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1. Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity [2021]

  • Koshy, Cherian, Wise, Emma, Cortes, Nick, Lynch, Jessica, Kidd, Stephen, Mori, Matilde, Fairley, Derek J., Curran, Tanya, McKenna, James P., Adams, Helen, Fraser, Christophe, Golubchik, Tanya, Bonsall, David, Moore, Catrin, Caddy, Sarah L., Khokhar, Fahad A., Wantoch, Michelle, Reynolds, Nicola, Warne, Ben, Maksimovic, Joshua, Spellman, Karla, McCluggage, Kathryn, John, Michaela, Beer, Robert, Afifi, Safiah, Morgan, Sian, Marchbank, Angela, Price, Anna, Kitchen, Christine, Gulliver, Huw, Merrick, Ian, Southgate, Joel, Guest, Martyn, Munn, Robert, Workman, Trudy, Connor, Thomas R., Fuller, William, Bresner, Catherine, Snell, Luke B., Charalampous, Themoula, Nebbia, Gaia, Batra, Rahul, Edgeworth, Jonathan, Robson, Samuel C., Beckett, Angela, Loveson, Katie F., Aanensen, David M., Underwood, Anthony P., Yeats, Corin A., Abudahab, Khalil, Taylor, Ben E.W., Menegazzo, Mirko, Clark, Gemma, Smith, Wendy, Khakh, Manjinder, Fleming, Vicki M., Lister, Michelle M., Howson-Wells, Hannah C., Berry, Louise, Boswell, Tim, Joseph, Amelia, Willingham, Iona, Bird, Paul, Helmer, Thomas, Fallon, Karlie, Holmes, Christopher, Tang, Julian, Raviprakash, Veena, Campbell, Sharon, Sheriff, Nicola, Loose, Matthew W., Holmes, Nadine, Moore, Christopher, Carlile, Matthew, Wright, Victoria, Sang, Fei, Debebe, Johnny, Coll, Francesc, Signell, Adrian W., Betancor, Gilberto, Wilson, Harry D., Feltwell, Theresa, Houldcroft, Charlotte J., Eldirdiri, Sahar, Kenyon, Anita, Davis, Thomas, Pybus, Oliver, du Plessis, Louis, Zarebski, Alex, Raghwani, Jayna, Kraemer, Moritz, Francois, Sarah, Attwood, Stephen, Vasylyeva, Tetyana, Torok, M. Estee, Hamilton, William L., Goodfellow, Ian G., Hall, Grant, Jahun, Aminu S., Chaudhry, Yasmin, Hosmillo, Myra, Pinckert, Malte L., Georgana, Iliana, Yakovleva, Anna, Meredith, Luke W., Moses, Samuel, Lowe, Hannah, Ryan, Felicity, Fisher, Chloe L., Awan, Ali R., Boyes, John, Breuer, Judith, Harris, Kathryn Ann, Brown, Julianne Rose, Shah, Divya, Atkinson, Laura, Lee, Jack C.D., Alcolea-Medina, Adela, Moore, Nathan, Cortes, Nicholas, Williams, Rebecca, Chapman, Michael R., Levett, Lisa J., Heaney, Judith, Smith, Darren L., Bashton, Matthew, Young, Gregory R., Allan, John, Loh, Joshua, Randell, Paul A., Cox, Alison, Madona, Pinglawathee, Holmes, Alison, Bolt, Frances, Price, James, Mookerjee, Siddharth, Rowan, Aileen, Taylor, Graham P., Ragonnet-Cronin, Manon, Nascimento, Fabricia F., Jorgensen, David, Siveroni, Igor, Johnson, Rob, Boyd, Olivia, Geidelberg, Lily, Volz, Erik M., Brunker, Kirstyn, Smollett, Katherine L., Loman, Nicholas J., Quick, Joshua, McMurray, Claire, Stockton, Joanne, Nicholls, Sam, Rowe, Will, Poplawski, Radoslaw, Martinez-Nunez, Rocio T., Mason, Jenifer, Robinson, Trevor I., O'Toole, Elaine, Watts, Joanne, Breen, Cassie, Cowell, Angela, Ludden, Catherine, Sluga, Graciela, Machin, Nicholas W., Ahmad, Shazaad S.Y., George, Ryan P., Halstead, Fenella, Sivaprakasam, Venkat, Thomson, Emma C., Shepherd, James G., Asamaphan, Patawee, Niebel, Marc O., Li, Kathy K., Shah, Rajiv N., Jesudason, Natasha G., Parr, Yasmin A., Tong, Lily, Broos, Alice, Mair, Daniel, Nichols, Jenna, Carmichael, Stephen N., Nomikou, Kyriaki, Aranday-Cortes, Elihu, Johnson, Natasha, Starinskij, Igor, da Silva Filipe, Ana, Robertson, David L., Orton, Richard