Author "Shukla, Gauri"

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1. Optimization of Plasmonic U-Shaped Optical Fiber Sensor for Mercury Ions Detection Using Glucose Capped Silver Nanoparticles [2019]

  • Shukla, Gauri M., Punjabi, Nirmal, Kundu, Tapanendu, and Mukherji, Soumyo
  • IEEE sensors journal. 19(9):3224-3231

2. Telehealth for COVID-19 in World Trade Center Responders: Meeting the Needs of This Unique Population [2021]

  • Senay, Emily, Byrne, Dawn, Mattson, Christina, Shukla, Gauri, and Crowley, Laura
  • Journal of Occupational and Environmental Medicine
Subjects
Letter to the Editors

3. The Response to September 11: A Disaster Case Study [2014]

  • Crane, Michael A., Levy-Carrick, Nomi C., Crowley, Laura, Barnhart, Stephanie, Dudas, Melissa, Onuoha, Uchechukwu, Globina, Yelena, Haile, Winta, Shukla, Gauri, and Ozbay, Fatih
  • In Annals of Global Health July-August 2014 80(4):320-331

4. Telehealth for COVID-19 in World Trade Center Responders: Meeting the Needs of This Unique Population. [2021]

  • Senay, Emily, Byrne, Dawn, Mattson, Christina, Shukla, Gauri, and Crowley, Laura
  • Journal of Occupational & Environmental Medicine; Nov2021, Vol. 63 Issue 11, pe834-e837, 4p

5. Sarcoid Like Granulomatous Pulmonary Disease in World Trade Center Disaster Responders [2011]

  • CROWLEY, Laura E, HERBERT, Robin, SHAPIRO, Moshe, WONG, Karen, SACKS, Henry S, LANDRIGAN, Philip J, TEIRSTEIN, Alvin S, MOLINE, Jacqueline M, WALLENSTEIN, Sylvan, SHUKLA, Gauri, SCHECHTER, Clyde, SKLOOT, Gwen S, UDASIN, Iris, LUFT, Benjamin J, and HARRISON, Denise
  • American journal of industrial medicine. 54(3):175-184
Subjects
Hygiene and public health, epidemiology, occupational medicine, Hygiène et santé publique, épidémiologie, médecine du travail, Toxicology, Toxicologie, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Sarcoidoses. Granulomatoses d'etiologie indeterminee. Maladies du tissu conjonctif. Maladies du tissu elastique. Vascularites, Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis, Maladie de système, Systemic disease, Enfermedad sistémica, Pathologie de l'appareil respiratoire, Respiratory disease, Aparato respiratorio patología, Capacité vitale forcée, Forced vital capacity, Capacidad vital forzada, Epidémiologie, Epidemiology, Epidemiología, Etiologie, Etiology, Etiología, Etude cas témoin, Case control study, Estudio caso control, Fonction respiratoire, Lung function, Función respiratoria, Granulomatose, Granulomatosis, Homme, Human, Hombre, Médecine catastrophe, Disaster medicine, Medicina catástrofe, Pathologie des poumons, Lung disease, Pulmón patología, Santé publique, Public health, Salud pública, Sarcoïdose, Sarcoidosis, Terrorisme, Terrorism, Terrorismo, Attentats 11 septembre 2001, World Trade Center (WTC), a case control etiologic study of sarcoidosis (ACCESS), forced vital capacity (FVC), granulomatous disease, and sarcoidosis
Abstract
Background More than 20, 000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTCfirefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of sarcoid like granulomatous pulmonary disease in other WTC responders. Methods Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only definite cases are reported. Results Thirty-eight patients were classified as definite cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. Conclusions Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.

6. Comparative evaluation of Bis(thiosemicarbazone)- Biotin and Met-ac-TE3A for tumor imaging [2016]

  • Singh, Sweta, Tiwari, Anjani K., Varshney, Raunak, Mathur, R., Shukla, Gauri, Bag, N., Singh, B., and Mishra, Anil K.
  • Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. Jan 15, 2016, Vol. 153, p566, 6 p.

