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Leptospirosis ialah penyakit infeksius yang diakibatkan oleh bakteri motil dari genus Leptospira. Prevalensi leptospirosis pada anjing di Indonesia berkisar 13,8% – 44% dengan varian Leptospira antara lain serovar Ichterohaemorrhagiae, Celledoni, Canicola, Pyrogenes, Cynopteri, Rachmati, Bataviae, Javanica, Grippotyphosa dan Tarrasovi. Leptospira sp. dapat ditularkan melalui kontak langsung atau melalui tanah dan air yang terkontaminasi Leptospira sp. Hewan pengerat, babi, kuda, hewan ternak, anjing dan berbagai hewan liar seperti tupai dan rusa dapat berperan sebagai karier Leptospira. Gejala klinis leptospirosis pada anjing di Indonesia berupa demam, letargi, anoreksia, muntah, ikterus, gangguan ginjal, dispnea, poliuria, urin berwarna kuning, dehidrasi dan kematian. Gold standard pengujian leptospirosis pada anjing adalah MAT, namun uji PCR dan ELISA memiliki sensitivitas yang lebih tinggi. Upaya pencegahan kejadian leptospirosis dilakukan dengan vaksinasi, penggunaan disinfeksi rutin pada lingkungan kandang dan mencegah anjing kontak langsung dengan hewan reservoir seperti tikus.

Ovariohisterectomy (OH) pada kucing domestik menyebabkan beberapa efek samping, diantaranya yaitu obesitas. Obesitas berhubungan sangat erat dengan penyakit diabetes. Gen glukoregulator yang mungkin akan menjadi penyebab resistensi insulin jika mengalami mutasi gen adalah gen PDX-1. Resistensi insulin tersebut akan berpengaruh sangat erat dengan glukosa darah dalam tubuh. Tujuan penelitian adalah melihat hubungan antara polimorfisme gen PDX-1 dengan kadar glukosa darah pada kucing domestik yang mengalami OH. Metode yang digunakan pada penelitian ini adalah amplifikasi invitro PCR gen PDX-1 dengan primer Forward ‘CCG AGC TGT CAA AGC TAG CG’ dan Reverse ‘GAA CCG GTA GAG GGT CTT GG’ dan dilanjutkan dengan sekuensing terhadap produk PCR. Hasil penelitian menunjukkan bahwa terdapat perbedaan mendasar pada urutan basa dalam sekuen gen PDX-1 pada c.435G>A, c.927A>T, dan c.584A>G. Perbedaan mendasar pada urutan gen PDX-1 merupakan silent mutation.

Haemobartonellosis is a disease caused by Haemobartonella felis or Mycoplasma haemofelis, which attacks red blood cells. Ctenocephalides felis could transmit Haemobartonellosis. Further, vertical transmission from mother to offspring and blood transfusion from infected animals could transfer the disease to other animals. This report aimed to describe the diagnosis and medical treatment of haemobartonellosis in a domestic cat in Indonesia. Physical examinations and blood analysis were carried out. The cat weighed 1,4 kg with 39,3°C temperature, CRT was three seconds, mucosa looked pale, and many Ctenocephalides felis fleas were found. The clinical symptoms detected were weakness, loss of appetite, and hair loss. A blood test indicated normocytic normochromic anemia. The rod-like formation within erythrocytes in blood smear was observed. Infection with Hemobartonella felis was diagnosed based on the blood test and the presence of numerous Ctenocephalides felis. Doxycycline was administrated at 10 mg/kg BW once a day for 21 days. The cat recovered clinically after 21 days, with a good appetite, normal mucosal color, and normal temperature