J., Hughes, Joseph, Vattipally, Sreenu, Singer, Joshua B., Hale, Antony D., Macfarlane-Smith, Louissa R., Harper, Katherine L., Taha, Yusri, Payne, Brendan A.I., Burton-Fanning, Shirelle, Waugh, Sheila, Collins, Jennifer, Eltringham, Gary, Templeton, Kate E., McHugh, Martin P., Dewar, Rebecca, Wastenge, Elizabeth, Dervisevic, Samir, Stanley, Rachael, Prakash, Reenesh, Stuart, Claire, Elumogo, Ngozi, Sethi, Dheeraj K., Meader, Emma J., Coupland, Lindsay J., Potter, Will, Graham, Clive, Barton, Edward, Padgett, Debra, Scott, Garren, Swindells, Emma, Greenaway, Jane, Nelson, Andrew, Yew, Wen C., Resende Silva, Paola C., Andersson, Monique, Shaw, Robert, Peto, Timothy, Justice, Anita, Eyre, David, Crooke, Derrick, Hoosdally, Sarah, Sloan, Tim J., Duckworth, Nichola, Walsh, Sarah, Chauhan, Anoop J., Glaysher, Sharon, Bicknell, Kelly, Wyllie, Sarah, Butcher, Ethan, Elliott, Scott, Lloyd, Allyson, Impey, Robert, Levene, Nick, Monaghan, Lynn, Bradley, Declan T., Allara, Elias, Pearson, Clare, Muir, Peter, Vipond, Ian B., Hopes, Richard, Pymont, Hannah M., Hutchings, Stephanie, Curran, Martin D., Parmar, Surendra, Lackenby, Angie, Mbisa, Tamyo, Platt, Steven, Miah, Shahjahan, Bibby, David, Manso, Carmen, Hubb, Jonathan, Chand, Meera, Dabrera, Gavin, Ramsay, Mary, Bradshaw, Daniel, Thornton, Alicia, Myers, Richard, Schaefer, Ulf, Groves, Natalie, Gallagher, Eileen, Lee, David, Williams, David, Ellaby, Nicholas, Harrison, Ian, Hartman, Hassan, Manesis, Nikos, Patel, Vineet, Bishop, Chloe, Chalker, Vicki, Osman, Husam, Bosworth, Andrew, Robinson, Esther, Holden, Matthew T.G., Shaaban, Sharif, Birchley, Alec, Adams, Alexander, Davies, Alisha, Gaskin, Amy, Plimmer, Amy, Gatica-Wilcox, Bree, McKerr, Caoimhe, Moore, Catherine, Williams, Chris, Heyburn, David, De Lacy, Elen, Hilvers, Ember, Downing, Fatima, Shankar, Giri, Jones, Hannah, Asad, Hibo, Coombes, Jason, Watkins, Joanne, Evans, Johnathan M., Fina, Laia, Gifford, Laura, Gilbert, Lauren, Graham, Lee, Perry, Malorie, Morgan, Mari, Bull, Matthew, Cronin, Michelle, Pacchiarini, Nicole, Craine, Noel, Jones, Rachel, Howe, Robin, Corden, Sally, Rey, Sara, Kumziene-Summerhayes, Sara, Taylor, Sarah, Cottrell, Simon, Jones, Sophie, Edwards, Sue, O’Grady, Justin, Page, Andrew J., Wain, John, Webber, Mark A., Mather, Alison E., Baker, David J., Rudder, Steven, Yasir, Muhammad, Thomson, Nicholas M., Aydin, Alp, Tedim, Ana P., Kay, Gemma L., Trotter, Alexander J., Gilroy, Rachel A.J., Alikhan, Nabil-Fareed, de Oliveira Martins, Leonardo, Le-Viet, Thanh, Meadows, Lizzie, Kolyva, Anastasia, Diaz, Maria, Bell, Andrew, Gutierrez, Ana Victoria, Charles, Ian G., Adriaenssens, Evelien M., Kingsley, Robert A., Casey, Anna, Simpson, David A., Molnar, Zoltan, Thompson, Thomas, Acheson, Erwan, Masoli, Jane A.H., Knight, Bridget A., Hattersley, Andrew, Ellard, Sian, Auckland, Cressida, Mahungu, Tabitha W., Irish-Tavares, Dianne, Haque, Tanzina, Bourgeois, Yann, Scarlett, Garry P., Partridge, David G., Raza, Mohammad, Evans, Cariad, Johnson, Kate, Liggett, Steven, Baker, Paul, Essex, Sarah, Lyons, Ronan A., Caller, Laura G., Castellano, Sergi, Williams, Rachel J., Kristiansen, Mark, Roy, Sunando, Williams, Charlotte A., Dyal, Patricia L., Tutill, Helena J., Panchbhaya, Yasmin N., Forrest, Leysa M., Niola, Paola, Findlay, Jacqueline, Brooks, Tony T., Gavriil, Artemis, Mestek-Boukhibar, Lamia, Weeks, Sam, Pandey, Sarojini, Berry, Lisa, Jones, Katie, Richter, Alex, Beggs, Andrew, Smith, Colin