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1. Effects of COVID-19 pandemic on pediatric kidney transplant in the United States. [2021]

  • Charnaya, Olga, Chiang, Teresa Po-Yu, Wang, Richard, Motter, Jennifer D., Boyarsky, Brian J., King, Elizabeth A., Werbel, William A., Durand, Christine M., Avery, Robin K., Segev, Dorry L., Massie, Allan B., and Garonzik-Wang, Jacqueline M.
  • Pediatric Nephrology; 2021, Vol. 36 Issue 1, p143-151, 9p, 3 Charts, 2 Graphs
Subjects
KIDNEY transplants, ORGAN donors, PEDIATRICS, KIDNEY failure, TRANSPLANTATION of organs, tissues, etc., STATISTICAL significance, DESCRIPTIVE statistics, and COVID-19 pandemic
Abstract
Background: In March 2020, COVID-19 infections began to rise exponentially in the USA, placing substantial burden on the healthcare system. As a result, there was a rapid change in transplant practices and policies, with cessation of most procedures. Our goal was to understand changes to pediatric kidney transplantation (KT) at the national level during the COVID-19 epidemic. Methods: Using SRTR data, we examined changes in pediatric waitlist registration, waitlist removal or inactivation, and deceased donor and living donor (DDKT/LDKT) events during the start of the disease transmission in the USA compared with the same time the previous year. Results: We saw an initial decrease in DDKT and LDKT by 47% and 82% compared with expected events and then a continual increase, with numbers reaching expected prepandemic levels by May 2020. In the early phase of the pandemic, waitlist inactivation and removals due to death or deteriorating condition rose above expected values by 152% and 189%, respectively. There was a statistically significant decrease in new waitlist additions (IRR 0.49 0.65 0.85) and LDKT (IRR 0.17 0.38 0.84) in states with high vs. low COVID activity. Transplant recipients during the pandemic were more likely to have received a DDKT, but had similar calculated panel–reactive antibody (cPRA) values, waitlist time, and cause of kidney failure as before the pandemic. Conclusions: The COVID-19 pandemic initially reduced access to kidney transplantation among pediatric patients in the USA but has not had a sustained effect. [ABSTRACT FROM AUTHOR]

2. Using Teacher Ratings to Investigate Developmental Regression as a Potential Indicator of School-Age Symptoms in Students with Autism Spectrum Disorder [2018]

  • Mire, Sarah S., Anderson, Jacqueline R., Manis, Jamie K., Hughes, K. R., Raff, Natalie S., and Goin-Kochel, Robin P.
  • School mental health. 10(1):77-90

3. Implementing a Clostridium difficile testing algorithm and its effect on isolation duration and treatment initiation: a pre- and post-implementation study. [2020]

  • Vogelzang, Erik Hans, Lankelma, Jacqueline Marleen, van Mansfeld, Rosa, van Prehn, Joffrey, and van Houdt, Robin
  • European Journal of Clinical Microbiology & Infectious Diseases; Jun2020, Vol. 39 Issue 6, p1071-1076, 6p
Subjects
CLOSTRIDIUM difficile, GLUTAMATE dehydrogenase, TREATMENT duration, and ENZYME-linked immunosorbent assay
Abstract
A proportion of patients suspected of Clostridium difficile infection are unnecessarily placed in contact isolation. By introducing a random-access glutamate dehydrogenase (GDH) test for C. difficile, we aimed to reduce isolation time. In addition, we investigated whether the result of the toxin A&B enzyme immunoassay (EIA) was associated with the decision to initiate antibiotic treatment against C. difficile. This retrospective pre- and post-implementation study was from June 3, 2016, to June 4, 2018. Pre-implementation, only a NAAT was performed. In the post-implementation period, a GDH test was performed; if positive, a toxin A&B EIA followed the same day and subsequently a NAAT. Contact isolation for CDI was discontinued when the GDH test was negative. Median time in isolation was 50.8 h pre-implementation (n = 189) versus 28.0 h post-implementation (n = 119), p < 0.001. The GDH test had a negative predictive value of 98.8% (95% CI 97.9–99.4). In 7/31 (22.6%) patients with a positive NAAT and GDH test and a negative toxin A&B EIA, no antibiotics against C. difficile were initiated versus 4/28 (14.3%) patients who were NAAT, GDH and toxin A&B EIA positive. Introducing a random-access screening test resulted in a significant decrease in patient isolation time. The GDH test had a high negative predictive value making it suitable to determine whether contact isolation can be discontinued. Furthermore, the result of a toxin A&B EIA had limited added value on the percentage of patients in whom antibiotic treatment against C. difficile was initiated. [ABSTRACT FROM AUTHOR]

