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1. Bioinorganic chemistry : a short course [2007]
- Roat-Malone, Rosette M.
- 2nd ed. - Hoboken, N.J. : Wiley-Interscience, c2007.
- Description
- Book — xix, 501 p., [16] p. of plates : ill. (some col.) ; 24 cm.
- Summary
-
- Chapter 1: Inorganic Chemistry Essentials.Introduction .Essential Chemical Elements.Metals in Biological Systems: A Survey.Inorganic Chemistry Basics.Biological Metal Ion Complexation.Thermodynamics.Kinetics.Electronic and Geometric Structures of Metals in Biological Systems.Bioorganometallic Chemistry.Electron Transfer.Introduction to Biological Metal Homeostasis, Transport, and Storage.
- Chapter 2: Biochemistry Fundamentals.Introduction.Proteins.Amino Acid Building Blocks.Protein Structure.Protein Sequencing and Proteomics.Protein Function, Enzymes and Enzyme Kinetics.Nucleic Acids.DNA and RNA Building Blocks.DNA and RNA Molecular Structures.Transmission of Genetic Information.Genetic Mutations and Site-Directed Mutagenesis.Genes and Cloning.Genomics and the Human Genome.The ATP-binding cassette (ABC) Transporter Superfamily.
- Chapter 3: Instrumental Methods.Introduction.Analytical Instrument-Based Methods.Spectroscopy.X-ray Absorption Spectroscopy (XAS) and Extended X-ray Absorption Fine Structure (EXAFS).Theoretical Aspects and Hardware.Descriptive Examples.X-ray Crystallography.Introduction.Crystallization and Crystal Habits.Theory and Hardware.Descriptive Examples.Electron Paramagnetic Resonance.Theory and Determination of g-values.Hyperfine and Superhyperfine Interactions.Descriptive Examples.Nuclear Magnetic Resonance.Theoretical Aspects.Nuclear Screening and the Chemical Shift.Spin-Spin coupling.Techniques of Spectral Integration and Spin-Spin Decoupling.Nuclear Magnetic Relaxation.The nuclear Overhauser Effect (NOE).Obtaining the NMR spectrum.Two-dimensional NMR Spectroscopy.Correlation Spectroscopy (COSY).Nuclear Overhauser Effect Spectroscopy (NOESY).Descriptive Examples.Mossbauer Spectroscopy.Theoretical Aspects.Quadrupole Splitting and the Isomer Shift.Magnetic Hyperfine Interactions.Descriptive Examples.Atomic Force Microscopy.Fast Methods.Stopped-Flow Kinetic Methods.Flash Photolysis.Time-Resolved Crystallography.
- Chapter 4: Introduction to Computer-Based Methods.Computer Hardware .Molecular Modeling and Molecular Mechanics.Introduction to MM.Molecular Modeling, Molecular Mechanics and Molecular Dynamics.Biomolecule Modeling.Molecular Modeling Descriptive Examples.Quantum Mechanics-Based Computational Methods.Introduction.Ab-initio Methods.Density Functional Theory.Semi-empirical Methods.Computer Software for Chemistry.Mathematical Software.World Wide Web Online Resources.Nomenclature and Visualization Resources.Online Societies, Literature, Materials, Equipment Webservers.
- Chapter 5: Group I and II metals in biological systems.Transport and storage of metal ions.Homeostasis involving Na+, K+, Ca2+, Mg2+, Zn2+ (as well as P, Cl, and H).Movement of molecules and ions across membranes.Proton pumps.Ion pumps.Active versus passive transport .Na+/ K+ ATPases.Magnesium dependent biomolecules.Kinases.ATP-pumps.Catalytic RNA and Magnesium.Magnesium in chlorophyll.Calcium dependent biomolecules.Calmodulins and triggering.Biochemistry of nitrogen oxides, nitroxyl, and peroxynitrite ion.