P., Bucca, Giselda, Hesketh, Andrew R., Harrison, Ewan M., Peacock, Sharon J., Palmer, Sophie, Churcher, Carol M., Bellis, Katherine L., Girgis, Sophia T., Naydenova, Plamena, Blane, Beth, Sridhar, Sushmita, Ruis, Chris, Forrest, Sally, Cormie, Claire, Gill, Harmeet K., Dias, Joana, Higginson, Ellen E., Maes, Mailis, Young, Jamie, Kermack, Leanne M., Hadjirin, Nazreen F., Aggarwal, Dinesh, Griffith, Luke, Swingler, Tracey, Davidson, Rose K., Rambaut, Andrew, Williams, Thomas, Balcazar, Carlos E., Gallagher, Michael D., O'Toole, Áine, Rooke, Stefan, Jackson, Ben, Colquhoun, Rachel, Ashworth, Jordan, Hill, Verity, McCrone, J.T., Scher, Emily, Yu, Xiaoyu, Williamson, Kathleen A., Stanton, Thomas D., Michell, Stephen L., Bewshea, Claire M., Temperton, Ben, Michelsen, Michelle L., Warwick-Dugdale, Joanna, Manley, Robin, Farbos, Audrey, Harrison, James W., Sambles, Christine M., Studholme, David J., Jeffries, Aaron R., Darby, Alistair C., Hiscox, Julian A., Paterson, Steve, Iturriza-Gomara, Miren, Jackson, Kathryn A., Lucaci, Anita O., Vamos, Edith E., Hughes, Margaret, Rainbow, Lucille, Eccles, Richard, Nelson, Charlotte, Whitehead, Mark, Turtle, Lance, Haldenby, Sam T., Gregory, Richard, Gemmell, Matthew, Kwiatkowski, Dominic, de Silva, Thushan I., Smith, Nikki, Angyal, Adrienn, Lindsey, Benjamin B., Groves, Danielle C., Green, Luke R., Wang, Dennis, Freeman, Timothy M., Parker, Matthew D., Keeley, Alexander J., Parsons, Paul J., Tucker, Rachel M., Brown, Rebecca, Wyles, Matthew, Constantinidou, Chrystala, Unnikrishnan, Meera, Ott, Sascha, Cheng, Jeffrey K.J., Bridgewater, Hannah E., Frost, Lucy R., Taylor-Joyce, Grace, Stark, Richard, Baxter, Laura, Alam, Mohammad T., Brown, Paul E., McClure, Patrick C., Chappell, Joseph G., Tsoleridis, Theocharis, Ball, Jonathan, Gramatopoulos, Dimitris, Buck, David, Todd, John A., Green, Angie, Trebes, Amy, MacIntyre-Cockett, George, de Cesare, Mariateresa, Langford, Cordelia, Alderton, Alex, Amato, Roberto, Goncalves, Sonia, Jackson, David K., Johnston, Ian, Sillitoe, John, Palmer, Steve, Lawniczak, Mara, Berriman, Matt, Danesh, John, Livett, Rich, Shirley, Lesley, Farr, Ben, Quail, Mike, Thurston, Scott, Park, Naomi, Betteridge, Emma, Weldon, Danni, Goodwin, Scott, Nelson, Rachel, Beaver, Charlotte, Letchford, Laura, Jackson, David A., Foulser, Luke, McMinn, Liz, Prestwood, Liam, Kay, Sally, Kane, Leanne, Dorman, Matthew J., Martincorena, Inigo, Puethe, Christoph, Keatley, Jon-Paul, Tonkin-Hill, Gerry, Smith, Christen, Jamrozy, Dorota, Beale, Mathew A., Patel, Minal, Ariani, Cristina, Spencer-Chapman, Michael, Drury, Eleanor, Lo, Stephanie, Rajatileka, Shavanthi, Scott, Carol, James, Keith, Buddenborg, Sarah K., Berger, Duncan J., Patel, Gaurang, Garcia-Casado, Maria V., Dibling, Thomas, McGuigan, Samantha, Rogers, Hazel A., Hunter, Adam D., Souster, Emily, Neaverson, Alexandra S., Volz, Erik, Hill, Verity, McCrone, John T., Price, Anna, Jorgensen, David, O’Toole, Áine, Southgate, Joel, Johnson, Robert, Jackson, Ben, Nascimento, Fabricia F., Rey, Sara M., Nicholls, Samuel M., Colquhoun, Rachel M., da Silva Filipe, Ana, Shepherd, James, Pascall, David J., Shah, Rajiv, Jesudason, Natasha, Li, Kathy, Jarrett, Ruth, Pacchiarini, Nicole, Bull, Matthew, Geidelberg, Lily, Siveroni, Igor, Goodfellow, Ian, Loman, Nicholas J., Pybus, Oliver G., Robertson, David L., Thomson, Emma C., Rambaut, Andrew, and Connor, Thomas R.
  • In Cell 7 January 2021 184(1):64-75