4. International Society for Therapeutic Ultrasound Conference 2016 [2017]

  • Fowlkes, Brian, Ghanouni, Pejman, Sanghvi, Narendra, Coussios, Constantin, Lyon, Paul C., Gray, Michael, Mannaris, Christophoros, Victor, Marie de Saint, Stride, Eleanor, Cleveland, Robin, Carlisle, Robert, Wu, Feng, Middleton, Mark, Gleeson, Fergus, Aubry, Jean-Franҫois, Pauly, Kim Butts, Moonen, Chrit, Vortman, Jacob, Sharabi, Shirley, Daniels, Dianne, Last, David, Guez, David, Levy, Yoav, Volovick, Alexander, Grinfeld, Javier, Rachmilevich, Itay, Amar, Talia, Zibly, Zion, Mardor, Yael, Harnof, Sagi, Plaksin, Michael, Weissler, Yoni, Shoham, Shy, Kimmel, Eitan, Naor, Omer, Farah, Nairouz, Paeng, Dong-Guk, Xu, Zhiyuan, Snell, John, Quigg, Anders H., Eames, Matthew, Jin, Changzhu, Everstine, Ashli C., Sheehan, Jason P., Lopes, Beatriz S., Kassell, Neal, Looi, Thomas, Khokhlova, Vera, Mougenot, Charles, Hynynen, Kullervo, Drake, James, Slayton, Michael, Amodei, Richard C., Compton, Keegan, McNelly, Ashley, Latt, Daniel, Kearney, John, Melodelima, David, Dupre, Aurelien, Chen, Yao, Perol, David, Vincenot, Jeremy, Chapelon, Jean-Yves, Rivoire, Michel, Guo, Wei, Ren, Guoxin, Shen, Guofeng, Neidrauer, Michael, Zubkov, Leonid, Weingarten, Michael S., Margolis, David J., Lewin, Peter A., McDannold, Nathan, Sutton, Jonathan, Vykhodtseva, Natalia, Livingstone, Margaret, Kobus, Thiele, Zhang, Yong-Zhi, Schwartz, Michael, Huang, Yuexi, Lipsman, Nir, Jain, Jennifer, Chapman, Martin, Sankar, Tejas, Lozano, Andres, Yeung, Robert, Damianou, Christakis, Papadopoulos, Nikolaos, Brokman, Omer, Zadicario, Eyal, Brenner, Ori, Castel, David, Wu, Shih-Ying, Grondin, Julien, Zheng, Wenlan, Heidmann, Marc, Karakatsani, Maria Eleni, Sánchez, Carlos J. Sierra, Ferrera, Vincent, Konofagou, Elisa E., Yiannakou, Marinos, Cho, HongSeok, Lee, Hwayoun, Han, Mun, Choi, Jong-Ryul, Lee, Taekwan, Ahn, Sanghyun, Chang, Yongmin, Park, Juyoung, Ellens, Nicholas, Partanen, Ari, Farahani, Keyvan, Airan, Raag, Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Lafon, Cyril, Delattre, Jean-yves, Idbaih, Ahmed, Odéen, Henrik, Bolster, Bradley, Jeong, Eun Kee, Parker, Dennis L., Gaur, Pooja, Feng, Xue, Fielden, Samuel, Meyer, Craig, Werner, Beat, Grissom, William, Marx, Michael, Weber, Hans, Taviani, Valentina, Hargreaves, Brian, Tanaka, Jun, Kikuchi, Kentaro, Ishijima, Ayumu, Azuma, Takashi, Minamihata, Kosuke, Yamaguchi, Satoshi, Nagamune, Teruyuki, Sakuma, Ichiro, Takagi, Shu, Santin, Mathieu D., Marsac, Laurent, Maimbourg, Guillaume, Monfort, Morgane, Larrat, Benoit, François, Chantal, Lehéricy, Stéphane, Tanter, Mickael, Samiotaki, Gesthimani, Wang, Shutao, Acosta, Camilo, Feinberg, Eliza R., Kovacs, Zsofia I., Tu, Tsang-Wei, Papadakis, Georgios Z., Reid, William C., Hammoud, Dima A., Frank, Joseph A., Kovacs, Zsofia i., Kim, Saejeong, Jikaria, Neekita, Bresler, Michele, Qureshi, Farhan, Xia, Jingjing, Tsui, Po-Shiang, Liu, Hao-Li, Plata, Juan C., Sveinsson, Bragi, Salgaonkar, Vasant A., Adams, Matthew, Diederich, Chris, Ozhinsky, Eugene, Bucknor, Matthew D., Rieke, Viola, Mikhail, Andrew, Severance, Lauren, Negussie, Ayele H., Wood, Bradford, de Greef, Martijn, Schubert, Gerald, Ries, Mario, Poorman, Megan E., Dockery, Mary, Chaplin, Vandiver, Dudzinski, Stephanie O., Spears, Ryan, Caskey, Charles, Giorgio, Todd, Costa, Marcia M., Papaevangelou, Efthymia, Shah, Anant, Rivens, Ian, Box, Carol, Bamber, Jeff, ter Haar, Gail, Burks, Scott R., Nagle, Matthew, Nguyen, Ben, Milo, Blerta, Le, Nhan M., Song, Shaozhen, Zhou, Kanheng, Nabi, Ghulam, Huang, Zhihong, Ben-Ezra, Shmuel, Rosen, Shani, Mihcin, Senay, Strehlow, Jan, Karakitsios, Ioannis, Le, Nhan, Schwenke, Michael, Demedts, Daniel, Prentice, Paul, Haase, Sabrina, Preusser, Tobias, Melzer, Andreas, Mestas, Jean-Louis, Chettab, Kamel, Gomez, Gustavo Stadthagen, Dumontet, Charles, Werle, Bettina, Marquet, Fabrice, Bour, Pierre, Vaillant, Fanny, Amraoui, Sana, Dubois, Rémi, Ritter, Philippe, Haïssaguerre, Michel, Hocini, Mélèze, Bernus, Olivier, Quesson, Bruno, Livneh, Amit, Adam, Dan, Robin, Justine, Arnal, Bastien, Fink, Mathias, Pernot, Mathieu, Khokhlova, Tatiana D., Schade, George R., Wang, Yak-Nam, Kreider, Wayne, Simon, Julianna, Starr, Frank, Karzova, Maria, Maxwell, Adam, Bailey, Michael R., Lundt, Jonathan E., Allen, Steven P., Sukovich, Jonathan R., Hall, Timothy, Xu, Zhen, May, Philip, Lin, Daniel