Penggunaan Antibiotics Growth Promotors (AGP) sintetis dalam pemeliharaan ayam broiler menyebabkan efek negatif jangka panjang. Penggunaan infused water buah naga merah (IWBNM) sebagai suplemen alami sangat diperlukan. Penelitian dilakukan guna mengetahui pengaruh IWBNM terhadap pertumbuhan ayam broiler. Rancangan acak lengkap menggunakan 5 kelompok dengan tiga ulangan adalah desain penelitian yang digunakan. Setiap ulangan berjumlah 20 ekor DOC. IWBNM diberikan melalui air minum. Perlakuan dilakukan hingga umur 21 hari. Perlakuan terdiri atas P0 (Kontrol) air biasa : P (Perlakuan) konsentrasi buah naga. Kelompok perlakuan yaitu 1 = konsentrasi 0,25% ; 2 = konsentrasi 0,5% ; 3 = konsentrasi 1% ; 4 = konsentrasi 2%. Data penelitian diuji dengan One Way ANOVA, dengan uji Least Significant Difference (LSD) dan Duncan sebagai uji lanjutan. Hasil pengujian, 1 ml IWBNM mengandung total flavonoid sebesar 676,19 µg. Pemberian IWBNM selama 21 hari secara umum dapat meningkatkan performa pertumbuhan ayam broiler. Pengukuran morfometri dan berat badan pada hari ke-21 merupakan indikator peningkatan performa pertumbuhan ayam broiler dengan rata-rata performa paling tinggi terdapat dalam kelompok P4 dibandingkan dengan P1, P2, P3, dan P0. Sedangkan untuk rasio organ visceral terhadap berat badan, IWBNM tidak berpengaruh signifikan baik pada organ jantung atau hepar

Jarak Pagar atau Jatropha curcas L merupakan tanaman famili Eurphobiaceae dengan kegunaan secara medis dan non medis, diantaranya yaitu sebagai kontrasepsi oral. Bagian Jarak Pagar yang sering dimanfaatkan adalah bagian biji. Namun, Jarak Pagar juga mengandung saponin, phorbol ester, kursin, tanin yang dapat menyebabkan keracunan organ. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak biji Jarak Pagar terhadap histopatologi hati dan kadar SGPT tikus Rattus Norvegicus, dengan menggunakan metode Rancangan Acak Lengkap. Hewan coba dibagi dalam 4 kelompok, setiap kelompok terdiri dari 5 ekor tikus betina. Kelompok tersebut yaitu kelompok kontrol tanpa perlakuan dan kelompok perlakuan per oral ekstrak biji Jarak Pagar pada dosis 10, 50, dan 100 mg/kg BB. Proses induksi dilakukan setiap hari selama 14 hari, pada hari ke-15 dilakukan nekropsi. Organ hati diambil untuk analisis histologi dan sampel darah diambil untuk mengukur kadar SGPT. Hasil penelitian menunjukkan bahwa pemberian ekstrak biji Jarak Pagar dapat meningkatkan kadar SGPT. Pemberian ekstrak biji Jarak Pagar pada dosis 100 mg/kg berat badan menginduksi kerusakan hepatosit paling parah di antara kelompok perlakuan.

Channa striata, Acepromazine, biology, Traditional medicine, medicine, , Ketamine, Premedication, Curcuma, biology.organism_classification, Wound healing, medicine.drug, and Snakehead

This study aimed to determine the effect of snakehead fish extracts (Channa striata) and turmeric extract (Curcuma domestica) towards incision wound healing in rats (Rattus norvegicus). Twenty-four male rats, aged 8-week-old, 200-300 grams of body weight divided into 4 groups: control (P0), treatment with povidone iodine as positive control (P1), treatment with snakehead fish extract (P2) and treatment with turmeric extract (P3). The rats were given premedication consisting of acepromazine 0.5 mg kg / BW and atropine 10 mg / kg BW. The rats were then anesthetized using ketamine 0.1 mg / kg BW. An incision was made on each rats’ back area along 2 cm with 0.05 mm depth and observed for 14 days. Observations were carried out every day with data collection at

Mature animal, Veterinary medicine, business.industry, Animal product, Transmissible disease, Medicine, Body Score, Visual observation, and business

As an annual Muslim celebration, Eid al-Adha Feast is celebrated every year in Malang City. In 2019 feast, animals were sacrificed in Malang City consisting of 1202 cattle, 3572 goats and 302 sheep. Antemortem and postmortem examination were very important steps to ensure the quality of consumable animal product produced during the feast. The importance of these examination was to prevent zoonotic food-borne and transmissible disease from contaminated animal product to other livestocks nearby. Fascioliosis was listed into routine disease check due to its potential to reduce the quality of animal product, especially the liver. This study was held in 5 sub-districts in Malang City according to descriptive data collected by interview and structural questionnaire as well as visual observation. The result showed that fascioliosis happened in 26,03% of cattle, 2,93% of goats, and 1,32% of sheep being slaughtered. We also analized several risk factors influencing fascioliosis incidence rate such as body score condition and age. The fascioliosis tent to happen in medium and mature animal by age in respectively 31,62% of cattle, 54,28% of goats, and 75% of sheep. Thus, prevention and curative evaluation of fascioliosis should be continuously developed in order to provide excellent animal products.

