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xii, 402 p. : ill. (some col.) ; 28 cm.
  • Part 1 New lead discovery - historical perspectives: past approaches to discovering new drugs-- reflections and perspectives-- strategies for the creation of new drugs - trends in lead identification - a structural approach-- from membrane to genomic pharmacoloy or from short-term to long-term effects-- future applications of oligonucleotides in antiviral and antitumoral chemotherapy. Part 2 Protein structure - function relationships - cloning and structural studies on recepors and enzymes: the impact of molecular biology upon drug reseach - multiple targets provided by the reverse pharmacology-- a structural basis of proteinase-protein inhibitor interation-- detection of new enzymes and receptors by hybridization technique - new approaches to isolation, expression, expression and molecular modelling of proteases-- new era of biochemistry - cytokine signal transduction-- molecular diversity of signal transduction systems - a puzzle for pharmacologists of today and tomorrow. Part 3 Pharmacophore studies_ pharmacophore mimickry modelling - the future of the computer-aided drug design-- pharmacophore identification based on molecular electrostatic potentials (MEPS)-- synthesis of peptido-memetics - rational design of peptidomimetics - structural and pharmacological aspects - nonpeptide legands for peptide receptors-- peptidomimetric researc, design and synthesis-- peptidomimetics as tools for the initiation and analysis of peptide and protein secondary structure-- the prospects for unnatural proteins by design-- optimization - on the future of QSAR-- computer assisted drug designing in the 21st century. Part 4 Bioavailability manipulations - prodrugs: trends in design of prodrugs for improved drug delivery-- drug targeting - antibody based drug targeting approaches - perspectives and challenges-- novel drug delivery systems-- lipid microsphere preparations and lecithinized peptides for drug delivery systems.
  • (source: Nielsen Book Data)9780632034086 20160527
The new Chemistry for the 21st Century series is a collection of specialist monographs which consist of review papers written by scientists of world renown from a variety of countries. Each volume outlines the perspectives of various fields of chemistry in opening up new horizons for science and technology. This new addition to the Series contains contributions from leading scientists selected from the fields of medicinal chemistry and pharmacology and will serve as a guide for professionals to the future direction of medicinal chemical development. Medicinal Chemistry for the 21st Century is divided into four major sections as follows: Part I: New Lead Discovery : Historical perspectives; Strategies for the creation of new drugs Part II: Protein Structure-function relationships : Cloning and structural studies on receptors and enzymes; Detection of new enzymes and receptors by hybridization technique; Signal transduction mechanisms. Part III: Pharmacophore studies : Pharmacophore mimickry modelling; Synthesis of peptido-mimetics; Optimization Part IV: Bioavailability manipulation : Prodrugs; Drug targeting.
(source: Nielsen Book Data)9780632034086 20160527
SAL3 (off-campus storage)
1 online resource (8 volumes) : illustrations (some color)
  • Volume 1: General Perspective - The Future of Drug Discovery Volume 2: Drug Discovery Technologies Volume 3: In Silico Drug Discovery Tools Volume 4: Experimental ADME and Toxicology Volume 5: Cancer, Immunology and Inflammation, and Infectious Disease Volume 6: CNS, Pain, Metabolic Syndrome, Urology, Gastrointestinal and Cardiovascular Volume 7: Biologics Medicine Volume 8: Case Histories in Recent Drug Discovery.
  • (source: Nielsen Book Data)9780128032008 20170724
Comprehensive Medicinal Chemistry III, Third Edition provides a contemporary and forward looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery.
(source: Nielsen Book Data)9780128032008 20170724
1 online resource (361 pages) : illustrations, tables
Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.
(source: Nielsen Book Data)9783110468755 20170502
1 online resource (252 pages) : illustrations
xii, 270 pages : illustrations (some color) ; 25 cm
  • States of matter related to pharmacuetical formulations / Beverly J. Sandmann, Ann Newman, and Gregory T. Knipp
  • Physical properties of solutions / Beverly Sandmann, Antoine Al-Achi, Robert Greenwood
  • Ionic equilibrium and buffers / Beverly Sandmann, Alekha K. Dash, Antoine Al-Achi, Robert Greenwood
  • Solubility, dissolution, and partitioning/ Beverly J. Sandmann and Mansoor M. Amiji
  • Mass transport / Mansoor M. Amiji
  • Complexation and protein binding / Mansoor M. Amiji
  • Dispersed systems / W. Cary Mobley
  • Interfacial phenomena / Maria Polikandritou Lambros and SHihong Li Nocolaou
  • Rheology / Maria Polikandritou Lambros
  • Chemical kinetics of pharmaceuticals / Thomas J. Cook.