W., Constans, Charlotte, Deffieux, Thomas, Aubry, Jean-Francois, Park, Eun-Joo, Ahn, Yun Deok, Kang, Soo Yeon, Park, Dong-Hyuk, Lee, Jae Young, Vidal-Jove, J., Perich, E., Ruiz, A., Jaen, A., Eres, N., del Castillo, M. Alvarez, Myers, Rachel, Kwan, James, Coviello, Christian, Rowe, Cliff, Crake, Calum, Finn, Sean, Jackson, Edward, Pouliopoulos, Antonios, Li, Caiqin, Tinguely, Marc, Tang, Meng-Xing, Garbin, Valeria, Choi, James J., Folkes, Lisa, Stratford, Michael, Nwokeoha, Sandra, Li, Tong, Farr, Navid, D’Andrea, Samantha, Gravelle, Kayla, Chen, Hong, Lee, Donghoon, Hwang, Joo Ha, Tardoski, Sophie, Ngo, Jacqueline, Gineyts, Evelyne, Roux, Jean-Pau, Clézardin, Philippe, Conti, Allegra, Magnin, Rémi, Gerstenmayer, Matthieu, Lux, François, Tillement, Olivier, Mériaux, Sébastien, Penna, Stefania Della, Romani, Gian Luca, Dumont, Erik, Sun, Tao, Power, Chanikarn, Miller, Eric, Sapozhnikov, Oleg, Tsysar, Sergey, Yuldashev, Petr V., Svet, Victor, Li, Dongli, Pellegrino, Antonio, Petrinic, Nik, Siviour, Clive, Jerusalem, Antoine, Yuldashev, Peter V., Cunitz, Bryan W., Dunmire, Barbrina, Inserra, Claude, Guedra, Matthieu, Mauger, Cyril, Gilles, Bruno, Solovchuk, Maxim, Sheu, Tony W. H., Thiriet, Marc, Zhou, Yufeng, Neufeld, Esra, Baumgartner, Christian, Payne, Davnah, Kyriakou, Adamos, Kuster, Niels, Xiao, Xu, McLeod, Helen, Dillon, Christopher, Payne, Allison, Khokhova, Vera A., Sinilshchikov, Ilya, Andriyakhina, Yulia, Rybyanets, Andrey, Shvetsova, Natalia, Berkovich, Alex, Shvetsov, Igor, Shaw, Caroline J., Civale, John, Giussani, Dino, Lees, Christoph, Ozenne, Valery, Toupin, Solenn, Salgaonkar, Vasant, Kaye, Elena, Monette, Sebastien, Maybody, Majid, Srimathveeravalli, Govindarajan, Solomon, Stephen, Gulati, Amitabh, Bezzi, Mario, Jenne, Jürgen W., Lango, Thomas, Müller, Michael, Sat, Giora, Tanner, Christine, Zangos, Stephan, Günther, Matthias, Dinh, Au Hoang, Niaf, Emilie, Bratan, Flavie, Guillen, Nicolas, Souchon, Rémi, Lartizien, Carole, Crouzet, Sebastien, Rouviere, Olivier, Han, Yang, Payen, Thomas, Palermo, Carmine, Sastra, Steve, Olive, Kenneth, van Breugel, Johanna M., van den Bosch, Maurice A., Fellah, Benjamin, Le Bihan, Denis, Hernandez-Garcia, Luis, Cain, Charles A., Lyka, Erasmia, Elbes, Delphine, Li, Chunhui, Tamano, Satoshi, Jimbo, Hayato, Yoshizawa, Shin, Fujiwara, Keisuke, Itani, Kazunori, Umemura, Shin-ichiro, Stoianovici, Dan, Zaini, Zulfadhli, Takagi, Ryo, Zong, Shenyan, Watkins, Ron, Pascal-Tenorio, Aurea, Jones, Peter, Butts-Pauly, Kim, Bouley, Donna, Chen, Yazhu, Lin, Chung-Yin, Hsieh, Han-Yi, Wei, Kuo-Chen, Garnier, Camille, Renault, Gilles, Seifabadi, Reza, Wilson, Emmanuel, Eranki, Avinash, Kim, Peter, Lübke, Dennis, Huber, Peter, Georgii, Joachim, Dresky, Caroline V., Haller, Julian, Yarmolenko, Pavel, Sharma, Karun, Celik, Haydar, Li, Guofeng, Qiu, Weibao, Zheng, Hairong, Tsai, Meng-Yen, Chu, Po-Chun, Webb, Taylor, Vyas, Urvi, Walker, Matthew, Zhong, Jidan, Waspe, Adam C., Hodaie, Mojgan, Yang, Feng-Yi, Huang, Sin-Luo, Zur, Yuval, Assif, Benny, Aurup, Christian, Kamimura, Hermes, Carneiro, Antonio A., Rothlübbers, Sven, Schwaab, Julia, Houston, Graeme, Azhari, Haim, Weiss, Noam, Sosna, Jacob, Goldberg, S. Nahum, Barrere, Victor, Jang, Kee W., Lewis, Bobbi, Wang, Xiaotong, Suomi, Visa, Edwards, David, Larrabee, Zahary, Hananel, Arik, Rafaely, Boaz, Debbiny, Rasha Elaimy, Dekel, Carmel Zeltser, Assa, Michael, Menikou, George, Mouratidis, Petros, Pineda-Pardo, José A., de Pedro, Marta Del Álamo, Martinez, Raul, Hernandez, Frida, Casas, Silvia, Oliver, Carlos, Pastor, Patricia, Vela, Lidia, Obeso, Jose, Greillier, Paul, Zorgani, Ali, Catheline, Stefan, Solovov, Vyacheslav, Vozdvizhenskiy, Michael O., Orlov, Andrew E., Wu, Chueh-Hung, Sun, Ming-Kuan, Shih, Tiffany T., Chen, Wen-Shiang, Prieur, Fabrice, Pillon, Arnaud, Cartron, Valerie, Cebe, Patrick, Chansard, Nathalie, Lafond, Maxime, Seya, Pauline Muleki, Bera, Jean-Christophe, Boissenot, Tanguy, Fattal, Elias, Bordat, Alexandre, Chacun, Helene, Guetin, Claire, Tsapis, Nicolas, Maruyama, Kazuo, Unga, Johan, Suzuki, Ryo, Fant, Cécile, Rogez, Bernadette, Afadzi, Mercy, Myhre, Ola Finneng, Vea, Siri, Bjørkøy, Astrid, Yemane, Petros Tesfamichael, van Wamel, Annemieke, Berg, Sigrid, Hansen, Rune, Angelsen, Bjørn, and Davies, Catharina
  • Journal of Therapeutic Ultrasound
Subjects
Meeting Abstracts

