Ge, Haitao, Sha, Aimin, Han, Zhenqiang, and Xiong, Xiaowei
Construction & Building Materials. Nov2018, Vol. 188, p58-67. 10p.
MINERAL aggregates, IMAGE analysis, LIMESTONE, ABRASION resistance, and MECHANICAL behavior of materials
Highlights • The specific scanning process was used obtain shape information of aggregate. • FEI, SI and SSA are proposed to characterize the morphology of aggregate. • The minimum bounding box algorithm was developed to calculate FEI of aggregate. • Abrasion decay laws of the quantitative indexes were illustrated by image analysis. Abstract In order to quantitatively evaluate morphological characteristics and abrasion decay laws of coarse aggregate so that make an accurate performance evaluation for aggregates, flat-elongated index, sphericity index and specific surface area are proposed to characterize the shape properties of coarse aggregate. Limestone aggregate particles ranging in size scale of 4.75–9.5 mm, 9.5–13.2 mm, 19–26.5 mm were worn by the Los Angeles Abrasion tester respectively. Three-dimensional (3-D) laser scanner was used to obtain three-dimensional points cloud data of aggregate particles experienced 0, 500, 1000 and 2000 abrasion cycles. Afterwards, the data was processed by the software of reverse engineering based on morphology evaluation indexes, and the minimum bounding box algorithm was developed to calculate flat-elongated index, illustrating the morphological characteristics of coarse aggregate particles with different size and abrasion cycles. Test results show that: aggregates with small size have bigger quantity proportion of elongated particle; the greater the angularity of aggregates was, the faster the angular decay rate of the aggregates was; aggregate particles with small size has richer surface texture but easier to lost in abrasion process. Sphericity index increased, while specific surface area and flat-elongated index presented a downward trend as the particle size became bigger for different abrasion cycles. However, the flat-elongated index of aggregate particles with different size increased abnormally when abrasion cycles increased at 2000 abrasion cycles as the result of aggregate crushing. Besides, the sphericity and specific surface area of some 4.75 mm aggregate under 500 abrasion cycles showed an abnormal increasing compared to its 1000 abrasion cycles, which caused by inadequate abrasion under low abrasion cycles. Therefore, the indexes proposed in the study are able to characterize different aspects of coarse aggregates morphological property, and it is beneficial for the evaluation and selection of aggregates used in engineering construction. [ABSTRACT FROM AUTHOR]
Objective: To study the expression of T cell immunoglobulin and mucin domain 3 (Tim-3) on peripheral blood immunocytes, and the relationship between Tim-3 and the systemic inflammatory response or brain injury in patients with intracerebral hemorrhage (ICH).Methods: According to the volume of hematoma at 12 hours after onset of ICH, 60 newly diagnosed patients with ICH were divided into the small (volume of hematoma <30 mL, 30 cases) and large (volume of hematoma ≥30 mL, 30 cases) ICH groups. The expression of Tim-3 on peripheral blood immunocytes was analyzed by flow cytometry. Real-time reverse transcriptase polymerase chain reaction was used to detect Tim-3 mRNA on peripheral blood mononuclear cells (PBMCs). Meanwhile, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and S-100B protein were measured by enzyme-linked immunosorbent assay. Glasgow outcome scale (GOS) score at Day 30 was used to estimate prognosis of patients.Results: The leukocyte count, neutrophil count, monocyte count, TNF-α, IL-1β, and S-100B protein increased remarkably after ICH. However, all of them in the large ICH group increased more obviously, and there were significant differences when compared with those in the small ICH group (P < .01). The expression of Tim-3 mRNA on PBMCs in the large ICH group increased remarkably, peaked at Day 3, and was positively associated with the concentrations of TNF-α, IL-1β, and S-100B protein (P < .01). Tim-3 was predominantly expressed itself on CD14+ monocytes. There was a negative correlation between GOS score and Tim-3 mRNA, TNF-α, IL-1β, or S-100B protein.Conclusions: The expression of Tim-3 on CD14 + monocytes involves in systemic inflammatory reaction after ICH and may be a novel treatment target. [ABSTRACT FROM AUTHOR]