This is a unique practice-oriented introduction to physical pharmacy. Applied Physical Pharmacy explores the fundamental physicochemical properties and processes important for understanding how drugs are transformed into usable and stable drug products that release their drug upon administration, and for understanding the different processes that the released drug may encounter on its way to its pharmacological target prior to being eliminated by the body. Applied Physical Pharmacy begins with a review of key biopharmaceutics concepts of drug liberation, absorption, distribution, metabolism, and excretion. These concepts, which describe the fate of the drug in the body, set the framework for subsequent chapters that describe physicochemical properties and processes such as states of matter, solutions, ionization, dissolution and partitioning, mass transport, complexation, and protein binding. Concepts in these chapters are important for not only understanding a drug's fate in the body, but also for providing a scientific basis for rational drug formulation and usage. Other physical pharmacy topics important to drug formulation are discussed in the chapters that follow, which describe dispersed systems, rheology, and interfacial phenomena. The book concludes with an overview of the principles of kinetics that are essential to understanding the rates at which many of the processes discussed in previous chapters occur. To facilitate learning, chapters are enhanced by Learning Objectives, Key Points, Problems, and Clinical Questions. To make the book as relevant to real-world practice as possible, this edition includes an increased number of clinical examples and applications.
(source: Nielsen Book Data)9780071747509 20160617
Science Library (Li and Ma)
xxiii, 789 p. : col. ill. ; 27 cm.
  • 1. Drugs and drug targets - an overview -- PART A DRUG TARGETS- STRUCTURE AND FUNCTION -- 2. Protein structure and function -- 3. Enzymes: structure and function -- 4. Receptors: structure and function -- 5. Receptors and signal transduction -- 6. Nucleic acids: structure and function -- PART B PHARMACODYNAMICS AND PHARMACOKINETICS -- 7. Enzymes as drug targets -- 8. Receptors as drug targets -- 9. Nucleic acids as drug targets -- 10. Miscellaneous drug targets -- 11. Pharmacokinetics and related topics -- Case study 1: Statins -- PART C DRUG DISCOVERY, DESIGN, AND DEVELOPMENT -- 12. Drug discovery: finding a lead -- 13. Drug design: optimizing target interactions -- 14. Drug design: optimizing access to the target -- 15. Getting the drug to market -- Case study 2: The design of ACE inhibitors -- Case study 3: Artemisinin and related antimalarial drugs -- Case study 4 : The design of oxamniquine -- PART D TOOLS OF THE TRADE -- 16. Combinatorial synthesis -- 17. Computers in medicinal chemistry -- 18. Quantitative structure-activity relationships (QSAR) -- Case study 5: De novo design of a thymidylate synthase inhibitor -- PART E SELECTED TOPICS IN MEDICINAL CHEMISTRY -- 19. Antibacterial agents -- 20. Antiviral agents -- 21. Anticancer agents -- 22. Cholinergics, anticholinergics, and anticholinesterases -- 23. Drugs acting on the adrenergic nervous system -- 24. Opioid analgesics -- 25. Antiulcer agents -- Case study 6: Steroidal anti-inflammatory agents -- Case Study 7: Design of a novel antidepressant -- APPENDICES.
  • (source: Nielsen Book Data)9780199697397 20160610
An Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents. Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Multiple Choice Questions * Web articles * Molecular Modelling Exercises * 3D Rotatable structures.
(source: Nielsen Book Data)9780199697397 20160610
Science Library (Li and Ma)
xi, 353 pages : illustrations (chiefly colour) ; 27 cm.
  • 1. The importance of pharmaceutical chemistry -- 2. Organic structure and bonding -- 3. Stereochemistry and drug action -- 4. Properties of aliphatic hydrocarbons -- 5. Alcohols, phenols, ethers, organic halogen compounds, and amines -- 6. The carbonyl group and its chemistry -- 7. Introduction to aromatic chemistry -- 8. Inorganic chemistry in pharmacy -- 9. The chemistry of biologically important macromolecules -- 10. Origins of drug molecules -- 11. Introduction to pharmaceutical analysis -- 12. The molecular characteristics of good drugs.
  • (source: Nielsen Book Data)9780199655304 20160612
Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutical Chemistry provides a wide-ranging overview of organic chemistry as applied to the study and practice of pharmacy. Drugs are simply chemicals, so to fully understand their manufacture, formulation, and the way they work in our bodies, an understanding of organic compounds and their reactions is essential. Online Resource Centre The Online Resource Centre to accompany Pharmaceutical Chemistry features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter. - Related addtional resources.
(source: Nielsen Book Data)9780199655304 20160612
Science Library (Li and Ma)
xi, 273 pages : color illustrations ; 27 cm.
