Techniques that may be used for detecting a primary content (e.g., a web page) that the user is viewing and presenting one or more pieces of supplemental content (e.g., social media data) together with the primary content. The supplemental content presented to the user together with the primary content may be content that is matched to the primary content and therefore detected to be relevant to the user. Detection of primary content and matching to supplemental content may be carried out based on a comparison of entities related to the primary and supplemental content. In some embodiments, an analysis of the primary content for entities may include ordering entities according to significance in the primary content and selecting top entities for comparison. Also, in some embodiments, multiple pieces of supplemental content may be displayed to a user categorized based on entity.
Objective: Our study aims to evaluate the etiologic and clinical features of cerebral venous sinus thrombosis (CVST) in Saudi Arabia, and secondarily whether gender plays a role in CVST. Materials and Methods: Data were collected retrospectively from the stroke registry during the period from January 2008 to April 2018, and the patients with the diagnosis of CVST were identified, and data were analyzed for any gender-specific differences in clinical presentation and etiology of cerebral venous thrombosis. Results: There were 15 females while 11 males with a female:male ratio of 1.4:1. The mean age was 29.4± standard deviation 8.9 with the age range of 15–49. Headache was the most common and usually the first presenting symptoms present in 65% followed by hemiparesis and cranial nerve palsies. The first neurological examination was normal in 9/26 (34.6%) of the patients, while the common abnormality was cranial nerve palsies. Infections and trauma played an important part in risk factor analysis of our patient after the pregnancy- and hormone-related conditions. Some significant differences between the clinical presentation and risk factors among males and females were noted as age at presentation was higher in females while trauma and infections were common in male patients, although the involvement of the sinuses and response to treatment did not prove to be statistically significant. Conclusion: The results of this study were similar to the available literature with few differences. The relatively higher proportion of males in our study can be explained partly with more cases of traumatic CVST. Some important differences were noted between the risk factors and clinical presentation among genders. Large-scale prospective studies are needed to further clarify these differences.
Al-Qallaf, Danah A. A. A. Q., Tomlinson, Darren, Bell, Sandra, and McPherson, Michael
Biomarkers are molecules present in the patients' samples. They are used to detect the presence of a disease or an infection. An array of laboratory tools is used to monitor changes in the biomarker levels for diagnostic and prognostic purposes. Affimers are relatively new tools, which can be used in similar ways to commonly used antibodies with many advantages over the later. The work described in this PhD thesis has focused on a number of methodologies for the generation of Affimers against purified proteins and cell-surface molecules, with the intention of using these to detect biomarkers in cancer. To ensure the development of functional Affimer reagents against different membrane target molecules, EGFR, HER2, and HER3 were used as models to optimise the process of Affimers isolation and selection using phage display technology. In vitro production of Affimers using bacterial cells was assessed and optimised. Following optimisation, a range of Affimers that bound to EGFR, HER2, and HER3 were generated and partially characterised by different molecular applications, including immunofluorescence, immunohistochemistry, and pull-down assay. Upon characterisation, the developed reagents were not only able to identify their targets on cells and to precipitate them down from cell lysates, but also exhibited a complete inhibition of the downstream signalling activation of both EGFR and HER3. In addition, this thesis provides clear evidence of the potential of Affimers in biomarker discovery studies. After multiple rounds on non-tumourigenic (HB2) and cancerous (MDA-MB-453) breast-cell lines, eight novel anti-breast-cancer Affimers were successfully isolated and characterised. Following pull-down assay and mass spectrometry analysis, the target proteins to which these Affimers were found to bind was identified as CK18 and 19. Upon identification, the specificity of Affimers was further validated on a panel of breast cells, tissues, and on multiple breast-tissue microarrays (TMAs). There is a need to develop the knowledge to utilise this new Affimers-based technology to encourage adoption of this useful tool. With the aid of such technology, several novel detection reagents were generated, partially validated and proved to be promising tools for biomarker detection in different conventional assays.
