Wacker, Warren E. C., Haynes, Harley, Druyan, Robert, Fisher, Waldo, and Coleman, Joseph E.
JAMA: Journal of the American Medical Association; December 1965, Vol. 194 Issue: 11 p1231-1233, 3p
Abstract
In the course of phylogenetic evolution, the substrate specificity of alcohol dehydrogenase, the enzyme which detoxicates ethyl alcohol, has apparently broadened. Thus, while the enzyme from yeast oxidizes ethyl alcohol and only a few other alcohols,1 the enzyme of the horse liver is capable of oxidizing a range of other alcohols.1,2 The human enzyme has an even wider range,3 since contrary to the horse enzyme it oxidizes both ethyl alcohol and ethylene glycol. While chemically ethylene glycol is very similar to ethyl alcohol, both these compounds are toxic to man. Detailed studies of the enzymatic oxidation of ethylene glycol demonstrate that ethyl alcohol, the natural substrate, is a potent competitive inhibitor of the oxidation of ethylene glycol.3 Hence, low concentrations of ethyl alcohol prevent the oxidation of large concentrations of ethylene glycol.These biochemical features of the catalytic behavior of human-liver alcohol dehydrogenase have served as
Sheppard, Haynes W., Winkelstein Jr, Warren, Osmond, Dennis, Moss, Andrew R., Sheppard, H W, Winkelstein, W Jr, Osmond, D, and Moss, A R
JAMA: Journal of the American Medical Association; 10/23/91-10/30/91, Vol. 266 Issue 16, p2221-2221, 1p
Subjects
T cells, HIV-positive persons, AIDS, AIDS epidemiology, COMPARATIVE studies, HOMOSEXUALITY, RESEARCH methodology, MEDICAL cooperation, RESEARCH, RESEARCH funding, EVALUATION research, DISEASE incidence, DISEASE prevalence, and LEUKOCYTE count
Abstract
Presents a letter to the editor in the October 23, 1991 issue of the 'Journal of the American Medical Association,' about the U.S. Centers for Disease Control and Prevention's proposal that the CD4[sup +] T-lymphocyte cell count in a person seropositive for HIV be added to the list of defining conditions for AIDS.
