Zou, Yun-Xiang, Liu, Xiao-Yan, Zhang, Jing, Yang, Hong-Li, Yang, Xin-Yue, Liu, Xiao-Ling, Chu, Yi-Wen, and Chen, Long
Advanced Synthesis & Catalysis. Dec 3, 2019, Vol. 361 Issue 23, p5311, 6 p.
Oxides and Phosphonates
Keywords: 3-Indolylmethanols; Phosphorylated indoles; 1,2-addition; Phosphorylation; Metal-free Abstract An efficient and practical method for synthesis of C2-phosphorylated indoles has been disclosed via a metal-free 1,2-phosphorylation of 3-indolylmethanols with H-phosphine oxides or H-phosphonates. This alternative protocol features a broad substrate scope with respect to both 3-indolylmethanols derived from isatins, acyclic [alpha]-keto amide, [alpha]-keto ester, 1,2-diketone and simple ketones and H-phosphine oxides or H-phosphonates, moderate to high yields and mild reaction conditions. Mechanistic studies indicate that this reaction proceeds via an unusual direct 1,2-addition pathway, in which the existence of an electron-withdrawing group adjacent to the hydroxyl group of 3-indolylmethanols plays a decisive role. Supporting information: Additional Supporting Information may be found in the online version of this article As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. CAPTION(S): Supplementary Byline: Yun-Xiang Zou, Xiao-Yan Liu, Jing Zhang, Hong-Li Yang, Xin-Yue Yang, Xiao-Ling Liu, Yi-Wen Chu, Long Chen
Qiao, Congzhen, Zou, Yun, Qiu, Yajing, and Lin, Xiaoxi
Annals of Plastic Surgery. Oct 2019, Vol. 83 Issue 4S S 1, S77, 5 p.
Mole (Dermatology) -- Care and treatment, Excision (Surgery) -- Complications and side effects, Cheek -- Care and treatment, Surgery, Plastic -- Methods, Surgery -- Complications, Surgery -- Causes of, and Surgery -- Care and treatment
Byline: Congzhen Qiao, From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Yun Zou; Yajing Qiu; Xiaoxi Lin Abstract BACKGROUND: Surgical management of cheek congenital melanocytic nevus (CMN) remains a huge challenge because of undesirable defects in repair. The use of direct closure is often limited to defect reconstruction with a diameter less than 4 cm. OBJECTIVE: This study aimed to evaluate the safety and efficacy of direct vertical closure combined with extensive subcutaneous tissue undermining boundaries for intermediate-to-large cheek defects. METHODS AND MATERIALS: A retrospective review was conducted to evaluate patients with cheek CMN who underwent the aforementioned procedure. Projected adult size, defect size, and incision length were measured. The Vancouver scar scale and visual analog scale were applied to assess scar formation and postoperative appearance. Complications within 1 year postoperatively were recorded. RESULTS: A total of 35 patients with CMN >3.5 cm underwent the procedure. Patients' age ranged from 3 to 36 years. The average projected adult size of the facial CMN was 5.5 [+ or -] 1.6 cm. The mean Vancouver scar scale and visual analog scale scores were 2.6 [+ or -] 1.0 and 8.0 [+ or -] 0.7, respectively. There were 2 cases of dog ear deformity (5.7%) and 1 case of hematoma (2.9%). CONCLUSION: This simple algorithm yields satisfying results with low complication rate in the repair of intermediate-to-large cheek defects and may become a useful alternative to cheek reconstruction.