Childhood obesity has reached epidemic proportions globally, and poses a considerable burden on a child’s short- and long-term health. Most obesity presents in the early (preschool) years, and once established tracks into later life. Therefore, identification of risk factors in the preschool period is considered critical for prevention of long-term obesity. In the United Arab Emirate (UAE), the rising prevalence of childhood obesity is of great public health concern. However, no previous study has explored risk factors for obesity in preschool children. This PhD aimed to: (i) identify risk factors for preschool obesity in the UAE (Study 1); (ii) describe dietary intake and patterns of preschool children, and explore their associations with risk of obesity (Study 2); and (iii) in a randomised controlled trial investigate the effectiveness of the ‘Eat Right Emirates’ (ERE) tool, a simple leaflet intervention designed to encourage a healthy lifestyle and prevent preschool obesity (Study 3). Study 1 showed that a longer duration of breastfeeding, and later introduction of complementary foods were associated with lower BMI z-score. Study 2 found that, compared with UK dietary guidelines, preschool children in the UAE exceeded intakes of protein, but did not meet recommended intakes for fibre. A high carbohydrate intake as a percentage of energy was associated with lower BMI z-score, whereas a high fat intake was associated with higher BMI z-score. A priori derived diet score found diets of preschool children were suboptimal, and principal component analysis identified three dietary patterns (‘traditional/health-conscious’, ‘processed/western’ and ‘convenience/snack’), which were not associated with BMI z-score. Study 3 found that the ERE tool was effective in reducing obesity risk compared to controls at 6-month follow-up. These findings, and the high compliance rate, suggest that the simple intervention is a promising approach for prevention of obesity in the UAE.
This research considers the possibility of a locally-centric design education curricula in Amman, Jordan by investigating the philosophies, theories, practices and models of curriculum and pedagogy most appropriate for design education. It describes perceptions of design and examines the possibilities for shifting these perceptions to move towards transforming design education. Jordan is a neopatriarchal society, and education re-enacts the dominant structures of the state within curriculum and pedagogy centred on the authority of the educator. This thesis argues for a decolonised design education based on a student-centred pedagogy drawn from the process and praxis curriculum models - a design education and design otherwise. Working with a range of designers, students and educators, it investigates the potential of these actors to contribute to the development of a pedagogy for design education in Jordan that is relevant to the milieu and locality. It poses the following questions: What philosophies, theories, practices, models of curriculum, and pedagogy are appropriate?; What potential shifts could this require and create?; How do we shift perceptions? This qualitative research uses interviews, focus groups, and design charrettes for data collection. Through participation and engagement with people that have most at stake in design education - designers, design educators and design students - I argue for an emancipatory design education that reflects on design beyond its traditional service-provider definition. Drawing on scholarship from design and education studies, and literature from fields such as history, decolonial studies, architecture and urbanism, political science, economics and philosophy, I argue for a curriculum model and student-centred pedagogy that considers design's role in society. Literature on Arab higher education is preoccupied with reforms to help the Arab region build a knowledge-society without considering the role of curriculum models and pedagogy nor addressing power structures. In addition, within design, little literature exists on the Arab region or Jordan, leaving its design culture(s) largely undocumented. My thesis investigates design education in higher education in Jordan by concentrating on models of pedagogy and curriculum and provides an overview of Jordan's contemporary design culture.
de Oliveira, Janaina, Henriksen, Danah, Castañeda, Linda, Marimon, Marta, Barberà, Elena, Monereo, Carles, Coll, César, Mahiri, Jabari, and Mishra, Punya
International Journal of Educational Technology in Higher Education (ETHE); 2015: Vol. 12 Núm.: 2. Número especial: nous escenaris d'aprenentatge des d'una visió transformadora; p. 14-29
knowledge production, technology, learner identity, solidarity, social practices, bottom-up pedagogies, producción de conocimiento, tecnología, identidad, solidaridad, prácticas sociales, pedagogías emergentes, producció de coneixement, tecnologia, identitat, solidaritat, pràctiques socials, and pedagogies emergents
