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xii, 402 p. : ill. (some col.) ; 28 cm.
  • Part 1 New lead discovery - historical perspectives: past approaches to discovering new drugs-- reflections and perspectives-- strategies for the creation of new drugs - trends in lead identification - a structural approach-- from membrane to genomic pharmacoloy or from short-term to long-term effects-- future applications of oligonucleotides in antiviral and antitumoral chemotherapy. Part 2 Protein structure - function relationships - cloning and structural studies on recepors and enzymes: the impact of molecular biology upon drug reseach - multiple targets provided by the reverse pharmacology-- a structural basis of proteinase-protein inhibitor interation-- detection of new enzymes and receptors by hybridization technique - new approaches to isolation, expression, expression and molecular modelling of proteases-- new era of biochemistry - cytokine signal transduction-- molecular diversity of signal transduction systems - a puzzle for pharmacologists of today and tomorrow. Part 3 Pharmacophore studies_ pharmacophore mimickry modelling - the future of the computer-aided drug design-- pharmacophore identification based on molecular electrostatic potentials (MEPS)-- synthesis of peptido-memetics - rational design of peptidomimetics - structural and pharmacological aspects - nonpeptide legands for peptide receptors-- peptidomimetric researc, design and synthesis-- peptidomimetics as tools for the initiation and analysis of peptide and protein secondary structure-- the prospects for unnatural proteins by design-- optimization - on the future of QSAR-- computer assisted drug designing in the 21st century. Part 4 Bioavailability manipulations - prodrugs: trends in design of prodrugs for improved drug delivery-- drug targeting - antibody based drug targeting approaches - perspectives and challenges-- novel drug delivery systems-- lipid microsphere preparations and lecithinized peptides for drug delivery systems.
  • (source: Nielsen Book Data)9780632034086 20160527
The new Chemistry for the 21st Century series is a collection of specialist monographs which consist of review papers written by scientists of world renown from a variety of countries. Each volume outlines the perspectives of various fields of chemistry in opening up new horizons for science and technology. This new addition to the Series contains contributions from leading scientists selected from the fields of medicinal chemistry and pharmacology and will serve as a guide for professionals to the future direction of medicinal chemical development. Medicinal Chemistry for the 21st Century is divided into four major sections as follows: Part I: New Lead Discovery : Historical perspectives; Strategies for the creation of new drugs Part II: Protein Structure-function relationships : Cloning and structural studies on receptors and enzymes; Detection of new enzymes and receptors by hybridization technique; Signal transduction mechanisms. Part III: Pharmacophore studies : Pharmacophore mimickry modelling; Synthesis of peptido-mimetics; Optimization Part IV: Bioavailability manipulation : Prodrugs; Drug targeting.
(source: Nielsen Book Data)9780632034086 20160527
SAL3 (off-campus storage)
1 online resource (8 volumes) : illustrations (some color)
  • Volume 1: General Perspective - The Future of Drug Discovery Volume 2: Drug Discovery Technologies Volume 3: In Silico Drug Discovery Tools Volume 4: Experimental ADME and Toxicology Volume 5: Cancer, Immunology and Inflammation, and Infectious Disease Volume 6: CNS, Pain, Metabolic Syndrome, Urology, Gastrointestinal and Cardiovascular Volume 7: Biologics Medicine Volume 8: Case Histories in Recent Drug Discovery.
  • (source: Nielsen Book Data)9780128032008 20170724
Comprehensive Medicinal Chemistry III, Third Edition provides a contemporary and forward looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery.
(source: Nielsen Book Data)9780128032008 20170724
xxxi, 877 pages : illustrations (some color) ; 27 cm
  • (source: Nielsen Book Data)9780198749691 20180409
For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market? An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development. The Online Resource Centre features: For students: * Multiple Choice Questions to support self-directed learning * Web articles describing recent developments in the field and further information on topics covered in the book * Journal Club to encourage students to critically analyse the research literature * Molecular Modelling Exercises, with new exercises in Chem3D * New assignments to help students develop data analysis and problem solving skills For registered adopters of the book: * A test bank of additional multiple-choice questions, with links to relevant sections in the book * Answers to end-of-chapter questions. * Figures from the book, ready to download. * Power Point slides to accompany every chapter in the book.
(source: Nielsen Book Data)9780198749691 20180409
Science Library (Li and Ma)
1 online resource (361 pages) : illustrations, tables
Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.
