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xxxiv, 1172, AS-34, G-20, I-45 pages : illustrations (chiefly color), color maps ; 29 cm
  • The foundations of biochemistry
  • I. Structure and catalysis. Water
  • Amino Acids, peptides, and proteins
  • The three-dimensional structure of proteins
  • Protein function
  • Enzymes
  • Carbohydrates and glycobiology
  • Nucleotides and nucleic acids
  • DNA-based information technologies
  • Lipids
  • Biological membranes and transport
  • Biosignaling
  • II. Bioenergetics and metabolism. Bioenergetics and biochemical reaction types
  • Glycolysis, gluconeogenesis, and the pentose phosphate pathway
  • Principles of metabolic regulation
  • The citric acid cycle
  • Fatty acid catabolism
  • Amino acid oxidation and the production of urea
  • Oxidative phosphorylation
  • Photosynthesis and carbohydrate synthesis in plants
  • Lipid biosynthesis
  • Biosynthesis of amino acids, nucleotides, and related molecules
  • Hormonal regulation and integration of mammalian metabolism
  • III. Information pathways. Genes and chromosomes
  • DNA metabolism
  • RNA metabolism
  • Protein metabolism
  • Regulation of gene expression
  • Abbreviated solutions to problems
  • Glossary
  • Index.
"Lehninger Principles of Biochemistry ... brings clarity and coherence to an often unwieldy discipline, offering a thoroughly updated survey of biochemistry's enduring principles, definitive discoveries, and groundbreaking new advances with each edition.This new Seventh Edition maintains the qualities that have distinguished the text since Albert Lehninger's original edition—clear writing, careful explanations of difficult concepts, helpful problem-solving support, and insightful communication of contemporary biochemistry's core ideas, new techniques, and pivotal discoveries. Again, David Nelson and Michael Cox introduce students to an extraordinary amount of exciting new findings without an overwhelming amount of extra discussion or detail." -- Publisher description.
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01
1 volume (various pagings) : color illustrations ; 29 cm
  • 1 Biochemistry and the Language of Chemistry 2 The Chemical Foundation of Life: Weak Interactions in an Aqueous Environment 3 The Energetics of Life 4 Nucleic Acids 5 Introduction to Proteins: The Primary Level of Protein Structure 6 The Three-Dimensional Structure of Proteins 7 Protein Function and Evolution 8 Enzymes: Biological Catalysts 9 Carbohydrates: Sugars, Saccharides, Glycans 10 Lipids, Membranes, and Cellular Transport 11 Chemical Logic of Metabolism 12 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway 13 The Citric Acid Cycle 14 Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism 15 Photosynthesis 16 Lipid Metabolism 17 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates 18 Amino Acid and Nitrogen Metabolism 19 Nucleotide Metabolism 20 Mechanisms of Signal Transduction 21 Genes, Genomes, and Chromosomes 22 DNA Replication 23 DNA Repair, Recombination, and Rearrangement 24 Transcription and Post-transcriptional Processing 25 Information Decoding: Translation and Post-translational Protein Processing 26 Regulation of Gene Expression.