  • 1. Introduction to pharmaceutics -- 2. Solids -- 3. Liquids -- 4. Gases -- 5. Thermodynamics -- 6. Acids and bases -- 7. Phase equilibria and transitions -- 8. Partitioning and hydrophobicity -- 9. Surface phenomena -- 10. Disperse systems -- 11. Colligative properties -- 12. Kinetics and drug stability -- 13. Drug development and delivery.
  • (source: Nielsen Book Data)9780199655311 20160612
Taking medication is a common occurrence for many people, whether it is to soothe an aching head, regulate blood sugars, or to treat life threatening conditions, such as HIV or cancer. In the UK alone, over 900 million prescriptions are dispensed every year. Overseeing all of this are pharmacists: experts in medicines and their use. The Integrated Foundations of Pharmacy series supports those who are at the beginning of their journey to become a pharmacist. The reader will begin to understand how a drug molecule is made; the process that turns it into a medicine; the role the pharmacist has when dispensing that medicine; and what happens in the body when it is taken. Most importantly, the series shows how each of these aspects are integrated, reflecting the most up-to-date teaching practices. Pharmaceutics: The science of medicine design explores the different forms that medicines can take, and demonstrates how being able to select the best form - be it a tablet, injectable liquid, or an inhaled gas - requires an understanding of how chemicals behave in different physical states. Online Resource Centre The Online Resource Centre to accompany Pharmaceutics: the science of medicine design features: For registered adopters of the book: - Figures from the book, available to download. For students: - Self-assessment questions to help the reader to check and reinforce understanding of the material introduced in each chapter.
(source: Nielsen Book Data)9780199655311 20160612
Science Library (Li and Ma)
1 online resource.
  • INTRODUCTION TO SCAFFOLD HOPPING Identifying and representing scaffolds Markush structures and chemical patents Diversity of scaffolds from natural products Scaffold diversity in medicinal chemistry space Exploring virtual scaffold spaces TOPOLOGICAL METHODS FOR SCAFFOLD HOPPING CATS vectors Reduced graphs Feature trees (FTrees) Extended connectivity fingerprints (ECFP) Maximum common substructure determination in MedChem Studio SHAPE-BASED METHODS FOR SCAFFOLD HOPPING Radial distribution function codes Rapid overlay of chemical structures (ROCS) FEPOPS ParaFit XED Forcefields and Fieldstere Ultrafast shape recognition (USR) PHARMACOPHORE AND STRUCTURE-BASED METHODS SkelGen Molecular interaction fingerprints ReCore SHOP SCAFFOLD HOPPING CASE STUDIES JAK2 inhibitors mGluR5 inhibitors Phosphatase inhibitors.
  • (source: Nielsen Book Data)9783527665174 20160612
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following parts contain a general description as well as case studies of the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
(source: Nielsen Book Data)9783527665174 20160612
xviii, 237 p. : ill.
  • List of Contributors XI Preface XV A Personal Foreword XVII Part One Principles 1 1 Bioisosterism in Medicinal Chemistry 3 Nathan Brown 1.1 Introduction 3 1.2 Isosterism 3 1.3 Bioisosterism 6 1.4 Bioisosterism in Lead Optimization 9 1.5 Conclusions 13 References 14 2 Classical Bioisosteres 15 Caterina Barillari and Nathan Brown 2.1 Introduction 15 2.2 Historical Background 15 2.3 Classical Bioisosteres 17 2.4 Nonclassical Bioisosteres 20 2.5 Summary 27 References 27 3 Consequences of Bioisosteric Replacement 31 Dennis A. Smith and David S. Millan 3.1 Introduction 31 3.2 Bioisosteric Groupings to Improve Permeability 32 3.3 Bioisosteric Groupings to Lower Intrinsic Clearance 40 3.4 Bioisosteric Groupings to Improve Target Potency 43 3.5 Conclusions and Future Perspectives 47 References 49 Part Two Data 53 4 BIOSTER: A Database of Bioisosteres and Bioanalogues 55 Istvan Ujvary and Julian Hayward 4.1 Introduction 55 4.2 Historical Overview and the Development of BIOSTER 56 4.3 Description of BIOSTER Database 59 4.4 Examples 64 4.5 Applications 69 4.6 Summary 70 4.7 Appendix 70 References 71 5 Mining