Fibrosis in Disease : an Organ-Based Guide to Disease Pathophysiology and Therapeutic Considerations
- Monte S. Willis, Cecelia C. Yates, Jonathan C. Schisler, editors.
- Cham : Humana Press, ©2019.
- Physical description
- 1 online resource (474 pages).
- Molecular and translational medicine.
- Intro; Acknowledgments; Contents; Contributors; Introduction; Fibrotic Signaling in the Skin; Fibrotic Signaling in the Lung; Fibrotic Signaling in Heart; Fibrotic Signaling in the Vasculature, Liver, Kidney, and Eye; Part I: Skin, Cell Injury, and Wound Healing;
- Chapter 1: The Role of Chemokines in Fibrotic Dermal Remodeling and Wound Healing; Introduction; Normal Dermal Architecture and Function; Dermal Wounds; Dermal Wound Healing Is a Complex, Multistep Process that Involves Many Cell Types and Secreted Factors; The Discovery of Chemokines as Soluble Signaling Molecules.
- The Chemokine Family TreeChemokine Receptors and Signaling; Chemokines in the Hemostasis and Inflammation Stages of Wound Healing; Chemokines in the Proliferative Stage of Wound Healing; Chemokines in the Remodeling Stage of Wound Healing; Chemokines in the Fibrotic Phase of Healing; Conclusion; References;
- Chapter 2: Fibrosis and Immune Dysregulation in Systemic Sclerosis; Introduction; Epidemiology and Clinical Background; Pathogenesis: Genetic and Environmental Factors; Animal Models; Bleomycin-Induced Skin Fibrosis Mouse Model; Tight Skin-1 Mouse Model; Tight Skin-2 Mouse Model.
- Interleukin-6Interleukin-4; Interleukin-13; Interleukin-17; Conclusion; References;
- Chapter 3: Macrophage Plasticity in Skin Fibrosis; Introduction; Mechanotransduction and Macrophage Activation in Hypertrophic Scar Formation; Macrophage Alterations in the Early and Proliferating Wound with Implications in Hypertrophic Scar Formation; Macrophage Activation During Wound Remodeling and Its Association with Hypertrophic Scar Formation; Macrophages in Scleroderma; Macrophages in the Foreign Body Response and Fibrosis.
- Tissue-Resident Macrophage Responses in Other Forms of Fibrosis: Lessons from the Lung and LiverLung Fibrosis; Liver Fibrosis; Conclusion; References; Part II: Lung;
- Chapter 4: Fibrotic Signaling in the Lung; Introduction; Idiopathic Pulmonary Fibrosis: Definition and Clinical Concepts; Lung Injury and Repair; Lessons from Therapy; Epithelial Cell Signaling in Pulmonary Fibrosis; Epithelial Cell Integrity; Epithelial-Mesenchymal Transition; Epithelial Cells as Sources of Intercellular Signals; Epithelial Cell Migration.
- Publication date
- Molecular and Translational Medicine
- Newer Technologies and Recently Described Signaling Pathways in Epithelial Cells.
- 9783319981437 (electronic bk.)
- 3319981439 (electronic bk.)