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• ""Front Cover""; ""Handbook of Aging and the Social Sciences""; ""Copyright Page""; ""Dedications""; ""Contents""; ""Foreword""; ""Preface""; ""About the Editors""; ""List of Contributors""; ""I. Theory and Methods""; ""1 Aging and the Social Sciences: Progress and Prospects""; ""Theoretical and Conceptual Developments""; ""Cumulative Advantage/Disadvantage Theory""; ""Cumulative Inequality Theory""; ""Methods and Data""; ""Data Developments""; ""Statistical Sophistication""; ""Emerging Themes in Aging Research""; ""Increased Attention to Cohort Analysis""

• ""The Effects of Social and Economic Disruptions on Aging""""The Great Recession""; ""Hurricane Katrina and Other Disasters""; ""Gradual, Incremental Cultural Change""; ""Income Inequality and Health""; ""What Aging Research Contributes to the Social Sciences: The Big Picture""; ""References""; ""2 Trajectory Models for Aging Research""; ""Growth Modeling in a Nutshell""; ""Example 2.1""; ""Latent Class Modeling in a Nutshell""; ""Example 2.2""; ""Example 2.3""; ""Example 2.4""; ""Latent Class Growth Analysis""; ""Example 2.5""; ""Growth Mixture Modeling""; ""Example 2.6""

• ""Important Issues in the Implementation of Trajectory Methods""""Data Structure and Method""; ""Measurement of Time""; ""Importance of Assumptions""; ""Extraction of Classes and Inclusion of Covariates""; ""Conclusion""; ""References""; ""II. Social Structures and Processes""; ""3 Biodemography: Adding Biological Insight into Social, Economic, and Psychological Models of Population and Individual Hea ...""; ""Introduction""; ""Expansion of the Demographic Approach: The Process of Health Change""; ""The Expanded Biodemographic Model of Health""; ""Measuring Biomarkers in Population Studies""

• ""Use of Biomarkers in Assessing Population Health and Health Care Use and Its Effectiveness""""Summary Indices of Biological Risk""; ""Genetic Markers as a New Frontier""; ""Summary""; ""Appendix: Information on Biomarkers often Used in Social Science Research""; ""References""; ""4 Late-Life Disability Trends and Trajectories""; ""Introduction""; ""The Conceptualization of Disability""; ""Measuring Disability""; ""Evidence on Trends in Disability Prevalence""; ""Overall Trends""; ""Between-Group Differences, Compositional Change, and “Trueâ€? Change""

• ""Potential Explanations for “Trueâ€? Change""""Individual-Level Disability Trajectories""; ""Time to Death as an Additional “Timeâ€? Variable""; ""Accounting for Sample Losses due to Death""; ""Conclusion""; ""References""; ""5 Early Life Origins of Adult Health and Aging""; ""Introduction""; ""Historical Overview""; ""Early Origins of Adult Disease: From FOAD Through DOHaD to a Life Course Perspective""; ""The Intrauterine Environment""; ""The Postnatal Environment""; ""Physical Growth and Development""; ""Early Adverse Environments and the Stress Response""

Handbook of Aging and the Social Sciences, Eighth Edition, presents the extraordinary growth of research on aging individuals, populations, and the dynamic culmination of the life course, providing a comprehensive synthesis and review of the latest research findings in the social sciences of aging. As the complexities of population dynamics, cohort succession, and policy changes modify the world and its inhabitants in ways that must be vigilantly monitored so that aging research remains relevant and accurate, this completely revised edition not only includes the foundational, classic themes of aging research, but also a rich array of emerging topics and perspectives that advance the field in exciting ways. New topics include families, immigration, social factors, and cognition, caregiving, neighborhoods, and built environments, natural disasters, religion and health, and sexual behavior, amongst others. * Covers the key areas in sociological gerontology research in one volume, with an 80% update of the material* Headed up by returning editor Linda K. George, and new editor Kenneth Ferraro, highly respected voices and researchers within the sociology of aging discipline* Assists basic researchers in keeping abreast of research and clinical findings* Includes theory and methods, aging and social structure, social factors and social institutions, and aging and society* Serves as a useful resource-an inspiration to those searching for ways to contribute to the aging enterprise, and a tribute to the rich bodies of scholarship that comprise aging research in the social sciences.
(source: Nielsen Book Data)

