Ferro, Albert, Loke, Yoon K., Lewis, Lionel D., Somogyi, Andrew, Cohen, Adam F., and Ritter, James M.
British Journal of Clinical Pharmacology; Feb2014, Vol. 77 Issue 2, p228-232, 5p
CLINICAL pharmacology and BIOLOGICALS
An introduction to the journal is presented in which the editors discuss its publication of articles in 2013 related to clinical pharmacology such as first in man (FIM) research of chemical entities and biologics as well as old drugs.
British Journal of Clinical Pharmacology; Jan2014, Vol. 77 Issue 1, p1-4, 4p
CLINICAL pharmacology, CLINICAL medicine, PHARMACODYNAMICS, PHARMACOKINETICS, and DRUG metabolism
The article presents the author's insights concerning the developments in clinical pharmacology from 1974-2014. It highlights the research articles published in the journal which focused on pharmacodynamics, pharmacokinetics, drug metabolism, therapeutics, and analytical methodology. It cites the changes which include changes in intellectual approach and theory and advances that have occurred in some areas of therapeutics.
Loke, Yoon K., Ferro, Albert, Lewis, Lionel D., Cohen, Adam F., Somogyi, Andrew, and Ritter, James M.
British Journal of Clinical Pharmacology; Jan2011, Vol. 71 Issue 1, p3-6, 4p
CLINICAL pharmacology, HEALTH risk assessment, SIDE effects of antipsychotic drugs, PHYSIOLOGICAL effects of antidepressants, GENERIC drugs, THERAPEUTIC use of immunoglobulins, and TUMOR treatment
The article offers the author's insights on topics related to clinical pharmacology. The author mentions the assessment of risk in patients who take antipsychotic and antidepressant drugs. The author relates the topical debate on lifestyle and generic drugs that received attention in the journal. The author also tackles the topic on bispecific monoclonal antibodies called trifunctional antibodies which has the capacity of activating various immune effector cells and anti-tumour immune response.
Rambaran, Curtis, Benyu Jiang, Ritter, James M., Shah, Ajay, Kalra, Lalit, and Chowienczyk, Philip J.
British Journal of Clinical Pharmacology; Feb2008, Vol. 65 Issue 2, p238-243, 6p, 2 Charts, 3 Graphs
ENDOTHELIUM, ADRENERGIC receptors, NITROGLYCERIN, BRACHIAL artery, and CLINICAL pharmacology
Aims To assess the reproducibility of the digital pulse wave response to β2-adrenoreceptor stimulation and to determine if an attenuated response to β2-adrenoceptor stimulation is associated with impaired flow mediated dilatation (FMD). Methods Subjects ( n = 20) with endothelial dysfunction (ED), were compared with healthy control subjects ( n = 20). Change in reflection index (ΔRI) of the digital volume pulse in response to salbutamol (SALB, 5 µg min−1 i.v) and to nitroglycerin (NTG, 5 µg min−1 i.v) was used to assess endothelium-dependent (ΔRISALB) and endothelium-independent (ΔRINTG) pressure wave reflection. ΔRISALB was assessed on two occasions to examine reproducibility. High resolution ultrasound of the brachial artery was used to measure FMD and also dilation to NTG (NTGD). Results The mean difference in ΔRISALB between two visits was −0.2%, with SD of the difference 4.9%. Both ΔRISALB and FMD were impaired in subjects with ED compared with values in control subjects (5.0 ± 0.7 vs. 11.3 ± 1.2%, mean values ± SEM, P < 0.01 and 4.2 ± 0.6 vs. 7.5 ± 0.8%, P < 0.02 for ΔRISALB and FMD, respectively), whereas ΔRINTG and NTGD were similar in the two groups. ΔRISALB was correlated with FMD ( r = 0.44, P < 0.01) and had 88% sensitivity and 79% specificity to detect abnormal (FMD < 4%). Conclusions The pulse wave response to a β2-adrenoceptor agonist correlates with FMD and has high sensitivity and specificity in detecting abnormal endothelial function as defined by FMD. However, FMD is the preferred test to detect effects of interventions on endothelial function. [ABSTRACT FROM AUTHOR]
Loke, Yoon K., Cohen, Adam F., Ferro, Albert, Flockhart, Dave A., Ritter, James M., and Somogyi, Andrew A.
British Journal of Clinical Pharmacology; Jan2015, Vol. 79 Issue 1, p4-5, 2p
CLINICAL pharmacology, EDITORS, CAREER development, and TELECONFERENCING
The article offers information on the submission of articles at "British Journal of Clinical Pharmacology" (BJCM), announces career development of editors such as the junction of Ton de Boer as European editor, and reports on the continuous monthly teleconference of the management board of BJCM.
Aronson, Jeffrey K., Lennard, Martin S., Ritter, James M., Begg, Evan J., Lewis, Lionel D., and Schachter, Michael
British Journal of Clinical Pharmacology; Jan2007, Vol. 63 Issue 1, p1-4, 4p
CLINICAL medicine research, CLINICAL pharmacology, PHARMACODYNAMICS, and GENETICS
The article examines the different papers published in the 2006 issue of the "British Journal of Clinical Pharmacology." Among these studies are G. Ziere, J. P. Dieleman and A. Hofman's work on polypharmacy which is a risk factor on some drugs, and the plasma concentrations of citalopram by L. E. Friberg, G. K. Isbister and S. B. Duffull. Furthermore, they also include a study on the ethnic variability of genes associated with the long Q-T syndrome.
British Journal of Clinical Pharmacology; Dec2011, Vol. 72 Issue 6, p869-870, 2p
GUIDELINES, PRESCRIPTION of drugs, DRUG side effects, CLINICAL medicine, and CLINICAL pharmacology
The article presents the authors' insight regarding the importance of treatment guidelines in demonstrating treatment recommendations to patients. The authors state that treatment guidelines should render act and guidance to aid complicated medications. Meanwhile, the authors mentions the use of disproportionality analysis in reporting adverse drug reactions.