articles+ search results

PARTITIONS (Mathematics), MATHEMATICIANS, CONFERENCES & conventions, ODD numbers, INTEGERS, LOGICAL prediction, and GENERALIZATION

Euler's identity equates the number of partitions of any non-negative integer n into odd parts and the number of partitions of n into distinct parts. Beck conjectured and Andrews proved the following companion to Euler's identity: the excess of the number of parts in all partitions of n into odd parts over the number of parts in all partitions of n into distinct parts equals the number of partitions of n with exactly one even part (possibly repeated). Beck's original conjecture was followed by generalizations and so-called "Beck-type" companions to other identities. In this paper, we establish a collection of Beck-type companion identities to the following result mentioned by Lehmer at the 1974 International Congress of Mathematicians: the excess of the number of partitions of n with an even number of even parts over the number of partitions of n with an odd number of even parts equals the number of partitions of n into distinct, odd parts. We also establish various generalizations of Lehmer's identity, and prove related Beck-type companion identities. We use both analytic and combinatorial methods in our proofs. [ABSTRACT FROM AUTHOR]

SEXISM, MEDICAL research, CLINICAL trials, HEALTH equity, and MEDICAL specialties & specialists

Sex bias is present in clinical research resulting in disparities in the treatment of women. Our objective was to identify the prevalence of sex inclusiveness of participants in human clinical trials after the passage of National Institutes of Health (NIH) and United States Congress policies in 2015 and 2016 to increase female enrollment in clinical research. We performed an observational analysis of data from registered clinical trials published in three high-impact biomedical journals from January 1, 2015 to December 31, 2019. One thousand four hundred and forty two manuscripts with 4,765,783 human subjects were included for analysis. Significantly more males (56%) than females (44%) were included in all three journals (P < 0.0001). Sex matching ≥ 80% was found in 24.6% of publications. Industry funded 43.7% of all studies enrolling significantly more males than females (60.8% versus 39.2%, P < 0.0001). NIH funded 10.2% of studies enrolling significantly more females than males (52.7% versus 47.3%, P < 0.0001). North America and Europe contributed 82.6% of the studies with each enrolling significantly more males than females (P < 0.0001). The United States was the country contributing the most studies (36.1%), enrolling significantly more males than females (55.5% versus 45.5%, P < 0.0001). Cardiovascular disease was the subject area of the most manuscripts among medical specialties (19%), enrolling significantly more males than females (64.9% versus 35.1%, P < 0.0001). Studies analyzed by clinical trial phase, type, trial, and allocation enrolled significantly more males than females (P < 0.0001). Sex bias remains prevalent in human clinical research trials. Improvements have been made in NIH-funded clinical trials; however, this constitutes a small percentage of overall studies. [ABSTRACT FROM AUTHOR]

The Sino-U.S. relations tumbled during the Trump Administration. The talk of decoupling permeated the decision-making circle in Washington D.C. Many factors have contributed to the free fall. The roles Congress has played are undoubtedly one of them. Based on the new institutionalist approach, this study provides three analyses of recent China-related legislative activities. First, the historical analysis of legislative data illustrates a surge in congressional activism on China-related legislative activities. Second, the content analysis reveals some of the triggers in the deterioration of bilateral relations in recent years. Third, the political analysis of the critical congressional players and the structures and procedures Congress created provides some insight into the domestic and political logic of the congressional crusade against China. Finally, the paper ends with assessing the impact of the surge in Congressional activism on the new Biden Administration. [ABSTRACT FROM AUTHOR]