- Chapter 6: Iron Containing Proteins and Enzymes.Iron-containing proteins with porphyrin ligand systems.Hemoglobin and Myoglobin (first edition material somewhat condensed).Cytochrome P-450: a monooxygenase.Iron-containing cytochromes in photosynthesis.Green plant cytochromes.Cytochrome bc559.Cytochrome bf.Bacterial cytochromes.Cytochrome c2.Cytochrome bc1.Iron-containing cytochromes in the respiratory pathway.Cytochrome c.Cytochrome c oxidase.Non-Heme Iron-containing proteins.MMO-Methane Monooxygenase.Catechol dioxygenases.Iron-oxo clusters.Transferrin for metal transport .Ferritin for metal storage.Hemerythrin.Purple acid phosphatase.Iron-sulfur cluster proteins.Rubredoxin.Ferrodoxins.Aconitase.
- Chapter 7: Enzymes containing zinc, nickel, and enzymes with multiple metal cofactors.Zinc homeostasis, transport, and storage.Zinc Enzymes.Alkaline phosphatase.Alcohol dehydrogenase.Aspartate transcarbamoylase.Carbonic anhydrase.Carboxypeptidase A and B.Zinc Fingers.Nickel Enzymes.Urease.F430.Enzymes with multiple metal cofactors.Hydrogenases.Carbon monoxide dehydrogenases.
- Chapter 8 Disease, Disease Diagnosis and Treatment Utilizing Inorganic Species.Metal Transport and Metallochaperones.Disease States.Metal deficiency.Metal toxicity.Copper toxicity.FALS.Wilson and Menkes diseases.Disease Diagnosis.Technetium Imaging Agents.Gadolinium MRI Imaging Agents.Quantum Dots for In vivo Imaging.Metals in Medicine.Manganese superoxide mimetics.Vanadium-based Diabetes Drugs.Platinum-containing Anticancer Agents.Nanomedicine.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
SAL3 (off-campus storage)
SAL3 (off-campus storage) | Status |
---|---|
Stacks | Request (opens in new tab) |
QP531 .R63 2007 | Available |
2. Bioinorganic chemistry : a short course [2007]
- Roat-Malone, Rosette M.
- 2nd ed. - Hoboken, N.J. : Wiley-Interscience, c2007.
- Description
- Book — computer files (xix, 501 pages, [16] pages of plates : illustrations (some color) ; 24 cm)
- Summary
-
- ch.
- 1. Inorganic chemistry essentials
- ch.
- 2. Biochemistry fundamentals
- ch.
- 3. Instrumental methods
- ch.
- 4. Computer hardware, software, and computational chemistry methods
- ch. 5 Group I and II metals in biological systems : homeostasis and group I biomolecules
- ch.
- 6. Group I and II metals in biological systems : group II
- ch.
- 7. Iron-containing proteins and enzymes.
- Online
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Lane Library catalog for status | |
WILEY | Unknown |
3. Bioinorganic chemistry : a short course [2002]
- Roat-Malone, Rosette M.
- Hoboken, N.J. : Wiley, c2002.
- Description
- Book — xvii, 348 p. : ill. ; 22 cm.
