Kitahara CM, Linet MS, Brenner AV, Wang SS, Melin BS, Wang Z, Inskip PD, Freeman LE, Braganza MZ, Carreón T, Feychting M, Gaziano JM, Peters U, Purdue MP, Ruder AM, Sesso HD, Shu XO, Waters MA, White E, Zheng W, Hoover RN, Fraumeni JF Jr, Chatterjee N, Yeager M, Chanock SJ, Hartge P, and Rajaraman P
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2014 Jan; Vol. 23 (1), pp. 47-54. Date of Electronic Publication: 2013 Nov 12.
Aged, Case-Control Studies, China epidemiology, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Observational Studies as Topic, Polymorphism, Single Nucleotide, Risk Factors, Surveys and Questionnaires, Treatment Outcome, United States epidemiology, Brain Neoplasms epidemiology, Brain Neoplasms genetics, Diabetes Mellitus epidemiology, Diabetes Mellitus genetics, Glioma epidemiology, and Glioma genetics
Background: Brain glioma is a relatively rare and fatal malignancy in adulthood with few known risk factors. Some observational studies have reported inverse associations between diabetes and subsequent glioma risk, but possible mechanisms are unclear. Methods: We conducted a pooled analysis of original data from five nested case-control studies and two case-control studies from the United States and China that included 962 glioma cases and 2,195 controls. We examined self-reported diabetes history in relation to glioma risk, as well as effect modification by seven glioma risk-associated single-nucleotide polymorphisms (SNP). We also examined the associations between 13 diabetes risk-associated SNPs, identified from genome-wide association studies, and glioma risk. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable-adjusted logistic regression models. Results: We observed a 42% reduced risk of glioma for individuals with a history of diabetes (OR = 0.58; 95% CI, 0.40-0.84). The association did not differ by sex, study design, or after restricting to glioblastoma, the most common histological subtype. We did not observe any significant per-allele trends among the 13 diabetes-related SNPs examined in relation to glioma risk. Conclusion: These results support an inverse association between diabetes history and glioma risk. The role of genetic susceptibility to diabetes cannot be excluded, and should be pursued in future studies together with other factors that might be responsible for the diabetes-glioma association. Impact: These data suggest the need for studies that can evaluate, separately, the association between type 1 and type 2 diabetes and subsequent risk of adult glioma.
Journal of diabetes [J Diabetes] 2013 Dec; Vol. 5 (4), pp. 369-71. Date of Electronic Publication: 2013 Sep 18.
Adult, Age Distribution, Aged, Aged, 80 and over, China epidemiology, Humans, Middle Aged, Prevalence, United States epidemiology, Young Adult, Aging physiology, Diabetes Mellitus epidemiology, and Diabetes Mellitus physiopathology
Kandula NR, Diez-Roux AV, Chan C, Daviglus ML, Jackson SA, Ni H, and Schreiner PJ
Diabetes care [Diabetes Care] 2008 Aug; Vol. 31 (8), pp. 1621-8. Date of Electronic Publication: 2008 May 05.
Aged, Aged, 80 and over, Asian Continental Ancestry Group, China ethnology, Cross-Sectional Studies, Emigrants and Immigrants statistics numerical data, Female, Hispanic Americans, Humans, Longitudinal Studies, Male, Middle Aged, United States epidemiology, Atherosclerosis epidemiology, Diabetes Mellitus epidemiology, Diabetic Angiopathies epidemiology, and Ethnic Groups statistics numerical data
Objective: The prevalence of type 2 diabetes among Hispanic and Asian Americans is increasing. These groups are largely comprised of immigrants who may be undergoing behavioral and lifestyle changes associated with development of diabetes. We studied the association between acculturation and diabetes in a population sample of 708 Mexican-origin Hispanics, 547 non-Mexican-origin Hispanics, and 737 Chinese participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Research Design and Methods: Diabetes was defined as fasting glucose >/=126 mg/dl and/or use of antidiabetic medications. An acculturation score was calculated for all participants using nativity, years living in the U.S., and language spoken at home. The score ranged from 0 to 5 (0 = least acculturated and 5 = most acculturated). Relative risk regression was used to estimate the association between acculturation and diabetes. Results: For non-Mexican-origin Hispanics, the prevalence of diabetes was positively associated with acculturation score, after adjustment for sociodemographics. The prevalence of diabetes was significantly higher among the most acculturated versus the least acculturated non-Mexican-origin Hispanics (prevalence ratio 2.49 [95% CI 1.14-5.44]); the higher the acculturation score is, the higher the prevalence of diabetes (P for trend 0.059). This relationship between acculturation and diabetes was partly attenuated after adjustment for BMI or diet. Diabetes prevalence was not related to acculturation among Chinese or Mexican-origin Hispanics. Conclusions: Among non-Mexican-origin Hispanics in MESA, greater acculturation is associated with higher diabetes prevalence. The relation is at least partly mediated by BMI and diet. Acculturation is a factor that should be considered when predictors of diabetes in racial/ethnic groups are examined.
American journal of epidemiology [Am J Epidemiol] 2008 Jun 01; Vol. 167 (11), pp. 1365-74. Date of Electronic Publication: 2008 Mar 28.
African Americans statistics numerical data, China epidemiology, European Continental Ancestry Group statistics numerical data, Female, Humans, Incidence, Least-Squares Analysis, Logistic Models, Male, Middle Aged, Prospective Studies, Risk Factors, United States epidemiology, Body Mass Index, Diabetes Mellitus epidemiology, Diabetes Mellitus ethnology, Hypertension epidemiology, and Hypertension ethnology
Researchers have hypothesized that the impact of body mass index on chronic disease may be greater in Asians than in Whites; however, most studies are cross-sectional and have no White comparison group. The authors compared the associations with body mass index in Chinese Asians (n = 5,980), American Whites (n = 10,776), and American Blacks (n = 3,582) using prospective data from the People's Republic of China Study (1983-1994) and the Atherosclerosis Risk in Communities Study (1987-1998). Slopes of risk differences over body mass index levels were compared among the three ethnic groups in adjusted analyses. The authors found larger associations with body mass index in Chinese Asians compared with American Whites and Blacks for hypertension (p < 0.05). The increase in the incidence of hypertension associated with a one-unit increase in body mass index over approximately 8 years of follow-up was 2.5, 1.7, and 1.8 percentage points for Chinese Asians, American Whites, and American Blacks, respectively. For diabetes, the estimates were 1.7, 1.1, and 1.6 percentage points for the same groups- higher in Chinese Asians than in American Whites (p < 0.05) but similar between Chinese Asians and American Blacks. Given the ethnic differences in associations, the results support advocacy of public health and medical actions toward obesity prevention and treatment in China.
Archives of physiology and biochemistry [Arch Physiol Biochem] 2001 Jul; Vol. 109 (3), pp. 197-9.
China epidemiology, Diabetes Complications, Diabetes Mellitus epidemiology, Diabetes Mellitus, Type 1 epidemiology, Diabetes Mellitus, Type 2 epidemiology, Forecasting, Humans, India epidemiology, Prevalence, United States epidemiology, and Diabetes Mellitus etiology