(source: Nielsen Book Data)9783110468755 20170502
1 online resource (252 pages) : illustrations
xii, 270 pages : illustrations (some color) ; 25 cm
  • States of matter related to pharmacuetical formulations / Beverly J. Sandmann, Ann Newman, and Gregory T. Knipp
  • Physical properties of solutions / Beverly Sandmann, Antoine Al-Achi, Robert Greenwood
  • Ionic equilibrium and buffers / Beverly Sandmann, Alekha K. Dash, Antoine Al-Achi, Robert Greenwood
  • Solubility, dissolution, and partitioning/ Beverly J. Sandmann and Mansoor M. Amiji
  • Mass transport / Mansoor M. Amiji
  • Complexation and protein binding / Mansoor M. Amiji
  • Dispersed systems / W. Cary Mobley
  • Interfacial phenomena / Maria Polikandritou Lambros and SHihong Li Nocolaou
  • Rheology / Maria Polikandritou Lambros
  • Chemical kinetics of pharmaceuticals / Thomas J. Cook.
This is a unique practice-oriented introduction to physical pharmacy. Applied Physical Pharmacy explores the fundamental physicochemical properties and processes important for understanding how drugs are transformed into usable and stable drug products that release their drug upon administration, and for understanding the different processes that the released drug may encounter on its way to its pharmacological target prior to being eliminated by the body. Applied Physical Pharmacy begins with a review of key biopharmaceutics concepts of drug liberation, absorption, distribution, metabolism, and excretion. These concepts, which describe the fate of the drug in the body, set the framework for subsequent chapters that describe physicochemical properties and processes such as states of matter, solutions, ionization, dissolution and partitioning, mass transport, complexation, and protein binding. Concepts in these chapters are important for not only understanding a drug's fate in the body, but also for providing a scientific basis for rational drug formulation and usage. Other physical pharmacy topics important to drug formulation are discussed in the chapters that follow, which describe dispersed systems, rheology, and interfacial phenomena. The book concludes with an overview of the principles of kinetics that are essential to understanding the rates at which many of the processes discussed in previous chapters occur. To facilitate learning, chapters are enhanced by Learning Objectives, Key Points, Problems, and Clinical Questions. To make the book as relevant to real-world practice as possible, this edition includes an increased number of clinical examples and applications.
(source: Nielsen Book Data)9780071747509 20160617
Science Library (Li and Ma)
xxiii, 789 p. : col. ill. ; 27 cm.
  • 1. Drugs and drug targets - an overview -- PART A DRUG TARGETS- STRUCTURE AND FUNCTION -- 2. Protein structure and function -- 3. Enzymes: structure and function -- 4. Receptors: structure and function -- 5. Receptors and signal transduction -- 6. Nucleic acids: structure and function -- PART B PHARMACODYNAMICS AND PHARMACOKINETICS -- 7. Enzymes as drug targets -- 8. Receptors as drug targets -- 9. Nucleic acids as drug targets -- 10. Miscellaneous drug targets -- 11. Pharmacokinetics and related topics -- Case study 1: Statins -- PART C DRUG DISCOVERY, DESIGN, AND DEVELOPMENT -- 12. Drug discovery: finding a lead -- 13. Drug design: optimizing target interactions -- 14. Drug design: optimizing access to the target -- 15. Getting the drug to market -- Case study 2: The design of ACE inhibitors -- Case study 3: Artemisinin and related antimalarial drugs -- Case study 4 : The design of oxamniquine -- PART D TOOLS OF THE TRADE -- 16. Combinatorial synthesis -- 17. Computers in medicinal chemistry -- 18. Quantitative structure-activity relationships (QSAR) -- Case study 5: De novo design of a thymidylate synthase inhibitor -- PART E SELECTED TOPICS IN MEDICINAL CHEMISTRY -- 19. Antibacterial agents -- 20. Antiviral agents -- 21. Anticancer agents -- 22. Cholinergics, anticholinergics, and anticholinesterases -- 23. Drugs acting on the adrenergic nervous system -- 24. Opioid analgesics -- 25. Antiulcer agents -- Case study 6: Steroidal anti-inflammatory agents -- Case Study 7: Design of a novel antidepressant -- APPENDICES.
  • (source: Nielsen Book Data)9780199697397 20160610
An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents. Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Multiple Choice Questions * Web articles * Molecular Modelling Exercises * 3D Rotatable structures.
(source: Nielsen Book Data)9780199697397 20160610
SAL3 (off-campus storage)
xi, 353 pages : illustrations (chiefly colour) ; 27 cm.
