United States. Centers for Disease Control and Prevention, Suicide -- Health aspects, Liability (Law) -- Health aspects, Bullying -- Health aspects, and Students -- Health aspects
Educators' responsibility for student safety includes the familiar concerns about slip-and-fall accidents and sports injuries. Increasingly, however, that responsibility goes beyond the physical to include mental and emotional harms, such [...]
Morrow, Angel, Underwood, Julie, Seldin, Lindsey, Hinnant, Taylor, and Lechler, Terry
eLife. Oct 2, 2019, Vol. 8
Introduction The epidermis is a proliferative tissue that turns over repeatedly throughout life. Remarkably, in aged sun-exposed skin, homeostasis and the architecture of the epidermis is maintained despite prevalent clones [...] Tissue homeostasis requires a balance between progenitor cell proliferation and loss. Mechanisms that maintain this robust balance are needed to avoid tissue loss or overgrowth. Here we demonstrate that regulation of spindle orientation/asymmetric cell divisions is one mechanism that is used to buffer changes in proliferation and tissue turnover in mammalian skin. Genetic and pharmacologic experiments demonstrate that asymmetric cell divisions were increased in hyperproliferative conditions and decreased under hypoproliferative conditions. Further, active K-Ras also increased the frequency of asymmetric cell divisions. Disruption of spindle orientation in combination with constitutively active K-Ras resulted in massive tissue overgrowth. Together, these data highlight the essential roles of spindle orientation in buffering tissue homeostasis in response to perturbations.