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metaheuristic search, continuous optimisation, insulin infusion protocol, simulated validation, Information technology, T58.5-58.64, Electronic computers. Computer science, and QA75.5-76.95

Metaheuristic search algorithms are used to develop new protocols for optimal intravenous insulin infusion rate recommendations in scenarios involving hospital in-patients with Type 1 Diabetes. Two metaheuristic search algorithms are used, namely, Particle Swarm Optimization and Covariance Matrix Adaption Evolution Strategy. The Glucose Regulation for Intensive Care Patients (GRIP) serves as the starting point of the optimization process. We base our experiments on a methodology in the literature to evaluate the favorability of insulin protocols, with a dataset of blood glucose level/insulin infusion rate time series records from 16 patients obtained from the Waikato District Health Board. New and significantly better insulin infusion strategies than GRIP are discovered from the data through metaheuristic search. The newly discovered strategies are further validated and show good performance against various competitive benchmarks using a virtual patient simulator.

Gut microbiota, Host nutrient metabolism, Microbiota–gut–brain axis, Microbiota diurnal rhythmicity, Animal culture, and SF1-1100

Gut microbiota is generally recognized to play a crucial role in maintaining host health and metabolism. The correlation among gut microbiota, glycolipid metabolism, and metabolic diseases has been well reviewed in humans. However, the interplay between gut microbiota and host metabolism in swine remains incompletely understood. Given the limitation in conducting human experiments and the high similarity between swine and humans in terms of anatomy, physiology, polyphagy, habits, and metabolism and in terms of the composition of gut microbiota, there is a pressing need to summarize the knowledge gained regarding swine gut microbiota, its interplay with host metabolism, and the underlying mechanisms. This review aimed to outline the bidirectional regulation between gut microbiota and nutrient metabolism in swine and to emphasize the action mechanisms underlying the complex microbiome–host crosstalk via the gut microbiota–gut–brain axis. Moreover, it highlights the new advances in knowledge of the diurnal rhythmicity of gut microbiota. A better understanding of these aspects can not only shed light on healthy and efficient pork production but also promote our knowledge on the associations between gut microbiota and the microbiome–host crosstalk mechanism. More importantly, knowledge on microbiota, host health and metabolism facilitates the development of a precise intervention therapy targeting the gut microbiota.

Motor vehicles. Aeronautics. Astronautics and TL1-4050

Drag reduction technology plays a significant role in extending the flight range for a high-speed vehicle. A wave drag reduction strategy via heat addition to a blunt body with a spike was proposed and numerically validated. The heat addition is simulated with continuous heating in a confined area upstream of the blunt body. The effects of heat addition on drag reduction in three flow conditions (M=3.98,5,6) were compared, and the influence of power density qh (q1=2.0×108 W/m3, q2=5.0×108 W/m3, and q3=1.0×109 W/m3) of heating was evaluated. Results show that the heat addition has a positive way to reduce the drag of the body with a spike alone, and more satisfactory drag reduction effectiveness can be achieved at a higher Mach number. The drag reduction coefficient increases with qh in the same flow condition, with a maximum of 38.9% (M=6) as q3=1.0×109 W/m3. The wave drag reduction principle was discussed by a transient calculation, which indicates that the separation region has entrainment of the heated air and expanded with its sonic line away from the blunt cone, which results in an alleviation of the pressure load caused by shock/shock interaction.

Arteriosclerosis, Atherosclerosis, Atherosclerotic plaque, Carotid femoral artery pulse wave velocity, CF-PWV, Diseases of the circulatory (Cardiovascular) system, and RC666-701

Abstract Background Arteriosclerosis can be reflected in various aspect of the artery, including atherosclerotic plaque formation or stiffening on the arterial wall. Both arteriosclerosis and atherosclerosis are important and closely associated with cardiovascular disease (CVD). The aim of the study was to evaluate the association between systemic arteriosclerosis and multi-site atherosclerotic plaques. Methods The study was designed as an observational cross-sectional study. A total of 1178 participants (mean age 67.4 years; 52.2% male) enrolled into the observational study from 2010 to 2017. Systemic arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and multi-site atherosclerotic plaques (MAP, > = 2 of the below sites) were reflected in the carotid or subclavian artery, abdominal aorta and lower extremities arteries using ultrasound equipment. The associations were assessed by multivariable logistic regression. Results The prevalence of CF-PWV > 12 m/s and MAP were 40.2% and 74.4%. Atherosclerotic plaques in 3 sites were more common in male compared with that in female (48.9% versus 36.9%, p 12 m/s corresponded to a mean 82% probability of MAP with age and sex-adjusted. Patients with peripheral artery disease showed the highest odds ratio (OR) (3.88) for MAP, followed by smoking (2.485), CF-PWV > 12 m/s (2.25), dyslipidemia (1.89), male (1.84), stroke (1.64), hypoglycemic agents (1.56) and age (1.09) (all p