5. The College of Podiatry Annual Conference 2015: meeting abstracts [2016]

  • Tong, Jasper W. K., Kong, Veni P., Sze, Lily, Gale, Susie, Veto, John, McArdle, Carla, Tunprasert, Thanaporn, Bradley, Victoria, Strike, Siobhan, Ashford, Robert, Naemi, Roozbeth, Chocklingam, Nachiappan, de Blasc, Xavi, Farndon, Lisa, Robinson, Vicki, Nicholls, Emily, Birch, Tabitha, Birch, Ivan, Otter, Simon, Kumar, Sunil, Gow, Peter, Dalbeth, Nicola, Corkill, Michael, Davies, Kevin, Panthakalam, Sam, Rohan, Maheswaran, Rome, Keith, Egan, Chloe, Chandler, Lisa, Tehan, Peta, Chuter, Vivienne, Sonter, Jennifer, Lanting, Sean, Hicks, Lorna, Joyce, Christopher, Watterson, David, McIntosh, Caroline, Roberts, Nigel, Forss, Jacqueline, Charalambous, Chrystalla, Kirby, Jack, Ojo, Oluwakemi, Caukill, Sarah, Capon, Jacqueline, Fong, Radiance, Loy, Louis, Diment, Matthew, Murray, Madeleine, Ellis, Mairghread, Oldmeadow, Christopher, Carey, Nicola, Stenner, Karen, Gage, Heather, Brown, Jane, Williams, Peter, Moore, Ann, Edwards, Jude, Mold, Freda, Courtenay, Molly, Bray, Alan, Hindmoor, Pamela, Gwynne, Craig, Curran, Sarah, Bridgen, Andy, Fairhurst, Caroline, Adamson, Joy, Martin, Belen Corbacho, Cockayne, Sarah, Hewitt, Catherine, Hicks, Kate, Keenan, Anne-Maree, Loughrey-Green, Lorraine, Menz, Hylton, Redmond, Anthony, Rodgers, Sara, Watson, Jude, Torgerson, David, Hull, Robin, Lamb, Sarah, Vernon, Wesley, Wylie, Gavin, Young, Zoe, Williams, Brian, Sullivan, Frank, Ogston, Simon, Morris, Jacqui, Bowen, Cathy, Kunkel, Dorit, Cole, Mark, Donovan-Hall, Margaret, Pickering, Ruth, Burnett, Malcolm, Bader, Dan, Robison, Judy, Mamode, Louis, Ashburn, Ann, McQueen, Peter, Daniels, Maxine, Doherty, Michael, Arden, Nigel, Dando, Charlotte, Cherry, Lindsey, Stefanou, Nichola, Lamb, Sally, Corbacho, Belen, Alcacer-Pitarch, Begonya, and Buch, Maya
  • Journal of Foot and Ankle Research
Subjects
Meeting Abstracts and Orthopedics and Sports Medicine
Abstract
Table of content P3 Medial longitudinal arch development of school children Jasper W.K. Tong, Veni P. Kong P4 Is measuring the subtalar joint reliable? Lily Sze, Susie Gale, John Veto, Carla McArdle P5 Comparison of turning gait biomechanics between able-bodied and unilateral transtibial amputee participants Thanaporn Tunprasert, Victoria Bradley, Siobhan Strike P6 Comparison of walking gait biomechanics between able-bodied and unilateral transtibial amputee participants using a new model of energy-storage-and-return (ESAR) prosthetic Thanaporn Tunprasert, Victoria Bradley, Siobhan Strike P7 An observational study of in-shoe plantar and dorsal pressures of skilled downhill skiers on a dry ski slope Robert Ashford, Roozbeth Naemi, Nachiappan Chocklingam, Xavi de Blasc P8 If the shoe fits: a footwear choice toolkit informed by social science methodologies Lisa Farndon, Vicki Robinson, Emily Nicholls P9 The identification of emotions from gait Tabitha Birch, Ivan Birch P11 Experience of foot problems in patients with systemic lupus erythematosus Simon Otter, Sunil Kumar, Peter Gow, Nicola Dalbeth, Michael Corkill, Kevin Davies, Sam Panthakalam, Maheswaran Rohan, Keith Rome P14 Negative pressure wound therapy for the management of foot wounds in the diabetic population: a review of the literature Chloe Egan, Lisa Chandler P15 Lower limb vascular assessment in diabetes: a multifaceted assessment of objective screening techniques Peta Tehan, Vivienne Chuter, Jennifer Sonter, Sean Lanting P16 Improving outcomes for diabetes foot complications Lorna Hicks P17 Acupuncture… an alternative or adjunctive treatment option for diabetes-related neuropathic pain? Christopher Joyce, David Watterson, Caroline McIntosh P18 “My back is in agony” – A cross-sectional study into the relationship between musculoskeletal complaints and a whole body postural risk assessment in podiatry students Christopher Joyce, Nigel Roberts P19 Swabs of the treatment couches: Does the material type and texture of podiatric treatment couches increase microorganism contamination? Jacqueline Forss, Chrystalla Charalambous, Jack Kirby, Oluwakemi Ojo P20 Does increased exudate viscosity effect the absorption rate of exudate into four different wound dressings? Jacqueline Forss, Sarah Caukill, Jacqueline Capon, Radiance Fong, Louis Loy P21 An investigation into the microbial load of a 40 °C and 60 °C wash Matthew Diment, Madeleine Murray, Mairghread Ellis, Carla McArdle P23 The sensitivity and specificity of the toe brachial index in detecting peripheral arterial disease: a systematic review and meta-analysis Peta Tehan, Vivienne Chuter, Christopher Oldmeadow P24 Medicines management activities and non-medical prescribing within podiatry and physiotherapy: an integrative review of the literature Nicola Carey, Karen Stenner, Heather Gage, Jane Brown, Peter Williams, Simon Otter, Ann Moore, Jude Edwards, Freda Mold, Molly Courtenay A7.2 Non-invasive vascular assessment in the foot with Diabetes: Diagnostic accuracy of ankle brachial index, toe brachial index and continuous wave Doppler Peta Tehan, Alan Bray, Vivienne Chuter A7.5 The efficacy of dressings on post nail surgery phenolised wounds Pamela Hindmoor B7.1 Cross-sectional study investigating the role of proximal and distal factors in the development of patellofemoral joint pain Craig Gwynne, Sarah Curran B7.2 Podiatrist’s interpretation and use of evidence in MSK practice Andy Bridgen B7.4 Predictors of falling in older podiatry patients – findings from the REFORM study Caroline Fairhurst, Dr Joy Adamson, Belen Corbacho Martin, Sarah Cockayne, Prof Catherine Hewitt, Kate Hicks, Anne-Maree Keenan, Lorraine Loughrey-Green, Hylton Menz, Anthony Redmond, Sara Rodgers, Jude Watson, David Torgerson, Robin Hull, Sarah Lamb, Caroline McIntosh, Wesley Vernon, Lisa Farndon B7.5 The REFORM study: Insole preference, requirements and compliance of podiatry patient’s aged 65 and over and at risk of falling Lorraine Loughrey-Green, Sarah Cockayne, Anthony Redmond, Anne-Maree Keenan, Sara Rodgers, Lisa Farndon, Wesley Vernon, David Torgerson, Caroline Fairhurst, Jude Watson, Hylton Menz, Sarah Lamb, Robin Hull B7.6 A podiatry intervention to reduce falls in care home residents is feasible and demonstrates benefits: results from PIRFECT, a feasibility randomised controlled trial Gavin Wylie, Zoe Young, Brian Williams, Frank Sullivan, Hylton Menz, Simon Ogston, Jacqui Morris C7.1 A survey exploring footwear habits in people with stroke and people with Parkinson’s Cathy Bowen, Dorit Kunkel, Mark Cole, Margaret Donovan-Hall, Ruth Pickering, Malcolm Burnett, Dan Bader, Judy Robison, Louis Mamode, Ann Ashburn C7.2 Painful foot osteoarthritis; a common symptom in a common pathology? Peter McQueen, Maxine Daniels, Michael Doherty, Nigel Arden, Cathy Bowen C7.4 Clinical diagnosis of symptomatic forefoot neuroma in the general population: Delphi based recommendations Charlotte Dando, Lindsey Cherry, Cathy Bowen C7.5 The development and implementation of a Clinical Quality Improvement Framework suitable for use in community services Nichola Stefanou C7.6 The REFORM study - methodological considerations in running a cohort randomised controlled trial within a podiatry patient caseload Sarah Cockayne, Joy Adamson, Caroline Fairhurst, Catherine Hewitt, Anne-Maree Keenan, Sally Lamb, Lorraine Loughrey-Green, Caroline McIntosh, Hylton Menz, Anthony Redmond, Sara Rodgers, Wesley Vernon, Jude Watson, Lisa Farndon, Belen Corbacho, Robin Hull, David Torgerson A31 Jewel in the crown: Exploring the factors contributing to the development and impact of foot problems in Systemic Sclerosis (SSc) Begonya Alcacer-Pitarch, Anthony Redmond, Maya Buch, Anne-Maree Keenan

