Kuchar, S., Mozes, S., Rybosova, Z., Novakova, V., and Michalov, M.
Physiology and behavior (USA), Oct 1992, v. 52(4) p. 695-698.
Physiology of human nutrition, Diet and diet-related diseases, MALNUTRITION, ENFANT EN BAS AGE, NUTRITION HUMAINE, METABOLISME DES LIPIDES, TISSU ADIPEUX, ARN, ENCEPHALE, NERF, TISSU ANIMAL, RAT, ANIMAL NOUVEAU NE, MALNUTRICION, BEBES, NUTRICION HUMANA, METABOLISMO DE LIPIDOS, TEJIDO ADIPOSO, CEREBRO, NERVIOS, TEJIDOS ANIMALES, RATA, and ANIMAL RECIEN NACIDO
references The RNA content of the ventromedial hypothalamus (VMH) and lateral hypothalamic area (LHA) neurons, and the epididymal, retroperitoneal, and liver fat content of 150-day-old male rats submitted to neonatal undernutrition, were investigated. The neonatal undernutrition was carried out by two different ways. First, by reducing the litters to two pups per nest from birth to weaning. The pups from normal litters (eight pups/nest) served as controls. Secondly, by separating half of the pups (four pups) from normal litters for 8 h daily during the first 5 postnatal days. The remaining nonseparated pups served as their controls. The data show that both groups of early undernourished pups had a significantly increased RNA content in the VMH neurons (RNA content in the LHA neurons was unchanged) and a significantly decreased epididymal, retroperitoneal, and liver fat content in comparison with their controls. The results indicate that early undernutrition leads to a permanent increase in the functional activity of VMH and alteration in fat metabolism in rats