  • (source: Nielsen Book Data)9780321839763 20160618
NOTE: Before purchasing, check with your instructor to ensure you select the correct ISBN. Several versions of Pearson's MyLab & Mastering products exist for each title, and registrations are not transferable. To register for and use Pearson's MyLab & Mastering products, you may also need a Course ID, which your instructor will provide. Used books, rentals, and purchases made outside of Pearson If purchasing or renting from companies other than Pearson, the access codes for Pearson's MyLab & Mastering products may not be included, may be incorrect, or may be previously redeemed. Check with the seller before completing your purchase. For one or two semester biochemistry courses (science majors). This package includes MasteringChemistry(R). A highly visual, precise and fresh approach to guide today's mixed-science majors to a deeper understanding of biochemistry Biochemistry: Concepts and Connections engages students in the rapidly evolving field of biochemistry, better preparing them for the challenges of 21st century science through quantitative reasoning skills and a rich, chemical perspective on biological processes. This concise first edition teaches mixed-science-majors the chemical logic underlying the mechanisms, pathways, and processes in living cells through groundbreaking biochemical art and a clear narrative that illustrates biochemistry's relation to all other life sciences. Integration of biochemistry's experimental underpinnings alongside the presentation of modern techniques encourages students to appreciate and consider how their understanding of biochemistry can and will contribute to solving problems in medicine, agricultural sciences, environmental sciences, and forensics. The text is fully integrated with MasteringChemistry to provide support for students before, during, and after class. Highlights include interactive animations and tutorials based on the textbook's biochemical art program and Foundation Figures to help students visualize complex processes, apply, and test conceptual understanding as well as quantitative reasoning. Superior support beyond the classroom with MasteringChemistry MasteringChemistry from Pearson is the leading online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive prepared by assigning interaction with relevant biochemical concepts before class, and encourage critical thinking, visualization, and retention with in-class resources such as Learning CatalyticsTM. Students can further master concepts after class by interacting with biochemistry animations, problem sets, and tutorial assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions. Mastering brings learning full circle by continuously adapting to each student and making learning more personal than ever-before, during, and after class. 0321839765 / 9780321839763 Biochemistry: Concepts and Connections Plus MasteringChemistry with eText -- Access Card Package Package consists of: 0133871975 / 9780133871975 MasteringChemistry with Pearson eText -- ValuePack Access -- for Biochemistry: Concepts and Connections 0321839927 / 9780321839923 Biochemistry: Concepts and Connections.
(source: Nielsen Book Data)9780321839763 20160618
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01

3. Organic chemistry [2016]

xxx, 1054, 59, 34 pages : illustrations ; 26 cm
  • 1. Structure and Bonding. 2. Polar Covalent Bonds-- Acids and Bases. 3. Organic Compounds: Alkanes and Their Stereochemistry. 4. Organic Compounds: Cycloalkanes and Their Stereochemistry 5. Stereochemistry at Tetrahedral Centers. 6. An Overview of Organic Reactions. 7. Alkenes: Structure and Reactivity. Practice Your Scientific Analysis and Reasoning I: The Chiral Drug Thalidomide 8. Alkenes: Reactions and Synthesis. 9. Alkynes: An Introduction to Organic Synthesis. 10. Organohalides. 11. Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations. Practice Your Scientific Analysis and Reasoning II: From Mustard Gas to Alkylating Anticancer Drugs 12. Structure Determination: Mass Spectrometry and Infrared Spectroscopy. 13. Structure Determination: Nuclear Magnetic Resonance Spectroscopy. 14. Conjugated Compounds and Ultraviolet Spectroscopy. 15. Benzene and Aromaticity. Practice Your Scientific Analysis and Reasoning III: Photodynamic Therapy (PDT) 16. Chemistry of Benzene: Electrophilic Aromatic Substitution. 17. Alcohols and Phenols. 18. Ethers and Epoxides-- Thiols and Sulfides. Preview of Carbonyl Chemistry. 19. Aldehydes and Ketones: Nucleophilic Addition Reactions. Practice Your Scientific Analysis and Reasoning IV: SSRIs 20. Carboxylic Acids and Nitriles. 21. Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions. 22. Carbonyl Alpha-Substitution Reactions. 23. Carbonyl Condensation Reactions. Practice Your Scientific Analysis and Reasoning V: Thymine in DNA 24. Amines and Heterocycles. 25. Biomolecules: Carbohydrates. 26. Biomolecules: Amino Acids, Peptides, and Proteins. Practice Your Scientific Analysis and Reasoning VI: Melatonin and Serotonin 27. Biomolecules: Lipids. 28. Biomolecules: Nucleic Acids. 29. The Organic Chemistry of Metabolic Pathways. 30. Orbitals and Organic Chemistry: Pericyclic Reactions. 31. Synthetic Polymers. Practice Your Scientific Analysis and Reasoning VII: The Potent Antibiotic of Endiandric Acid C.
