Author "Ismael Conejero"

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1. Evaluating and mitigating clinical samples matrix effects on TX-TL cell-free performance [2022]

  • Peter L. Voyvodic, Ismael Conejero, Khouloud Mesmoudi, Eric Renard, Philippe Courtet, Diego I. Cattoni, and Jerome Bonnet
  • Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Subjects
Medicine and Science
Abstract
Abstract Cell-free biosensors are promising tools for medical diagnostics, yet their performance can be affected by matrix effects arising from the sample itself or from external components. Here we systematically evaluate the performance and robustness of cell-free systems in serum, plasma, urine, and saliva using two reporter systems, sfGFP and luciferase. In all cases, clinical samples have a strong inhibitory effect. Of the different inhibitors, only RNase inhibitor mitigated matrix effects. However, we found that the recovery potential of RNase inhibitor was partially muted by interference from glycerol contained in the commercial buffer. We solved this issue by designing a strain producing an RNase inhibitor protein requiring no additional step in extract preparation. Furthermore, our new extract yielded higher reporter levels than previous conditions and tempered interpatient variability associated with matrix effects. This systematic evaluation and improvements of cell-free system robustness unified across many types of clinical samples is a significant step towards developing cell-free diagnostics for a wide range of conditions.

2. A rapid and standardized workflow for functional assessment of bacterial biosensors in fecal samples [2022]

  • Ana Zúñiga, Geisler Muñoz-Guamuro, Lucile Boivineau, Pauline Mayonove, Ismael Conejero, Georges-Philippe Pageaux, Romain Altwegg, and Jerome Bonnet
  • Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Subjects
synthetic biology, diagnostics, whole-cell biosensor, engineered bacteria, metabolite detection, gut microbiome, Biotechnology, and TP248.13-248.65
Abstract
Gut metabolites are pivotal mediators of host-microbiome interactions and provide an important window on human physiology and disease. However, current methods to monitor gut metabolites rely on heavy and expensive technologies such as liquid chromatography-mass spectrometry (LC-MS). In that context, robust, fast, field-deployable, and cost-effective strategies for monitoring fecal metabolites would support large-scale functional studies and routine monitoring of metabolites biomarkers associated with pathological conditions. Living cells are an attractive option to engineer biosensors due to their ability to detect and process many environmental signals and their self-replicating nature. Here we optimized a workflow for feces processing that supports metabolite detection using bacterial biosensors. We show that simple centrifugation and filtration steps remove host microbes and support reproducible preparation of a physiological-derived media retaining important characteristics of human feces, such as matrix effects and endogenous metabolites. We measure the performance of bacterial biosensors for benzoate, lactate, anhydrotetracycline, and bile acids, and find that they are highly sensitive to fecal matrices. However, encapsulating the bacteria in hydrogel helps reduce this inhibitory effect. Sensitivity to matrix effects is biosensor-dependent but also varies between individuals, highlighting the need for case-by-case optimization for biosensors’ operation in feces. Finally, by detecting endogenous bile acids, we demonstrate that bacterial biosensors could be used for future metabolite monitoring in feces. This work lays the foundation for the optimization and use of bacterial biosensors for fecal metabolites monitoring. In the future, our method could also allow rapid pre-prototyping of engineered bacteria designed to operate in the gut, with applications to in situ diagnostics and therapeutics.

3. Programmable receptors enable bacterial biosensors to detect pathological biomarkers in clinical samples [2021]

  • Hung-Ju Chang, Ana Zúñiga, Ismael Conejero, Peter L. Voyvodic, Jerome Gracy, Elena Fajardo-Ruiz, Martin Cohen-Gonsaud, Guillaume Cambray, Georges-Philippe Pageaux, Magdalena Meszaros, Lucy Meunier, and Jerome Bonnet
  • Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subjects
Science
Abstract
Bacterial biosensors have promising applications in medical and environmental diagnostics. Here the authors use EMeRALD synthetic receptors to design bile salt sensors for use in liver transplant patient serum.