2. Early impact of COVID-19 on transplant center practices and policies in the United States [2020]

  • Boyarsky, Brian J., Po-Yu Chiang, Teresa, Werbel, William A., Durand, Christine M., Avery, Robin K., Getsin, Samantha N., Jackson, Kyle R., Kernodle, Amber B., Van Pilsum Rasmussen, Sarah E., Massie, Allan B., Segev, Dorry L., and Garonzik-Wang, Jacqueline M.
  • American Journal of Transplantation. July 2020, Vol. 20 Issue 7, p1809, 10 p.

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4. Hypothyroidism. [2017]

  • Chaker, Layal, Bianco, Antonio C, Jonklaas, Jacqueline, and Peeters, Robin P
  • The Lancet. 2017, Vol. 390, Issue 10101, pages. 1550

5. Pulseless Electric Activity: Definition, Causes, Mechanisms, Management, and Research Priorities for the Next Decade: Report From a National Heart, Lung, and Blood Institute Workshop [2013]

  • MYERBURG, Robert J, HALPERIN, Henry, ORNATO, Joseph P, SOPKO, George, VAN EYK, Jennifer E, WALCOTT, Gregory P, WEISFELDT, Myron L, WRIGHT, Jacqueline D, ZIPES, Douglas P, EGAN, Debra A, BOINEAU, Robin, CHUGH, Sumeet S, GILLIS, Anne M, GOLDHABER, Joshua I, LATHROP, David A, LIU, Peter, and NIEMANN, James T
  • Circulation (New York, N.Y.). 128(23):2532-2541
Subjects
Cardiology, blood circulation, phlebology, Cardiologie, appareil circulatoire, phlébologie, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Cardiologie. Appareil circulatoire, Cardiology. Vascular system, Coeur, Heart, Trouble du rythme et de la conduction, Cardiac dysrhythmias, Vaisseaux sanguins et lymphatiques, Blood and lymphatic vessels, Maladies vasculaires des membres. Pathologie de la veine cave. Maladies vasculaires diverses, Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous, Appareil respiratoire, Respiratory system, Aparato respiratorio, Cardiopathie, Heart disease, Cardiopatía, Epidémiologie, Epidemiology, Epidemiología, Activité, Activity, Actividad, Aigu, Acute, Agudo, Appareil circulatoire, Circulatory system, Aparato circulatorio, Arrêt cardiocirculatoire, Cardiocirculatory arrest, Paro cardiocirculatorio, Atelier, Workshop, Taller, Brutal, Sudden, Súbito, Cardiologie, Cardiology, Cardiología, Cause, Causa, Coeur, Heart, Corazón, Conduite à tenir, Clinical management, Actitud médica, Définition, Definition, Definición, Electrique, Electric, Eléctrico, Liquide biologique, Biological fluid, Líquido biológico, Mort, Death, Muerte, Mortalité, Mortality, Mortalidad, Mécanisme, Mechanism, Mecanismo, Pathologie de l'appareil circulatoire, Cardiovascular disease, Aparato circulatorio patología, Poumon, Lung, Pulmón, Priorité, Priority, Prioridad, Pronostic, Prognosis, Pronóstico, Recherche scientifique, Scientific research, Investigación científica, Sang, Blood, Sangre, Traitement, Treatment, Tratamiento, Trouble du rythme cardiaque, Arrhythmia, Arritmia, arrhythmias, cardiac, death, sudden, cardiac, and heart arrest

6. Increased Rates of Asthma Among World Trade Center Disaster Responders [2012]

  • KIM, Hyun, HERBERT, Robin, LANDRIGAN, Philip, MARKOWITZ, Steven B, MOLINE, Jacqueline M, SAVITZ, David A, TODD, Andrew C, UDASIN, Iris G, and WISNIVESKY, Juan P
  • American journal of industrial medicine. 55(1):44-53
Subjects
Hygiene and public health, epidemiology, occupational medicine, Hygiène et santé publique, épidémiologie, médecine du travail, Toxicology, Toxicologie, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Pneumologie, Pneumology, Bronchopneumopathie obstructive chronique, asthme, Chronic obstructive pulmonary disease, asthma, Bronchopneumopathie obstructive, Obstructive pulmonary disease, Enfermedad pulmonar obstructiva, Epidémiologie, Epidemiology, Epidemiología, Pathologie de l'appareil respiratoire, Respiratory disease, Aparato respiratorio patología, Pathologie des bronches, Bronchus disease, Bronquio patología, Pathologie des poumons, Lung disease, Pulmón patología, Asthme, Asthma, Asma, Etude cohorte, Cohort study, Estudio cohorte, Homme, Human, Hombre, Médecine catastrophe, Disaster medicine, Medicina catástrofe, Santé publique, Public health, Salud pública, Terrorisme, Terrorism, Terrorismo, Attentats 11 septembre 2001, NHIS, World Trade Center responders, and asthma
Abstract
Background Studies have documented high rates of asthma symptoms among responders to the World Trade Center (WTC) disaster. However, whether there are increased rates of asthma among responders compared to the general population is unknown. Methods The study population consisted of a prospective cohort of 20,834 responders participating in the WTC Medical Monitoring and Treatment Program between July 2002 and December 2007. We calculated prevalence and standardized morbidity ratios (SMRs) of lifetime asthma and 12-month asthma (defined as ≥1 attacks in the prior 12 months) among WTC responders. The comparison population consisted of >200,000 adults who completed the National Health Interview Survey in 2000 (for pre-9/11 comparisons) and between 2002 and 2007 (for post-9/11 comparisons). Results WTC responders were on average 43 ± 9 years old, 86% male, 59% white, and 42% had an occupation in protective services. The lifetime prevalence of asthma in the general population was relatively constant at about 10% from 2000 to 2007. However, among WTC responders, lifetime prevalence increased from 3% in 2000, to 13% in 2002, and 19% in 2007. The age-adjusted overall SMR for lifetime asthma among WTC responders was 1.8 (95% CI: 1.8-1.9) for men and 2.0 (95% CI: 1.9―2.1) for women. Twelve-month asthma was also more frequent among WTC responders compared to the general population (SMR 2.4, 95% CI: 2.2-2.5) for men and 2.2 (95% CI: 2.0―2.5) for women. Conclusions WTC responders are at an increased risk of asthma as measured by lifetime prevalence or active disease.