7. Multiple Myeloma in World Trade Center Responders: A Case Series [2009]

  • MOLINE, Jacqueline M, HERBERT, Robin, SAVITZ, David A, CROWLEY, Laura, TROY, Kevin, HODGMAN, Erica, SHUKLA, Gauri, UDASIN, Iris, LUFT, Benjamin, WALLENSTEIN, Sylvan, and LANDRIGAN, Philip
  • Journal of occupational and environmental medicine. 51(8):896-902
Subjects
Environment, Environnement, Hygiene and public health, epidemiology, occupational medicine, Hygiène et santé publique, épidémiologie, médecine du travail, Toxicology, Toxicologie, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Immunopathologie, Immunopathology, Immunodéficits. Immunoglobulinopathies, Immunodeficiencies. Immunoglobulinopathies, Immunoglobulinopathies, Hemopathies, Hematologic and hematopoietic diseases, Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde, Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis, Cancer, Cáncer, Hémopathie maligne, Malignant hemopathy, Hemopatía maligna, Immunoglobulinopathie, Immunoglobulinopathy, Inmunoglobulinopatía, Immunopathologie, Immunopathology, Inmunopatología, Médecine du travail, Occupational medicine, Medicina ocupacional, Syndrome lymphoprolifératif, Lymphoproliferative syndrome, Linfoproliferativo síndrome, Exposition professionnelle, Occupational exposure, Exposición profesional, Homme, Human, Hombre, Industrie construction, Construction industry, Industria construcción, Myélome, Myeloma, Mieloma, Reconstruction, Reconstrucción, Secouriste, Rescuer, Socorrista, and Attentats 11 septembre 2001
Abstract
Objectives: We report on cases of multiple myeloma (MM) observed in World Trade Center (WTC) responders registered in the WTC Medical Program. Methods: Possible cases of MM diagnosed between September 11, 2001, and September 10, 2007, in responders were confirmed if they met the World Health Organization and Mayo Clinic diagnostic criteria. Results: Among 28, 252 responders of known sex and age, eight cases of MM were observed (6.8 expected). Four of these cases were observed in responders younger than 45 years at the time of diagnosis (1.2 expected). A slight deficit of MM cases was observed in responders older than 45 years (4 observed, 5.6 expected). Conclusion: In this case series, we observe an unusual number of MM cases in WTC responders under 45 years. This finding underscores the importance of maintaining surveillance for cancer and other emerging diseases in this highly exposed population.

8. Synthesis, characterization and biological activity of Schiff base analogues of indole-3-carboxaldehyde [2008]

  • SINHA, Deepa, TIWARI, Anjani K, SINGH, Sweta, SHUKLA, Gauri, MISHRA, Pushpa, CHANDRA, Harish, and MISHRA, Anil K
  • European journal of medicinal chemistry. 43(1):160-165
Subjects
Organic chemistry, Chimie organique, Pharmacology drugs, Pharmacologie, galénique, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Pharmacologie. Traitements medicamenteux, Pharmacology. Drug treatments, Antibiotiques. Antiinfectieux. Antiparasitaires, Antibiotics. Antiinfectious agents. Antiparasitic agents, Généralités, General aspects, Produits de contraste. Produits radioisotopiques, Contrast media. Radiopharmaceuticals, Mammalia, Rodentia, Vertebrata, Activité biologique, Biological activity, Actividad biológica, Agent scintigraphique, Scintigraphic agent, Agente centelleográfico, Aminophénols, Aminophenols, Aminofenoles, Animal, Antibactérien, Antibacterial agent, Antibacteriano, Antifongique, Antifungal agent, Antifúngico, Antimicrobien, Antimicrobial agent, Antimicrobiano, Base Schiff, Schiff base, Distribution, Distribución, Dérivé de l'indole, Indole derivatives, Indol derivado, Imine, Imina, In vitro, Marquage radioisotopique, Radiolabelling, Marcación radioisotópica, Produit diagnostic, Diagnostic agent, Producto diagnóstico, Produit radioisotopique, Radioisotopic product, Producto radioisotópico, Souris, Mouse, Ratón, Stabilité, Stability, Estabilidad, Synthèse chimique, Chemical synthesis, Síntesis química, Technétium Complexe, Technetium Complexes, Tecnecio Complejo, Tissu, Tissue, Tejido, α-Aminoacide, α-Aminoacid, α-Aminoácido, Biodistribution, Indole-3-carbaldéhyde dérivé, Technétium 99m, Antimicrobial, Heterocyclic, and Spectroscopic
Abstract
Eight novel heterocyclic Schiff bases derived from the condensation reactions of indole 3-carboxaldehyde with different L-amino acids (histidine, glutamic acid, aspartic acid, leucine, valine) as well as with some aminophenols, have been synthesized and characterized by various spectroscopic methods (IR, MS, 1H NMR). Schiff base derivatives of indole 3-carboxaldehyde were labeled with 99mTc and radiochemical purity was above 97% which is ascertained by instant thin layer chromatography using different solvent conditions. Stability studies of all the derivatives of indole 3-carboxaldehyde was determined under physiological conditions and were stable for more than 24 h. Blood clearance showed a quick wash out from the circulation and biological half life was found to be t½(F) = 1 h 15 min; t½(S) = 10 h 05 min. Excellent quality radioimages of tumor bearing mice were recorded showing rapid clearance of background activity, visualization of tumor at 3 h and clearance from kidneys of histidine analogue which was further evidenced in biodistribution studies. Antimicrobial activity of these Schiff base compounds was evaluated against Bacillus subtilis, Pseudomonas fluorescence, Staphylococcus aureus, Aspergillus niger, Candida albicans and Trichophyton rubrum.

