Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2007, Vol. 48 Issue 21, p3709-3712. 4p.
IRON, FLUORESCENCE, AMIDES, and METAL ions
Abstract: A novel compound FD1 was demonstrated as a turn-on fluorescent sensor for imaging of iron(III) ion in biological samples. Based on the spirolactam (nonfluorescence) to ring-open amide (fluorescence) equilibrium, FD1 exhibited high selectivity and sensitivity for Fe3+ over other metal ions. Moreover, fluorescent microscopy experiments further established that FD1 could be used for sensing Fe3+ within living cells. [Copyright &y& Elsevier]