4. In Search of Digital Dopamine: How Apps Can Motivate Depressed Patients, a Review and Conceptual Analysis [2021]

  • Stephane Mouchabac, Redwan Maatoug, Ismael Conejero, Vladimir Adrien, Olivier Bonnot, Bruno Millet, Florian Ferreri, and Alexis Bourla
  • Brain Sciences, Vol 11, Iss 1454, p 1454 (2021)
Subjects
dopamine, digital phenotype, EMI, EMA, depression, Neurosciences. Biological psychiatry. Neuropsychiatry, and RC321-571
Abstract
Introduction: Depression is highly prevalent and causes considerable suffering and disease burden despite the existence of wide-ranging treatment options. Momentary assessment is a promising tool in the management of psychiatric disorders, and particularly depression. It allows for a real-time evaluation of symptoms and an earlier detection of relapse or treatment efficacy. Treating the motivational and hedonic aspects of depression is a key target reported in the literature, but it is time-consuming in terms of human resources. Digital Applications offer a major opportunity to indirectly regulate impaired motivational circuits through dopaminergic pathways. Objective: The main objective of this review was twofold: (1) propose a conceptual and critical review of the literature regarding the theoretical and technical principles of digital applications focused on motivation in depression, activating dopamine, and (2) suggest recommendations on the relevance of using these tools and their potential place in the treatment of depression. Material and Methods: A search for words related to “dopamine”, “depression”, “smartphone apps”, “digital phenotype” has been conducted on PubMed. Results: Ecological momentary interventions (EMIs) differ from traditional treatments by providing relevant, useful intervention strategies in the context of people’s daily lives. EMIs triggered by ecological momentary assessment (EMA) are called “Smart-EMI”. Smart-EMIs can mimic the “dopamine reward system” if the intervention is tailored for motivation or hedonic enhancement, and it has been shown that a simple reward (such as a digital badge) can increase motivation. Discussion: The various studies presented support the potential interest of digital health in effectively motivating depressed patients to adopt therapeutic activation behaviors. Finding effective ways to integrate EMIs with human-provided therapeutic support may ultimately yield the most efficient and effective intervention method. This approach could be a helpful tool to increase adherence and motivation. Conclusion: Smartphone apps can motivate depressed patients by enhancing dopamine, offering the opportunity to enhance motivation and behavioral changes, although longer term studies are still needed.

5. Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors [2019]

  • Peter L. Voyvodic, Amir Pandi, Mathilde Koch, Ismael Conejero, Emmanuel Valjent, Philippe Courtet, Eric Renard, Jean-Loup Faulon, and Jerome Bonnet
  • Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Subjects
Science
Abstract
The range of chemicals detectable by cell-free systems is still limited. Here the authors combine metabolic cascades with transcription factor networks to detect small molecules in complex environments.

6. A Complex Relationship Between Suicide, Dementia, and Amyloid: A Narrative Review [2018]

  • Ismael Conejero, Sophie Navucet, Jacques Keller, Emilie Olié, Philippe Courtet, and Audrey Gabelle
  • Frontiers in Neuroscience, Vol 12 (2018)
Subjects
amyloid, Alzheimer's dementia, decision-making, suicide, depression, Neurosciences. Biological psychiatry. Neuropsychiatry, and RC321-571
Abstract
Background: Suicide rates are high among older adults and many conditions have been related to suicide in this population: chronic illnesses, physical disabilities, cancer, social isolation, mental disorders and neurocognitive disorders.Objectives: Among neurocognitive disorders, analysis of the relationships between dementia and suicidal behaviors led to conflicting results and some questions are still without answer. Particularly, it is not known whether (i) Alzheimer's disease (AD) increases the risk of suicidal ideation and suicide attempts (SA) or the frequency of death by suicide; (ii) the presence of suicidal ideation or SA in people older than 65 years of age is an early dementia sign; and (iii) amyloid load in frontal areas facilitates SA by modifying the decision-making pathway.Methods: Therefore, in this narrative review, we searched the PubMed database using the medical subject heading (MeSH) terms (“Suicide” AND “Depression”) OR (“Amyloid” OR “Dementia”) to identify recent (from 2000 to 2017) original studies on the links between suicidal behavior, dementia and brain amyloid load. We also explored the clinical and pathophysiological role of depression in these relationships.Results and Discussion: The findings from these studies suggest that late stage dementia could protect against suicidal ideation and SA. Conversely, the risk of complete suicide is increased during the early phase of cognitive decline.Conclusions: Serious cognitive impairment and decline of executive functions could protect against negative thoughts related to cognitive disability awareness and against suicide planning.Several factors, including brain amyloid load, could be involved in the increased suicide rate early after the diagnosis of dementia.

