Author "Apicella, Luca"

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1. Antiproteinuric effect of paricalcitol in kidney transplant recipients with severe proteinuria: a prospective cohort study [2022]

  • Garofalo, Carlo, Secondulfo, Carmine, Apicella, Luca, Bilancio, Giancarlo, De Nicola, Luca, Minutolo, Roberto, Borrelli, Silvio, Provenzano, Michele, Luciani, Remo, and Bellizzi, Vincenzo
  • Journal of Nephrology. :1-3

2. Tutamen pauperum sive tractatus absolutissimus de dilatione quinquennali quae ex iustitia dicitur moratoria principis, remissione debitorum et cessione bonorum [1621]

  • Apicella, Maurizio de and Apicella, Luca Matteo

3. Sublingual administration improves systemic exposure of tacrolimus in kidney transplant recipients: comparison with oral administration [2016]

  • Federico, Stefano, Carrano, Rosa, Sabbatini, Massimo, Nappi, Riccardo, Russo, Luigi, Apicella, Luca, Balletta, Mario Maria, Santangelo, Michele, Mosca, Teresa, Tarantino, Giovanni, and Capone, Domenico
  • European Journal of Clinical Investigation. Jun 17, 2016

4. Effects of a Diet Rich in N-3 Polyunsaturated Fatty Acids on Systemic Inflammation in Renal Transplant Recipients [2013]

  • SABBATINI, Massimo, APICELLA, Luca, FEDERICO, Stefano, GUIDA, Bruna, CATALDI, Mauro, MARESCA, Immacolata, NASTASI, Annamaria, VITALE, Sossio, MEMOLI, Bruno, POSTIGLIONE, Loredana, RICCIO, Eleonora, and GALLO, Riccardo
  • Journal of the American College of Nutrition. 32(6):375-383
Subjects
Nutrition, obesity, metabolic disorders, Nutrition, obésité, maladies métaboliques, Sciences biologiques et medicales, Biological and medical sciences, Sciences biologiques fondamentales et appliquees. Psychologie, Fundamental and applied biological sciences. Psychology, Vertebres: anatomie et physiologie, organisme dans son ensemble ou etude de plusieurs organes ou systemes, Vertebrates: anatomy and physiology, studies on body, several organs or systems, Alimentation. Comportement alimentaire, Feeding. Feeding behavior, Alimentation, Feeding, Alimentación, Appareil urinaire, Urinary system, Aparato urinario, Cytokine, Citoquina, Lipide, Lipids, Lípido, Acide gras polyinsaturé, Polyunsaturated fatty acid, Acido graso poliinsaturado, Inflammation, Inflamación, Interleukine 6, Interleukin 6, Interleuquina 6, Nutrition, Nutrición, Protéine C réactive, C reactive protein, Proteína reactiva, Rein, Kidney, Riñón, Régime alimentaire, Diet, Régimen alimentario, Transplantation, Trasplantación, C-reactive protein, diet, interleukin-6, polyunsaturated fatty acids, and renal transplantation
Abstract
Objective: n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients. However, patient compliance is poor because bad-tasting fish oils are used as an n-3 PUFA source. Therefore, we explored whether the beneficial effects of n-3 can be obtained by administering a diet based on n-3-rich foods. Methods: Sixty kidney transplant recipients were assigned to 2 different groups: the CON group (n = 28), which continued with their usual diet, and the DIET group (n = 32), which followed an n-3-rich diet for 6 months. Twenty-six patients in the DIET group and 24 in the CON group completed the study. End points of the study were changes in n-3 PUFAs intake, n-6:n-3 PUFAs ratio, systemic inflammation markers, and renal function during the 6 months of the dietary treatment. Results: Three and 6 months after the beginning of the study, n-3 PUFA intake was significantly higher and the n-6:n-3 PUFA ratio was markedly lower than baseline in the DIET group. Plasma total cholesterol, triglycerides, C-reactive protein, and interleukin (IL)-6 decreased as well. IL-6 mRNA levels in peripheral blood mononuclear cells were also lower than at the beginning of the study. Proteinuria and microalbuminuria were reduced by 50% with respect to the baseline, whereas glomerular filtration rate (GFR) was unchanged. No change in the aforementioned parameters was observed in the CON group throughout the study. Conclusion: In long-term kidney transplant recipients a naturally n-3 PUFA-rich dietary plan causes an increase in n-3 PUFA intake, decreases systemic inflammation and proteinuria, and improves plasma lipid pattern.

