Author "Andersen, Chad C"

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1. Intravenous fat induces changes in PUFA and their bioactive metabolites: Comparison between Japanese and Australian preterm infants. [2020]

  • Suganuma, Hiroki, McPhee, Andrew J, Collins, Carmel T, Liu, Ge, Leemaqz, Shalem, Andersen, Chad C, Ikeda, Naho, Ohkawa, Natsuki, Taha, Ameer Y, and Gibson, Robert A
Subjects
Milk, Human, Humans, Dietary Fats, Fatty Acids, Unsaturated, Dietary Supplements, Adult, Infant, Newborn, Infant, Premature, Japan, Australia, Female, Male, Administration, Intravenous, Free fatty acid, Lipid emulsion, Oxylipin, Polyunsaturated fatty acid, Preterm infant, Nutrition & Dietetics, Biochemistry and Cell Biology, Clinical Sciences, and Nutrition and Dietetics
Abstract
ObjectiveOxylipins are biologically active signaling molecules that initiate and resolve inflammation; they are synthesized by oxidation of polyunsaturated fatty acids (PUFAs) and reflect PUFA intake and status. The PUFA intake in preterm infants differs between countries because of the type of lipid emulsions used and the PUFA content of breast milk. We compared total blood PUFA, free PUFA and their oxylipin levels in dried whole blood samples from preterm infants born in Australia and Japan.MethodsWe enrolled 30 and 14 preterm infants born less than 31 weeks' gestation, from Adelaide and Japan respectively. Blood samples were obtained from cord blood, and on postnatal days 4, 7, 14 and 28. Total PUFAs were measured using gas chromatography, while free fatty acids and oxylipins were screened using ultra high-performance liquid chromatography mass spectroscopy.ResultsDifferences in the levels of blood PUFA between the centres were found which were in line with the timing and type of lipid emulsion administration. Significant differences in longitudinal levels were seen more often in free PUFA and their oxylipins than in total blood PUFA. This was particularly true for AA and DHA. In contrast, differences in the levels could be seen in total blood EPA, as well as in free EPA and its oxylipins. Further, levels of many free PUFA and their oxylipins were higher in Japanese infants than in Australian infants.ConclusionDifferences in total and free fatty acids and unesterified oxylipins, were observed during the first weeks of life and between preterm infants born in Australia and Japan, which were likely a reflection of the type of lipid emulsion and timing of administration. The clinical significance of these changes remains to be explored.

2. Effect of parenteral lipid emulsion on preterm infant PUFAs and their downstream metabolites [2021]

  • Suganuma, Hiroki, Collins, Carmel T, McPhee, Andrew J, Leemaqz, Shalem, Liu, Ge, Andersen, Chad C, Bonney, Dennis, and Gibson, Robert A
  • In Prostaglandins, Leukotrienes and Essential Fatty Acids January 2021 164

3. Intravenous fat induces changes in PUFA and their bioactive metabolites: Comparison between Japanese and Australian preterm infants [2020]

  • Suganuma, Hiroki, McPhee, Andrew J, Collins, Carmel T, Liu, Ge, Leemaqz, Shalem, Andersen, Chad C, Ikeda, Naho, Ohkawa, Natsuki, Taha, Ameer Y, and Gibson, Robert A
  • In Prostaglandins, Leukotrienes and Essential Fatty Acids May 2020 156

4. Effect of washed versus unwashed red blood cells on transfusion‐related immune responses in preterm newborns [2022]

  • Crawford, Tara M, Andersen, Chad C, Hodyl, Nicolette A, Robertson, Sarah A, and Stark, Michael J
  • Clinical & translational immunology. 11(3)

5. Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): a multicentre, double-blind, randomised controlled trial [2019]