- Summary
-
- Preface.Acknowledgments.1 Inorganic Chemistry Essentials.1.1 Introduction.1.2 Essential Chemical Elements.1.3 Metals in Biological Systems: A Survey.1.4 Inorganic Chemistry Basics.1.5 Biological Metal Ion Complexation.1.5.1 Thermodynamics.1.5.2 Kinetics.1.6 Electronic and Geometric Structures of Metals in Biological Systems.1.7 Bioorganometallic Chemistry.1.8 Electron Transfer.1.9 Conclusions.References.2 Biochemistry Fundamentals.2.1 Introduction.2.2 Proteins.2.2.1 Amino Acid Building Blocks.2.2.2 Protein Structure.2.2.3 Protein Sequencing and Proteomics.2.2.4 Protein Function, Enzymes, and Enzyme Kinetics.2.3 Nucleic Acids.2.3.1 DNA and RNA Building Blocks.2.3.2 DNA and RNA Molecular Structures.2.3.3 Transmission of Genetic Information.2.3.4 Genetic Mutations and Site-Directed Mutagenesis.2.3.5 Genes and Cloning.2.3.6 Genomics and the Human Genome.2.4 Zinc-Finger Proteins.2.4.1 Descriptive Examples.2.5 Conclusions.References.3 Instrumental and Computer-Based Methods.3.1 Introduction.3.1.1 Analytical Instrument-Based Methods.3.1.2 Spectroscopy.3.2 X-Ray Absorption Spectroscopy (XAS) and Extended X-Ray Absorption Fine Structure (EXAFS).3.2.1 Theoretical Aspects and Hardware.3.2.2 Descriptive Examples.3.3 X-Ray Crystallography.3.3.1 Introduction.3.3.2 Crystallization and Crystal Habits.3.3.3 Theory and Hardware.3.3.4 Descriptive Examples.3.4 Electron Paramagnetic Resonance.3.4.1 Theory and Determination of g-Values.3.4.2 Hyperfine and Superhyperfine Interactions.3.4.3 Descriptive Examples.3.5 Nuclear Magnetic Resonance.3.5.1 Theoretical Aspects.3.5.2 Nuclear Screening and the Chemical Shift.3.5.3 Spin-Spin Coupling.3.5.4 Techniques of Spectral Integration and Spin-Spin Decoupling.3.5.5 Nuclear Magnetic Relaxation.3.5.6 The Nuclear Overhauser Effect (NOE).3.5.7 Obtaining the NMR Spectrum.3.5.8 Two-Dimensional (2D) NMR Spectroscopy.3.5.9 Two-Dimensional Correlation Spectroscopy (COSY).3.5.10 Nuclear Overhauser Effect Spectroscopy (NOESY).3.5.11 Descriptive Examples.3.6 Mo ssbauer Spectroscopy.3.6.1 Theoretical Aspects.3.6.2 Quadrupole Splitting and the Isomer Shift.3.6.3 Magnetic Hyperfine Interactions.3.6.4 Descriptive Examples.3.7 Other Instrumental Methods.3.7.1 Atomic Force Microscopy.3.7.2 Fast and Time-Resolved Methods.3.7.2.1 Stopped-Flow Kinetic Methods.3.7.2.2 Flash Photolysis.3.7.2.3 Time-Resolved Crystallography.3.8 Introduction to Computer-Based Methods.3.9 Computer Hardware.3.10 Molecular Modeling and Molecular Mechanics.3.10.1 Introduction to MM.3.10.2 Molecular Modeling, Molecular Mechanics, and Molecular Dynamics.3.10.3 Biomolecule Modeling.3.10.4 Molecular Modeling Descriptive Examples.3.11 Quantum Mechanics-Based Computational Methods.3.11.1 Introduction.3.11.2 Ab-Initio Methods.3.11.3 Density Function Theory.3.11.4 Semiempirical Methods.3.12 Computer Software for Chemistry.3.12.1 Mathematical Software.3.13 World Wide Web Online Resources.3.13.1 Nomenclature and Visualization Resources.3.13.2 Online Societies, Literature, Materials, Equipment Web Servers.3.14 Summary and Conclusions.References.4 Iron-Containing Oxygen Carriers and Their Synthetic Models.4.1 Introduction.4.2 Myoglobin and Hemoglobin Basics.4.3 Structure of the Prosthetic Group.4.4 Analytical Techniques.4.5 Mechanism for Reversible Binding of Dioxygen and Cooperativity of Oxygen Binding.4.6 Behavior of Dioxygen Bound to Metals.4.7 Structure of the Active Site in Myoglobin and Hemoglobin: Comparison to Model Compounds.4.8 Model Compounds.4.8.1 Cobalt-Containing Model Compounds.4.8.2 Iron-Containing Model Compounds.4.9 Binding of CO to Myoglobin, Hemoglobin, and Model Compounds.4.10 Conclusions.References.5 Copper Enzymes.5.1 Introduction, Occurrence, Structure, Function.5.2 Discussion of Specific Enzymes.5.2.1 Azurin.5.2.2 Plastocyanin.5.2.3 Superoxide Dismutase.5.2.4 Hemocyanin.5.3 Model Compounds.5.3.1 Introduction.5.3.2 Type I Copper Enzyme Models.5.3.3 Type II Copper Enzyme Models.5.3.4 Type III Copper Enzyme Models.5.3.4.1 Karlin Group Tridentate Model Compounds.5.3.4.2 Tolman Group Tetradentate Model Compounds.5.3.4.3 Kitajima Group Tetradentate Model Compounds.5.3.4.4 Karlin Group Tetradentate Model Compounds.5.3.5 Summary.5.4 Conclusions.References.6 The Enzyme Nitrogenase.6.1 Introduction.6.2 Detailed Mechanistic Studies.6.3 Iron-Sulfur Clusters.6.4 Fe-Protein Structure.6.5 MoFe-Protein Structure.6.5.1 Overview.6.5.2 Details of the P-Cluster.6.5.3 Details of the M Center.6.6 Nitrogenase Model Compounds.6.6.1 Structural Models.6.6.2 Functional Models.6.7 Conclusions.References.7 Metals in Medicine.7.1 Introduction.7.1.1 Inorganic Medicinal Chemistry.7.1.2 Metal Toxicity and Homeostasis.7.2 Therapeutic Compounds.7.2.1 Superoxide Dismutase Mimics.7.2.2 Vanadium-Based Diabetes Drugs.7.2.2.1 Introduction.7.2.2.2 Examples of Vanadium Compounds Tested as Insulin Mimetic Agents.7.2.2.3 The Role of Chromium.7.2.3 Platinum-Containing Anticancer Agents.7.2.3.1 Cis- and trans-Dichlorodiammineplatinum(II).7.2.3.2 Mechanism of cisDDP Antitumor Activity.7.2.3.3 Drug Resistance and DNA Repair Mechanisms.7.2.3.4 A New Nonclassical Platinum Antitumor Agent.7.2.3.5 Other Platinum-Containing Anticancer Compounds.7.2.3.6 Conclusions.7.3 Diagnostic Agents.7.3.1 Technetium Imaging Agents.7.3.1.1 Introduction.7.3.1.2 "Technetium Essential" Radiopharmaceuticals.7.3.1.3 "Technetium Tagged" Radiopharmaceuticals.7.3.2 Gadolinium MRI Imaging Agents.7.3.2.1 Introduction.7.3.2.2 Magnetic Imaging Considerations, Kinetics, and Thermodynamics of Complexes.7.3.2.3 Selected Drugs in Usage or in Trials.7.4 Metal Transport and Metallochaperones.7.4.1 Introduction.7.4.2 The Atx1 Metallochaperone.7.4.3 Hah1 or Atox1 Metallochaperone.7.4.4 Superoxide Dismutase Metallochaperones.7.4.5 Copper Toxicity, Disease States, and Treatments.7.4.5.1 Familial Amyotrophic Lateral Sclerosis (FALS).7.4.5.2 Wilson and Menkes Diseases.7.4.6 Conclusions.7.5 Metals in Medicine (MIM).7.5.1 Summary, Goals-- Past, Present, and Future MIM Development.References.Index.
- (source: Nielsen Book Data)
(source: Nielsen Book Data)
SAL3 (off-campus storage)
SAL3 (off-campus storage) | Status |
---|---|
Stacks | Request (opens in new tab) |
QP531 .R63 2002 | Available |
4. Bioinorganic chemistry : a short course [2002]
- Roat-Malone, Rosette M.
- Hoboken, N.J. : Wiley, c2002.
- Description
- Book — online resource (xvii, 348 pages) : illustrations ; 22 cm
- Summary
-
- ch.
- 1. Inorganic chemistry essentials
- ch.
- 2. Biochemistry fundamentals
- ch.
- 3. Instrumental and computer-based methods
- ch.
- 4. Iron containing oxygen carriers and their synthetic models
- ch.
- 5. Copper Enzymes
- ch.
- 6. The Enzyme nitrogenase
- ch.
- 7. Metals in medicine.
- Online
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Lane Library catalog for status | |
WILEY | Unknown |
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