7. Sarcoid Like Granulomatous Pulmonary Disease in World Trade Center Disaster Responders [2011]

  • CROWLEY, Laura E, HERBERT, Robin, SHAPIRO, Moshe, WONG, Karen, SACKS, Henry S, LANDRIGAN, Philip J, TEIRSTEIN, Alvin S, MOLINE, Jacqueline M, WALLENSTEIN, Sylvan, SHUKLA, Gauri, SCHECHTER, Clyde, SKLOOT, Gwen S, UDASIN, Iris, LUFT, Benjamin J, and HARRISON, Denise
  • American journal of industrial medicine. 54(3):175-184
Subjects
Hygiene and public health, epidemiology, occupational medicine, Hygiène et santé publique, épidémiologie, médecine du travail, Toxicology, Toxicologie, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Sarcoidoses. Granulomatoses d'etiologie indeterminee. Maladies du tissu conjonctif. Maladies du tissu elastique. Vascularites, Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis, Maladie de système, Systemic disease, Enfermedad sistémica, Pathologie de l'appareil respiratoire, Respiratory disease, Aparato respiratorio patología, Capacité vitale forcée, Forced vital capacity, Capacidad vital forzada, Epidémiologie, Epidemiology, Epidemiología, Etiologie, Etiology, Etiología, Etude cas témoin, Case control study, Estudio caso control, Fonction respiratoire, Lung function, Función respiratoria, Granulomatose, Granulomatosis, Homme, Human, Hombre, Médecine catastrophe, Disaster medicine, Medicina catástrofe, Pathologie des poumons, Lung disease, Pulmón patología, Santé publique, Public health, Salud pública, Sarcoïdose, Sarcoidosis, Terrorisme, Terrorism, Terrorismo, Attentats 11 septembre 2001, World Trade Center (WTC), a case control etiologic study of sarcoidosis (ACCESS), forced vital capacity (FVC), granulomatous disease, and sarcoidosis
Abstract
Background More than 20, 000 responders have been examined through the World Trade Center (WTC) Medical Monitoring and Treatment Program since September 11, 2001. Studies on WTCfirefighters have shown elevated rates of sarcoidosis. The main objective of this study was to report the incidence of sarcoid like granulomatous pulmonary disease in other WTC responders. Methods Cases of sarcoid like granulomatous pulmonary disease were identified by: patient self-report, physician report and ICD-9 codes. Each case was evaluated by three pulmonologists using the ACCESS criteria and only definite cases are reported. Results Thirty-eight patients were classified as definite cases. Six-year incidence was 192/100,000. The peak annual incidence of 54 per 100,000 person-years occurred between 9/11/2003 and 9/11/2004. Incidence in black responders was nearly double that of white responders. Low FVC was the most common spirometric abnormality. Conclusions Sarcoid like granulomatous pulmonary disease is present among the WTC responders. While the incidence is lower than that reported among firefighters, it is higher than expected.

8. The association of serum testosterone levels and ventricular repolarization [2010]

  • VAN NOORD, Charlotte, DÖRR, Marcus, NAUCK, Matthias, UITTERLINDEN, André G, WALLASCHOFSKI, Henri, WITTEMAN, Jacqueline C. M, VÖLZKE, Henry, STRICKER, Bruno H. Ch, STURKENBOOM, Miriam C. J. M, STRAUS, Sabine M. J. M, REFFELMANN, Thorsten, FELIX, Stephan B, HOFMAN, Albert, KORS, Jan A, HARING, Robin, and DE JONG, Frank H
  • European journal of epidemiology. 25(1):21-28
Subjects
Hygiene and public health, epidemiology, occupational medicine, Hygiène et santé publique, épidémiologie, médecine du travail, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Sante publique. Hygiene-medecine du travail, Public health. Hygiene-occupational medicine, Santé publique. Hygiène, Public health. Hygiene, Généralités, General aspects, Epidémiologie, Epidemiology, Divers, Miscellaneous, Androgène, Androgen, Andrógeno, Hormone stéroïde sexuelle, Sex steroid hormone, Hormona esteroide sexual, Hormone testiculaire, Testicular hormone, Hormona testicular, Association, Asociación, Biologie clinique, Clinical biology, Biología clínica, Epidémiologie, Epidemiology, Epidemiología, Homme, Human, Hombre, Intervalle QT, QT interval, Intervalo QT, Santé publique, Public health, Salud pública, Sérum, Serum, Suero, Testostérone, Testosterone, Testosterona, QTc interval, RR interval, Serum testosterone, and Ventricular repolarization
Abstract
It is assumed that testosterone is an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels of testosterone are associated with QTc, QT and RR interval variation. Setting: two independent population-based cohort studies. Participants: 445 male participants (>55 years) from the Rotterdam study cohort and 1,428 male participants from the study of health in Pomerania (SHIP) with an electrocardiogram who were randomly sampled for assessment of serum testosterone at baseline, after exclusion of participants with testosterone altering drugs, QTc prolonging drugs or dig(it)oxin, left ventricular hypertrophy and left and right bundle branch block. Endpoints: length of the QTc, QT and RR intervals. Analysis: linear regression model, adjusted for the two individual studies and a pooled analysis of both studies. The pooled analysis of the Rotterdam study and SHIP showed that the QTc interval gradually decreased among the tertiles (P value for trend 0.024). The third tertile of serum testosterone was associated with a lower QTc interval compared to the first tertile [—3.4 ms (-6.5; -0.3)]. However, the third tertile of serum testosterone was not associated with a lower QT interval compared to the first tertile [-0.7 ms (-3.1; 1.8)]. The RR interval gradually increased among the tertiles (P value for trend 0.002) and the third tertile of serum testosterone showed an increased RR interval compared to the first tertile [33.5 ms (12.2; 54.8)]. In the pooled analysis of two population-based studies, serum testosterone levels were not associated with the QT interval, which could be due to a lack of power. Lower QTc intervals in men with higher serum testosterone levels could be due to the association of serum testosterone with prolongation of the RR interval.

9. Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms [2010]

  • SOFAT, Reecha, HINGORANI, Aroon D, WAREHAM, Nicholas, KAY TEE KHAW, KUMARI, Meena, KIVIMAKI, Mika, MARMOT, Michael, ASSELBERGS, Folkert W, VAN DER HARST, Pim, DULLAART, Robin P. F, NAVIS, Gerjan, VAN VELDHUISEN, Dirk J, SMEETH, Liam, VAN GILST, Wiek H, THOMPSON, John F, MCCASKIE, Pamela, PALMER, Lyle J, ARCA, Marcello, QUAGLIARINI, Fabiana, GAUDIO, Carlo, CAMBIEN, François, NICAUD, Viviane, POIRER, Odette, HUMPHRIES, Steve E, GUDNASON, Vilmundur, ISAACS, Aaron, WITTEMAN, Jacqueline C. M, VAN DUIJN, Cornelia M, PENCINA, Michael, VASAN, Ramachandran S, D'AGOSTINO, Ralph B, ORDOVAS, Jose, LI, Tricia Y, KAKKO, Sakari, TALMUD, Philippa J, KAUMA, Heikki, SAVOLAINEN, Markku J, ANTERO KESÄNIEMI, Y, SANDHOFER, Anton, PAULWEBER, Bernhard, SORLI, Jose V, GOTO, Akimoto, YOKOYAMA, Shinji, OKUMURA, Kenji, HORNE, Benjamin D, COOPER, Jackie, PACKARD, Chris, FREEMAN, Dilys, FORD, Ian, SATTAR, Naveed, MCCORMACK, Valerie, LAWLOR, Debbie A, EBRAHIM, Shah, SHAH, Tina, SANDHU, Manjinder S, RICKETTS, Sally L, and MATTHIJS BOEKHOLDT, S
  • Circulation (New York, N.Y.). 121(1):52-62
Subjects
Cardiology, blood circulation, phlebology, Cardiologie, appareil circulatoire, phlébologie, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Pharmacologie. Traitements medicamenteux, Pharmacology. Drug treatments, Système cardiovasculaire, Cardiovascular system, Divers, Miscellaneous, Cardiologie. Appareil circulatoire, Cardiology. Vascular system, Vaisseaux sanguins et lymphatiques, Blood and lymphatic vessels, Maladies vasculaires des membres. Pathologie de la veine cave. Maladies vasculaires diverses, Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous, Epidémiologie, Epidemiology, Epidemiología, Lipoprotéine, Lipoprotein, Lipoproteina, Pathologie de l'appareil circulatoire, Cardiovascular disease, Aparato circulatorio patología, Pharmacologie, Pharmacology, Farmacología, Polymorphisme, Polymorphism, Polimorfismo, epidemiology, genetics, high-density lipoproteins, and pharmacology
Abstract
Background-Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP inhibition or an off-target action of torcetrapib has been debated. We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target. Methods and Results-We compared the effect of CETP single-nucleotide polymorphisms and torcetrapib treatment on lipid fractions, blood pressure, and electrolytes in up to 67 687 individuals from genetic studies and 17 911 from randomized trials. CETP single-nucleotide polymorphisms and torcetrapib treatment reduced CETP activity and had a directionally concordant effect on 8 lipid and lipoprotein traits (total, low-density lipoprotein, and HDL cholesterol; HDL2; HDL3; apolipoproteins A-I and B; and triglycerides), with the genetic effect on HDL cholesterol (0.13 mmol/L, 95% confidence interval [CI] 0.11 to 0.14 mmol/L) being consistent with that expected of a 10-mg dose of torcetrapib (0.13 mmol/L, 95% CI 0.10 to 0.15). In trials, 60 mg of torcetrapib elevated systolic and diastolic blood pressure by 4.47 mm Hg (95% CI 4.10 to 4.84 mm Hg) and 2.08 mm Hg (95% CI 1.84 to 2.31 mm Hg), respectively. However, the effect of CETP single-nucleotide polymorphisms on systolic blood pressure (0.16 mm Hg, 95% CI -0.28 to 0.60 mm Hg) and diastolic blood pressure (-0.04 mm Hg, 95% CI -0.36 to 0.28 mm Hg) was null and significantly different from that expected of 10 mg of torcetrapib. Conclusions-Discordance in the effects of CETP single-nucleotide polymorphisms and torcetrapib treatment on blood pressure despite the concordant effects on lipids indicates the hypertensive action of torcetrapib is unlikely to be due to CETP inhibition or shared by chemically dissimilar CETP inhibitors. Genetic studies could find a place in drug-development programs as a new source of randomized evidence for drug-target validation in humans.

10. Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States—September—October 2009 [2011]

  • the 2009 Pandemic Influenza A (H1N1) Virus Fall Hospitalizations Investigation Team, Skarbinski Jacek, Jain Seema, Bramley Anna, Lee Esther J., Huang Jean, Kirschke David, Stone Allison, Wedlake Tiffany, Richards Shawn M., Page Shannon, Ragan Patti, Bullion Lesley, Neises Daniel, Williams Robin M., Petruccelli Bruno P., Vandermeer Meredith, Lofy Kathryn H., Gindler Jacqueline, and Finelli Lyn
  • Clinical Infectious Diseases. 52:S50-S59