Veterinary medicine, Geography, Service location, Java, Lameness, business.industry, Distribution (economics), business, computer, and computer.programming_language

Eid al-Adha is an annual Muslim celebration throughout the world indicated by sacrificing animals such as cattles, goats or sheep. This study aimed to analyse the distribution of slaughtering points, types and the number of animals being slaughtered as well as antemortem and postmortem abnormalities of the carcasses during Eid al-Adha 1440 H in Malang City. Data were collected from the geocode service location and the secondary data were obtained through questionnaire. This study listed a total of 145 slaughtering points located in Blimbing, Kedung Kandang, Klojen, Lowokwaru, and Sukun District with 3102 animals being sacrificed. The slaughtering points were taken place in the office yards, mosque yards, home yards, school yards or other public fields. As many as 75.86% of slaughtering points provided special shelters for the animals before being slaughtered. The antemortem examination resulted that animals from 21.38% of the slaughtering points suffered from conjunctivitis, lesions on the skin, broken horns, and lameness. Proportions of apparent postmortem abnormalities were measured respectively: cattle 64.83%, goat 41.38%, and sheep 4.14%. Hence, we recommend to further involve the veterinarians to monitor the animal condition during Eid al-Adha and to ensure the slaughtering processes were done properly.

business.industry, Physiology, Ultraviolet b, Anorexia, law.invention, Red-eared slider, Trachemys scripta, law, Closed eyes, medicine, Juvenile, sense organs, Turtle (robot), medicine.symptom, business, and After treatment

Conjunctivitis is a common problem among red-eared sliders (Trachemys scripta elegans) with improper husbandry care. A 30 grams T. s. elegans was presented with complaints of anorexia, dullness, inflamed, and closed eyes. The owner informed that the turtle was kept indoors without ultraviolet B (UVB) light or sunlight exposure and the water was not changed by the owner for a week. Clinical examination showed inflammation and watery discharge was found on the left eye. Conjunctivitis was diagnosed based on history and clinical examination. Treatments consist of topical antibiotic drops, vitamin A and B-complex, and husbandry care improvement. The turtle started eating five days after treatment. Ten days after the treatment the turtle was brought back for a checkup and eye have recovered.

Veterinary medicine, education, Community service, Business, Dispose pattern, Know-how, and Theme (narrative)

Currently, there are many pet shops, animal clinics, and animal lover communities in Malang. Data from UB's animal education hospitals showed an increasing number of patients visiting there. This reflects that the owner had considered his favorite animal as part of his family that must be treated if they are sick. Drugs medicine plays an important role in the treatment of animal diseases. Therefore, pet owners must know how to use and store drugs properly so that the efficacy of the drug does not change, and the results of treatment are achieved. When the drug is not used anymore, the owner must know how to properly dispose of the drug to prevent the drug from being mixed, polluting the environment, or even being used by irresponsible people. The aim of this community service was to provide additional knowledge about how to use, store and dispose of veterinary medicines. The theme we took was "Increasing Knowledge of Al-Huda MTS Students on the Use, Storage and Disposal of Animal Medicine through Educational Seminars and Demonstration". Community service methods used were counseling and seminars on the use, storage and disposal of veterinary medicines and demonstrations on how to give medicines to cats. The evaluation tools used were pretest and posttest. The pretest and posttest results showed an increase in the knowledge of MTS Al-Huda students about how to give medicines to pets - especially cats -, how to store and dispose of drugs that are not used. While the results of the questionnaire showed a very good response related to community service.

Sample quality, education.field_of_study, Dilution ratio, business.industry, Shock (circulatory), Anesthesia, Cell density, Population, Medicine, medicine.symptom, business, Ulnar vein, and education

Most of raptor species rehabilitated for conservation purpose at WRC Jogja are eagles. Annually, we perform general raptor examination involving conventional routine hematologic examination. However, low sample quality and over dense blood cell population during total erythrocyte and leukocyte counting were deemed as obstacles. This study aimed to give wider insight in how total erythrocyte and leukocyte counting was performed at WRC Jogja to overcome those obstacles. Firstly, handling and restraint were done physically adapting the Aba method. One-to-two half millilitres of blood was collected from the ulnar vein using 3-ml-syringe with 24-gauge-needle which was then preserved in an EDTA-containing tube and proceeded to subsequent method no more than 3 hours after collection. No hypovolemic shock was observed. During total erythrocyte and leukocyte counting using Neubauer-ruled counting chamber, we modified the dilution factor to be 250-fold and 50-fold respectively. This method yielded a countable cell density and can be applied in other species in similar condition.