  • Crowther, Caroline, Ashwood, Pat, Andersen, Chad, Middleton, Philippa, Tran, Thach, Ball, Vincent, Holst, Carol, Robinson, Kaye, Zhang, Sasha, Robinson, Jeffrey, Khong, Yee, McPhee, Andrew, Groom, Katie, Alsweiler, Jane, Eaglen, Deb, Harding, Jane, Hauch, Helga, Vallely, Alenna, Angus, Sonia, Chenia, Feisal, Drew, Alison, Gavranich, John, Green, Ann, Jack, Susan, Mahomed, Kassam, Sebastian, Rebecca, Turner, Laura, Baldwin, Michelle, Dennis, Amanda, Fisher, Eleanor, Gee, Karen, Gee, Michael, Strong, David, Boord, Donna, Edge, Nicole, Marsh, Michelle, Staehr, Casie, Chaplin, Jackie, Gardener, Glenn, Gray, Peter, Hurrion, Elizabeth, Jardine, Luke, Kan, Janet, Lynn, Lisa, Poulsen, Leith, Tremellen, Anne, Codner, Tracey, Cubis, Wendy, Downward, Sue, Dunn, Cathy, Furey, Jacquelyn, Hansen, Di, Lampropoulos, Bessy, Masson, Emily, Peek, Michael, Sellar, Susan, Butterley, Karen, Chadwick, Michelle, Davis, Caroline, DePaoli, Tony, Green, Leesa, Matzolic, Tammy, Woodhead, Gregory, Biggs, Vikki, Henry, Amanda, Lainchbury, Anne, Nesbitt-Hawes, Erin, Oei, Ju Lee, Rodrigues, Christina, Shand, Antonia, Sutton, Lee, Welsh, Alec, Bowen, Jennifer, Hayes-Cameron, Linda, Howard, Glynis, Jacobs, Claire, Milligan, Jill, Morris, Jonathan, Rickard, Kristen, Sedgley, Jocelyn, White-Matthews, Katrina, Blandthorn, Julie, Brownfoot, Fiona, Burnett, Alice, Callanan, Kate, Davis, Noni, Deluca, Cinzia, Doyle, Lex, Duff, Julianne, Howard, Kelly, Hutchinson, Esther, Kelly, Elaine, Kornman, Louise, Kuschel, Carl, Maxwell, Dianna, McDonald, Marion, Poth, Megan, Co, Julie, Davis, Greg, Fonsesca, Bob, Khouri, Joseph, Roberts, Lynne, Rowe, Clare, Boniface, Cherie, Boynton, Christine, Davies, Christine, Dickinson, Corrine, Edmonds, Liza, Ireland, Susan, Koh, Guan, Kumar, Prasanna, Lawrence, Annemarie, Lock, Ros, Watson, David, Bahtia, Vineesh, Cash, Sarah, Gagliardi, Daniela, Gooding, Michaela, Gowling, Kate, Grivell, Rosalie, Haslam, Ross, Headley, Bevan, Johnson, Melanie, Kobayashi, Namiko, Kochar, Anu, Nikpoor, Payam, Simmonds, Lucy, Siwicki, Kasia, Stark, Michael, Trenowden, Sophie, Crowther, Caroline A, Ashwood, Pat, Andersen, Chad C, Middleton, Philippa F, Tran, Thach, Doyle, Lex W, Robinson, Jeffrey S, and Harding, Jane E
  • In The Lancet Child & Adolescent Health November 2019 3(11):769-780

6. Red Blood Cell Donor Sex Associated Effects on Morbidity and Mortality in the Extremely Preterm Newborn. [2022]

  • Crawford, Tara M., Andersen, Chad C., and Stark, Michael J.
  • Children; Dec2022, Vol. 9 Issue 12, p1980, 11p
Abstract
Transfusion exposure increases the risk of death in critically ill patients of all ages. This was thought to relate to co-morbidities in the transfusion recipient. However, donor characteristics are increasingly recognised as critical to transfusion recipient outcome with systematic reviews suggesting blood donor sex influences transfusion recipient health. Originally focusing on plasma and platelet transfusions, retrospective studies report greater risks of adverse outcomes such as transfusion related acute lung injury in those receiving products from female donors. There is increasing awareness that exposure to red blood cells (RBCs) poses a similar risk. Recent studies focusing on transfusion related outcomes in extremely preterm newborns report conflicting data on the association between blood donor sex and outcomes. Despite a renewed focus on lower versus higher transfusion thresholds in neonatal clinical practice, this group remain a heavily transfused population, receiving on average 3–5 RBC transfusions during their primary hospital admission. Therefore, evidence supporting a role for better donor selection could have a significant impact on clinical outcomes in this high-risk population. Here, we review the emerging evidence for an association between blood donor sex and clinical outcomes in extremely preterm newborns receiving one or more transfusions. [ABSTRACT FROM AUTHOR]

7. Effect of repeat transfusion exposure on plasma cytokine and markers of endothelial activation in the extremely preterm neonate [2020]

  • Crawford, Tara M., Andersen, Chad C., and Stark, Michael J.
  • Transfusion. Oct 2020, Vol. 60 Issue 10, p2217, 8 p.

8. Patterns of placental antimicrobial resistance in preterm birth before 30 completed weeks gestation complicated by preterm prelabour rupture of membranes [2020]

  • Axford, Samuel B., Andersen, Chad C., and Stark, Michael J.
  • Australian and New Zealand journal of obstetrics and gynaecology. 60(4):509-513

9. Determining the venous oxygen reservoir: A novel, hypothetical approach to titration of supplemental oxygen in preterm newborns [2018]

  • Andersen, Chad C., Hodyl, Nicolette A., Ziegler, Nina M., and Stark, Michael J.
  • In Medical Hypotheses March 2018 112:30-34

10. Does umbilical cord blood glucose extraction discriminate the risk of early neonatal hypoglycaemia in at-risk newborns? [2019]

  • Kennedy, Lydia M L, Crawford, Tara M, Andersen, Chad C, and Stark, Michael J
  • Journal of Paediatrics and Child Health. Dec 2019, Vol. 55 Issue 12, p1476, 5 p.