6. British Society of Breast Radiology Annual Scientific Meeting 2016 [2016]

  • Azmil, Ameerah Mohd, Bansal, Gaurav Jyoti, Davies, Eleri, Wallis, Matthew, Kilburn-Toppin, Fleur, Taylor-Phillip, Sian, Buckley, Anne, Healy, Nuala, Quinn, Aine, O’Keeffe, Sylvia, Ang, Teri, Maxwell, Anthony, Lim, Yit Y., Harkness, Elaine, Emsley, Richard, Astley, Susan, Gadde, Soujanya, Ferguson, Jennifer, Stevens, Guy, Hills, Robert, Thomas, Kate Gower, Rajan, Sabrina, Sharma, Nisha, Kishore, Ajit, O’ Dowd, John, Murphy, Claire, Lindsay, Ken, Dadayal, Guneesh, Moody, Anne Nielsen, Whitaker, Madeleine, Wolstenhulme, Stephen, Bull, Jane, Culpan, Anne-Marie, Roszkowski, Natalia, Grima, Alexis, Stahnke, Michaela, Rubin, Caroline, Walker, Ruth, Oeppen, Rachel, Puttagunta, Srikanth, Gray, Karen, Puri, Shama, Millican-Slater, Rebecca, Pascaline, Sana, Hajaj, Mohamad, Flinn, Janet, Thomson, Kim, Elsberger, Beatrix, Turnbull, Anne, Bagnall, Mark, York, Joanne, Benney, Stuart, Goyal, Amit, Topps, Ashley, Barr, Simon, Pikoulas, Panagiotis, Pritchard, Susan, Greenhalgh, Sophie, Sreenivas, Muthyala, Nandhra, Anju, Sharma, Sheetal, Gulati, Archita, Razzaq, Furhan, Khan, Sana, McKillen, Jacqueline, Larkin, Rupert, Kamat, Sachin, Goncalves, Carla, Tan, Alan, Eleti, Asha, Vidyaprakash, Nithya, McMahon, Michelle A., Dall, Barbara J. G., Majid, Faisal, Rattehalli, Ramachadra, Gaur, Vandana, Mackenzie, Alistair, Warren, Lucy, Patel, Mishal, Halling-Brown, Mark, Wilkinson, Louise, Young, Kenneth, Tanner, James, Currie, Rachael, Balyes, Sharron, Wragg, Julie, Zamfir, Georgiana, Ayra, Pallavi, Marsden, Max, Butterworth, James, Sinha, Shona, Desai, Anil, Metafa, Anna, Nielsen-Moody, Anne, Ward, Laura, Heller, Samantha, Hudson, Sue, Taylor, Kathryn, Xyda, Argyro, Allen, Steven, Orlowski, Elizabeth, Downey, Kate, Sidebottom, Richard, Lodhi, Ahmad, Howell, Anthony, Evans, Gareth, Lim, Yit, Chen, Yan, Lepine-Williams, Elizabeth, Henderson, Steven, Litherland, Janet, Altaf, Naveed, Bury, Yvonne, Forester, Nerys, Chin, Mei Chan, Taylor, Caroline, Skippage, Pippa, Sian, Aneet, McAvinchey, Rita, Evans, Tom, Nisbet, Sian, Murray, Alex, Castillo, Raquel Clark, Markham, Hannah, Thomas, Timothy, Jain, Anil, Molderson, Jaanilka, Wan, Joseph, Newman, Helen, Lowes, Simon, Lunt, Linsley, Sultana, Sadia, Chillal, Varun, Dalton, Rebecca, Reeves, David, Sergeant, Jamie, Edwards, Liz, Jenkins, Kate, Shaikh, Shaheeda, O’Flynn, Elizabeth, Bombroffe, Laura, Hughes, Julie, Scurr, Erica, Wilson, Robin, Jones, Lyn, Govindarajulu, Sasirekha, Sahu, Ajay K., Brown, Matthew, Allen, Steve, O’Flynn, Liz, deSouza, Nandita, Rahim, Rumana, Wasan, Rema, Goligher, Jane, Wijesuriya, Shalini, Morel, Juliet, Peacock, Clare, Michell, Michael, Iqbal, Asif, Evans, David, Batohi, Bhavna, Wasan, Tavleen, Phillips, Vivien, Manuel, Eden, Bowman, Gillian, Satchithananda, Keshthra, Fang, Cheng, Shah, Chirag, Hodkin, Leanne, Horgan, Keiran, Dodwell, David, Moloney, BM, Casey, M. C., Breathnach, A., Dwyer, R. M., McLoughlin, R., Sweeney, K. J., Malone, C., Healy, M. J., Kerin, M. J., Mitchell, Elizabeth, Twiddy, Maureen, Dobson, Hilary, Vinnicombe, Sarah, Evans, Andrew, Grant, David, Bishop, Briony, Giggens, Roxanne, Bhuva, Shaheel, Royds, Jennifer, Camilleri, Francesca, Babu, Gauripriya, Beveridge, Carolyn, Geach, Rebecca, Klimczak, Katherine, Massey, Helen, Lyburn, Iain, Salehi-Bird, Seema, Nishtala, Sahithi, Gunning, Liz, Changaradil, Deepthi Vinayan, Bansal, Jyoti, Davis, Joanna, Sharma, Ashwini, Del Voscovo, Elena, Etheridge, Harriet, Butler, Aisling, Fenne, David S. J., Rubin, Gary, Burt, Helen, Ridley, Nick, Taylor, Sarah, Seth, Subodh, and Seth, Archana
  • Breast Cancer Research : BCR
Subjects
Meeting Abstracts and Medicine(all)

7. Late onset hereditary sensory and autonomic neuropathy with cognitive impairment associated with Y163X prion mutation [2014]

  • Themistocleous, Andreas C., Kennett, Robin, Husain, Masud, Palace, Jacqueline, Mead, Simon, and Bennett, David L. H.
  • Journal of Neurology. 261
Subjects
Letter to the Editors, Clinical Neurology, and Neurology

8. Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. [2019]