7. Amyloid Burden and Depressive Symptom Trajectories in Older Adults at Risk of Developing Cognitive Decline [2021]

  • Ismael Conejero, Jonathan Dubois, Laure-Anne Gutierrez, Julien Delrieu, Christophe Arbus, Magalie Garcia, Jorge Lopez-Castroman, Philippe Courtet, Audrey Gabelle, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Centre Hospitalier Universitaire de Purpan (CHU Purpan), Toulouse Neuro Imaging Center (ToNIC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], and CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]
  • The Journal of clinical psychiatry
    The Journal of clinical psychiatry, 2021, 82 (5), pp.20m13410. ⟨10.4088/JCP.20m13410⟩
Subjects
[SDV]Life Sciences [q-bio], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychiatry and Mental health, and mental disorders
Abstract
International audience; Objective: Little is known about the amyloid load impact on depressive symptoms or disorders, although it can modulate the cognitive trajectory in older adults. Here, we analyzed, in individuals at risk of Alzheimer's dementia, the relationship between amyloid load and depressive symptoms changes over time.Methods: This study included ≥ 70-year-old participants from the French Multidomain Alzheimer Preventive Trial (MAPT) (May 2008 to February 2011) who underwent brain amyloid load measurement by β-amyloid-[18F] florbetapir-PET at baseline and had spontaneous memory complaints and/or limitation in 1 instrumental activity of daily living or slow walking gait (N = 264). Symptoms of depression were measured with the Geriatric Depression Scale-15 items (GDS) at baseline and 6, 12, 24, and 36 months of follow-up. Four GDS factors were determined by principal component analysis (PCA): life satisfaction, level of apathy, self-esteem, and anxiety. Amyloid positive status was defined based on the amyloid load in 6 Alzheimer's dementia-related regions. Regional amyloid load was based on 3 dimensions defined by PCA. The longitudinal links between depressive symptomatology and amyloid load (ie, cortical AV45 and amyloid load dimensions) were analyzed using linear mixed-multivariate models.Results: At baseline, 11% of participants had depressive symptoms (GDS > 5) and 34% were amyloid-positive. The global amyloid load was not associated with worsening of the total GDS score but only with the impairment of self-esteem factor during the follow-up after adjustment for age, sex, education level, and drug intake, dementia, and Mini-Mental State Examination score (β = -0.029, 95% CI [-0.052 to -0.007], P = .003). Regional amyloid load in hippocampus and bilateral caudate nucleus protected significantly from self-esteem decrease during the 3-year follow-up.Conclusions: Although amyloid load shows no impact on GDS score in subjects at risk of Alzheimer's dementia, amyloid load may influence the progression of depressive dimension (self-esteem) with different effects according to the regional burden.

8. A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria [2021]

  • Hung-Ju Chang, Ana Zuniga, Ismael Conejero, Peter L. Voyvodic, Jerome Gracy, Elena Fajardo-Ruiz, Martin Cohen-Gonsaud, Guillaume Cambray, Georges-Philippe Pageaux, Magdalena Meszaros, Lucy Meunier, and Jerome Bonnet
Subjects
genetic structures, psychological phenomena and processes, behavioral disciplines and activities, and nervous system
Abstract
Bacterial biosensors, or bactosensors, are promising field-deployable agents for medical and environmental diagnostics. However, the lack of scalable frameworks to systematically program ligand detection limits their applications. Here we present a synthetic receptor platform, termed EMeRALD (Engineered Modularized Receptors Activated via Ligand-induced Dimerization) which supports the modular assembly of sensing modules onto a high-performance, generic signaling scaffold controlling gene expression in E. coli. We applied EMeRALD to detect bile salts, a biomarker of liver dysfunction, by repurposing sensing modules from enteropathogenic Vibrio species. We improved the sensitivity and lowered the limit-of-detection of the sensing module by directed evolution. We then engineered a colorimetric bactosensor detecting pathological bile salt levels in serum from patients having undergone liver transplant, providing an output detectable by the naked-eye. The EMeRALD technology enables functional exploration of natural sensing modules and rapid engineering of synthetic receptors for diagnostics, environmental monitoring, and control of therapeutic microbes.