  • (source: Nielsen Book Data)9781305080485 20160618
Master organic chemistry with the help of this proven best-seller! John McMurry's Organic Chemistry is consistently praised as the most clearly written book available for the course. In John McMurry's words: "I wrote this book because I love writing. I get great pleasure and satisfaction from taking a complicated subject, turning it around until I see it clearly from a new angle, and then explaining it in simple words." Through his lucid writing and ability to show the beauty and logic of organic chemistry, McMurry makes learning enjoyable. The highest compliment that can be given to a chemistry book applies to McMurry: It works!.
(source: Nielsen Book Data)9781305080485 20160618
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01
xvii, 557 pages : illustrations (chiefly color) ; 24 cm
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01
vi, 1116, [1] pages : illustrations ; 28 cm
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01

6. Biochemistry [2015]

1 volume (various pagings) : illustrations ; 29 cm
  • 1. Biochemistry and the Organization of Cells. 2. Water: The Solvent for Biochemical Reactions. 3. Amino Acids and Peptides. 4. The Three-Dimensional Structure of Proteins. 5. Protein Purification and Characterization Techniques. 6. The Behavior of Proteins: Enzymes. 7. The Behavior of Proteins: Enzymes, Mechanisms, and Control. 8. Lipids and Proteins Are Associated in Biological Membranes. 9. Nucleic Acids: How Structure Conveys Information. 10. Biosynthesis of Nucleic Acids: Replication. 11. Transcription of the Genetic Code: The Biosynthesis of RNA. 12. Protein Synthesis: Translation of the Genetic Message. 13. Nucleic Acid Biotechnology Techniques. 14. Viruses, Cancer and Immunology. 15. The Importance of Energy Changes and Electron Transfer in Metabolism. 16. Carbohydrates. 17. Glycolysis. 18. Storage Mechanisms and Control in Carbohydrate Metabolism. 19. The Citric Acid Cycle. 20. Electron Transport and Oxidative Phosphorylation. 21. Lipid Metabolism. 22. Photosynthesis. 23. The Metabolism of Nitrogen. 24. Integration of Metabolism: Cellular Signaling. Answers. Glossary. Index.
  • (source: Nielsen Book Data)9781285429106 20160618
Discover how the latest developments in biotechnology and genomics directly affect your life with this best-selling biochemistry text. This new edition reflects recent developments in stem cell research, cloning, and immunology, and offers revised coverage of major topics, such as Molecular Biology. Known for its logical organization and appropriate depth of coverage, Biochemistry, 8th Edition, balances scientific detail with readability that's ideal for those studying biochemistry for the first time. A unique magazine insert, "Hot Topics in Biochemistry, " introduces the latest advances in the field. State-of-the art visuals throughout the book help clarify concepts, while "Biochemical Connections" demonstrate how biochemistry affects other fields, such as health and sports medicine New in-text questions help you master key concepts of biochemistry, while end-of-chapter problem sets grouped by problem types help you master problem-solving skills.