medicine.medical_specialty, Hematology, Chemistry, Diabetic rat, Positive control, Streptozotocin, law.invention, One-way analysis of variance, Basal (phylogenetics), Animal science, law, Internal medicine, medicine, Hemoglobin, Essential oil, and medicine.drug

This research was conducted to determine the effect of Clove’s and Lemongrass’s essential oil (EO) in basal feed on performances and hematology profile of Sterptozotocin-induced diabetic rat. 20 rats aged 40 days were divided into four groups of feed treatments, which are: negative control feed (basal feed-non-diabetic) (R1); positive control feed (commercial diabetic food) (R2); basal feed+Clove’s EO (R3); and basal feed+Lemongrass’s EO (R4). Each treatments using 5 rats. Collected data were performances and blood hematology profile. Data were analyzed using one way ANOVA design, the significance of different was tested using Least Significant Different (LSD) test. The result from this research showed that Clove’s and Lemongrass’s EO were significantly affected (P

education.field_of_study, Antioxidant, biology, Traditional medicine, Ceiba, medicine.medical_treatment, Population, biology.organism_classification, Solasodine, Sperm, Future study, chemistry.chemical_compound, chemistry, medicine, Solanum torvum, education, and Spermatogenesis

Rabies related to increasing canine population in Bali. Uncontrolled wild animal populations caused disease transmission from animal to human. Various attempt at population control are carried out such as the use of natural contraception. Some compounds are known to have potential as antifertility are solasodine and gosipol. Solasodine is known have an antifertility affect. Gosipol, fenolic compound in Ceiba pentandra, inhibits spermatogenesis, reduce sperm concentration, motility and viability. This research aims to compare effectiveness of terong cepoka and Ceiba pentandra as antifertility. This research was conducted at Mei-November 2018. Eight-teen rats were used in this study and divided into three groups: control, P1 extract Solanum torvum 1g/kg BW and P2 extract Ceiba pentandra 0,1g/kg BW PO. Rats were treated with extract for 10 days and euthanazed at day 11. Testis were collected for histopathology using HE staining to observe spermatogenesis and using immunohistochemistry to observe LH expression. The result are analyzed using one way ANOVA P

Gynecology, medicine.medical_specialty, business.industry, Medicine, Subclinical mastitis, and business

Peradangan ambing pada sapi perah yang lebih dikenal sebagai mastitis masih menjadi masalah utama dalam industri susu. Kerugian peternak karena mastitis disebabkan oleh penurunan produksi susu dan penurunan kualitas susu yang dihasilkan. Pada umumnya pengetahuan peternak rakyat akan mastitis sebatas pada mastitis klinis karena gejala klinis yang dapat teramati. Mastitis yang sifatnya subklinis sulit dideteksi dan apabila dibiarkan tanpa penanganan dapat menjadi sumber penularan ke sapi perah lainnya. Deteksi mastitis subklinis pada sapi perah menggunakan uji tidak langsung yaitu california mastitis test (CMT) atau menggunakan uji langsung dengan penghitungan jumlah sel somatis (JSS). Penelitian ini merupakan studi lintas seksional dengan menggunakan sampel susu kwartir pada peternakan sapi perah rakyat di dusun Bakir, desa Sukomulyo, kabupaten Batu. Pengujian mastitis dilakukan di lapangan dengan uji CMT dan di laboratorium untuk penghitungan JSS. Pengambilan data dengan kuesioner untuk mengetahui faktor predisposisi mastitis. Prevalensi mastitis subklinis berdasarkan JSS adalah 60,22% dan berdasarkan uji CMT di lapangan adalah 18,20% dari total sampel kwartir. Faktor predisposisi yang mempengaruhi masih adanya kejadian mastitis pada peternakan antara lain kebersihan sapi, kandang, dan sanitasi sebelum dan sesudah pemerahan.