9. Nanoplasmonic biosensors: current perspectives [2015]

  • Shukla, Gauri M. and Mukherji, Soumyo
  • Nanobiosensors in Disease Diagnosis. Annual, 2015, Vol. 4, p75, 14 p.

10. ⁹⁹mTc-DTPA-Amino Acids Conjugate as Specific SPECT Pharmaceuticals for Tumor Imaging [2009]

  • Sinha, Deepa, Shukla, Gauri, Tiwari, Anjani K., Chaturvedi, Shubhra, Chuttani, Krishna, Chandra, Harish, and Mishra, Anil K.
  • Chemical biology & drug design, 2009 Aug., v. 74, no. 2, p. 159-164.
Subjects
tumor imaging, radiopharmaceutical, and spectroscopy
Abstract
Includes references
⁹⁹mTc-Diethylene triamine pentaacetic acid-bis (amide) conjugates have been synthesized and evaluated as a potential radiopharmaceutical for tumor imaging. The compounds were synthesized by the condensation reaction of DTPA bis(anhydride) with different l-amino acids (methyl tryptophan, and 5-hydroxy tryptophan) and were characterized on the basis of IR, NMR, and Mass spectroscopy. ⁹⁹mTc-labeled compounds were found stable for about 24 h under physiological conditions with more than 95% radiolabeling yield. Blood kinetic studies of all these complexes showed a bi-exponential pattern as well as quick wash out from the blood circulation. The biological t₁/₂(F) and t₁/₂(S) were found to be 20 ± 0.001 min for DTPA-(Me-Trp)₂ and 18 ± 0.001 min for DTPA-(5HT)₂ and t₁/₂ (slow) 5 h 45 min ± 0.001, 5 h 30 ± 0.001 min for DTPA-(Me-Trp)₂, and DTPA-(5HT)₂, respectively. Imaging and biodistribution studies were performed in mice bearing Ehrlich ascites tumor (EAT) tumors in right thigh. Radioconjugate derived from l-5-hydroxytryptophan exhibited remarkable localization at tumor site; whereas radiotracer derived from l-methyl tryptophan shows relatively less accumulation at the tumor site. Tumor-to-muscles ratios were 5.07 ± 0.001, and 4.2 ± 0.001 at 1 and 4 h for ⁹⁹mTc-DTPA-(Me trp)₂ and 4.97 ± 0.001 and 5.8 ± 0.001 at 1 and 4 h after postinjection for ⁹⁹mTc-DTPA-(5HT)₂, respectively. The preliminary results with these amino acid based ligands are encouraging to carrying out further in vivo experiments for targeted tumor imaging.