9. Épidémie de COVID-19 et prise en charge des conduites suicidaires : challenge et perspectives [2020]

  • Ismael Conejero, Emilie Olié, Vincent Jardon, P. Courtet, Déborah Ducasse, Marion Leboyer, and Sofian Berrouiguet
  • LEncéphale
    L'Encephale
Subjects
Psychiatry and Mental health, Arts and Humanities (miscellaneous), Article, Covid-19, vulnérabilité suicidaire, suicide, crise économique, déconnexion sociale, prévention, suicidal vulnerability, suicidal behavior, economic crisis, social disconnection, suicide prevention, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Political science, Suicidal behavior, and Humanities
Abstract
Resume Objectifs La pandemie de COVID-19 touche a ce jour plus de 3 000 000 de personnes a travers le monde et les mesures de prevention ont conduit au confinement de plus de la moitie de l’humanite. La communaute scientifique et les autorites politiques redoutent une epidemie de suicides secondaires a cette crise. L’objectif de cette revue de la litterature est d’analyser l’impact de la pandemie de COVID-19 sur les dimensions du processus suicidaire, son interaction avec les differents facteurs de risque. Nous proposons egalement des solutions innovantes pour y remedier. Methodes Nous avons realise une revue narrative des articles internationaux traitant des grandes pandemies (COVID-19, SRAS) et de leur influence sur la vulnerabilite suicidaire. Resultats De nombreux facteurs sont susceptibles de majorer l’emergence d’idees de suicide et le passage a l’acte suicidaire au cours de cette crise. La distanciation et le confinement pourraient favoriser un sentiment de deconnexion et la perception d’une douleur sociale chez les individus vulnerables. Certaines populations deja « a risque suicidaire eleve » pourraient etre encore fragilisees par la pandemie actuelle : personnes âgees, personnel medical et individus exposes a une forte precarite economique. Plusieurs solutions innovantes adaptees aux contraintes de la distanciation et du confinement permettront de prevenir le risque suicidaire : outils de sante connectee, protocole VigilanS, therapie comportementale et cognitive de troisieme vague et pratique artistique. Conclusions Il est possible que cette crise inedite exacerbe certaines dimensions du processus suicidaire. Cependant, a l’heure de l’innovation, plusieurs outils de prevention du suicide ont toute leur place dans les nouveaux modes de soins et devront etre experimentes a grande echelle.

10. Neuroanatomy of conversion disorder: towards a network approach [2018]

  • Emilie Olié, Philippe Courtet, Mocrane Abbar, Ismael Conejero, Eric Thouvenot, and Stéphane Mouchabac
  • Reviews in the Neurosciences. 29:355-368
Subjects
General Neuroscience, Supplementary motor area, medicine.anatomical_structure, medicine, Neuropsychology, Cognition, Conversion disorder, medicine.disease, Neuroscience, Neuroimaging, Motor disorder, Systematic review, Functional magnetic resonance imaging, and medicine.diagnostic_test
Abstract
The pathophysiology of conversion disorder is not well understood, although studies using functional brain imaging in patients with motor and sensory symptoms are progressively increasing. We conducted a systematic review of the literature with the aim of summarising the available data on the neuroanatomical features of this disorder. We also propose a general model of the neurobiological disturbance in motor conversion disorder. We systematically searched articles in Medline using the Medical Subject Headings terms ‘(conversion disorder or hysterical motor disorder) and (neuropsychology or cognition) or (functional magnetic resonance imaging or positron emission tomography or neuroimaging) or (genetics or polymorphisms or epigenetics) or (biomarkers or biology)’, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Two authors independently reviewed the retrieved records and abstracts, assessed the exhaustiveness of data abstraction, and confirmed the quality rating. Analysis of the available literature data shows that multiple specialised brain networks (self-agency, action monitoring, salience system, and memory suppression) influence action selection and modulate supplementary motor area activation. Some findings suggest that conceptualisation of movement and motor intention is preserved in patients with limb weakness. More studies are needed to fully understand the brain alterations in conversion disorders and pave the way for the development of effective therapeutic strategies.