  • Dashti, Hassan S., Jones, Samuel E., Wood, Andrew R., Lane, Jacqueline M., van Hees, Vincent T., Wang, Heming, Rhodes, Jessica A., Song, Yanwei, Patel, Krunal, Anderson, Simon G., Beaumont, Robin N., Bechtold, David A., Bowden, Jack, Cade, Brian E., Garaulet, Marta, Kyle, Simon D., Little, Max A., Loudon, Andrew S., Luik, Annemarie I., and Scheer, Frank A. J. L.
  • Nature Communications; 3/7/2019, Vol. 10 Issue 1, p1-1, 1p
Abstract
Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p < 5 × 10−8; 43 loci at p < 6 × 10−9). Replication is observed for PAX8, VRK2, and FBXL12/UBL5/PIN1 loci in the CHARGE study (n = 47,180; p < 6.3 × 10−4), and 55 signals show sign-concordant effects. The 78 loci further associate with accelerometer-derived sleep duration, daytime inactivity, sleep efficiency and number of sleep bouts in secondary analysis (n = 85,499). Loci are enriched for pathways including striatum and subpallium development, mechanosensory response, dopamine binding, synaptic neurotransmission and plasticity, among others. Genetic correlation indicates shared links with anthropometric, cognitive, metabolic, and psychiatric traits and two-sample Mendelian randomization highlights a bidirectional causal link with schizophrenia. This work provides insights into the genetic basis for inter-individual variation in sleep duration implicating multiple biological pathways. Sleep is essential for homeostasis and insufficient or excessive sleep are associated with adverse outcomes. Here, the authors perform GWAS for self-reported habitual sleep duration in adults, supported by accelerometer-derived measures, and identify genetic correlation with psychiatric and metabolic traits [ABSTRACT FROM AUTHOR]

9. Implementation of a Model of Robotic Tele-Presence (RTP) in the Neuro-ICU: Effect on Critical Care Nursing Team Satisfaction. [2012]

  • Rincon, Fred, Vibbert, Matthew, Childs, Valerie, Fry, Robin, Caliguri, Dennis, Urtecho, Jacqueline, Rosenwasser, Robert, and Jallo, Jack
  • Neurocritical Care; Aug2012, Vol. 17 Issue 1, p97-101, 5p
Subjects
MEDICAL robotics, TEAM nursing, TELEMEDICINE, INTENSIVE care units, NEUROLOGICAL intensive care, TELEPRESENCE, and INTENSIVE care nursing
Abstract
Introduction: Robotic Tele-Presence (RTP) is a form of mobile telemedicine, which enables a direct face-to-face rapid response by the physician, instead of the traditional telephonic paradigm. We hypothesized that a model of RTP for after-hour ICU rounds and emergencies would be associated with improved ICU nurse satisfaction. Methods: We implemented a prospective nighttime multidisciplinary ICU round time, using RTP at our Neuro-ICU. To test for critical ICU nurse team satisfaction, a questionnaire was implemented. The primary outcome was nurse satisfaction measured through a questionnaire with answers trichotomized into: agreement, disagreement, and no opinion. The occurrence of outcomes was compared between the groups by χ or Fisher exact tests for the difference in proportions (PD) with Bonferroni correction for multiple pairwise comparisons. Results: In total, 34 nurses completed the pre-survey and 40 nurses completed the post-survey. Night nurses were more likely to agree that RTP was associated with: ICU physicians being sufficiently available in the ICU (agreement 6-20 %, PD 14 %, p = 0.008), present during acute emergencies (agreement 44-65 %, PD 21 %, p = 0.007), and had enough time to get questions answered from the physician team (agreement 41-53 %, PD 11 %, p = NS). Conclusions: This data suggest improvement in critical care nursing team satisfaction with a model of RTP in the Neuroscience ICU, particularly during nighttime hours. RTP is a tool that may enhance communication among components of the ICU team. [ABSTRACT FROM AUTHOR]

10. Barriers to Cognitive Behavioral Therapy Homework Completion Scale-Depression Version: Development and Psychometric Evaluation. [2012]

  • Callan, Judith A., Dunbar-Jacob, Jacqueline, Sereika, Susan M., Stone, Clement, Fasiccka, Amy, Jarrett, Robin B., and Thase, Michael E.
  • International Journal of Cognitive Therapy; Jun2012, Vol. 5 Issue 2, p219-235, 17p

11. Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. [2019]

  • Jones, Samuel E., Lane, Jacqueline M., Wood, Andrew R., van Hees, Vincent T., Tyrrell, Jessica, Beaumont, Robin N., Jeffries, Aaron R., Dashti, Hassan S., Hillsdon, Melvyn, Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Sharp, Seth A., Jie, Yingjie, Thompson, William D., Harrison, Jamie W., Dawes, Amy, Byrne, Enda M., Tiemeier, Henning, and Allebrandt, Karla V.
  • Nature Communications; 1/29/2019, Vol. 10 Issue 1, p1-1, 1p
Abstract
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans. GWAS have previously found 24 genomic loci associated with chronotype, an individual's preference for early or late sleep timing. Here, the authors identify 327 additional loci in a sample of 697,828 individuals and further explore the relationships of chronotype with metabolic and psychiatric diseases. [ABSTRACT FROM AUTHOR]

12. Species-Specific Chemical Signatures in Scale Insect Honeydew. [2011]

  • Dhami, Manpreet, Gardner-Gee, Robin, Houtte, Jeremy, Villas-Bôas, Silas, and Beggs, Jacqueline
  • Journal of Chemical Ecology; Nov2011, Vol. 37 Issue 11, p1231-1241, 11p
Subjects
HONEYDEW (Entomology), HONEY, METABOLITES, NATURAL sweeteners, and NECTAR
Abstract
The quantity and chemical composition of honeydew produced by scale insects may influence wider community structure, but little is known about the detailed chemical composition of the honeydew found in forest ecosystems. We used gas chromatography-mass spectrometry to examine the amino acid and carbohydrate composition of honeydew from three New Zealand communities. Low molecular weight carbohydrates (mono-, di-, and tri-saccharides) were derivatized using a modified trimethylsilyl (TMS) method, and amino and non-amino organic acids were derivatized using methylchloroformate (MCF). These recently developed derivatization methods allowed us to detect atypical compounds such as sugar alcohols, fatty acids, and non-amino organic acids, in addition to the more routinely studied compounds such as sugars and amino acids. Some compounds could not be identified and may be novel. Multivariate analysis showed that honeydew from each scale insect species had a distinctive amino acid and carbohydrate signature. We suggest these chemical signatures may influence the types of consumers that are attracted to different honeydews and may explain the characteristic communities associated with these honeydews. [ABSTRACT FROM AUTHOR]

13. Odor identification ability and self-reported upper respiratory symptoms in workers at the post-9/11 World Trade Center site. [2011]