11. Quantitative Structure-Property Relationship (Correlation Analysis) of Phosphonic Acid-Based Chelates in Design of MRI Contrast Agent [2009]

  • Tiwari, Anjani K., Ojha, Himanshu, Kaul, Ankur, Dutta, Anupama, Srivastava, Pooja, Shukla, Gauri, Srivastava, Rakesh, and Mishra, Anil K.
  • Chemical biology & drug design, 2009 July, v. 74, no. 1, p. 87-91.
Subjects
MRI, QSPR, chelating agent, and linear models
Abstract
Includes references
Nuclear magnetic resonance imaging is a very useful tool in modern medical diagnostics, especially when gadolinium (III)-based contrast agents are administered to the patient with the aim of increasing the image contrast between normal and diseased tissues. With the use of soft modelling techniques such as quantitative structure-activity relationship/quantitative structure-property relationship after a suitable description of their molecular structure, we have studied a series of phosphonic acid for designing new MRI contrast agent. Quantitative structure-property relationship studies with multiple linear regression analysis were applied to find correlation between different calculated molecular descriptors of the phosphonic acid-based chelating agent and their stability constants. The final quantitative structure-property relationship mathematical models were found as - quantitative structure-property relationship Model for phosphonic acid series (Model 1) - log KML = {5.00243(±0.7102)}- MR {0.0263(±0.540)}n = 12 l r l = 0.942 s = 0.183 F = 99.165 quantitative structure-property relationship Model for phosphonic acid series (Model 2) - log KML = {5.06280(±0.3418)}- MR {0.0252(± .198)}n = 12 l r l = 0.956 s = 0.186 F = 99.256.

12. Effect of a Novel Series of Benzothiazolo-Quinazolones on Epidermal Growth Factor Receptor (EGFR) and Biological Evaluations [2008]

  • Shukla, Gauri, Tiwari, Anjani K., Singh, Vinay K., Bajpai, Aruna, Chandra, Harish, and Mishra, Anil K.
  • Chemical biology & drug design, 2008 Dec., v. 72, no. 6, p. 533-539.
Subjects
anti-bacterial, benzothiazole, anti-fungal, anti-cancer, and spectroscopy
Abstract
Includes references
A newly designed benzothiazolo-quinazolone series was synthesized by an aromatic amine and potassium thiocyanate in the presence of bromine in glacial acetic acid, and the final product was obtained by subsequent reaction with 5-arylamido/imidoalkyl-2-chlorobenzoic acid in the presence of potassium carbonate and further cyclization with sulphuric acid. A preliminary radiolabelling study with technetium shows a promising potential for further in vivo evaluation. Anti-bacterial, anti-viral and anti-tumor activities were evaluated for biological properties. Lead compounds are able to block epidermal growth factor receptor (EGFR) in human breast adenocarcinoma cell line, MCF-7.

13. Authors' Response [2009]

  • Moline, Jacqueline M., Herbert, Robin, Crowley, Laura, Troy, Kevin, Hodgman, Erica, Shukla, Gauri, Udasin, Iris, Luft, Benjamin, Wallenstein, Sylvan, Landrigan, Philip, and Savitz, David A.
  • Journal of Occupational and Environmental Medicine. 51(12):1357-1358

14. Optimization of Plasmonic U-Shaped Optical Fiber Sensor for Mercury Ions Detection Using Glucose Capped Silver Nanoparticles [2019]

  • Shukla, Gauri M., Punjabi, Nirmal, Kundu, Tapanendu, and Mukherji, Soumyo
Subjects
Electrical and Electronic Engineering, Instrumentation, Aqueous solution, Nanoparticle, Silver nanoparticle, Metal ions in aqueous solution, Inorganic chemistry, Colloidal gold, Tap water, Materials science, Mercury (element), chemistry.chemical_element, chemistry, and Fiber optic sensor
Abstract
Heavy metal contamination of water bodies has an adverse effect on human health and the environment even at very low concentrations. In this paper, we report U-shaped fiber optic probe coated with glucose capped silver nanoparticles (AgNPs) for label-free detection of mercury ions in aqueous solution. The reaction between glucose capped AgNPs and mercury ions resulted in a reduction in the plasmonic absorbance. The developed sensor probe was able to detect mercury ions concentration as low as 2 ppb, which is less than the World Health Organization acceptable limit for mercury ions in drinking water. The sensor probes displayed excellent selectivity towards mercury ions over other metal ions. Furthermore, the developed sensor probe was able to detect mercury ions down to 5 ppb in domestic tap water, i.e., selective detection of mercury even in real matrix having high concentration mixtures of various essential ions. The response of AgNPs coated sensor probe was found to be better than glucose capped gold nanoparticles and hollow gold-silver nanostructures coated fiber-optic probes.