11. Author response for 'Biological bases of suicidal behaviours: a narrative review' [2019]

  • Aiste Lengvenyte, Ismael Conejero, Philippe Courtet, and Emilie Olié
Subjects
Psychology, Narrative review, and Psychoanalysis

12. Refus scolaire anxieux : efficacité d’un programme de TCC en hospitalisation de jour [2018]

  • Martine Bouvard, Sandie Fendeleur, Amaria Baghdadli, Ismael Conejero, Hélène Denis, Chloé Girod, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique, Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), and Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
  • Journal de Thérapie Comportementale et Cognitive
    Journal de Thérapie Comportementale et Cognitive, Elsevier Masson, 2018, 28 (3), pp.123-130. ⟨10.1016/j.jtcc.2018.06.005⟩
Subjects
[SHS.PSY]Humanities and Social Sciences/Psychology, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, Medicine, business.industry, business, and Humanities
Abstract
Resume Contexte Le refus scolaire anxieux (RSA) est une pathologie severe appartenant au spectre des troubles anxieux et un motif frequent de consultations en milieu hospitalier. L’effet des TCC dont les benefices sont pourtant mis en avant dans le traitement des troubles anxieux, n’est pas etudie dans le RSA. Methode Etudier l’efficacite d’un programme multidisciplinaire de TCC dans un groupe de 28 adolescents beneficiant d’une hospitalisation de jour. Vingt-sept patients sur 28 ont reintegre le milieu scolaire, apres un delai moyen de 18,9 (SD = 5) semaines de prise en charge. L’effet du programme est estime au travers de mesures effectuees avant/apres hospitalisation : delai de reintegration scolaire, fonctionnement global, severite et evolution clinique (echelles C-GAS et CGI), et symptomatologie anxieuse (echelles FSSC-R, STAIC, RC-MAS, MASC et ECAP). Resultats Les scores aux echelles d’anxiete ont diminue significativement (p Conclusion Le programme TCC apparait comme un traitement efficace du RSA. Des etudes mieux controlees, effectuees en aveugle sur des effectifs plus importants devront confirmer ces resultats en s’interessant egalement au maintien des benefices a long terme.

13. A Complex Relationship Between Suicide, Dementia, and Amyloid: A Narrative Review [2018]

  • Ismael Conejero, Sophie Navucet, Jacques Keller, Emilie Olié, Philippe Courtet, Audrey Gabelle, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie [Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), and Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
  • Frontiers in Neuroscience
    Frontiers in Neuroscience, Frontiers, 2018, 12, pp.371. ⟨10.3389/fnins.2018.00371⟩
    Frontiers in Neuroscience, Vol 12 (2018)
Subjects
suicide, decision-making, Alzheimer's dementia, amyloid, depression, [SDV]Life Sciences [q-bio], General Neuroscience, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571, Population, education.field_of_study, education, Anxiety, medicine.symptom, medicine, Cognitive decline, Suicidal ideation, Disease, Dementia, medicine.disease, Executive functions, Psychiatry, medicine.medical_specialty, business.industry, business, and Neurocognitive
Abstract
International audience; Background: Suicide rates are high among older adults and many conditions have been related to suicide in this population: chronic illnesses, physical disabilities, cancer, social isolation, mental disorders and neurocognitive disorders. Objectives: Among neurocognitive disorders, analysis of the relationships between dementia and suicidal behaviors led to conflicting results and some questions are still without answer. Particularly, it is not known whether (i) Alzheimer's disease (AD) increases the risk of suicidal ideation and suicide attempts (SA) or the frequency of death by suicide; (ii) the presence of suicidal ideation or SA in people older than 65 years of age is an early dementia sign; and (iii) amyloid load in frontal areas facilitates SA by modifying the decision-making pathway. Methods: Therefore, in this narrative review, we searched the PubMed database using the medical subject heading (MeSH) terms ("Suicide" AND "Depression") OR ("Amyloid" OR "Dementia") to identify recent (from 2000 to 2017) original studies on the links between suicidal behavior, dementia and brain amyloid load. We also explored the clinical and pathophysiological role of depression in these relationships. Results and Discussion: The findings from these studies suggest that late stage dementia could protect against suicidal ideation and SA. Conversely, the risk of complete suicide is increased during the early phase of cognitive decline. Conclusions: Serious cognitive impairment and decline of executive functions could protect against negative thoughts related to cognitive disability awareness and against suicide planning.Several factors, including brain amyloid load, could be involved in the increased suicide rate early after the diagnosis of dementia.