the Cambridge Structural Database for Bioisosteres 75 Colin R. Groom, Tjelvar S. G. Olsson, John W. Liebeschuetz, David A. Bardwell, Ian J. Bruno, and Frank H. Allen 5.1 Introduction 75 5.2 The Cambridge Structural Database 76 5.3 The Cambridge Structural Database System 78 5.4 The Relevance of the CSD to Drug Discovery 83 5.5 Assessing Bioisosteres: Conformational Aspects 84 5.6 Assessing Bioisosteres: Nonbonded Interactions 86 5.7 Finding Bioisosteres in the CSD: Scaffold Hopping and Fragment Linking 91 5.8 A Case Study: Bioisosterism of 1H-Tetrazole and Carboxylic Acid Groups 94 5.9 Conclusions 97 References 98 6 Mining for Context-Sensitive Bioisosteric Replacements in Large Chemical Databases 103 George Papadatos, Michael J. Bodkin, Valerie J. Gillet, and Peter Willett 6.1 Introduction 103 6.2 Definitions 104 6.3 Background 105 6.4 Materials and Methods 109 6.5 Results and Discussion 113 6.6 Conclusions 124 References 125 Part Three Methods 129 7 Physicochemical Properties 131 Peter Ertl 7.1 Introduction 131 7.2 Methods to Identify Bioisosteric Analogues 132 7.3 Descriptors to Characterize Properties of Substituents and Spacers 132 7.4 Classical Methods for Navigation in the Substituent Space 135 7.5 Tools to Identify Bioisosteric Groups Based on Similarity in Their Properties 136 7.6 Conclusions 138 References 138 8 Molecular Topology 141 Nathan Brown 8.1 Introduction 141 8.2 Controlled Fuzziness 141 8.3 Graph Theory 142 8.4 Data Mining 144 8.5 Topological Pharmacophores 146 8.6 Reduced Graphs 149 8.7 Summary 151 References 152 9 Molecular Shape 155 Pedro J. Ballester and Nathan Brown 9.1 Methods 156 9.2 Applications 161 9.3 Future Prospects 164 References 165 10 Protein Structure 167 James E. J. Mills 10.1 Introduction 167 10.2 Database of Ligand-Protein Complexes 168 10.3 Generation of Ideas for Bioisosteres 173 10.4 Context-Specific Bioisostere Generation 177 10.5 Using Structure to Understand Common Bioisosteric Replacements 178 10.6 Conclusions 180 References 180 Part Four Applications 183 11 The Drug Guru Project 185 Kent D. Stewart, Jason Shanley, Karam B. Alsayyed Ahmed, and J. Phillip Bowen 11.1 Introduction 185 11.2 Implementation of Drug Guru 187 11.3 Bioisosteres 188 11.4 Application of Drug Guru 194 11.5 Quantitative Assessment of Drug Guru Transformations 195 11.6 Related Work 197 11.7 Summary: The Abbott Experience with the Drug Guru Project 197 References 198 12 Bioisosteres of an NPY-Y5 Antagonist 199 Nicholas P. Barton and Benjamin R. Bellenie 12.1 Introduction 199 12.2 Background 199 12.3 Potential Bioisostere Approaches 201 12.4 Template Molecule Preparation 204 12.5 Database Molecule Preparation 206 12.6 Alignment and Scoring 206 12.7 Results and Monomer Selection 207 12.8 Synthesis and Screening 208 12.9 Discussion 209 12.10 SAR and Developability Optimization 211 12.11 Summary and Conclusion 214 References 214 13 Perspectives from Medicinal Chemistry 217 Nicholas A. Meanwell, Marcus Gastreich, Matthias Rarey, Mike Devereux, Paul L.A. Popelier, Gisbert Schneider, and Peter Willett 13.1 Introduction 217 13.2 Pragmatic Bioisostere Replacement in Medicinal Chemistry: A Software Maker's Viewpoint 219 13.3 The Role of Quantum Chemistry in Bioisostere Prediction 221 13.4 Learn from "Naturally Drug-Like" Compounds 223 13.5 Bioisosterism at the University of Sheffield 224 References 227 Index 231.
  • (source: Nielsen Book Data)9783527654338 20160608
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
(source: Nielsen Book Data)9783527654338 20160608
1 online resource (xv, 282 p.) : ill.
  • Preface Efavirenz(R), a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate CCR5 Receptor Antagonist 5a-Reductase Inhibitors - The Finasteride Story Rizatriptan (Maxalt(R)): A 5-HT1D Receptor Agonist SERM: Selective Estrogen Receptor Modulator HIV Integrase Inhibitor: Raltegravir Cyclopentane-Based NK1 Receptor Antagonist Glucokinase Activator CB1R Inverse Agonist - Taranabant.
  • (source: Nielsen Book Data)9783527324705 20160605
Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.
(source: Nielsen Book Data)9783527324705 20160605
xxx, 718 p. : ill.
xxii, 752 p. : ill. (some col.) ; 27 cm.