  • 1. The importance of pharmaceutical chemistry -- 2. Organic structure and bonding -- 3. Stereochemistry and drug action -- 4. Properties of aliphatic hydrocarbons -- 5. Alcohols, phenols, ethers, organic halogen compounds, and amines -- 6. The carbonyl group and its chemistry -- 7. Introduction to aromatic chemistry -- 8. Inorganic chemistry in pharmacy -- 9. The chemistry of biologically important macromolecules -- 10. Origins of drug molecules -- 11. Introduction to pharmaceutical analysis -- 12. The molecular characteristics of good drugs.
  • (source: Nielsen Book Data)9780199655304 20160612
Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as applied to the study and practice of pharmacy. Drugs are simply chemicals, so to fully understand their manufacture, formulation, and the way they work in our bodies, an understanding of organic compounds and their reactions is essential. Online Resource Centre The Online Resource Centre to accompany Pharmaceutical Chemistry features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter. - Related addtional resources.
(source: Nielsen Book Data)9780199655304 20160612
Science Library (Li and Ma)
xi, 273 pages : color illustrations ; 27 cm.
  • 1. Introduction to pharmaceutics -- 2. Solids -- 3. Liquids -- 4. Gases -- 5. Thermodynamics -- 6. Acids and bases -- 7. Phase equilibria and transitions -- 8. Partitioning and hydrophobicity -- 9. Surface phenomena -- 10. Disperse systems -- 11. Colligative properties -- 12. Kinetics and drug stability -- 13. Drug development and delivery.
  • (source: Nielsen Book Data)9780199655311 20160612
Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutics: The science of medicine design explores the different forms that medicines can take, and demonstrates how being able to select the best form - be it a tablet, injectable liquid, or an inhaled gas - requires an understanding of how chemicals behave in different physical states. Online Resource Centre The Online Resource Centre to accompany Pharmaceutics: the science of medicine design features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter.
(source: Nielsen Book Data)9780199655311 20160612
Science Library (Li and Ma)
1 online resource.
  • INTRODUCTION TO SCAFFOLD HOPPING Identifying and representing scaffolds Markush structures and chemical patents Diversity of scaffolds from natural products Scaffold diversity in medicinal chemistry space Exploring virtual scaffold spaces TOPOLOGICAL METHODS FOR SCAFFOLD HOPPING CATS vectors Reduced graphs Feature trees (FTrees) Extended connectivity fingerprints (ECFP) Maximum common substructure determination in MedChem Studio SHAPE-BASED METHODS FOR SCAFFOLD HOPPING Radial distribution function codes Rapid overlay of chemical structures (ROCS) FEPOPS ParaFit XED Forcefields and Fieldstere Ultrafast shape recognition (USR) PHARMACOPHORE AND STRUCTURE-BASED METHODS SkelGen Molecular interaction fingerprints ReCore SHOP SCAFFOLD HOPPING CASE STUDIES JAK2 inhibitors mGluR5 inhibitors Phosphatase inhibitors.
  • (source: Nielsen Book Data)9783527665174 20160612
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following parts contain a general description as well as case studies of the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
(source: Nielsen Book Data)9783527665174 20160612
xviii, 237 p. : ill.