15. Synthesis and characterization of size- and shape-controlled silver nanoparticles [2019]

  • Mukherji, Suparna, Bharti, Sharda, Shukla, Gauri, and Mukherji, Soumyo
Subjects
General Physics and Astronomy, General Materials Science, General Chemistry, Silver nanoparticle, Nanorod, and Nanotechnology
Abstract
Silver nanoparticles (AgNPs) have application potential in diverse areas ranging from wound healing to catalysis and sensing. The possibility for optimizing the physical, chemical and optical properties for an application by tailoring the shape and size of silver nanoparticles has motived much research on methods for synthesis of size- and shape-controlled AgNPs. The shape and size of AgNPs are reported to vary depending on choice of the Ag precursor salt, reducing agent, stabilizing agent and on the synthesis technique used. This chapter provides a detailed review on various synthesis approaches that may be used for synthesis of AgNPs of desired size and shape. Silver nanoparticles may be synthesized using diverse routes, including, physical, chemical, photochemical, biological and microwave -based techniques. Synthesis of AgNPs of diverse shapes, such as, nanospheres, nanorods, nanobars, nanoprisms, decahedral nanoparticles and triangular bipyramids is also discussed for chemical-, photochemical- and microwave-based synthesis routes. The choice of chemicals used for reduction and stabilization of nanoparticles is found to influence their shape and size significantly. A discussion on the mechanism of synthesis of AgNPs through nucleation and growth processes is discussed for AgNPs of varying shape and sizes so as to provide an insight on the various synthesis routes. Techniques, such as, electron microscopy, spectroscopy, and crystallography that can be used for characterizing the AgNPs formed in terms of their shape, sizes, crystal structure and chemical composition are also discussed in this chapter. Graphical Abstract

16. Response To Dr. Reichʼs Letter: “‘Sarcoid-Like&@rsquo; Granulomatous Pulmonary Disease in World Trade Center Disaster Responders: Influence of Incidence Computation Methodology in Inferring Airborne Dust Causation”: “Sarcoid-Like” Granulomatous Pulmonary Disease in World Trade Center Disaster Responders [2011]

  • Crowley, Laura E., Herbert, Robin, Moline, Jacqueline M., Wallenstein, Sylvan, Shukla, Gauri, Schechter, Clyde, Skloot, Gwen S., Udasin, Iris, Luft, Benjamin J., Harrison, Denise, Shapiro, Moshe, Wong, Karen, Sacks, Henry S., Teirstein, Alvin S., and Landrigan, Philip J.
  • American Journal Of Industrial Medicine. Nov 01, 2011 54(11):894-895

17. 99mTc-DTPA-Amino Acids Conjugate as Specific SPECT Pharmaceuticals for Tumor Imaging [2009]

  • Sinha, Deepa, Shukla, Gauri, Tiwari, Anjani K., Chaturvedi, Shubhra, Chuttani, Krishna, Chandra, Harish, and Mishra, Anil K.
  • Chemical Biology and Drug Design. Aug 01, 2009 74(2):159-164

18. 99mTc-methionine scintimammography in the evaluation of breast cancer [2009]

  • Sharma, Rajnish, Tripathi, Madhavi, Panwar, Puja, Chuttani, Krishna, Jaimini, Abhinav, Maitra, Sudeshna, Chopra, Mahinder Kumar, Sawroop, Krishan, Shukla, Gauri, Mondal, Anupam, and Mishra, Anil
  • Nuclear Medicine Communications. May 01, 2009 30(5):338-342

19. Synthesis and biological evaluation of [sup.99m]Tc-DTPA-bis(His) as a potential probe for tumor imaging with SPECT [2009]

  • Sinha, Deepa, Shukla, Gauri, Chuttani, Krishna, Chandra, Harish, and Mishra, Anil K.
  • Cancer Biotherapy & Radiopharmaceuticals. Oct 2009, Vol. 24 Issue 5, p615, 6 p.

20. Synthesis and assessment of [sup.99m]Tc chelate-conjugated alendronate for development of specific radiopharmaceuticals [2009]

  • Shukla, Gauri, Tiwari, Anjani K., Sinha, Deepa, Srivastava, Rakesh, Cahndra, Hairsh, and Mishra, Anil K.
  • Cancer Biotherapy & Radiopharmaceuticals. April 2009, Vol. 24 Issue 2, p209, 6 p.

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