Interleukin 2, integumentary system, medicine.diagnostic_test, Vitamin C, business.industry, Therapeutic effect, Cell, H&E stain, Inflammation, Pharmacology, medicine.anatomical_structure, Skin biopsy, medicine, Immunohistochemistry, medicine.symptom, business, and medicine.drug

Open wounds healing is need more time because of the long inflammatory phase. Dragon fruit skin contains flavonoids and vitamin C which function as anti-inflammatory and cell regeneration. The purpose of this study was to determine the therapeutic effects of dragon fruit skin extract ointment (Hylicereus costaricensis) on the area of IL-2 expression and the number of mononuclear inflammatory cells in skin tissue in open wounds of rats (Rattus norvegicus) for 6 days of treatment. As many as 20 male rats, ± 180 grams, Wistar were divided into 5 groups namely negative control, positive control, ointment of dragon fruit skin extract with concentration of 5% (P1), concentration of 10% (P2) and concentration of 15% (P3). Wound formed as dorsal skin biopsy of dorsal 1x1 cm. Ointment was given topically 2x/day for 6 days. Rats were euthanized on day 7th and the skin tissues of the wound area were collected. The number of mononuclear inflammatory cells was counted in skin slides of HE staining and Expression Area expression of IL-2 was measured by ImmunoRatio® in immunohistochemical slides. Data were analyzed statistically using One Way ANOVA and Tukey Post Hoc Test. The results showed that dragon fruit skin extract ointment was able to reduce significantly (p

Vaccination rate, Veterinary medicine, Geography, biology, Classical swine fever, Pig farming, and biology.organism_classification

Classical Swine Fever (CSF) is an important disease in the pig industry. In the end of 2003, CSF caused a mortality outbreak involved thousands of pigs in Timika, Papua. Control of CSF in Timika has been through vaccination program using strain C vaccine. However, demographic data of pig farming in Timika was unavailable, made the assessment of the vaccination rate impossible. The research aimed to comprehend the demography of pig farming dan the rate of vaccination impossible. The research aimed to comprehend the demography of pig farming and the rate of vaccination against CSF in five districts in Timika. The study was conducted in 25 of 40 villages in five districts. Data of the demography was collected from all families in sample villages. Data of vaccine delivery during 2018 was collected in village level. Data of demography and vaccination rate was analysed descriptively, correlations between vaccination rate and the pig population, the number of farms the size of farmsat village level were analysed at 0.05, using Excel 2010 (Microsoft Excel, USA). Results showed that pig population was 16.846 heads, farmers were 2.560 families, human population was 133.186 persons, farm size was 6.6 heads per farm, ratio of pigs to humans was 0.13 pigs per-person. Only four villages obtained vaccination rates of above 70% of their respective pig populations. In seven other villages vaccination covered less than 30% of pig populations, while other 14 villages did not obtain CSF vaccine delivery. No correlation appeared between thevaccination rate in a village with the size of its pig population, the number off arms in it or the average size of farm in it (P>0.05). This study could become a reference point for designing CSF vaccination program in Timika in the future.

medicine.medical_specialty, Diazinon, Eosin, Organophosphate, medicine.disease, Malondialdehyde, Lipid peroxidation, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Toxicity, medicine, Analysis of variance, and Cell damage

Diazinon is an insecticide that has a higher toxicity than other insecticides. Normally, insecticides are detoxified by liver, but this process produced free radicals which causes cell damage. Free radicals also increase lipid peroxidation which directly increase malondialdehyde levels. This research was aimed to determine the influence of diazinon toxicity to the liver histopathology and levels of malondialdehyde (MDA) in the serum of rats (Rattus norvegicus). The rats were divided into 4 groups which consist of negative control group and three experimental groups which were given diazinon 20 mg/kgBW (P1), 40 mg/ kgBW (P2), and 60 mg/ kgBW (P3). The rats were given diazinon for 8 weeks orally. The parameters used in this research was liver histopathology with hematoxilin eosin stain and Malondialdehyde levels with Thiobarbituric test. Liver histopathology was analyzed in descriptive qualitative and the level of MDA was analyzed quantitatively using ANOVA and Tukey's exact test with α = 0.05. The result of this research showed the influence of organophosphate (diazinon) on liver histolopathology was shown by inflammatory cells infiltration in hepatic parenchyma, sinusoidal congestion, and cytoplasmic vacuolation of the hepatocytes. Statistical analysis proved that the diazinon was able to increase the level of MDA serum significantly (p

medicine.medical_specialty, Kidney, biology, Traditional medicine, food and beverages, Positive control, Metabolism, biology.organism_classification, Body weight, Pluchea indica, Jejunum, medicine.anatomical_structure, medicine, Potency, and Histopathology