11. Epidemiology of 2009 Pandemic Influenza A (H1N1) Deaths in the United States, April—July 2009 [2011]

  • Fowlkes Ashley L., Arguin Paul, Biggerstaff Matthew S., Gindler Jacqueline, Blau Dianna, Jain Seema, Dhara Roseline, McLaughlin Joe, Turnipseed Elizabeth, Meyer John J., Louie Janice K., Siniscalchi Alan, Hamilton Janet J., Reeves Ariane, Park Sarah Y., Richter Deborah, Ritchey Matthew D., Cocoros Noelle M., Blythe David, Peters Susan, Lynfield Ruth, Peterson Lesha, Anderson Jannifer, Moore Zack, Williams Robin, McHugh Lisa, Cruz Carmen, Waters Christine L., Page Shannon L., McDonald Christie K., Vandermeer Meredith, Waller Kirsten, Bandy Utpala, Jones Timothy F., Bullion Lesley, Vernon Valoree, Lofy Kathryn H., Haupt Thomas, and Finelli Lyn
  • Clinical Infectious Diseases. 52:S60-S68

12. The prevalence, correlates, and costs of depression in people living with HIV/AIDS in ontario : Implications for service directions [2005]

  • WILLIAMS, Peter, NARCISO, Lea, BROWNE, Gina, ROBERTS, Jacqueline, WEIR, Robin, and GAFNI, Amiram
  • AIDS education and prevention. 17(2):119-130
Subjects
Hygiene and public health, epidemiology, occupational medicine, Hygiène et santé publique, épidémiologie, médecine du travail, Microbiology, infectious diseases, Microbiologie, maladies infectieuses, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Pathologie infectieuse, Infectious diseases, Viroses, Viral diseases, Viroses humaines, Human viral diseases, Viroses du tissu lymphoïde et du sang. Sida, Viral diseases of the lymphoid tissue and the blood. Aids, Economie santé, Health economy, Economía salud, Epidémiologie, Epidemiology, Epidemiología, Immunodéficit, Immune deficiency, Inmunodeficiencia, Immunopathologie, Immunopathology, Inmunopatología, Infection, Infección, Lentivirus, Retroviridae, Santé publique, Public health, Salud pública, Trouble humeur, Mood disorder, Trastorno humor, Virose, Viral disease, Virosis, Virus, Accessibilité, Accessibility, Accesibilidad, Caractéristique, Characteristic, Característica, Coping, Coronación, Coût, Costs, Coste, Crise, Crisis, Education santé, Health education, Educación sanitaria, Etat dépressif, Depression, Estado depresivo, Phytohémagglutinine, Phytohemagglutinin, Fitohemaglutinina, Prévalence, Prevalence, Prevalencia, Prévention, Prevention, Prevención, Qualité vie, Quality of life, Calidad vida, SIDA, AIDS, Service santé, Health service, Servicio sanidad, Virus immunodéficience humaine, and Human immunodeficiency virus
Abstract
As new technologies extend the lives of people living with HIV/AIDS (PHA), the need increases for services that optimize their quality-of-life cost effectively. This study of PHAs (n = 297) in Ontario, Canada, examined the prevalence of depression, and its association with quality-of-life, coping strategies, social support, and use of health and social services. Results showed that depression was widespread (54.2%) and largely unrelated to demographic characteristics, but associated with diminished health status, health-related quality-of-life, and coping strategies. Depressed PHAs used significantly more crisis health care and related services, and community-based HIV/AIDS service organizations (ASOs). Findings suggest quality-of-life of PHAs may be improved by expanding the capacity of ASO workers to recognize and address depression, including helping depressed PHA access appropriate medication and sustain medication regimes.

13. Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 U.S. Case-Control Studies. VI. Nonepithelial Cancers among Adults [1992]

  • Pamela L. Horn-Ross, Alice S. Whittemore, Robin Harris, Jacqueline Itnyre, and The Collaborative Ovarian Cancer Group
  • Epidemiology. 3(6):490-495

14. Cancer Incidence in World Trade Center Rescue and Recovery Workers, 2001-2008. [2013]

  • Solan, Samara, Wallenstein, Sylvan, Shapiro, Moshe, Teitelbaum, Susan L., Stevenson, Lori, Kochman, Anne, Kaplan, Julia, Dellenbaugh, Cornelia, Kahn, Amy, Biro, F. Noah, Crane, Michael, Crowley, Laura, Gabrilove, Janice, Gonsalves, Lou, Harrison, Denise, Herbert, Robin, Luft, Benjamin, Markowitz, Steven B., Moline, Jacqueline, and Niu, Xiaoling
  • Environmental Health Perspectives. Jun2013, Vol. 121 Issue 6, p699-704. 6p. 3 Charts.
Subjects
Carcinogens, Dust, Environmental exposure, Confidence intervals, Disasters, Mass casualties, Questionnaires, Regression analysis, Rescue work, Research funding, Terrorism, Tumors, Disease incidence, Data analysis software, and Descriptive statistics
Abstract
Background: World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. Objective: The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. Methods: Cancers among 20,984 consented participants in the WTC Health Program were identified through linkage to state tumor registries in New York, New Jersey, Connecticut, and Pennsylvania. Standardized incidence ratios (SIRs) were calculated to compare cancers diagnosed in responders to predicted numbers for the general population. Multivariate regression models were used to estimate associations with degree of exposure. Results: A total of 575 cancers were diagnosed in 552 individuals. Increases above registry-based expectations were noted for all cancer sites combined (SIR = 1.15; 95% CI: 1.06, 1.25), thyroid cancer (SIR = 2.39; 95% CI: 1.70, 3.27), prostate cancer (SIR = 1.21; 95% CI: 1.01, 1.44), combined hematopoietic and lymphoid cancers (SIR = 1.36; 95% CI: 1.07, 1.71), and soft tissue cancers (SIR = 2.26; 95% CI: 1.13, 4.05). When restricted to 302 cancers diagnosed ≥ 6 months after enrollment, the SIR for all cancers decreased to 1.06 (95% CI: 0.94, 1.18), but thyroid and prostate cancer diagnoses remained greater than expected. All cancers combined were increased in very highly exposed responders and among those exposed to significant amounts of dust, compared with responders who reported lower levels of exposure. Conclusion: Estimates should be interpreted with caution given the short follow-up and long latency period for most cancers, the intensive medical surveillance of this cohort, and the small numbers of cancers at specific sites. However, our findings highlight the need for continued follow-up and surveillance of WTC responders. [ABSTRACT FROM AUTHOR]

