1 - 6
Number of results to display per page
Online 1. Strategies to enhance anti-tumor immunity [electronic resource] : translating preclinical models [2012]
- Kohrt, Holbrook E.
- 2012.
- Description
- Book — 1 online resource.
- Summary
-
Purpose: The immune modulatory effects of total lymphoid irradiation (TLI) for graft-versus-host disease (GVHD) protection and transplantation tolerance following allogeneic bone marrow and organ transplantation have been studied for years in animal models. In preclinical models non-myeloablative TLI conditioning alters residual host T cell subsets to favor regulatory natural killer (NK) T cells that suppress GVHD and prevent organ allograft rejection. These preclinical models have been recently adapted to human transplantation. Recent findings: Patients receiving allogeneic hematopoietic cell transplantation (HCT) for hematological malignancies conditioned with TLI and depletive T cell antibodies showed sustained donor chimerism, a reduced incidence of acute GVHD yet retained graft anti-tumor activity. As in the pre-clinical models, nonmyeloablative TLI conditioning significantly altered residual host T cell subsets favoring NK T cells, and the low incidence of GVHD was associated with increased IL-4 secretion by chimeric donor T cells. The TLI regimen used in cancer patients was modified to determine conditions for stable mixed chimerism and tolerance induction following combined hematopoietic cell and kidney transplantation. Summary: This review summarizes the evolution of the pre-clinical TLI protocols and their recent translation to clinical trials, and discusses the mechanisms involved in protection from GVHD and the induction of tolerance following mixed chimerism.
- Also online at
-
Special Collections
Special Collections | Status |
---|---|
University Archives | Request on-site access (opens in new tab) |
3781 2012 K | In-library use |
- Kohrt, Holbrook E.
- Aug. 2012.
- Description
- Book — online resource (iii, 209 pages) : illustrations (some color)
- Summary
-
Purpose: The immune modulatory effects of total lymphoid irradiation (TLI) for graft-versus-host disease (GVHD) protection and transplantation tolerance following allogeneic bone marrow and organ transplantation have been studied for years in animal models. In preclinical models non-myeloablative TLI conditioning alters residual host T cell subsets to favor regulatory natural killer (NK) T cells that suppress GVHD and prevent organ allograft rejection. These preclinical models have been recently adapted to human transplantation. Recent findings: Patients receiving allogeneic hematopoietic cell transplantation (HCT) for hematological malignancies conditioned with TLI and depletive T cell antibodies showed sustained donor chimerism, a reduced incidence of acute GVHD yet retained graft anti-tumor activity. As in the pre-clinical models, nonmyeloablative TLI conditioning significantly altered residual host T cell subsets favoring NK T cells, and the low incidence of GVHD was associated with increased IL-4 secretion by chimeric donor T cells. The TLI regimen used in cancer patients was modified to determine conditions for stable mixed chimerism and tolerance induction following combined hematopoietic cell and kidney transplantation. Summary: This review summarizes the evolution of the pre-clinical TLI protocols and their recent translation to clinical trials, and discusses the mechanisms involved in protection from GVHD and the induction of tolerance following mixed chimerism.
- Also online at
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Lane Library catalog for status | |
(no call number) | Unknown |
Online 3. New models for predicting non-sentinel lymph node status when sentinel lymph nodes are positive [2007]
- Kohrt, Holbrook E.
- Stanford, Calif. : Dept. of Statistics, Stanford University, [2007]
- Description
- Book — 1 online resource (23 pages)
- Also online at
4. Medicine [print] [2007]
- Li, Jonathan Z.
- 2nd ed. - Philadelphia : Lippincott Williams & Wilkins, 2007.
- Description
- Book — xx, 418 pages : illustrations ; 21 cm
- Summary
-
- Shortness of breath
- Chest pain
- Abdominal pain
- Hormonal and electrolyte imbalance
- Preventive medicine
- Head symptoms
- Blood issues
- Swelling, musculoskeletal, and skin issues.
- Online
Medical Library (Lane)
Medical Library (Lane) | Status |
---|---|
Check Lane Library catalog for status | |
RC66 .G36 2007 | Unknown |
Online 5. Targeting the CD47-SIRP alpha interaction to stimulate macrophage destruction of cancer [electronic resource] [2016]
- Weiskopf, Kipp.
- 2016.
- Description
- Book — 1 online resource.
- Summary
-
Cancer cells develop mechanisms to avoid detection by the immune system, and therapeutic approaches aimed at overcoming these mechanisms form the basis of cancer immunotherapy. In this dissertation, I employed macrophages as effector cells by targeting the CD47/SIRPa axis, which is a critical regulator of macrophage activation. CD47 is highly expressed on many different types of cancer, and it transduces inhibitory signals through SIRPa, a receptor on macrophages and other myeloid cells. Thus, the CD47/SIRPa axis serves as a myeloid-specific immune checkpoint. To create next-generation CD47 antagonists, we engineered high-affinity SIRPa variants that exhibited ~50,000-fold higher affinity for human CD47 relative to wild-type SIRPa. When produced as high-affinity SIRPa-Fc fusion proteins, these therapeutics acted as single agents for cancer with moderate on-target toxicity to normal cells expressing CD47. When produced as 14 kDa high-affinity SIRPa monomers, the therapeutics had minimal activity as single agents but instead acted as universal adjuvants to anti-cancer antibodies. Therefore, CD47 blockade is not sufficient to induce macrophage phagocytosis, but instead lowers the threshold for phagocytosis in the presence of a separate, tumor-opsonizing antibody. I demonstrated these principles could be extended to models of small cell lung cancer (SCLC), and I identified additional therapeutic targets on the surface of SCLC cells. Last, I generated anti-SIRPa antibodies and characterized KWAR23 as a clone that binds and antagonizes SIRPa directly on macrophages. Therapies targeting the CD47/SIRPa axis are now under investigation in clinical trials. These agents may differ in their pharmacokinetic, pharmacodynamic, and toxicity profiles, raising important considerations for further development and clinical evaluation. Overall, the therapies developed in this dissertation could be broadly applied to cancer and may benefit many patients suffering from disease.
- Also online at
-
Special Collections
Special Collections | Status |
---|---|
University Archives | Request on-site access (opens in new tab) |
3781 2016 W | In-library use |
6. New models for predicting non-sentinel lymph node status when sentinel lymph nodes are positive [2007]
- Stanford, Calif. : Dept. of Statistics, Stanford University, [2007]
- Description
- Book — 23 p. ; 28 cm.
SAL3 (off-campus storage), Special Collections
SAL3 (off-campus storage) | Status |
---|---|
Stacks | Request (opens in new tab) |
262240 | Available |
Special Collections | Status |
---|---|
University Archives | Request on-site access (opens in new tab) |
262240 | In-library use |
Articles+
Journal articles, e-books, & other e-resources
Guides
Course- and topic-based guides to collections, tools, and services.