  • Altman, Kenneth W., Desai, Shaun C., Moline, Jacqueline, de la Hoz, Rafael E., Herbert, Robin, Gannon, Patrick J., and Doty, Richard L.
  • International Archives of Occupational & Environmental Health; Feb2011, Vol. 84 Issue 2, p131-137, 7p, 1 Chart, 1 Graph
Subjects
RESPIRATORY diseases and INDUSTRIAL safety
Abstract
Following the World Trade Center (WTC) collapse on September 11, 2001, more than 40,000 people were exposed to a complex mixture of inhalable nanoparticles and toxic chemicals. While many developed chronic respiratory symptoms, to what degree olfaction was compromised is unclear. A previous WTC Medical Monitoring and Treatment Program study found that olfactory and nasal trigeminal thresholds were altered by the toxic exposure, but not scores on a 20-odor smell identification test. Objectives: To employ a well-validated 40-item smell identification test to definitively establish whether the ability to identify odors is compromised in a cohort of WTC-exposed individuals and, if so, whether the degree of compromise is associated with self-reported severity of rhinitic symptoms. Methods: The University of Pennsylvania Smell Identification Test (UPSIT) was administered to 99 WTC-exposed persons and 99 matched normal controls. The Sino-Nasal Outcomes Test (SNOT-20) was administered to the 99 WTC-exposed persons and compared to the UPSIT scores. Results: The mean (SD) UPSIT scores were lower in the WTC-exposed group than in age-, sex-, and smoking history-matched controls [respective scores: 30.05 (5.08) vs 35.94 (3.76); p = 0.003], an effect present in a subgroup of 19 subjects additionally matched on occupation ( p < 0.001). Fifteen percent of the exposed subjects had severe microsmia, but only 3% anosmia. SNOT-20 scores were unrelated to UPSIT scores ( r = 0.20; p = 0.11). Conclusion: Exposure to WTC air pollution was associated with a decrement in the ability to identify odors, implying that such exposure had a greater influence on smell function than previously realized. [ABSTRACT FROM AUTHOR]

14. The Darwin Space Interferometer. [2000]

  • Bergeron, Jacqueline, Renzini, Alvio, Penny, Alan, Leger, Alain, Laurance, Robin, and Fridlund, Malcolm
  • From Extrasolar Planets to Cosmology: The VLT Opening Symposium; 2000, p535-538, 4p
Abstract
Darwin is a mid-IR(5-30 micron) interferometry observatory with baselines greater than 50 metres. As a long-duration general purpose observatory, ESA is studying it as part of its Horizons 2000 programme for a possible launch in the 2009 - 2016 timeframe. This paper describes some of the technical, scientific and programmatic aspects of the Darwin mission as presently conceived by the ESTEC study, the Alcatel industrial study and by the members of the Darwin Team. [ABSTRACT FROM AUTHOR]

15. Biomarkers of organophosphorus nerve agent exposure: comparison of phosphylated butyrylcholinesterase and phosphylated albumin after oxime therapy. [2010]

  • Read, Robert W., Riches, James R., Stevens, Jacqueline A., Stubbs, Sarah J., and Black, Robin M.
  • Archives of Toxicology; Jan2010, Vol. 84 Issue 1, p25-36, 12p, 2 Charts, 8 Graphs
Subjects
ORGANOPHOSPHORUS compounds, BUTYRYLCHOLINESTERASE, ALBUMINS, OXIMES, TYROSINE, BIOMARKERS, and CHOLINESTERASES
Abstract
Organophosphorus nerve agents inhibit the activity of cholinesterases by phosphylation of the active site serine. In addition, sarin, cyclosarin, soman and tabun have been shown to phosphylate a tyrosine residue in albumin. Therapies against nerve agent poisoning include the use of oximes to reactivate inhibited cholinesterases by displacement of the phosphyl moiety and hence detectable levels of adducts with cholinesterases may be reduced. Adducts with tyrosine have been shown to be persistent in the guinea pig in the presence of oxime therapy. Plasma samples obtained from an animal study aimed at improving therapy against nerve agent poisoning were used to compare the suitability of tyrosine and butyrylcholinesterase (BuChE) adducts as biomarkers of nerve agent exposure after treatment with therapeutic oximes. Under the terms of the project licence, these samples could be collected only on death of the animal, which occurred within hours of exposure or when culled at 23 or 24 days. Tyrosine adducts were detected in all samples collected following intra-muscular administration of twice the LD50 dose of the respective nerve agent. Aged BuChE adducts were detected in samples collected within a few hours after administration of soman and tabun, but not after 23 or 24 days. No BuChE adducts were detected in animals exposed to sarin and cyclosarin where samples were collected only after 23 or 24 days. [ABSTRACT FROM AUTHOR]

16. The association of serum testosterone levels and ventricular repolarization. [2010]

  • van Noord, Charlotte, Dörr, Marcus, Sturkenboom, Miriam C. J. M., Straus, Sabine M. J. M., Reffelmann, Thorsten, Felix, Stephan B., Hofman, Albert, Kors, Jan A., Haring, Robin, de Jong, Frank H., Nauck, Matthias, Uitterlinden, André G., Wallaschofski, Henri, Witteman, Jacqueline C. M., Völzke, Henry, and Stricker, Bruno H. Ch.
  • European Journal of Epidemiology; Jan2010, Vol. 25 Issue 1, p21-28, 8p, 3 Charts
Subjects
SERUM, TESTOSTERONE, COHORT analysis, ELECTROCARDIOGRAPHY, and HYPERTROPHY
Abstract
It is assumed that testosterone is an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels of testosterone are associated with QTc, QT and RR interval variation. Setting: two independent population-based cohort studies. Participants: 445 male participants (≥55 years) from the Rotterdam study cohort and 1,428 male participants from the study of health in Pomerania (SHIP) with an electrocardiogram who were randomly sampled for assessment of serum testosterone at baseline, after exclusion of participants with testosterone altering drugs, QTc prolonging drugs or dig(it)oxin, left ventricular hypertrophy and left and right bundle branch block. Endpoints: length of the QTc, QT and RR intervals. Analysis: linear regression model, adjusted for the two individual studies and a pooled analysis of both studies. The pooled analysis of the Rotterdam study and SHIP showed that the QTc interval gradually decreased among the tertiles ( P value for trend 0.024). The third tertile of serum testosterone was associated with a lower QTc interval compared to the first tertile [−3.4 ms (−6.5; −0.3)]. However, the third tertile of serum testosterone was not associated with a lower QT interval compared to the first tertile [−0.7 ms (−3.1; 1.8)]. The RR interval gradually increased among the tertiles ( P value for trend 0.002) and the third tertile of serum testosterone showed an increased RR interval compared to the first tertile [33.5 ms (12.2; 54.8)]. In the pooled analysis of two population-based studies, serum testosterone levels were not associated with the QT interval, which could be due to a lack of power. Lower QTc intervals in men with higher serum testosterone levels could be due to the association of serum testosterone with prolongation of the RR interval. [ABSTRACT FROM AUTHOR]