11. The contribution of red blood cell transfusion to neonatal morbidity and mortality [2019]

  • Crawford, Tara M, Andersen, Chad C, Hodyl, Nicolette A, Robertson, Sarah A, and Stark, Michael J
  • Journal of paediatrics and child health. 55(4):387-392

12. The efficacy and safety of peripheral intravenous parenteral nutrition vs 10% glucose in preterm infants born 30 to 33 weeks’ gestation: a randomised controlled trial [2020]

  • Suganuma, Hiroki, Bonney, Dennis, Andersen, Chad C., McPhee, Andrew J., Sullivan, Thomas R., Gibson, Robert A., and Collins, Carmel T.
  • BMC Pediatrics. 20(1)

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14. A theoretical and practical approach to defining 'adequate oxygenation' in the preterm newborn [2017]

  • Andersen, Chad C., Hodyl, Nicolette A., Kirpalani, Haresh M., and Stark, Michael J.
  • Pediatrics. April, 2017, Vol. 139 Issue 4

15. Early Cerebral Oxygen Extraction and the Risk of Death or Sonographic Brain Injury in Very Preterm Infants [2014]

  • Balegar, Kiran Kumar, Stark, Michael J., Briggs, Nancy, and Andersen, Chad C.
  • In The Journal of Pediatrics March 2014 164(3):475-480

16. High-Flow Nasal Cannulae in Very Preterm Infants after Extubation [2013]

  • MANLEY, Brett J, OWEN, Louise S, DOYLE, Lex W, ANDERSEN, Chad C, CARTWRIGHT, David W, PRITCHARD, Margo A, DONATH, Susan M, and DAVIS, Peter G
  • The New England journal of medicine. 369(15):1425-1433
Subjects
General medicine general surgery, Médecine et chirurgie générales, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Generalites, General aspects, Gynecologie. Andrologie. Obstetrique, Gynecology. Andrology. Obstetrics, Gestation. Foetus. Placenta, Pregnancy. Fetus. Placenta, Pathologie mère, foetus, gestation, Diseases of mother, fetus and pregnancy, Médecine, Medicine, Medicina, Nasopharynx, Nasofaringe, Nez, Nose, Nariz, Prématurité, Prematurity, and Prematuridad
Abstract
BACKGROUND The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation. However, data on the efficacy or safety of such cannulae in this population are lacking. METHODS In this multicenter, randomized, noninferiority trial, we assigned 303 very preterm infants to receive treatment with either high-flow nasal cannulae (5 to 6 liters per minute) or nasal CPAP (7 cm of water) after extubation. The primary outcome was treatment failure within 7 days. Noninferiority was determined by calculating the absolute difference in the risk of the primary outcome; the margin of noninferiority was 20 percentage points. Infants in whom treatment with high-flow nasal cannulae failed could be treated with nasal CPAP; infants in whom nasal CPAP failed were reintubated. RESULTS The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP, with treatment failure occurring in 52 of 152 infants (34.2%) in the nasal-cannulae group and in 39 of 151 infants (25.8%) in the CPAP group (risk difference, 8.4 percentage points; 95% confidence interval, -1.9 to 18.7). Almost half the infants in whom treatment with high-flow nasal cannulae failed were successfully treated with CPAP without reintubation. The incidence of nasal trauma was significantly lower in the nasal-cannulae group than in the CPAP group (P=0.01), but there were no significant differences in rates of serious adverse events or other complications. CONCLUSIONS Although the result for the primary outcome was close to the margin of noninferiority, the efficacy of high-flow nasal cannulae was similar to that of CPAP as respiratory support for very preterm infants after extubation.

17. Intrauterine inflammation, cerebral oxygen consumption and susceptibility to early brain injury in very preterm newborns [2016]

  • Stark, Michael J, Hodyl, Nicolette A, Belegar, Kiran Kumar, V, and Andersen, Chad C
  • Archives of Disease in Childhood: Fetal and Neonatal Edition. Mar 01, 2016 101(2):F137-F142

18. 8 - Anemia [2020]

  • Stark, Michael J., Kirpalani, Haresh M., and Andersen, Chad C.
  • In Workbook in Practical Neonatology Edition: Sixth Edition. 2020:110-128

19. Anaemia in the Premature Infant and Red Blood Cell Transfusion: New Approaches to an Age-Old Problem [2015]

  • Andersen, Chad C., Keir, Amy K., Kirpalani, Haresh M., and Stark, Michael J.
  • Current Treatment Options in Pediatrics. September 2015 1(3):191-201

20. Vitamin D in preterm infants: A prospective observational study [2015]

  • Pinto, Kieran, Collins, Carmel T, Gibson, Robert A, and Andersen, Chad C
  • Journal of Paediatrics and Child Health. Jul 01, 2015 51(7):679-681

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