Development of efficient transporter strategies for the delivery of chemotherapeutics and biomolecules
- Xiaoyu Zang (Janice).
- [Stanford, California] : [Stanford University], 2018.
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- All living systems require biological barriers. For therapeutic molecules to reach their targets, a diverse set of barriers needs to be breached in vivo, including but not limited to the lipid bilayer cell membrane, retinal-blood barrier, blood-brain barrier and skin barrier. Therefore, the design, synthesis and application of efficient delivery vehicles for therapeutic and diagnostic compounds across biological membranes are critical due to the increasing demand for precision medicine. Consequently, a number of novel physical, chemical and biological approaches have been explored to overcome these protective barriers. In addition to delivering into human cells or tissues, other colonizing organisms inside or on our body are also among the targets for drug delivery. The ultimate goal of this thesis is to develop efficient drug delivery strategies for clinical applications. Different approaches of delivery were explored by taking advantages of the chemical modification of drug molecules and delivery vehicles, either covalently or non-covalently. This thesis included 5 different projects covering the delivery of the largest known ribonulceoprotein, vaults; the delivery of oligonuleotide messenger RNAs; the delivery of glycopeptide antibiotics for Gram-positive bacterial infections; the delivery of glycopeptide antibiotics for Gram-negative bacterial infections; and the delivery of latency reversal agents for HIV/AIDS eradications.
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- Submitted to the Department of Chemistry.
- Thesis Ph.D. Stanford University 2018.
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