Spinocerebellar ataxia type 1 (SCA1) is one of nine polyglutamine (polyQ) diseases and is characterized as an adult late-onset, progressive, dominantly inherited genetic disease. SCA1 is caused by an increase in the number of CAG repeats in the ATXN1 gene leading to an expanded polyQ tract in the ATAXIN-1 protein. ATAXIN-1 is broadly expressed throughout the brain. However, until recently, SCA1 research has primarily centered on the cerebellum, given the characteristic cerebellar Purkinje cell loss observed in patients, as well as the progressive motor deficits, including gait and limb incoordination, that SCA1 patients present with. There are, however, also other symptoms such as respiratory problems, cognitive defects and memory impairment, anxiety, and depression observed in SCA1 patients and mouse models, which indicate that there are extra-cerebellar effects of SCA1 that cannot be explained solely through changes in the cerebellar region of the brain alone. The existing gap between human and mouse model studies of extra-cerebellar regions in SCA1 makes it difficult to answer many important questions in the field. This review will cover both the cerebellar and extra-cerebellar effects of SCA1 and highlight the need for further investigations into the impact of mutant ATXN1 expression in these regions. This review will also discuss implications of extra-cerebellar effects not only for SCA1 but other neurodegenerative diseases showing diverse pathology as well. [ABSTRACT FROM AUTHOR]

SUBSTANCE abuse prevention, SUBSTANCE abuse -- Law & legislation, CONFIDENCE intervals, RESEARCH methodology, RULES, HEALTH outcome assessment, DESCRIPTIVE statistics, STATISTICAL sampling, POLICY sciences, CONTENT analysis, ODDS ratio, MEDICAL research, FEDERAL government, and DIFFUSION of innovations

Background and Aims: The growing body of research evidence on substance use and substance use disorder (SU/SUD) prevention could be leveraged to strengthen the intended impact of policies that address SU/SUD. The aim of the present study was to explore how research was used in United States federal legislation that emphasized SU/SUD prevention. Design: Using a mixed‐methods approach, we assessed whether the use of research predicted a bill's legislative progress. We randomly sampled 10 bills that represented different types of research keywords to examine how research was used in these bills, applying content analysis. Setting: United States Congress. Participants/Cases: Federal legislation introduced between the 101st and the 114th Congresses (1989–2017; n = 1866). Measurements The quantitative outcome measures were bills' likelihood of passing out of committee and being enacted. Qualitative outcomes included the ways research was used in legislation. Findings Bills that used any research language were 2.2 times more likely to pass out of committee (OR = 2.18; 95% CI, 1.75, 2.72) and 82% more likely to be enacted (OR = 1.82; 95% CI, 1.23, 2.69) than bills not using research language. Bills using dissemination words were 57% more likely to pass out of committee (OR = 1.57; CI, 1.08, 2.28) and analysis words were 93% more likely (OR = 1.93; 95% CI, 1.51, 2.47) than bills not using dissemination or analysis words. Research was used to (i) define the problem to justify legislative action, (ii) address the problem by providing funding, and (iii) address the problem through industry regulations. However, there was a lack of research use that targets underlying risk and protective factors. Conclusions: In the US Congress, substance use and substance use disorder prevention bills that use research language appear to be more likely to progress in the legislative cycle than bills that do not, suggesting that legislation using research may be viewed as more credible. [ABSTRACT FROM AUTHOR]

ARTIFICIAL organs and CONFERENCES & conventions

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Date	Event	Venue	Contact
6-10 September 2022	48th Annual Congress of the European Society for Artificial Organs (ESAO)	Krems, Austria
10-14 September 2022	29th International Congress of The Transplantation Society	Buenos Aires, Argentina
14-17 September 2022	33rd Annual ELSO Conference	Boston, MA, USA

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COMPUTATIONAL intelligence, COMPUTATIONAL biology, and CONFERENCES & conventions

The recently concluded European Lung Cancer Congress 2022 (ELCC22) showcased some very exciting data, with more than 200 abstracts presented during the meeting. Through this review, we focus on selected clinically relevant abstracts that in our opinion represent significant updates in the current management of non-small cell lung cancer (NSCLC). Here, we summarize the updates in surgical management, adjuvant therapy and therapy for advanced stage NSCLC and put these advances in the context of the current clinical standard of care. [ABSTRACT FROM AUTHOR]

NERVE tissue, SHEAR waves, ELASTOGRAPHY, INFORMATION measurement, and PATIENT positioning