(source: Nielsen Book Data)9781285429106 20160618
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01

7. Biochemistry [2015]

xxxii, 1056, 48, 43, 43 pages : illustrations (some color) ; 29 cm
  • PART I: THE MOLECULAR DESIGN OF LIFE 1. Biochemistry: An Evolving Science 2. Protein Composition and Structure 3. Exploring Proteins and Proteomes 4. DNA, RNA, and the Flow of Genetic Information 5. Exploring Genes and Genomes 6. Exploring Evolution and Bioinformatics 7. Hemoglobin: Portrait of a Protein in Action 8. Enzymes: Basic Concepts and Kinetics 9. Catalytic Strategies 10. Regulatory Strategies 11. Carbohydrates 12. Lipids and Cell Membranes 13. Membrane Channels and Pumps 14. Signal-Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY 15. Metabolism: Basic Concepts and Design 16. Glycolysis and Gluconeogenesis 17. The Citric Acid Cycle 18. Oxidative Phosphorylation 19. The Light Reactions of Photosynthesis 20. The Calvin Cycle and the Pentose Phosphate Pathway 21. Glycogen Metabolism 22. Fatty Acid Metabolism 23. Protein Turnover and Amino Acid Catabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE 24. The Biosynthesis of Amino Acids 25. Nucleotide Biosynthesis 26. The Biosynthesis of Membrane Lipids and Steroids 27. The Integration of Metabolism 28. DNA Replication, Repair, and Recombination 29. RNA Synthesis and Processing 30. Protein Synthesis 31. The Control of Gene Expression in Prokaryotes 32. The Control of Gene Expression in Eukaryotes PART IV: RESPONDING TO ENVIRONMENTAL CHANGES 33. Sensory Systems 34. The Immune System 35. Molecular Motors 36. Drug Development.
  • (source: Nielsen Book Data)9781464126109 20160618
For four decades, this extraordinary textbook played an pivotal role in the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance. Those defining features are at the heart of this edition.
(source: Nielsen Book Data)9781464126109 20160618
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01, CHEM-183-01, CHEMENG-183-01, CHEMENG-283-01

8. Biochemistry [2013]

xxxviii, 1169, 48, 22 p. : ill. (chiefly col.) ; 29 cm.
  • Molecular components of cells
  • Facts of life: chemistry is the logic of biological phenomena
  • Water: the medium of life
  • Thermodynamics of biological systems
  • Amino acids and the peptide bond
  • Proteins: their primary structure and biological functions
  • Proteins: secondary, tertiary, and quaternary structure
  • Carbohydrates and the glycoconjugates of cell surfaces
  • Lipids
  • Membranes and membrane transport
  • Nucleotides and nucleic acids
  • Structure of nucleic acids
  • Recombinant DNA: cloning and creation of chimeric genes
  • Protein dynamics
  • Enzymes: kinetics and specificity
  • Mechanisms of enzyme action
  • Enzyme regulation
  • Molecular motors
  • Metabolism and its regulation
  • Metabolism: an overview
  • Glycolysis
  • Tricarboxylic acid cycle
  • Electron transport and oxidative phosphorylation
  • Photosynthesis
  • Gluconeogenesis, glycogen metabolism, and the pentose phosphate pathway
  • Fatty acid catabolism
  • Lipid biosynthesis
  • Nitrogen acquisition and amino acid metabolism
  • Synthesis and degradation of nucleotides
  • Metabolic integration and organ specialization
  • Information transfer
  • DNA metabolism: replication, recombination, and repair
  • Transcription and the regulation of gene expression
  • Protein synthesis
  • Completing the protein life cycle: folding, processing, and degradation
  • Reception and transmission of extracellular information.
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01
xxii, 1,008 p. : col. ill. ; 28 cm.
  • Part I. Biological Molecules 1. From Genes to RNA to Proteins 2. Nucleic Acid Structure 3. Glycans and Lipids 4. Protein Structure 5. Evolutionary Variation in Proteins Part II. Energy and Entropy 6. Energy and Intermolecular Forces 7. Entropy 8. Linking Energy and Entropy Part III. Free Energy 9. Free Energy 10. Chemical Potential and the Drive to Equilibrium 11. Voltages and Free Energy Part IV. Molecular Interactions 12. Molecular Recognition 13. Specificity of Macromolecular Recognition 14. Allostery Part V. Kinetics and Catalysis 15. Rates of Molecular Processes 16. Principles of Enzyme Catalysis 17. Diffusion and Transport Part VI. Assembly and Activity 18. Folding 19. Fidelity in DNA and Protein Synthesis.
