes can be used to prepare and analyze stereoisomerically pure compounds. It also presents prominent coverage of the stereochemistry of inorganic and organometallic compounds, which is likely to increase in importance, as these compounds are used as symmetric catalysts in asymmetric synthesis. Modern stereochemical terminology is used throughout, although reference is also made to older terms which are still widely used. A set of problems at the end of each chapter aims to further the reader's understanding of how the content can be applied. The book is designed mainly as a textbook for undergraduate students and as a reference source for more advanced levels, but is also intended for academic and professional organic chemists.
(source: Nielsen Book Data)
- Publication date
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