  • List of Contributors XI Preface XV A Personal Foreword XVII Part One Principles 1 1 Bioisosterism in Medicinal Chemistry 3 Nathan Brown 1.1 Introduction 3 1.2 Isosterism 3 1.3 Bioisosterism 6 1.4 Bioisosterism in Lead Optimization 9 1.5 Conclusions 13 References 14 2 Classical Bioisosteres 15 Caterina Barillari and Nathan Brown 2.1 Introduction 15 2.2 Historical Background 15 2.3 Classical Bioisosteres 17 2.4 Nonclassical Bioisosteres 20 2.5 Summary 27 References 27 3 Consequences of Bioisosteric Replacement 31 Dennis A. Smith and David S. Millan 3.1 Introduction 31 3.2 Bioisosteric Groupings to Improve Permeability 32 3.3 Bioisosteric Groupings to Lower Intrinsic Clearance 40 3.4 Bioisosteric Groupings to Improve Target Potency 43 3.5 Conclusions and Future Perspectives 47 References 49 Part Two Data 53 4 BIOSTER: A Database of Bioisosteres and Bioanalogues 55 Istvan Ujvary and Julian Hayward 4.1 Introduction 55 4.2 Historical Overview and the Development of BIOSTER 56 4.3 Description of BIOSTER Database 59 4.4 Examples 64 4.5 Applications 69 4.6 Summary 70 4.7 Appendix 70 References 71 5 Mining the Cambridge Structural Database for Bioisosteres 75 Colin R. Groom, Tjelvar S. G. Olsson, John W. Liebeschuetz, David A. Bardwell, Ian J. Bruno, and Frank H. Allen 5.1 Introduction 75 5.2 The Cambridge Structural Database 76 5.3 The Cambridge Structural Database System 78 5.4 The Relevance of the CSD to Drug Discovery 83 5.5 Assessing Bioisosteres: Conformational Aspects 84 5.6 Assessing Bioisosteres: Nonbonded Interactions 86 5.7 Finding Bioisosteres in the CSD: Scaffold Hopping and Fragment Linking 91 5.8 A Case Study: Bioisosterism of 1H-Tetrazole and Carboxylic Acid Groups 94 5.9 Conclusions 97 References 98 6 Mining for Context-Sensitive Bioisosteric Replacements in Large Chemical Databases 103 George Papadatos, Michael J. Bodkin, Valerie J. Gillet, and Peter Willett 6.1 Introduction 103 6.2 Definitions 104 6.3 Background 105 6.4 Materials and Methods 109 6.5 Results and Discussion 113 6.6 Conclusions 124 References 125 Part Three Methods 129 7 Physicochemical Properties 131 Peter Ertl 7.1 Introduction 131 7.2 Methods to Identify Bioisosteric Analogues 132 7.3 Descriptors to Characterize Properties of Substituents and Spacers 132 7.4 Classical Methods for Navigation in the Substituent Space 135 7.5 Tools to Identify Bioisosteric Groups Based on Similarity in Their Properties 136 7.6 Conclusions 138 References 138 8 Molecular Topology 141 Nathan Brown 8.1 Introduction 141 8.2 Controlled Fuzziness 141 8.3 Graph Theory 142 8.4 Data Mining 144 8.5 Topological Pharmacophores 146 8.6 Reduced Graphs 149 8.7 Summary 151 References 152 9 Molecular Shape 155 Pedro J. Ballester and Nathan Brown 9.1 Methods 156 9.2 Applications 161 9.3 Future Prospects 164 References 165 10 Protein Structure 167 James E. J. Mills 10.1 Introduction 167 10.2 Database of Ligand-Protein Complexes 168 10.3 Generation of Ideas for Bioisosteres 173 10.4 Context-Specific Bioisostere Generation 177 10.5 Using Structure to Understand Common Bioisosteric Replacements 178 10.6 Conclusions 180 References 180 Part Four Applications 183 11 The Drug Guru Project 185 Kent D. Stewart, Jason Shanley, Karam B. Alsayyed Ahmed, and J. Phillip Bowen 11.1 Introduction 185 11.2 Implementation of Drug Guru 187 11.3 Bioisosteres 188 11.4 Application of Drug Guru 194 11.5 Quantitative Assessment of Drug Guru Transformations 195 11.6 Related Work 197 11.7 Summary: The Abbott Experience with the Drug Guru Project 197 References 198 12 Bioisosteres of an NPY-Y5 Antagonist 199 Nicholas P. Barton and Benjamin R. Bellenie 12.1 Introduction 199 12.2 Background 199 12.3 Potential Bioisostere Approaches 201 12.4 Template Molecule Preparation 204 12.5 Database Molecule Preparation 206 12.6 Alignment and Scoring 206 12.7 Results and Monomer Selection 207 12.8 Synthesis and Screening 208 12.9 Discussion 209 12.10 SAR and Developability Optimization 211 12.11 Summary and Conclusion 214 References 214 13 Perspectives from Medicinal Chemistry 217 Nicholas A. Meanwell, Marcus Gastreich, Matthias Rarey, Mike Devereux, Paul L.A. Popelier, Gisbert Schneider, and Peter Willett 13.1 Introduction 217 13.2 Pragmatic Bioisostere Replacement in Medicinal Chemistry: A Software Maker's Viewpoint 219 13.3 The Role of Quantum Chemistry in Bioisostere Prediction 221 13.4 Learn from "Naturally Drug-Like" Compounds 223 13.5 Bioisosterism at the University of Sheffield 224 References 227 Index 231.
  • (source: Nielsen Book Data)9783527654338 20160608
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
(source: Nielsen Book Data)9783527654338 20160608
xviii, 237 p. : ill.