  • (source: Nielsen Book Data)9780815341888 20160609
The field of biochemistry is entering an exciting era in which genomic information is being integrated into molecular-level descriptions of the physical processes that make life possible. The Molecules of Life is a new textbook that provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine. The book integrates fundamental concepts in thermodynamics and kinetics with an introduction to biological mechanism at the level of molecular structure. The central theme is that the ways in which proteins, DNA, and RNA work together in a cell are connected intimately to the structures of these biological macromolecules. The structures, in turn, depend on interactions between the atoms in these molecules, and on the interplay between energy and entropy, which results in the remarkable ability of biological systems to self-assemble and control their own replication. The Molecules of Life deepens our understanding of how life functions by illuminating the physical principles underpinning many complex biological phenomena, including how nerves transmit signals, the actions of chaperones in protein folding, and how polymerases and ribosomes achieve high fidelity.
(source: Nielsen Book Data)9780815341888 20160609
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01

10. Biochemistry [2011]

xxv, 1428, 53 p. : ill. (some col.) ; 29 cm.
  • Guide to Media Resources xvi PART I INTRODUCTION AND BACKGROUND 1 1 Life 3 2 Aqueous Solutions 40 3 Thermodynamic Principles: A Review 52 PART II BIOMOLECULES 65 4 Amino Acids 67 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82 6 Techniques of Protein and Nucleic Acid Purifications 129 7 Covalent Structures of Proteins and Nucleic Acids 163 8 Three-Dimensional Structures of Proteins 221 9 Protein Folding, Dynamics, and Structural Evolution 278 10 Hemoglobin: Protein Function in Microcosm 323 11 Sugars and Polysaccharides 359 12 Lipids and Membranes 386 PART III MECHANISMS OF ENZYME ACTION 467 13 Introduction to Enzymes 469 14 Rates of Enzymatic Reactions 482 15 Enzymatic Catalysis 506 PART IV METABOLISM 557 16 Introduction to Metabolism 559 17 Glycolysis 593 18 Glycogen Metabolism 638 19 Signal Transduction 671 20 Transport through Membranes 744 21 Citric Acid Cycle 789 22 Electron Transport and Oxidative Phosphorylation 823 23 Other Pathways of Carbohydrate Metabolism 871 24 Photosynthesis 901 25 Lipid Metabolism 940 26 Amino Acid Metabolism 1019 27 Energy Metabolism: Integration and Organ Specialization 1088 28 Nucleotide Metabolism 1107 PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143 29 Nucleic Acid Structures 1145 30 DNA Replication, Repair, and Recombination 1173 31 Transcription 1260 32 Translation 1338 33 Viruses: Paradigms for Cellular Function W-1 34 Eukaryotic Gene Expression W-53 35 Molecular Physiology W-165 (Chapters 33--35 are available on our website, www.wiley.com/college/voet ) xii.
  • (source: Nielsen Book Data)9780470570951 20160604
This text is an unbound, binder-ready edition. The "Gold Standard" in Biochemistry text books, Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
(source: Nielsen Book Data)9780470917459 20160604
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01
xix, 740 p. : ill. ; 26 cm.