15. The association of serum testosterone levels and ventricular repolarization [2009]

  • van Noord, Charlotte, Dörr, Marcus, Sturkenboom, Miriam C. J. M., Straus, Sabine M. J. M., Reffelmann, Thorsten, Felix, Stephan B., Hofman, Albert, Kors, Jan A., Haring, Robin, de Jong, Frank H., Nauck, Matthias, Uitterlinden, André G., Wallaschofski, Henri, Witteman, Jacqueline C. M., Völzke, Henry, and Stricker, Bruno H. Ch.
  • European Journal of Epidemiology
Subjects
Ventricular repolarization, Epidemiology, Cardiovascular Disease, QTc interval, Serum testosterone, and RR interval
Abstract
It is assumed that testosterone is an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels of testosterone are associated with QTc, QT and RR interval variation. Setting: two independent population-based cohort studies. Participants: 445 male participants (≥55 years) from the Rotterdam study cohort and 1,428 male participants from the study of health in Pomerania (SHIP) with an electrocardiogram who were randomly sampled for assessment of serum testosterone at baseline, after exclusion of participants with testosterone altering drugs, QTc prolonging drugs or dig(it)oxin, left ventricular hypertrophy and left and right bundle branch block. Endpoints: length of the QTc, QT and RR intervals. Analysis: linear regression model, adjusted for the two individual studies and a pooled analysis of both studies. The pooled analysis of the Rotterdam study and SHIP showed that the QTc interval gradually decreased among the tertiles (P value for trend 0.024). The third tertile of serum testosterone was associated with a lower QTc interval compared to the first tertile [−3.4 ms (−6.5; −0.3)]. However, the third tertile of serum testosterone was not associated with a lower QT interval compared to the first tertile [−0.7 ms (−3.1; 1.8)]. The RR interval gradually increased among the tertiles (P value for trend 0.002) and the third tertile of serum testosterone showed an increased RR interval compared to the first tertile [33.5 ms (12.2; 54.8)]. In the pooled analysis of two population-based studies, serum testosterone levels were not associated with the QT interval, which could be due to a lack of power. Lower QTc intervals in men with higher serum testosterone levels could be due to the association of serum testosterone with prolongation of the RR interval.

16. Alcohol consumption and NHMRC guidelines: has the message got out, are people conforming and are they aware that alcohol causes cancer? [2014]

  • Bowden, Jacqueline A., Delfabbro, Paul, Room, Robin, Miller, Caroline L., and Wilson, Carlene
  • Australian & New Zealand Journal of Public Health; Feb2014, Vol. 38 Issue 1, p66-72, 7p, 5 Charts
Subjects
TUMOR risk factors, CHI-squared test, CLUSTER analysis (Statistics), CONFIDENCE intervals, CORRELATION (Statistics), ALCOHOL drinking, EPIDEMIOLOGY, MEDICAL protocols, QUESTIONNAIRES, STATISTICAL sampling, SELF-evaluation, SEX distribution, SOCIAL skills, STATISTICS, LOGISTIC regression analysis, DATA analysis, PREDICTIVE validity, CROSS-sectional method, HEALTH literacy, and DESCRIPTIVE statistics
Abstract
Objective: To examine self-reported alcohol consumption and relationships between consumption, awareness of the 2009 NHMRC guidelines of no more than two standard drinks per day, drinking in excess of the guideline threshold and perceptions of alcohol as a risk factor for cancer. Methods: Questions were included in annual, cross-sectional surveys of approximately 2,700 South Australians aged 18 years and over from 2004 to 2012. Consumption data for 2011 and 2012 were merged for the majority of analyses. Results: In 2011 and 2012, 21.6% of adults drank in excess of the guideline threshold (33.0% males; 10.7% females). While 53.5% correctly identified the NHMRC consumption threshold for women, only 20.3% did so for men (39.0% nominated a higher amount). A large minority said they did not know the consumption threshold for women (39.2%) or men (40.4%). In 2012, only 36.6% saw alcohol as an important risk factor for cancer. Important predictors of excess consumption for men were: higher household income; and not perceiving alcohol as an important risk factor for cancer. Predictors for women were similar but the role of household income was even more prominent. Conclusions: Men were nearly three times as likely to drink in excess of the guidelines as women. The majority of the population did not see an important link between alcohol and cancer. Awareness of the latest NHMRC guidelines consumption threshold is still low, particularly for men. Implications: A strategy to raise awareness of the NHMRC guidelines and the link between alcohol and cancer is warranted. [ABSTRACT FROM AUTHOR]

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