17. Stories Behind the Symptoms: A Qualitative Analysis of the Narratives of 9/11 Rescue and Recovery Workers. [2009]

  • Bills, Corey B., Dodson, Nancy, Stellman, Jeanne M., Southwick, Steven, Sharma, Vansh, Herbert, Robin, Moline, Jacqueline M., and Katz, Craig L.
  • Psychiatric Quarterly; Sep2009, Vol. 80 Issue 3, p173-189, 17p, 3 Charts
Subjects
PATHOLOGICAL psychology, MENTAL health, MEDICAL screening, TERRORISM, and MENTAL health services
Abstract
A qualitative study of the experiences of rescue and recovery workers/volunteers at Ground Zero following the terrorist attacks of 9/11/01 is reported. Information was extracted from a semi-structured clinical evaluation of 416 responders who were the initial participants in a large scale medical and mental health screening and treatment program for 9/11 responders. Qualitative analysis revealed themes that spanned four categories— occupational roles, exposures, attitudes/experiences, and outcomes related to the experience of Ground Zero. Themes included details regarding Ground Zero roles, grotesque experiences such as smells, the sense of the surreal nature of responding, and a turning to rituals to cope after leaving Ground Zero. These findings personalize the symptom reports and diagnoses that have resulted from the 9/11 responders’ exposure to Ground Zero, yielding richer information than would otherwise be available for addressing the psychological dimensions of disasters. This work shows that large scale qualitative surveillance of trauma-exposed populations is both relevant and feasible. [ABSTRACT FROM AUTHOR]

18. Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate. [2009]

  • Chiquet, Brett T., Hashmi, Syed S., Henry, Robin, Burt, Amber, Mulliken, John B., Stal, Samuel, Bray, Molly, Blanton, Susan H., and Hecht, Jacqueline T.
  • European Journal of Human Genetics; Feb2009, Vol. 17 Issue 2, p195-204, 10p, 1 Diagram, 8 Charts
Subjects
CLEFT lip, CLEFT palate, GENES, MYOSIN, GENETIC disorders, and HUMAN genetics
Abstract
Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common birth anomaly that requires prolonged multidisciplinary rehabilitation. Although variation in several genes has been identified as contributing to NSCLP, most of the genetic susceptibility loci have yet to be defined. To identify additional contributory genes, a high-throughput genomic scan was performed using the Illumina Linkage IVb Panel platform. We genotyped 6008 SNPs in nine non-Hispanic white NSCLP multiplex families and a single large African-American NSCLP multiplex family. Fourteen chromosomal regions were identified with LOD>1.5, including six regions not previously reported. Analysis of the data from the African-American and non-Hispanic white families revealed two likely chromosomal regions: 8q21.3–24.12 and 22q12.2–12.3 with LOD scores of 2.98 and 2.66, respectively. On the basis of biological function, syndecan 2 (SDC2) and growth differentiation factor 6 (GDF6) in 8q21.3–24.12 and myosin heavy-chain 9, non-muscle (MYH9) in 22q12.2–12.3 were selected as candidate genes. Association analyses from these genes yielded marginally significant P-values for SNPs in SDC2 and GDF6 (0.01≤P<0.05). Evidence for an altered transmission was found for four MYH9 SNPs (P<0.01). SNP rs1002246 exhibited altered transmission by all analytic methods. However, analysis of two SNP MYH9 haplotypes did not identify a single high-risk haplotype. Our results confirm a previous report that 8q21.3–24.12 may harbor a clefting gene and identify 22q12.2–12.3 as a new candidate region that contains MYH9. Most importantly, we confirm the previous report of an association with MYH9.European Journal of Human Genetics (2009) 17, 195–204; doi:10.1038/ejhg.2008.149; published online 20 August 2008 [ABSTRACT FROM AUTHOR]

19. Longitudinal twin study of early literacy development: Preschool through Grade 1. [2007]

  • Byrne, Brian, Samuelsson, Stefan, Wadsworth, Sally, Hulslander, Jacqueline, Corley, Robin, DeFries, John C., Quain, Peter, Willcutt, Erik G., and Olson, Richard K.
  • Reading & Writing; Jan2007, Vol. 20 Issue 1/2, p77-102, 26p, 6 Charts
Subjects
EMERGENT literacy, FIRST grade (Education), PHONOLOGICAL decoding, READING comprehension, SPELLING ability, PRESCHOOL education, and WORD recognition ability testing
Abstract
Grade 1 literacy skills of twin children in Australia (New South Wales) and the United States (Colorado) were explored in a genetically sensitive design ( N = 319 pairs). Analyses indicated strong genetic influence on word and nonword identification, reading comprehension, and spelling. Rapid naming showed more modest, though reliable, genetic influence. Phonological awareness was subject to high nonshared environment and no reliable genetic effects, and individual measures of memory and learning were also less affected by genes than nonshared environment. Multivariate analyses showed that the same genes affected word identification, reading comprehension, and spelling. Country comparisons indicated that the patterns of genetic influence on reading and spelling in Grade 1 were similar, though for the U.S. but not the Australian children new genes came on stream in the move from kindergarten to Grade 1. We suggest that this is because the more intensive kindergarten literacy curriculum in New South Wales compared with Colorado, consistent with the mean differences between the two countries, means that more of the genes are “online” sooner in Australia because of accelerated overall reading development. [ABSTRACT FROM AUTHOR]

20. Genetic and environmental influences on prereading skills and early reading and spelling development in the United States, Australia, and Scandinavia. [2007]

  • Samuelsson, Stefan, Olson, Richard, Wadsworth, Sally, Corley, Robin, DeFries, John C., Willcutt, Erik, Hulslander, Jacqueline, and Byrne, Brian
  • Reading & Writing; Jan2007, Vol. 20 Issue 1/2, p51-75, 25p, 8 Charts
Subjects
READING (Early childhood), PRESCHOOL children, KINDERGARTEN, SPELLING ability, TWINS, TEST of Early Reading Ability, READING Skills Competency Tests, CHILDREN & the environment, and GENETICS
Abstract
Genetic and environmental influences on prereading skills in preschool and on early reading and spelling development at the end of kindergarten were compared among samples of identical and fraternal twins from the U.S. (Colorado), Australia, and Scandinavia. Mean comparisons revealed significantly lower preschool print knowledge in Scandinavia, consistent with the relatively lower amount of shared book reading and letter-based activities with parents, and lack of emphasis on print knowledge in Scandinavian preschools. The patterns of correlations between all preschool environment measures and prereading skills within the samples were remarkably similar, as were the patterns of genetic, shared environment, and non-shared environment estimates: in all samples, genetic influence was substantial and shared environment influence was relatively weak for phonological awareness, rapid naming, and verbal memory; genetic influence was weak, and shared environment influence was relatively strong for vocabulary and print knowledge. In contrast, for reading and spelling assessed at the end of kindergarten in the Australian and U.S. samples, there was some preliminary evidence for country differences in the magnitude of genetic and environmental influences. We argue that the apparently higher genetic and lower shared environment influence in the Australian sample was related to a greater emphasis on formal reading instruction, resulting in more advanced reading and spelling skills at the end of kindergarten, and thus there was greater opportunity to observe genetic influences on response to systematic reading instruction among the Australian twins. [ABSTRACT FROM AUTHOR]

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