• High methodological heterogeneity was found across 375 shear wave elastography (SWE) articles due to lack of data collection and reporting standards. • Two surprising findings were that most studies did not contain information on depth of measurement or use of surface electromyography. • Adherence to our reporting recommendations/checklist will advance the diagnostic and prognostic capabilities of this technology. This scoping review of shear wave elastography (SWE) articles in musculoskeletal soft tissue and nerve research demonstrates methodological heterogeneity resulting from a lack of standardized data collection and reporting requirements. Seven literature databases were searched for original articles published in English from 2004–2020 that examine human skeletal muscles, tendons, and nerves in vivo. Although 5,868 records were initially identified, only 375 reports met inclusion criteria. Of the 375 articles, 260 examined 89 unique muscles, 94 examined 14 unique tendons, and 43 examined 8 unique nerves. Cohorts were often small (n = 11–20) and young (mean = 20–29 years), and participants were typically tested in the prone position. Regarding equipment, a variety of ultrasound systems (n = 11), ultrasound models (n = 18), and transducers (n = 19) were identified. Only 11% of articles contained information on the use of electromyography to confirm absence of muscle activity, and only 8% reported measurement depth. Since musculoskeletal soft tissue and nerve stiffness can vary significantly based on data collection methods, it is essential to standardize SWE collection and reporting procedures. This will allow SWE to serve as a valid and reproducible tool for assessing tissue pathology, disease progression, and response to intervention within a variety of musculoskeletal and nerve-related disorders. [ABSTRACT FROM AUTHOR]

VETO, WEAPONS exports & imports, STOCK prices, and DIPLOMATIC & consular service

On October 2nd, 2018, Jamal Khashoggi, a journalist and critic of the Saudi Arabian regime, disappeared after a visit to the Saudi Arabian consulate in Turkey nd was most likely murdered shortly afterwards. After this incident, a period of uncertainty started about whether or not a major arms deal that was signed between the United States and Saudi Arabia would still going to be approved by Congress or in turn will be rejected. The main findings presented in this study clearly demonstrate that the uncertainty surrounding the deal caused a significant drop in the daily return on the equity prices of US defense firms. This result suggests that investors believe that it is very likely that the major arms deal will be blocked by Congress in the short-run thereby reducing the business perspectives of the US defense-related industry. Besides these findings also imply that investors expect that the US president will not use its veto power or make permanently use of the exemption clause provided in the US arms trade legislation. [ABSTRACT FROM AUTHOR]

TRIALS (Law), CONVERSATION analysis, and LINGUISTICS

Through a 'micro' and 'macro' level analysis, this study focuses on elements of questioning and question design in the Senate Judiciary hearing conducted for Supreme Court nominee Brett Kavanaugh. Specifically, two lines of questioning are analyzed: that of Kamala Harris, D. California, and that of Ted Cruz, R. Texas. Through an analysis that builds heavily on prior research that uses Conversation Analysis (CA) to understand the news interview, this study attempts to expand such research to institutional talk done by politicians in Congress. The analysis portion of the paper investigates, on a 'micro' level, the linguistic elements at play in each line of questioning. In the discussion section, a 'macro' level analysis situates the findings of this paper within the broader US political climate among the public and in terms of the growing conservatism of the Supreme Court. [ABSTRACT FROM AUTHOR]

MEDICAID beneficiaries, MEDICAL care, MEDICAL personnel, MILITARY hospitals, MEDICAL quality control, MILITARY dependents, and UNITED States armed forces

Thus, it is reasonable to conclude that those receiving direct care were younger, had a highe proportiong of females, and were healthier than MHS beneficiaries receiving private care or the general civilian population. Costs for breast cancer care in the Military Health System: an analysis by benefit type and care source. The role of direct care federal health systems, including the Veterans Health Administration (VHA), the Indian Health Service (IHS), and the Military Health System (MHS), have long been a topic of debate in Congress and policy circles concerning access, cost, and quality. For the comparison between direct care and private care, those receiving direct care were also less senior in their military careers. [Extracted from the article]