  • 1. Drugs and drug targets: an overview-- PART A: DRUG TARGETS: STRUCTURE AND FUNCTION-- 2. Protein structure and function-- 3. Enzymes: structure and function-- 4. Receptors: structure and function-- 5. Receptors and signal transduction-- 6. Nucleic acids: structure and function-- PART B: PHARMACODYNAMICS AND PHARMACOKINETICS-- 7. Enzymes as drug targets-- 8. Receptors as drug targets-- 9. Nucleic acids as drug targets-- 10. Other drug targets-- 11. Pharmacokinetics and related topics-- CASE STUDY 1: STATINS-- PART C: DRUG DISCOVERY, DESIGN, AND DEVELOPMENT-- 12. Drug discovery: finding a lead-- 13. Drug design: optimizing target interactions-- 14. Drug design: optimizing access to the target-- 15. Getting the drug to market-- CASE STUDY 2: THE DESIGN OF ACE INHIBITORS-- CASE STUDY 3: ARTEMISININ AND RELATED ANTIMALARIAL DRUGS-- CASE STUDY 4: THE DESIGN OF OXAMNIQUINE-- PART D: TOOLS OF THE TRADE-- 16. Combinatorial synthesis-- 17. Computers in medicinal chemistry-- 18. Quantitative structure-activity relationships (QSAR)-- CASE STUDY 5: DE NOVO DESIGN OF A THYMIDYLATE SYNTHASE INHIBITOR-- CASE STUDY 6: DESIGN OF A SEROTONIN ANTAGONIST AS A POSSIBLE ANXIOLYTIC AGENT-- PART E: SELECTED TOPICS IN MEDICINAL CHEMISTRY-- 19. Antibacterial agents-- 20. Antiviral agents-- 21. Anticancer agents-- 22. Cholinergics, anticholinergics, and anticholinesterases-- 23. Drugs acting on the adrenergic nervous system-- 24. The opium analgesics-- 25. Anti-ulcer agents-- CASE STUDY 7: DESIGN OF A NOVEL ANTIDEPRESSANT.
  • (source: Nielsen Book Data)9780199234479 20160528
The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very accessible to students. Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to specific drugs from HIV inhibitors to painkillers. The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical issues and most frequently used techniques. An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses.With enhanced attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading. Online Resource Centre The Online Resource Centre features: For registered adoptors of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Hyperlinked bibliography * Six-monthly updates to text * 3D Rotatable structures.
(source: Nielsen Book Data)9780199234479 20160528
Science Library (Li and Ma)
x, 278 p. : ill. (some col.).
  • Folate biosynthesis : reappraisal of old and novel targets in the search for new antimicrobials / James Swarbrick ... [et al.]
  • Studies on anti-cancer agents : phenolic compounds and their pharmacological activity / Maria Dolors Pujol and Isabel Sánchez
  • Cytotoxic anticancer drugs from medicinal plants / Anh-Tho Nguyen and Pierre Duez
  • Emerging applications of quantum dots in medicinal chemistry and drug development / Ian D. Tomlinson, Michael R. Warnement and Sandra J. Rosenthal
  • Medicinal chemistry of copper and vanadium bioactive compounds / Susana B. Etcheverry and Patricia A.M. Williams
  • Antimalarial peroxides : from artemisinin to synthetic peroxides / Jernej Iskra
  • Chemical ecology and medicinal chemistry of marine NF-kB inhibitors / F. Folmer ... [et al.]
  • Layered double hydroxides and their intercalation compounds in photo-chemistry and in medicinal chemistry / Umberto Costantino and Morena Nocchetti.
xiii, 882 p. : ill.

17. Medicinal chemistry [2007]

xxiv, 621 p. : ill. ; 25 cm.
  • Preface Acknowledgements. Abbreviations. Chapter 1. An Introduction to Drugs, their Action and Discovery. Chapter 2. Drug Structure and Solubility. Chapter 3. Structure-activity and quantitative structures relationships. Chapter 4. Computer aided drug design. Chapter 5. Combinatorial Chemistry. Chapter 6. Drugs from natural sources. Chapter 7. Biological Membranes. Chapter 8. Receptors and Messengers. Chapter 9. Enzymes. Chapter 10. Nucleic Acids. Chapter 11. Pharmacokinetics. Chapter 12. Drug metabolism. Chapter 13. Complexes and chelating agents. Chapter 14. Nitric oxide. Chapter 15. An Introduction to drug and analogue synthesis. Chapter 16. Drug Development and Production. Selective further reading. Answers to Questions. Index.