14. Sociodemographic Antecedent Validators of Suicidal Behavior: A Review of Recent Literature [2016]

  • Lucas Giner, Ismael Conejero, Jorge Lopez-Castroman, Enrique Baca-García, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Universidad de Sevilla
  • Current Psychiatry Reports
    Current Psychiatry Reports, Current Medicine Group, 2016, 18 (10), pp.94. ⟨10.1007/s11920-016-0732-z⟩
Subjects
Economy, Marital status, Parenthood, Profession, Risk factor, Sexuality, Suicide attempts, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Psychiatry and Mental health, Medicine, business.industry, business, Human sexuality, Suicide prevention, Sexual orientation, Poison control, Psychiatry, medicine.medical_specialty, Clinical psychology, Human factors and ergonomics, Injury prevention, and Occupational safety and health
Abstract
International audience; Suicidal behavior and its prevention constitute a major public health issue. Etiology of suicidal behavior is multifactorial. Whereas current research is mostly focused on clinical and biological risk factors, the sociodemographic risk factors for suicidal behavior, first highlighted by Durkheim, have received less attention. Besides the well-known impact of age and gender, sociodemographic variables such as marital and parental status, education, occupation, income, employment status, religion, migration or minority status, and sexual orientation are repeatedly reported to play an important role in suicidal behavior. This narrative review aimed to summarize recent research on sociodemographic risk factors for suicidal behavior and to elicit possible implications for suicide prevention.

15. Suicide Sleep Monitoring (SSleeM): a feasibility and acceptability study of a wearable sleep tracking monitoring device in suicide attempters [2016]

  • Mathieu Simonnet, R. Billot, Michel Walter, P. Courtet, Elise Guillodo, E. Baca Garcia, Ismael Conejero, Sofian Berrouiguet, Philippe Lenca, Hopital de Bohars - CHRU Brest (CHU - BREST ), Lab-STICC_TB_CID_DECIDE, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Département Logique des Usages, Sciences sociales et Sciences de l'Information (LUSSI), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT), Lab-STICC_TB_CID_IHSEV, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Department of Psychiatry (Hospital Universitario Fundacion Jimenez Diaz ), Hopital de Bohars - CHRU Brest ( CHU - BREST ), Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance ( Lab-STICC ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ) -École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Bretagne Sud ( UBS ) -Université de Brest ( UBO ) -Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université européenne de Bretagne ( UEB ) -ENSTA Bretagne-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Département Logique des Usages, Sciences sociales et Sciences de l'Information ( LUSSI ), Université européenne de Bretagne ( UEB ) -Télécom Bretagne-Institut Mines-Télécom [Paris], Neuropsychiatrie : recherche épidémiologique et clinique, and Université Montpellier 1 ( UM1 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM )
  • ESSSB 2016 : 16th European Symposium on Suicide and Suicidal behaviour
    ESSSB 2016 : 16th European Symposium on Suicide and Suicidal behaviour, Sep 2016, Oviedo, Espagne
    ESSSB 2016 : 16th European Symposium on Suicide and Suicidal behaviour, Sep 2016, Oviedo, Espagne. ESSSB 2016 : 16th European Symposium on Suicide and Suicidal behaviour
Subjects
Suicide, Sleep monitoring, Sleep tracker, Accepability, [INFO.INFO-IU]Computer Science [cs]/Ubiquitous Computing, [INFO.INFO-CY]Computer Science [cs]/Computers and Society [cs.CY], [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [ INFO.INFO-IU ] Computer Science [cs]/Ubiquitous Computing, [ INFO.INFO-CY ] Computer Science [cs]/Computers and Society [cs.CY], [ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Psychiatry and Mental health, Medicine, business.industry, business, Suicide attempt, Emergency department, Wearable technology, Suicide attempters, Health technology, Wearable computer, After discharge, Medical emergency, and medicine.disease
Abstract
IntroductionSleep disturbances are associated with an increased risk of suicidal behavior. The evidence primarily stems from studies based on questionnaires about sleep quality. In recent years, the availability of wearable health technology has increased and offers an inexpensive, appealing, and accessible way to measure sleep.Our aim is to assess the feasibility and acceptability of wearable sleep tracking monitoring devices in a sample of suicide attempters.MethodsA prospective, open-label, 12-months study will be conducted in the emergency department (ED) and psychiatric unit (PU) of the university hospital of Brest, France. Inclusion criteria are male or female aged 18 or over, surviving a suicide attempt, discharged from ED or PU, and giving consent. The sleep tracker and a smartphone will be given to the patient after discharge. He or she will receive brief training on how to use the sleep tracker. Patient will be asked to monitor their sleep during the five days following the discharge. The feasibility will be explored by analyzing the data proceeding from the sleep tracker. The acceptability will be assessed during the five-days follow up visit, using a standardized questionnaire.ResultsPreliminary results of this ongoing study show that feasibility and acceptance may be related to technical features of wearable devices.DiscussionA better understanding of the bidirectional mechanism between sleep disturbances and suicide behavior will allow the design of tailored interventions to prevent suicide attempts.Disclosure of interestThe authors have not supplied their declaration of competing interest.