This paper identifies trends in the emerging models of knowledge production available in our society. We suggest it is crucial not only to be aware of these emerging models but also to be open to opportunities and possibilities that may still develop. We consider how people may express different levels of solidarity and commitment to these trends and models in their information consumption and distribution processes. We discuss how educators are now engaging in profound pedagogical renewal by expressing deeper levels of solidarity and commitment to knowledge production and educational projects through professional and personal interactions. These interactions are producing pedagogical models that allow both teachers and learners to become knowledgeable while simultaneously breaking away from domain conventions. These bottom-up pedagogies foster creativity, collaboration and the use of new digital tools. They are driven by learner interests and, as such, have the potential to bring the joy back into the learning process. Finally, we argue that emerging models of knowledge construction mediated by ICT provide new cultural landscapes and ecologies of learning that disrupt traditional inscriptions of individual identities and racial-cultural affinities. En este artículo, se identificarán algunos modelos y tendencias emergentes en la producción de conocimiento. Se hará hincapié especialmente en cómo los individuos implicados en los procesos de consumo y de distribución de la información expresan diferentes niveles de solidaridad y de compromiso, y se sugerirá que es crucial que las personas no solo conozcan estos procesos, sino que también estén abiertas a otros modelos, oportunidades y posibilidades que, dadas las condiciones sociotecnológicas y comunicativas actuales, aún deben desarrollarse. Se abordará con especial interés el ámbito de la educación, puesto que se entiende que los educadores están participando de forma comprometida en una profunda renovación pedagógica a través de proyectos compartidos cimentados en interacciones profesionales y personales facilitadas por las redes. Estas interacciones favorecen la emergencia de modelos pedagógicos que permiten a profesores y a alumnos convertirse en expertos al mismo tiempo que rompen con muchas convenciones epistemológicas clásicas. Estas pedagogías generadas de abajo arriba no solo fomentan la creatividad y la colaboración, y se sustentan en el uso de nuevas herramientas digitales, sino que las promueven e impulsan los intereses del alumnado, y por ello, tienen el potencial suficiente para devolverle la alegría al proceso de aprendizaje. Por último, se argumentará que los modelos emergentes en la construcción del conocimiento a través de las TIC ofrecen nuevos paisajes culturales y ecologías de aprendizaje que trastocan las inscripciones tradicionales de las identidades individuales y las afinidades raciales y culturales. En aquest article, s’identificaran alguns models i tendències emergents en la producció de coneixement. Es farà èmfasi especialment en com els individus implicats en els processos de consum i de distribució de la informació expressen diferents nivells de solidaritat i de compromís, i se suggerirà que és crucial que les persones no només coneguin aquests processos, sinó que també estiguin obertes a altres models, oportunitats i possibilitats que, donades les condicions sociotecnològiques i comunicatives actuals, encara s’han de desenvolupar. S’abordarà amb especial interès l’àmbit de l’educació, ja que s’entén que els educadors estan participant de forma compromesa en una profunda renovació pedagògica a través de projectes compartits cimentats en interaccions professionals i personals facilitades per les xarxes. Aquestes interaccions afavoreixen l’emergència de models pedagògics que permeten a professors i a alumnes convertir-se en experts al mateix temps que trenquen amb moltes convencions epistemològiques clàssiques. Aquestes pedagogies generades d’avall cap amunt no només fomenten la creativitat i la col·laboració i se sustenten en l’ús de noves eines digitals, sinó que les promouen i impulsen els interessos de l’alumnat, i per això, tenen el potencial suficient per tornar l’alegria al procés d’aprenentatge. Per acabar, s’argumentarà que els models emergents en la construcció del coneixement a través de les TIC ofereixen nous paisatges culturals i ecologies d’aprenentatge que trastoquen les inscripcions tradicionals de les identitats individuals i les afinitats racials i culturals.
Azra Zafar, Rizwana Shahid, Saima Nazish, Danah Aljaafari, Fahd Ali Alkhamis, Sadiq Alsalman, Amir H Msmar, Badaruddin Abbasi, Abdulla A Alsulaiman, and Majed Alabdali
Journal of Neurosciences in Rural Practice, Vol 10, Iss 1, Pp 106-112 (2019)
Antiepileptic drugs, epilepsy, nonadherence, Neurosciences. Biological psychiatry. Neuropsychiatry, and RC321-571
Context: Medication nonadherence is a significant barrier in achieving seizure freedom in patients with epilepsy. There is a deficiency of data about the reasons for nonadherence in Saudi population. Aims: The aim of this study is to prove the existence of nonadherence to antiepileptic drugs (AEDs) in patients with epilepsy and identify the responsible factors. Setting and Design: This is a prospective, cross-sectional study carried in the Department of Neurology at King Fahd Hospital of the University affiliated with Imam Abdulrahman Bin Faisal University. Subjects and Methods: Patients of all ages diagnosed to have epilepsy as mentioned in their medical record and taking antiepileptic medications were interviewed using a questionnaire. Statistical Analysis Used: Statistical analysis was performed using IBM Statistical Package for the Social Sciences version 21 (IBM Corp., Armonk, NY, USA). Statistical significance was defined as two-tailed with a P ≤ 0.05. Results: Among 152 participants, 52.6% were male and 47.4% were female. Mean age of the patients was 28 ± 14.3 (mean ± standard deviation) years. Of 152 patients, 48.7% were found to be nonadherent to their AED therapy. The most commonly identified factor was forgetfulness. Nonadherence was significantly associated with poor seizure control (P = 0.002). Conclusion: Nonadherence to the AED is common among patients with epilepsy and affects seizure control adversely.