In the weeks before it declared independence, the Continental Congress was already at work building the institutions it would need to maintain the new republic. In June 1776, a committee was appointed to explore linking the 13 provincial legislatures in a Confederation. Another was tasked to consider how the United Colonies, soon to become the United States of America, could protect itself against Great Britain by striking treaties with European powers. But before these committees were formed, the Congress first appointed a "Committee on Spies" to deal with a chronic problem: how the law should treat "persons giving intelligence to the enemy, or supplying them with provisions." The resolutions that were the Committee's answer re-defined the law of treason, substituting a new notion of American sovereignty in place of the allegiance that had been owed the British monarchy. They drew a bright line between those lukewarm or hostile to the Revolution, and the new American identity embraced by its supporters. And they placed limits on the military's ability to try civilians charged with spying by court-martial, setting a precedent for American military justice. This paper argues that the impact of the Committee's work has been under-examined, as has been its influence on George Washington and the evolving American policy of military deference to civil authority in matters of justice. It explores how the Committee's "Resolves" prompted the creation of new treason statutes in nearly all the United "States," which in turn prompted hundreds of prosecutions. The paper revises scholars' views on how and why the Spies Committee was formed. It traces the Committee's contribution to language incorporated by the Declaration of Independence and in the Constitution's article on treason, drafted 13 years later by a scholar who had been a Spies Committee member. [ABSTRACT FROM AUTHOR]

The Constitution's division of powers from which E. Corwin famously asserted an "invitation to struggle" in the making of US foreign policy (1957, 171) has become overshadowed by partisan conflict in the contemporary era. Although much of the extant literature points to Congress's subsidiary role in foreign policy relative to the presidency-centered model, the appeal of partisanship has worked to further deepen congressional abrogation and extend presidential unilateralism (Lindsay in Congress and the politics of U.S. Foreign Policy. The Johns Hopkins University Press, Baltimore, 1994; Kriner in After the rubicon: congress, presidents, and the politics of waging war. University of Chicago Press, Chicago, 2010; Potter in Pres Stud Quart 46(4):849–867, 2016). Our analysis illustrates a puzzle. On one hand, there are growing levels of majority support in the USA for political leadership on the world stage. But on the other hand, our analysis of congressional behavior such as voting, lawmaking, and oversight shows relatively clear patterns of congressional decline—Congress no longer exercises much of its power in foreign affairs, neither in form or substance. Partisan incentives for congressional abdication to the presidency carry at least one additional risk we point to: Congressional capitulation from its constitutional duty places democracy in the jeopardy that the Framers' design was intended to prevent. [ABSTRACT FROM AUTHOR]

VISIBLE spectra, PIEZOELECTRIC thin films, ORGANIC water pollutants, PHOTOCATALYSTS, CATALYTIC activity, PHOTOCATALYSIS, and RHODAMINE B

Piezocatalysis is realized in hydrothermally-derived CuBi 2 O 4 nanorods for the first time. Through bi-harvesting of photo- and vibration energies, 98.1% Rhodamine B (RhB) can be degraded, which is significantly higher than ∼38.7% from single photocatalysis and ∼72.8% from single piezocatalysis. The enhanced catalytic activity is attributed to the intensified separation of electron-hole under the piezoelectric potential. Results show that CuBi 2 O 4 is promising catalyst to decompose the organic pollutant in nature water. •Piezocatalysis activity has been realized in CBO for the first time. • Harvesting light and vibration energy has been realized in CBO. • Bi-catalytic degradation of RhB is higher than photocatalysis or piezocatalysis. • h + become the most important active specie instead of ·OH. [ABSTRACT FROM AUTHOR]