  • (source: Nielsen Book Data)9780470025987 20160528
  • Preface to the First Edition. Preface to the Second Edition. Acknowledgements. Abbreviations. 1 An introduction to drugs, their action and discovery. 1.1 Introduction. 1.2 What are drugs and why do we need new ones? 1.3 Drug discovery and design: a historical outline. 1.4 Leads and analogues: some desirable properties. 1.5 Sources of leads and drugs. 1.6 Methods and routes of administration: the pharmaceutical phase. 1.7 Introduction to drug action. 1.8 Classification of drugs. 1.9 Questions. 2 Drug structure and solubility. 2.1 Introduction. 2.2 Structure. 2.3 Stereochemistry and drug design. 2.3.1 Structurally rigid groups. 2.3.2 Conformation. 2.3.3 Configuration. 2.4 Solubility. 2.4.1 Solubility and the physical nature of the solute. 2.5 Solutions. 2.6 The importance of water solubility. 2.7 Solubility and the structure of the solute. 2.8 Salt formation. 2.9 The incorporation of water solubilising groups in a structure. 2.10 Formulation methods of improving water solubility. 2.11 The effect of pH on the solubility of acidic and basic drugs. 2.12 Partition. 2.13 Surfactants and amphiphiles. 2.14 Questions. 3 Structure-activity and quantitative structure relationships. 3.1 Introduction. 3.2 Structure-activity relationship (SAR). 3.3 Changing size and shape. 3.4 Introduction of new substituents. 3.5 Changing the existing substituents of a lead. 3.6 Case study: a SAR investigation to discover potent geminal bisphosphonates. 3.7 Quantitative structure-activity relationship (QSAR). 3.8 Questions. 4 Computer-aided drug design. 4.1 Introduction. 4.1.1 Models. 4.2 Molecular mechanics. 4.3 Molecular dynamics. 4.4 Quantum mechanics. 4.5 Docking. 4.6 Comparing three-dimensional structures by the use of overlays. 4.7 Pharmacophores and some of their uses. 4.8 Modelling protein structures. 4.9 Three-dimensional QSAR. 4.10 Other uses of computers in drug discovery. 4.11 Questions. 5 Combinatorial chemistry. 5.1 Introduction. 5.2 The solid support method. 5.3 Encoding methods. 5.4 Combinatorial synthesis in solution. 5.5 Deconvolution. 5.6 High-throughput screening (HTS). 5.7 Automatic methods of library generation and analysis. 5.8 Questions. 6 Drugs from natural sources. 6.1 Introduction. 6.2 Bioassays. 6.3 Dereplication. 6.4 Structural analysis of the isolated substance. 6.5 Active compound development. 6.6 Extraction procedures. 6.7 Fractionation methods. 6.8 Case history: the story of Taxol. 6.9 Questions. 7 Biological membranes. 7.1 Introduction. 7.2 The plasma membrane. 7.3 The transfer of species through cell membranes. 7.4 Drug action that affects the structure of cell membranes and walls. 7.5 Questions. 8 Receptors and messengers. 8.1 Introduction. 8.2 The chemical nature of the binding of ligands to receptors. 8.3 Structure and classification of receptors. 8.4 General mode of operation. 8.5 Ligand-response relationships. 8.6 Ligand-receptor theories. 8.7 Drug action and design. 8.8 Questions. 9 Enzymes. 9.1 Introduction. 9.2 Classification and nomenclature. 9.3 Active sites and catalytic action. 9.4 Regulation of enzyme activity. 9.5 The specific nature of enzyme action. 9.6 The mechanisms of enzyme action. 9.7 The general physical factors affecting enzyme action. 9.8 Enzyme kinetics. 9.9 Enzyme inhibitors. 9.10 Transition state inhibitors. 9.11 Enzymes and drug design: some general considerations. 9.12 Examples of drugs used as enzyme inhibitors. 9.13 Enzymes and drug resistance. 9.14 Ribozymes. 9.15 Questions. 10 Nucleic acids. 10.1 Introduction. 10.2 Deoxyribonucleic acid (DNA). 10.3 The general functions of DNA. 10.4 Genes. 10.5 Replication. 10.6 Ribonucleic acid (RNA). 10.7 Messenger RNA (mRNA). 10.8 Transfer RNA (tRNA). 10.9 Ribosomal RNA (rRNA). 10.10 Protein synthesis. 10.11 Protein synthesis in prokaryotic and eukaryotic cells. 10.12 Bacterial protein synthesis inhibitors (antimicrobials). 10.13 Drugs that target nucleic acids. 10.14 Viruses. 10.15 Recombinant DNA technology (genetic engineering). 10.16 Questions. 11 Pharmacokinetics. 11.1 Introduction. 11.2 Drug concentration analysis and its therapeutic significance. 11.3 Pharmacokinetic models. 11.4 Intravascular administration. 11.5 Extravascular administration. 