  • pt. 1. Principles
  • pt. 2. Data
  • pt. 3. Methods
  • pt. 4. Applications.
xii, 164 p. : ill.
1 online resource (xv, 282 p.) : ill.
  • Preface Efavirenz(R), a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate CCR5 Receptor Antagonist 5a-Reductase Inhibitors - The Finasteride Story Rizatriptan (Maxalt(R)): A 5-HT1D Receptor Agonist SERM: Selective Estrogen Receptor Modulator HIV Integrase Inhibitor: Raltegravir Cyclopentane-Based NK1 Receptor Antagonist Glucokinase Activator CB1R Inverse Agonist - Taranabant.
  • (source: Nielsen Book Data)9783527324705 20160605
Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.
(source: Nielsen Book Data)9783527324705 20160605
xxx, 718 p. : ill.
xxii, 752 p. : ill. (some col.) ; 27 cm.
  • 1. Drugs and drug targets: an overview-- PART A: DRUG TARGETS: STRUCTURE AND FUNCTION-- 2. Protein structure and function-- 3. Enzymes: structure and function-- 4. Receptors: structure and function-- 5. Receptors and signal transduction-- 6. Nucleic acids: structure and function-- PART B: PHARMACODYNAMICS AND PHARMACOKINETICS-- 7. Enzymes as drug targets-- 8. Receptors as drug targets-- 9. Nucleic acids as drug targets-- 10. Other drug targets-- 11. Pharmacokinetics and related topics-- CASE STUDY 1: STATINS-- PART C: DRUG DISCOVERY, DESIGN, AND DEVELOPMENT-- 12. Drug discovery: finding a lead-- 13. Drug design: optimizing target interactions-- 14. Drug design: optimizing access to the target-- 15. Getting the drug to market-- CASE STUDY 2: THE DESIGN OF ACE INHIBITORS-- CASE STUDY 3: ARTEMISININ AND RELATED ANTIMALARIAL DRUGS-- CASE STUDY 4: THE DESIGN OF OXAMNIQUINE-- PART D: TOOLS OF THE TRADE-- 16. Combinatorial synthesis-- 17. Computers in medicinal chemistry-- 18. Quantitative structure-activity relationships (QSAR)-- CASE STUDY 5: DE NOVO DESIGN OF A THYMIDYLATE SYNTHASE INHIBITOR-- CASE STUDY 6: DESIGN OF A SEROTONIN ANTAGONIST AS A POSSIBLE ANXIOLYTIC AGENT-- PART E: SELECTED TOPICS IN MEDICINAL CHEMISTRY-- 19. Antibacterial agents-- 20. Antiviral agents-- 21. Anticancer agents-- 22. Cholinergics, anticholinergics, and anticholinesterases-- 23. Drugs acting on the adrenergic nervous system-- 24. The opium analgesics-- 25. Anti-ulcer agents-- CASE STUDY 7: DESIGN OF A NOVEL ANTIDEPRESSANT.
  • (source: Nielsen Book Data)9780199234479 20160528
The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very accessible to students. Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitors to painkillers. The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques. An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses.With enhanced attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading. Online Resource Centre The Online Resource Centre features: For registered adoptors of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Hyperlinked bibliography * Six-monthly updates to text * 3D Rotatable structures.
(source: Nielsen Book Data)9780199234479 20160528
SAL3 (off-campus storage)
x, 278 p. : ill. (some col.).
  • Folate biosynthesis : reappraisal of old and novel targets in the search for new antimicrobials / James Swarbrick ... [et al.]
  • Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol and Isabel Sánchez
  • Cytotoxic anticancer drugs from medicinal plants / Anh-Tho Nguyen and Pierre Duez
  • Emerging applications of quantum dots in medicinal chemistry and drug development / Ian D. Tomlinson, Michael R. Warnement and Sandra J. Rosenthal
  • Medicinal chemistry of copper and vanadium bioactive compounds / Susana B. Etcheverry and Patricia A.M. Williams
  • Antimalarial peroxides : from artemisinin to synthetic peroxides / Jernej Iskra
  • Chemical ecology and medicinal chemistry of marine NF-kB inhibitors / F. Folmer ... [et al.]
  • Layered double hydroxides and their intercalation compounds in photo-chemistry and in medicinal chemistry / Umberto Costantino and Morena Nocchetti.
xiii, 882 p. : ill.
xiii, 882 p. : ill.


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