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6. PULMONARY MUCORMYCOSIS AND KIDNEY TRANSPLANTATION: A CASE REPORT [2015]

  • Carrano, Rosa, Apicella, Luca, Muro, Potito Di, Pietro, Renata Di, Sabbatini, Massimo, Mormile, Mauro, and Federico, Stefano

7. Dietary intake as a link between obesity, systemic inflammation, and the assumption of multiple cardiovascular and antidiabetic drugs in renal transplant recipients [2013]

  • Guida, Bruna, Cataldi, Mauro, Maresca, Immacolata Daniela, Germano, Roberta, Trio, Rossella, Nastasi, Anna Maria, Federico, Stefano, Memoli, Andrea, Apicella, Luca, Memoli, Bruno, and Sabbatini, Massimo
  • BioMed Research International. Annual 2013

8. Renal Sinus Lipomatosis in Transplanted Kidneys: An Unusual Clinical Case [2011]

  • Apicella, Luca, Vallone, Gianfranco, Vitale, Sossio, Garofalo, Gianluca, Russo, Luigi, Gallo, Riccardo, Federico, Stefano, and Sabbatini, Massimo
  • Case Reports in Transplantation.
Subjects
Article Subject
Abstract
Renal sinus lipomatosis (RSL) represents an abnormal proliferation of the adipose tissue surrounding the renal pelvis of uncertain origin, associated with aging, obesity, steroid excess, infections, and calculosis. It represents a rare complication in transplanted kidneys, and, despite the accurate and prolonged radiological followup of transplanted organs, only a few cases of RSL have been described in graft recipients, with no remarkable effects on renal function. The diagnosis relies on ultrasonography (US), magnetic resonance imaging (MRI), computed tomography (CT), and, finally, percutaneous biopsy. We describe the case of an extensive RSL in a 38-year-old renal transplant recipient, diagnosed by ultrasonography and computed tomography. The patient underwent a radiologic study because of an acute, asymptomatic renal impairment, that led to the diagnosis of a RSL of unusual dimensions, associated with a discrete hydronephrosis. Paradoxically, after a short course of steroids, the recovery of renal function and the partial resolution of calyceal dilatation were observed. The rarity of this affection, the need of a differential diagnosis with fat-containing tumors, and the possibility of parenchymal inflammation associated with RSL, potentially responsive to steroids, are also discussed.

9. Tutamen pauperum: sive tractatus absolutissimus de dilatione quinquennali, quæ ex justitia dicitur moratoria principis, remissione debitorum et cessione bonorum, cum commentariis ad pragmaticam IX cap. II de officio judicum [1621]

  • Apicella, Luca Matteo de. and Apicella, Luca Matteo de.

10. Renal Artery Stenosis: Percutaneous Revascularization or Medical Therapy? [2013]

  • Capuano, Maria, Morelli Coppola, Giuseppe, Terribile, Marco, Arienzo, Francesco, Morelli Coppola, Marco, Rossano, Roberta, and Apicella, Luca
  • Giornale di Tecniche Nefrologiche e Dialitiche; January 2013, Vol. 25 Issue: 1 p6-10, 5p
Abstract
Renal artery stenosis (RAS) is caused by atherosclerosis in 90% of the cases while it is related to fibromuscolar dysplasia in almost 10% of the cases. RAS may cause malignant hypertension and reduction of kidney function. Therefore it is important to carry out an optimal therapy to reduce complications. There is general agreement on the efficacy of a strict medical therapy. On the contrary, the usefulness of a contemporary percutaneous revascularization intervention to ameliorate BP and GFR is questionable. Thus we searched the literature using PubMed by entering the search terms “renal artery stenosis, atherosclerotic renal artery stenosis, renovascular hypertension”. In this review we analyze the epidemiology, physiopathology, diagnosis and, in particular, the different treatment options on the basis of the more recent clinical trials.

11. Tutamen pauperum sive tractatus absolutissimus de dilatione quinquennali quae ex iustitia dicitur moratoria principis, remissione debitorum et cessione bonorum [1620]

  • Apicella, Luca Matteo and Apicella, Maurizio de
  • Catálogo de la USAL
    GREDOS. Repositorio Institucional de la Universidad de Salamanca
    instname
Subjects
Derecho civil -- Obras anteriores a 1800 and Jurisprudencia -- Obras anteriores a 1800
Abstract
Obra perteneciente al Fondo Antiguo de la Biblioteca de la USAL

12. World Kidney Day “do-it-yourself” [2013]

  • Buonanno, Elisa, Apicella, Luca, and Battaglia, Yuri
  • Giornale di Tecniche Nefrologiche e Dialitiche; April 2013, Vol. 25 Issue: 2 p165-167, 3p
Abstract
Since more than 5 years, the World Kidney Day (WKD) is held in Italy in March. It represents an important event to stimulate kidney disease prevention among the population. We asked dr. Luca Apicella, a young nephrologist, to tell us about his experience organizing, for the first time, the WKD in his hometown, Salerno. In his report, Dr. Apicella outlines the main steps followed to organize the event and the difficulties that he faced in the preceding months. His account results in a practical checklist to be adopted by every young nephrologist who wishes to follow his example and successfully organize the WKD in his/her area.

