Rutstein, David D., Berenberg, William, Chalmers, Thomas C., Child, Charles G., Fishman, Alfred P., Perrin, Edward B., Feldman, Jacob J., Leaverton, Paul E., Lane, J. Michael, Sencer, David J., and Evans, Carleton C.
New England Journal of Medicine; March 1976, Vol. 294 Issue: 11 p582-588, 7p
RUTSTEIN, DAVID D., NICKERSON, RITA J., and HEALD, FELIX P.
Archives of Pediatrics & Adolescent Medicine; August 1952, Vol. 84 Issue: 2 p199-213, 15p
GREGG'S report1 in 1941 stimulated interest in the etiological relationship of environmental factors in early pregnancy to congenital defects in the child. His observations relating maternal rubella to congenital cataract and congenital heart disease were supported by the more extensive study of Swan and his associates,2 which also revealed that deaf-mutism and microcephaly were related to maternal rubella. Later Evans3 reported delayed eruption of teeth as another manifestation of the rubella syndrome.The frequent implication that patent ductus arteriosus and septal defects are related to maternal rubella4 is not supported by any conclusive data in existing literature. Among 442 reported cases of congenital heart disease following maternal rubella,5 it was possible to find only 77 in which a specific heart lesion was noted.6(Footnotes continued on next page) The specific lesions reported7 were as follows: 42 patent ductus arteriosus, of which 17 were
RUTSTEIN, DAVID D., REED, ELIZABETH A., LANGMUIR, ALEXANDER D., and ROGERS, EDWARD S.
Archives of Internal Medicine; July 1941, Vol. 68 Issue: 1 p25-56, 32p
Since Jan. 1, 1937 reports on the use of concentrated antipneumococcus serum have been submitted on a uniform record to the New York State Department of Health by physicians employing serums produced or purchased and distributed by the Division of Laboratories and Research.1 The questions on that form are concerned, so far as possible, with objective data, so that the effect of interpretation by the reporting physician is minimized. Through a follow-up system, complete reports were obtained in practically every case.2Early study of the material so collected brought to light a number of immediate reactions following intravenous serum therapy which were associated with severe circulatory collapse and which did not seem to be related to protein hypersensitivity in the usual sense. It was recognized that this impression was based on reports which had the disadvantage of containing second hand information of varying degrees of accuracy. In order
Kowalski, Henry J., Reynolds, William E., and Rutstein, David D.
Experimental Biology and Medicine; August 1953, Vol. 83 Issue: 4 p795-798, 4p
The data indicate that normal subjects given cortisone acetate respond in a similar manner to that observed in patients: salt and water retention occurs and serum electrolyte concentration and serum osmolarity are not appreciably altered(l2-14). The responses noted here in Evans blue space are similar to the variable results seen in subjects with disease during cortisone administration (15- 19). The uniform increase in thiocyanate space is not an unexpected finding since evidence of chloride retention was uniformly noted and since the thiocyanate space empirically parallels changes in chloride space(20-21). The weight gain noted by most of the subjects was considered to represent changes in total body water since the diets. including salt intake, were at the usual daily level for all subjects and the experiments were of brief duration. These data do not make it possible to separate salt and water retention from endogenous shifts of cell water to extracellular space.
GREENBERG, MORRIS, FRANT, SAMUEL, and RUTSTEIN, DAVID D.
JAMA: Journal of the American Medical Association; December 1944, Vol. 126 Issue: 15 p944-947, 4p
Three agents are currently recommended for the prophylaxis of measles—convalescent human serum, placental globulin (immune globulin-human) and gamma globulin derived from normal human serum (human immune serum globulin). Concentrated, pooled ascites fluid1 has also been suggested but has not come into general use and will not be discussed here. The prophylactic effectiveness of convalescent serum has been recently summarized in a well controlled study of 502 household contacts between the ages of 6 months and 15 years by Stillerman, Marks and Thalhimer.2 These authors obtained complete protection in 50 per cent, modified measles in 49 per cent and regular measles in 1 per cent of the individuals studied. While the effectiveness of convalescent serum is not questioned, its lack of ready availability and the comparatively large doses which are necessary make its use unpractical. This study is directed toward the comparison of the effectiveness and incidence of untoward
COLD prevention, PREVENTIVE medicine, and ANTIHISTAMINES
Focuses on the research on various preventive medicines for common cold. Symptoms of common cold; Recommendations for anti-histamine treatment for colds; Reasons for complaints filed by the Federal Trade Commission in 1950 against U.S. antihistamine drugs manufacturers; Remedies for problems encountered by the sale of antihistamines and bioflavonoids.
VACCINES, POLIO, PARALYTICS, EPIDEMICS, THERAPEUTICS, and THERAPEUTIC use
Discusses the effectiveness of the polio vaccine. Invasion mechanism of the polio virus; Accreditation of the reduced polio cases from 1955 to 1956 due to mass polio vaccination programs; Absence of explanations for patterns of polio cases from 1930 to 1956; Difference between paralytic and nonparalytic polio; Comparison of the size of epidemics as index of the value of the vaccine; Consideration of the reported vaccine failures.
PRESIDENTS, PHYSICIANS, NATIONAL security, and MEDICAL care
Discusses the influence that a medical decision may have on the national history of the U.S. Personal physicians' release of information regarding the health problems of President Dwight D. Eisenhower; Responsibility to the public of the physicians attending the president; Extent to which medical ethics insists that the leadership of the nation be jeopardized because of the physician-patient relationship.
Focuses on the issue concerning the medical care for the American families in the U.S. Cost of medical treatment; Recognition of the seriousness of the problem by the Congress; Coverage of the Social Security Act; Problems on medical care assistance.
Focuses on the principle of sentinel health event in relation to occupational diseases. Measurement of quality of the medical care; Derivation of the principle; Classification of the 'man-made diseases.'
JAMA: Journal of the American Medical Association; October 1944, Vol. 126 Issue: 8 p484-486, 3p
The need for the development of community rheumatic fever programs and the importance of the cardiac clinic in such programs has been supported by many clinical and epidemiologic facts. These include difficulties in the diagnosis of rheumatic disease, the chronic nature of rheumatic disease with its impact on family life, the low economic level in which the disease is most prevalent, the wide prevalence of the disease and the complexity of care necessary for the management of patients.I should like to discuss these individual factors in more detail. The reasons for the difficulty of diagnosis of rheumatic fever have been adequately summarized in the paper by Dr. T. Duckett Jones.1 I should like to reemphasize the unknown etiology of the disease, the lack of a specific diagnostic test and the fact that the diagnosis is frequently dependent on the physician's impression of a group of nonspecific symptoms and