Lead (Pb) is one of the heavy m metals polluting the environment which is harmful to t the organism. Pb accumulation triggers free radic cals and disrupts the body's metabolism. Pluche indic ca leaf extract is reported contain flavonoids whiich act as antioxidants and can counteract free radiccal attacks. The purpose of this study was to de etermine the role of Pluchea indica leaf extract preve entive therapy in counteracting free radicals due too exposure to Pb in rats (Rattus norvegicus). Wistar mmale rats aged of 8-10 weeks with a body weight of about 200-250 grams. Rats were divided into 5 tr reatment groups, were group A as negative contr rol, group B as positive control induced by lead (Pb)) 10 mg/rat/day, groups C,D,E given with ethano olic extract of Pluche indica leavesof 200 mg/kgBW, , 400 mg/kgBW, and 600 mg/kgBW and lead (Pb b) exposure of 10mg/ rat/day. Kidney, liver and jejunaal histopathology using HE staining was observed microscopically. The results showed that the administtration of Pluche indica leaves extract could preve ent tissue damage to the kidney, liver and jejunum in rats exposured to Pb. Dose of 600 mg/kgBW show wed histopathological improvement in kidney, liver annd jejunum. The greater the dose, the better prev ention of tissue damage as indicated by tissue condition resembling those of control rats. The conclusion of this study, the Pluchea indica leaf extract has the potential to prevent organ damaged exposed to lead.

Kidney, medicine.medical_specialty, urogenital system, business.industry, medicine.medical_treatment, Ultrasound, Urology, Lumen (anatomy), urologic and male genital diseases, Hydroureter, medicine.anatomical_structure, Ureter, Laparotomy, medicine, Ultrasonography, business, and Ligation

Unilateral ureteral obstruction can occur in all animals and it is located proximal, medial and distal. Obstruction causes abnormalities in ipsilateral ureters in the form of hydrouterers. The aim of this study was to detect hydroureters in post-unilateral medial and distal ureteric rats using a 10 MHz ultrasonography frequency. Thirty-six female Sprague Dawley rats aged 3 months were divided into 3 treatment groups. Each group consisted of 12 individuals. Group I as a control received laparotomy treatment. Group II laparotomy with medial right-hand ureteral ligation and group III with right distal ureteral ligation. Three rats taken randomly from each group at weeks 1, 2, 3 and 4 post-ligation is then performed ultrasonography. The results of ultrasonography were analyzed descriptively, comparatively but ureteral diameter were analyzed using statistical of 3x4 factorial patterns. Ultrasound examination showed that ligation in one ureter caused rat undergoing unilateral ureteral obstruction and hidroureter. The diameter of the ureter with a hydroureter has increased from the 1st to 4th week. The increase occurs because the urine in the lumen cannot be excreted. The contralateral ureter remains normal and cannot be observed. The conclusion of the study is that hydroureter in rats can be detected using the frequency of 10 MHz ultrasonography which is characterized by anekoic tubular formation posterior to the right kidney. The unilateral ureteral obstruction has no effect on the contralateral ureter because it is still able to compensate for the performance of the ipsilateral ureter that has a hydroureter. The difference in the location of ligation and time of examination affect the increase in ipsilateral ureteral diameter.

Fetus, business.industry, Uterus, Trophoblast, medicine.disease, Preeclampsia, Staining, Andrology, medicine.anatomical_structure, Blood pressure, Placenta, embryonic structures, medicine, business, reproductive and urinary physiology, and Blood vessel

Preeclampsia is one of the obstetrical problems that can cause maternal and fetal morbidity and mortality. Preeclampsia causes the fetus born prematurely and low fetal weight. This is caused by high blood pressure which causes decrease of blood delivery to the placenta, so the supply of oxygen and food to the fetus decreases. As a result, fetal development inhibits and trigger born prematurely. More fatal, this disease cause the release of placental tissue from the uterus prematurely. The aim of this study was to determine the effect of administration of triponyl sulfate as induction of increased blood pressure in preeclampsia animal models, fetal development with alizarin red staining and placental abnormalities. The experimental animals were rats Rattus norvegicus mated with male rats monomating , 4 months old and 250-300 grams body weigh. Pregnant female rats were induced by triponyl sulfate 70 mg / kg BW (k +) and without induced by triponyl sulfate (k-). The results of the study showed that there were formation of the sternal bone in k- and malformation of the sternum bone at k +. Placental abnormalities occured in k +, it could be seen in the presence of ghos villi in blood vessel abnormalities in the preeclampsia placenta caused by there was no invation of trophoblast cells in the whole or partial spiral arteries and the mean of blood pressure increased.