Tarțău, Liliana Mititelu, Buca, Beatrice Rozalina, and Popa, Eliza Grațiela
Farmacist.ro. 2016, Issue 6, p62-65. 4p.
Pregabalin, a structural analogue of gammaaminobutyric acid, is a potent ligand of the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. Along with gabapentin, it belongs to the gabapentinoid therapeutic group, which is used in the treatment of epilepsy, neuropathic pain, fibromyalgia and general anxiety disorders. Compared to gabapentin, pregabalin possesses superior analgesic and antiepileptic efficacy, which has been studied and demonstrated by both experimental and clinical research trials. The anticonvulsant activity of pregabalin is probably due to its ability of decreasing the neurotransmitter's release from active epileptogenic neurons and not due to its action directly on the GABA receptors. Clinical studies have shown positive effects of pregabalin in monotherapy or combined with opioid analgesics in several types of neuropathic pain (peripheral diabetic neuropathy in fibromyalgia, post-herpetic neuralgia, neoplastm pain). Experimental studies in rats or mice have demonstrated the analgesic action of pregabalin alone or combined with opioid and non-opioid analgesics: acute somatic pain (the hot plate test, the tail flick test, the tail compression test, the formalin test) and acute visceral pain (the contortion test, the colorectal distension test, the test of inducing colonic inflammation with capsaicin); also, its action on chronic neuropathic pain has been demonstrated: the streptozotocin-induced diabetes test or the sciatic nerve ligation test in rats. The synergistic analgesic action of the pregabalin-opioid combination is due to the link between GABAergic and opioid systems, both with important roles in the voltage-gated calcium channels which mediate the transmission of nociception. [ABSTRACT FROM AUTHOR]
Arsene, Andreea Letiţia, Nicolae, Alina Crenguţa, and Drăgoi, Cristina Manuela
Farmacist.ro. 2015, Issue 6, p48-50. 3p.
Blood-brain barrier (BBB) is the interface between peripheral circulation and central nervous system (CNS) with the anatomical substrate endothelium of cerebral micro vessels, which together with astrocytes, pericytes, neurons and extracellular matrix constitutes a “stroke unit” essential in the proper functioning of the central nervous system. Therefore, it is essential that the interface between the CNS and the peripheral circulation system to operate as a dynamic adjustor of the ionic balance, an element intended to facilitate the transport of nutrients, and a barrier for potentially harmful molecules. This homeostasis of cerebral microcirculation, historically called “blood-brain barrier”, fulfills all these functions. [ABSTRACT FROM AUTHOR]
Forensic Science Forum / Forum Criminalistic; jan-jun2016, Vol. 9 Issue 1, p17-20, 4p, 2 Black and White Photographs
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