  • (NOTE: Most chapters begin with Concepts and Applications and end with Summary, References, Suggested Readings and Problems.) Preface. About the Authors. 1. Introduction. The Human Genome and Beyond. Transcription and Translation. Ion Channels. 2. The First Law: Energy Is Conserved. Energy Conversion and Conservation. Describing the State of a System. Phase Changes. Chemical Reactions. Molecular Interpretations of Energy and Enthalpy. Mathematics Needed for Chapter 2. 3. The Second Law: The Entropy of the Universe Increases. Historical Development of the Second Law: The Carnot Cycle. A New State Function, Entropy. The Second Law of Thermodynamics: Entropy Is Not Conserved. Molecular Interpretation of Entropy. Measurement of Entropy. Chemical Reactions. Third Law of Thermodynamics. Gibbs Free Energy. Helmholtz Free Energy. Noncovalent Reactions. Use of Partial Derivatives in Thermodynamics. 4. Free Energy and Chemical Equilibria. Chemical Potential (Partial Molar Gibbs Free Energy). Reactions of Gases: The Ideal Gas Approximation. Nonideal Systems. The Equilibrium Constant and the Standard Gibbs Free Energies of the Reactants and Products. Galvanic Cells. Biochemical Applications of Thermodynamics. Mathematics Needed for Chapter 4. 5. Free Energy and Physical Equilibria. Phase Equilibria. Membranes. Active and Passive Transport. Colligative Properties. Molecular-Weight Determination. Internet. 6. Molecular Motion and Transport Properties. Kinetic Theory. Molecular Collisions. Mean Free Path. Diffusion. Sedimentation. Determination of Molecular Weights from Sedimentation and Diffusion. Viscosity. Electrophoresis. Size and Shape of Macromolecules. 7. Kinetics: Rates of Chemical Reactions. Kinetics. Reaction Mechanisms and Rate Laws. Temperature Dependence. Transition-State Theory. Electron Transfer Reactions: Marcus Theory. Ionic Reactions and Salt Effects. Isotopes and Stereochemical Properties. Very Fast Reactions. Diffusion-Controlled Reactions. Photochemistry and Photobiology. Photosynthesis. Mathematics Needed for Chapter 7. 8. Enzyme Kinetics. Enzyme Kinetics. Michaelis-Menten Kinetics. Competition and Inhibition. Mathematics Needed for Chapter 8. 9. Molecular Structures and Interactions: Theory. The Process of Vision. Origins of Quantum Theory. Quantum Mechanical Calculations. Schrodinger's Equation. Particle in a Box. Tunneling. Simple Harmonic Oscillator. Rigid Rotator. Hydrogen Atom. Electron Distribution. Molecular Structure and Molecular Orbitals. Intermolecular and Intramolecular Forces. Noncovalent Interactions. Molecular Dynamics Simulation. Outlook. Schrodinger's Equation. Some Useful Operators. Mathematics Needed for Chapter 9. 10. Molecular Structures and Interactions: Spectroscopy. Electromagnetic Spectrum. Color and Refractive Index. Absorption and Emission of Radiation. Proteins and Nucleic Acids: Ultraviolet Absorption Spectra. Fluorescence. Optical Rotatory Dispersion and Circular Dichroism. Circular Dichroism of Nucleic Acids and Proteins. Vibrational Spectra, Infrared Absorption, and Raman Scattering. Nuclear Magnetic Resonance. Interactions in Nuclear Magnetic Resonance. 11. Molecular Distributions and Statistical Thermodynamics. Binding of Small Molecules by a Polymer. The Random Walk. Helix-Coil Transitions. Statistical Thermodynamics. Mathematics Needed for Chapter 11. 12. Macromolecular Structure and X-Ray Diffraction. Visible Images. X Rays. Determination of Molecular Structure. Electron Diffraction. Neutron Diffraction. Electron Microscopy. Mathematics Needed for Chapter 12. Appendix. Answers. Index.
  • (source: Nielsen Book Data)9780130959430 20160528
For a one/two-term course in Physical Chemistry for students in the biological sciences. This best-selling text presents the principles and applications of contemporary physical chemistry as they are used to solve problems in biology, biochemistry, and medicine. This text puts the study of physical chemistry for these students in context. Each chapter starts with sections on concepts and applications. These provide students with an overview of the physical chemistry principle under discussion and how that topic can be applied to solving biological and biochemical problems.
(source: Nielsen Book Data)9780130959430 20160528
Science Library (Li and Ma)
CHEM-141-01, CHEM-141-01, CHEM-141-01