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15. Sublingual administration improves systemic exposure of tacrolimus in kidney transplant recipients: comparison with oral administration [2016]

  • Teresa Mosca, Luigi Russo, Massimo Sabbatini, Domenico Capone, Stefano Federico, M. Balletta, Rosa Carrano, Michele Santangelo, Riccardo Nappi, Giovanni Tarantino, Luca Apicella, Federico, Stefano, Carrano, Rosa, Sabbatini, Massimo, Nappi, Riccardo, Russo, Luigi, Apicella, Luca, Balletta, MARIO MARIA, Santangelo, Michele, Mosca, Teresa, Tarantino, Giovanni, and Capone, Domenico
  • European Journal of Clinical Investigation. 46:651-657
Subjects
Clinical Biochemistry, Biochemistry, General Medicine, Methylprednisolone, medicine.drug, medicine, Immunosuppressive drug, medicine.medical_treatment, Transplantation, Anesthesia, Cmin, Oral administration, business.industry, business, Pharmacokinetics, Tacrolimus, Sublingual administration, renal transplantation, sublingual tacrolimus administration, and tacrolimus pharmacokinetics
Abstract
Background Tacrolimus (TCR) is an immunosuppressive drug used by oral administration. Intravenous (IV) TCR administration is required under conditions of gastrointestinal diseases or abdominal surgery at the onset of paralytic ileus. The infusion formulation needs a large dilution and therefore a careful technical management during continuous infusion by 24 h and may determine anaphylaxis, cardiac arrhythmia, QT prolongation and torsades de pointes. Sublingual (SL) TCR administration was suggested as an alternative route. Design The aim of this study was to compare in the same kidney transplanted patients the TCR pharmacokinetic profiles by both the routes coupled with the pharmacoeconomic analysis. The study enrolled eight subjects undergoing renal transplantation and treated with TCR and methylprednisolone. TCR was administered by oral route at the scheduled dosage while the 50% of oral dosage was used by SL route, taking into account the absence of liver first pass. Results Except for AUC, which resulted significantly increased after oral administration, all exposure parameters were not significantly different between the two routes of administration. Analysis of dose-adjusted exposure parameters showed significant increases in AUC and Cmin after SL administration confirming a better bioavailability of the SL route compared with oral route. Cost saving was obtained using the SL rather than the IV route of TCR delivery. Conclusion When oral administration of TCR is not advised, SL delivery represents an attractive option to IV administration.

16. Dietary Intake as a Link between Obesity, Systemic Inflammation, and the Assumption of Multiple Cardiovascular and Antidiabetic Drugs in Renal Transplant Recipients [2013]

  • Massimo Sabbatini, Andrea Memoli, Mauro Cataldi, Bruno Memoli, Bruna Guida, Rossella Trio, Luca Apicella, Roberta Germanò, Anna Maria Nastasi, Immacolata Daniela Maresca, Stefano Federico, Guida, Bruna, Cataldi, Mauro, Maresca, Id, Germanò, R, Trio, Rossella, Nastasi, Am, Federico, Stefano, Memoli, Andrea, Apicella, Luca, Memoli, Bruno, and Sabbatini, Massimo
  • BioMed Research International
    BioMed Research International, Vol 2013 (2013)
Subjects
Article Subject, Clinical Study, lcsh:Medicine, lcsh:R, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, Regimen, Kidney transplantation, medicine.disease, medicine, Overweight, medicine.symptom, Gastroenterology, medicine.medical_specialty, Endocrinology, Internal medicine, Polyunsaturated fatty acid, chemistry.chemical_classification, chemistry, Obesity, business.industry, business, Body mass index, Transplantation, C-reactive protein, biology.protein, biology, and obesity, inflammation, drugs
Abstract
We evaluated dietary intake and nutritional-inflammation status in ninety-six renal transplant recipients, years after transplantation. Patients were classified as normoweight (NW), overweight (OW), and obese (OB), if their body mass index was between 18.5 and 24.9, 25.0 and 29.9, and ≥30 kg/m2, respectively. Food composition tables were used to estimate nutrient intakes. The values obtained were compared with those recommended in current nutritional guidelines. 52% of the patients were NW, 29% were OW, and 19% were OB. Total energy, fat, and dietary n-6 PUFAs intake was higher in OB than in NW. IL-6 and hs-CRP were higher in OB than in NW. The prevalence of multidrug regimen was higher in OB. In all patients, total energy, protein, saturated fatty acids, and sodium intake were higher than guideline recommendations. On the contrary, the intake of unsaturated and n-6 and n-3 polyunsaturated fatty acids and fiber was lower than recommended. In conclusion, the prevalence of obesity was high in our patients, and it was associated with inflammation and the assumption of multiple cardiovascular and antidiabetic drugs. Dietary intake did not meet nutritional recommendations in all patients, especially in obese ones, highlighting the need of a long-term nutritional support in renal transplant recipients.

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