11.6 The use of pharmacokinetics in drug design. 11.7 Extrapolation of animal experiments to humans. 11.8 Questions. 12 Drug metabolism. 12.1 Introduction. 12.2 Secondary pharmacological implications of metabolism. 12.2.4 Toxic metabolites. 12.3 Sites of action. 12.4 Phase I metabolic reactions. 12.5 Examples of Phase I metabolic reactions. 12.6 Phase II metabolic routes. 12.7 Pharmacokinetics of metabolites. 12.8 Drug metabolism and drug design. 12.9 Prodrugs. 12.10 Questions. 13 Complexes and chelating agents. 13.1 Introduction. 13.2 The shapes and structures of complexes. 13.3 Metal-ligand affinities. 13.4 The general roles of metal complexes in biological processes. 13.5 Therapeutic uses. 13.6 Drug action and metal chelation. 13.7 Questions. 14 Nitric oxide. 14.1 Introduction. 14.2 The structure of nitric oxide. 14.3 The chemical properties of nitric oxide. 14.4 The cellular production and role of nitric oxide. 14.5 The role of nitric oxide in physiological and pathophysiological states. 14.6 Therapeutic possibilities. 14.7 Questions. 15 An introduction to drug and analogue synthesis. 15.1 Introduction. 15.2 Some general considerations. 15.3 Asymmetry in syntheses. 15.4 Designing organic syntheses. 15.5 Partial organic synthesis of xenobiotics. 15.6 Questions. 16 Drug development and production. 16.1 Introduction. 16.2 Chemical development. 16.3 Pharmacological and toxicological testing. 16.4 Drug metabolism and pharmacokinetics. 16.5 Formulation development. 16.6 Production and quality control. 16.7 Patent protection. 16.8 Regulation. 16.9 Questions. Selected further reading. Answers to questions. Index.
  • (source: Nielsen Book Data)9780470025970 20160528
"Medicinal Chemistry: An Introduction, Second Edition" provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field.Written in an accessible style, "Medicinal Chemistry: An Introduction, Second Edition" carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. From the reviews of the First Edition: 'It contains a wealth of information in a compact form' - "Angewandte Chemie, International Edition". 'Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place' - "Physical Sciences and Educational Reviews".
(source: Nielsen Book Data)9780470025987 20160528
Science Library (Li and Ma)
xxv, 933 p. : ill.
x, 156 p. : ill.
  • Chapter 1: Introduction-- 1.1: Aims-- 1.2: The Classification of Drugs-- 1.3: Targets for the Medicinal Chemist-- 1.4: The Stages in the Development of a Drug-- 1.5: The Synthesis of a Drug-- 1.6: The History of Medicinal Chemistry-- Chapter 2: General Principles of Medicinal Chemistry-- 2.1: Aims-- 2.2: Administration and Absorption-- 2.3: The Gastrointestinal Tract-- 2.4: Other Routes of Administration-- 2.5: Physico-Chemical Measurements-- 2.6: Formulation-- 2.7: Drug Metabolism-- 2.8: Oxidation by Cytochrome P450s-- 2.9: The Hydroxylation of Aromatic Rings-- 2.10: The Hydroxylation of Aliphatic Systems-- 2.11: The Monoamine Oxidases-- 2.12: Other Phase One Changes-- 2.13: Phase Two Changes-- 2.14: Excretion-- 2.15: Pro-Drugs-- 2.16: Quantitative Structure: Activity Relationships-- 2.17: Hansch QSAR Analyses-- 2.18: Craig Plots and the Topliss Decision Tree-- 2.19: Drug: Receptor Interactions-- Chapter 3: Neurotransmitters as Targets-- 3.1: Aims-- 3.2: Introduction-- 3.3: The Nervous System-- 3.4: The Neurotransmitters-- 3.5: Cell-Surface Receptors-- 3.6: Ion-Channel-Linked Receptors-- 3.7: Kinase-Linked Receptors-- 3.8: G-Protein-Linked Receptors-- 3.9: Agonists and Antagonists-- 3.10: Acetylcholine-- 3.11: Neuromuscular Blocking Agents in Surgery-- 3.12: Muscarinic Agonists-- 3.13: Local Anaesthetics-- 3.14: Catecholamines as Neurotransmitters-- 3.15: The Adrenergic Receptors-- 3.16: a-Adrenergic Receptor Agonists-- 3.17: b-Adrenergic Receptor Agonists - The Developmentof Anti-Asthma Drugs-- 3.18: b1-Adrenergic Antagonists 'b-Blockers'-- 3.19: The Treatment of Hypertension-- Chapter 4 Medicinal Chemistry and the Central Nervous System-- 4.1: Aims-- 4.2: Introduction-- 4.3: The Treatment of Neurodegenerative Diseases-- 4.4: Dopamine Antagonists as Neuroleptic Agents-- 4.5: Serotonin as a Neurotransmitter-- 4.6: The Treatment of Depression-- 4.7: GABA as a Neurotransmitter-- 4.8: The Treatment of Epilepsy-- 4.9: Benzodiazepines as Anxiolytic Agents-- 4.10: Barbiturate Sleeping Tablets-- 4.11: Opioids as Analgesics-- Chapter 5: Local and Circulatory Hormone Targets-- 5.1: Aims-- 5.2: Introduction-- 5.3: Histamine as a Target-- 5.4: Histamine Antagonists in the Treatment of Peptic Ulcers-- 5.5: The Prostaglandins and Non-Steroidal Anti-Inflammatory Agents-- 5.6: The Development of Ibuprofen-- 5.7: The Mechanism of Action of Aspirin-- 5.8: Medicinal Uses of Prostaglandins-- 5.9: The Sterols and Steroid Hormones-- 5.10: The Biosynthesis of the Steroids-- 5.11: The Control of Cholesterol Biosynthesis-- 5.12: The Steroidal Anti-Inflammatory Agents-- 5.13: The Steroidal Oral Contraceptives-- 5.14: The Role of Nitric Oxide-- Chapter 6: Anti-infective Agents-- 6.1: Aims-- 6.2: Introduction-- 6.3: Bacterial Diseases-- 6.4: Antiseptics-- 6.5: The Sulfonamide Anti-Bacterial Agents-- 6.6: The Penicillins-- 6.7: Clavulanic Acid and the Inhibition of b-Lactamases-- 6.8: The Cephalosporins-- 6.9: The Mode of Action of the b-Lactam Antibiotics-- 6.10: Other Antibiotics-- 6.11: Synthetic Anti-Bacterial Agents-- 6.12: Anti-Viral Agents-- 6.13: The Inhibition of Nucleic Acid Biosynthesis-- 6.14: Inhibitors of Reverse Transcriptase-- 6.15: Neuraminidase Inhibitors-- 6.16: The Synthesis of Nucleoside Analogues-- 6.17: Anti-Fungal Agents-- 6.18: Ergosterol Biosynthesis Inhibitors-- 6.19: Other Anti-Fungal Agents-- 6.20: Parasitic Infections-- Chapter 7: Cancer Chemotherapy-- 7.1: Aims-- 7.2: Introduction-- 7.3: The Cell Cycle-- 7.4: Cancer Chemotherapy-- 7.5: Anti-Metabolites-- 7.6: Alkylating Agents-- 7.7: Intercalating Agents-- 7.8: Anti-Mitotic Agents-- 7.9: Interference with Selected Developmental Processes-- 7.10: Monoclonal Antibodies-- 7.11: Prostate Cancer-- Further Reading-- Glossary-- Subject Index.
  • (source: Nielsen Book Data)9781847555403 20160604
Medicinal chemistry incorporates bio-organic chemistry, organic synthetic methods, physical organic chemistry and organic reaction mechanisms. These areas of chemistry are crucial to the design and synthesis of new drugs, both in academia and the pharmaceutical industry. Chemistry and Medicines: An Introductory Text provides a general introduction to this fascinating subject. The first chapters contain a brief historical introduction followed by a description of the chemical features involved in the adsorption, distribution, metabolism and excretion of a drug. The remaining chapters describe the chemistry underlying the design and synthesis of some of the key drugs used to combat some major diseases of the peripheral and central nervous system, infectious diseases and cancers. A glossary and suggestions for further reading complete this textbook. The book is aimed at those studying advanced undergraduate and postgraduate courses in medicinal chemistry.
(source: Nielsen Book Data)9781847555403 20160604
xiii, 649 p. : ill. ; 24 cm.
  • PART I: GENERAL MOLECULAR PRINCIPLES OF DRUG DESIGN-- 1. Basic Principles of Drug Design I: Drug Molecules: Structure and Properties-- 2. Basic Principles of Drug Design II: Receptors: Structures and Properties-- 3. Basic Principles of Drug Design III: Designing Drug Molecules to Fit Receptors-- PART II: BIOCHEMICAL CONSIDERATIONS IN DRUG DESIGN: FROM DRUGGABLE TARGETS TO DISEASES-- 4. Messenger Targets for Drug Action I: Neurotransmitters and Their Receptors-- 5. Messenger Targets for Drug Action II: Hormones and Their Receptors-- 6. Messenger Targets for Drug Action III: Immunomodulators and Their Receptors-- 7. Nonmessenger Targets for Drug Action I: Endogenous Cellular Structures-- 8. Nonmessenger Targets for Drug Action II: Endogenous Macromolecules-- 9. Nonmessenger Targets for Drug Action III: Exogenous Pathogens and Toxins-- Appendix: Drugs arranged by pharmacologic activity.
  • (source: Nielsen Book Data)9780195104561 20160528
Fully updated and rewritten by a basic scientist who is also a practising physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, "Medicinal Chemistry" examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neurpharmacology and genetics or genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
(source: Nielsen Book Data)9780195104561 20160528


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