• Front Cover; Drug Design and Discovery in Alzheimer's Disease; Copyright; Contents; Preface; List of Contributors;
• Chapter 1: Pharmacotherapy of Alzheimer's Disease: Current State and Future Perspectives; Abstract;
• 1. Alzheimer's Disease
• Historic Overview;
• 2. Current Status and Prevalence of AD;
• 3. Risk Factors for AD;
• 4. Cholinergic Theory;
• 5. Cholinesterases;
• 6. Current Therapeutic Approaches to AD;
• 7. Conclusions; Acknowledgements; Conflict of Interest; References;
• Chapter 2: Challenges in Designing Therapeutic Agents for Treatingalzheimer's Disease-From Serendipity to Rationality

• AbstractIntroduction; Alzheimer's Disease (AD); Challenges in Designing Alzheimer's Medicines; Symptomatic Drugs; Disease Modifying Drugs (Investigative Approaches); Rational Approaches to Design AD Drugs; Multi-Target-Directed Ligand (MTDL) Design Strategy; Concluding Remarks & Future Prospects; Acknowledgements; Conflict of Interest; Abbreviations; References;
• Chapter 3: Enzyme Inhibitors Involved in the Treatment of Alzheimer's Disease; Abstract; Introduction; Pathophysiology of Alzheimer Disease; Overview on Key Enzymes Involved in Alzheimer's Disease

• Clinically Used Enzymes Inhibitors for Alzheimer's DiseaseCurrent Enzyme-Targeted Drug Development Foralzheimer's Disease; Conclusions; Acknowledgements; Conflict of Interest; Abbreviations; References;
• Chapter 4: Towards Small Molecules as Therapies for Alzheimer's Disease and Other Neurodegenerative Disorders; Abstract; Introduction to Neurodegenerative Diseases; Alzheimer's Disease: Etiology and the ß-Amyloid Hypothesis; BACE1 and the ß-Amyloid Hypothesis; The Evolution of BACE1 Inhibitors; BACE1 Inhibitors: Uncovering "Chemical Truffles" in Pre-Clinical Drug Discovery

• HD and Mitochondrial DysfunctionThe Synergy Between Aggregation and Autophagy; Transcriptional Regulation; Other Biological Pathway Deficits; Perspectives for HD; Conclusive Remarks; Acknowledgements; Conflict of Interest; Abbreviations; References;
• Chapter 5: Multifunctional Enzyme Inhibition for Neuroprotection
• A Focus on MAO, NOS, and AChE Inhibitors; Abstract; Introduction; Monoamine Oxidase
• Isoforms and Function; Nitric Oxide Synthase (NOS)
• Isoforms and Structure; Acetylcholinesterase
• Structure and Function; Conclusion and Future Developments; Acknowledgements

Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of -amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. * Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development* Describes existing drugs for AD and current molecular understanding of the condition* Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets.
(source: Nielsen Book Data)

This collection of papers has arisen from the belief that cultural understanding can be advanced by contrasting the work of scholars who share academic concerns but work from different cultural vantage-points. Divided into two sections - the Western perspective and the Eastern perspective - the contributions examine the issues surrounding the care of the elderly.
(source: Nielsen Book Data)

• pt.2.Deficiencies in monitoring and enforcing quality of care to nursing home patients.-pt.3.Lack of a planned, integrated system of services for the elderly.

• On the rationality of caring
• Between late modern and later modern elderly care in Norway and Japan
• Development of home help in Japan: a comparison with Norway
• Long-tern care insurance, marketization, and quality of care: 'good time living'
• The work situations of home helpers in Japan and Norway
• Care providers in Japan: the potential of and challenges for social enterprises
• Challenges for the future of public care - a lesson from Norway
• Aiming towards diversity welfare in a global society.

• Chapter 1 The Research Gap: Globalisation, Migration and Ageing Society
• Chapter 2 Participation and Engagement: Dynamics of Social Life
• Chapter 3 Economic Situation
• Chapter 4 Housing and Location Choice
• Chapter 5 Independence and Care: In Search of an Effective Care Model
• Chapter 6 Intergenerational Transfer and Transnational Migration Decisions in Later Life
• Chapter 7 Life Satisfaction and Quality of Life
• Chapter 8 Conclusion and Implications.
• (source: Nielsen Book Data)

This book provides a comprehensive view of the quality of life of older people from culturally and linguistically diverse (CALD) backgrounds living in Australia. The book is unique and significant because the descriptions and arguments presented are based on the lived experience and hence provide deep insights into the complexity and dynamics of CALD older migrants. Key areas of exploration include social connectedness and inclusion, post-retirement economic activities, living arrangement and housing choice, practice of care, intergenerational exchange, and life satisfaction. A focus is placed on the diversity of ageing experience. Pathways of ageing are one of the key factors in investigating inter and intra-ethnic commonalities and disparities. The policy and research implications presented will appeal to policy makers, practitioners and researchers.
(source: Nielsen Book Data)