16. Amyloid Burden and Depressive Symptom Trajectories in Older Adults at Risk of Developing Cognitive Decline. [2021]

  • Conejero I, Dubois J, Gutierrez LA, Delrieu J, Arbus C, Garcia M, Lopez-Castroman J, Courtet P, and Gabelle A
  • The Journal of clinical psychiatry [J Clin Psychiatry] 2021 Aug 03; Vol. 82 (5). Date of Electronic Publication: 2021 Aug 03.
Subjects
Aged, Aged, 80 and over, Anxiety psychology, Apathy, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction pathology, Cognitive Dysfunction psychology, Disease Progression, Female, Humans, Linear Models, Longitudinal Studies, Male, Personal Satisfaction, Plaque, Amyloid diagnostic imaging, Plaque, Amyloid pathology, Plaque, Amyloid psychology, Positron-Emission Tomography, Psychiatric Status Rating Scales, Risk Factors, Self Concept, Cognitive Dysfunction etiology, Depression etiology, and Plaque, Amyloid complications
Abstract
Objective: Little is known about the amyloid load impact on depressive symptoms or disorders, although it can modulate the cognitive trajectory in older adults. Here, we analyzed, in individuals at risk of Alzheimer's dementia, the relationship between amyloid load and depressive symptoms changes over time.
Methods: This study included ≥ 70-year-old participants from the French Multidomain Alzheimer Preventive Trial (MAPT) (May 2008 to February 2011) who underwent brain amyloid load measurement by β-amyloid-[18F] florbetapir-PET at baseline and had spontaneous memory complaints and/or limitation in 1 instrumental activity of daily living or slow walking gait (N = 264). Symptoms of depression were measured with the Geriatric Depression Scale-15 items (GDS) at baseline and 6, 12, 24, and 36 months of follow-up. Four GDS factors were determined by principal component analysis (PCA): life satisfaction, level of apathy, self-esteem, and anxiety. Amyloid positive status was defined based on the amyloid load in 6 Alzheimer's dementia-related regions. Regional amyloid load was based on 3 dimensions defined by PCA. The longitudinal links between depressive symptomatology and amyloid load (ie, cortical AV45 and amyloid load dimensions) were analyzed using linear mixed-multivariate models.
Results: At baseline, 11% of participants had depressive symptoms (GDS > 5) and 34% were amyloid-positive. The global amyloid load was not associated with worsening of the total GDS score but only with the impairment of self-esteem factor during the follow-up after adjustment for age, sex, education level, and drug intake, dementia, and Mini-Mental State Examination score (β = -0.029, 95% CI [-0.052 to -0.007], P  = .003). Regional amyloid load in hippocampus and bilateral caudate nucleus protected significantly from self-esteem decrease during the 3-year follow-up.
Conclusions: Although amyloid load shows no impact on GDS score in subjects at risk of Alzheimer's dementia, amyloid load may influence the progression of depressive dimension (self-esteem) with different effects according to the regional burden.
Trial Registration: ClinicalTrials.gov identifier: NCT00672685.
(© Copyright 2021 Physicians Postgraduate Press, Inc.)

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