Background: While substance use disorders (SUD) disproportionately impact people with HIV (PWH), HIV clinics inconsistently provide evidence-based medications for addiction treatment (MAT). Patient receptivity to MAT is critical to enhance addiction treatment in these settings. However, we know little from patients about how to best integrate MAT into HIV clinics.Methods: This qualitative study used four focus groups informed by the Promoting Action on Research Implementation in Health Services framework to identify barriers and facilitators to receiving opioid, alcohol, and tobacco use disorder care in HIV clinics. The study population included 28 patients with HIV and SUD receiving care at one of four HIV clinics in the northeastern United States. Focus groups were recorded and transcribed for content analysis. The study also performed a brief survey assessing demographics and behaviors.Results: Focus groups revealed several major themes related to MAT in HIV clinics. Barriers included stigma around MAT, knowledge deficits about available MAT options and the impact of substance use on PWH, concerns about medication side effects, substance use screening without adequate clinician follow-up, and peers who discouraged MAT. Facilitators included recognition of substance use as a threat to overall health, integrated care from HIV clinicians, and support for addiction treatment from peers with lived experience.Conclusions: Efforts to enhance MAT in HIV clinics should include patient education to help them recognize addiction as a chronic disease with available medication treatment options; clinician and staff training to promote integrated, multidisciplinary screening and treatment; and thoughtful inclusion of peers with lived experience. [ABSTRACT FROM AUTHOR]

CANCER fatigue, LUPUS nephritis, QUALITY of life, AUTOIMMUNE diseases, LITERATURE reviews, FATIGUE (Physiology), and SYSTEMIC lupus erythematosus

Background: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease characterized by abnormal B-cell activation and the presence of autoantibodies, which can result in organ damage. Lupus nephritis (LN) is the most common severe organ manifestation of SLE and may result in impaired kidney function. However, there is limited research on the health-related quality of life (HRQoL) burden amongst patients with LN. The objective of this systematic literature review was to assess the HRQoL, fatigue and health utilities associated with LN. Methods: A structured literature search (GSK Study 212980) of the MEDLINE and Embase databases was conducted in July 2019 and updated September 2021. Relevant international congress abstracts from 2016 to 2021 were searched, and gray literature searches and keyword-based searches in PubMed, Google, and Google Scholar were also conducted. Results were screened according to predefined criteria and data on the outcomes of interest were extracted. A quantitative analysis was conducted to supplement the narrative review, to provide 36-item Short Form survey (SF-36) estimates, and to determine variation by prognostic factors. Results: Of 1155 articles identified, 26 studies for a total of 3440 patients were included. Patients with LN showed poorer HRQoL and more fatigue than healthy controls/the general population, although these were similar between patients with SLE with and without LN. HRQoL was worse in patients with LN Class III/IV or with active disease. Fatigue was generally reported as the most burdensome symptom and was associated with lower HRQoL and increased treatment dissatisfaction. During induction treatment, HRQoL and fatigue were improved with mycophenolate mofetil versus cyclophosphamide. HRQoL improved over time with treatment amongst patients with active LN. Very limited data were identified assigning utilities to health states for cost-effectiveness analysis. Nine studies were considered for quantitative analysis of baseline SF-36 scores. The analysis suggested that LN has a significant impact across all SF-36 domains, with the lowest scores in the general health perceptions and role-physical domains and physical component summary. Conclusions: There is a large HRQoL burden in patients with LN, in particular regarding symptoms of fatigue. Future research should focus on investigating fatigue severity and health utilities in LN. [ABSTRACT FROM AUTHOR]

BLADDER obstruction, GASTRIC outlet obstruction, OVERACTIVE bladder, AMINO acids, PEPPERS, PATHOLOGY, and PATIENT satisfaction

Objective: To evaluate the efficacy and tolerability of a complementary and alternative medicine (CAM) called Kubiker (Naturmed, Montegranaro, FM, Italy), consisting of vitamins (C and D), herbal products (cucurbita maxima, capsicum annum, polygonum cuspidatum), and amino acid L-Glutamine, as first line treatment of (OAB) Materials and methods: According to institutional protocols, data on patients addressing to a tertiary referral centre for OAB symptoms were recorded. OAB was evaluated through validated questionnaires including ICIQ-SF, USS, and OAB-q-SF. Patients with previous antimuscarinic or β3 agonist treatment, neurological disease or pathologies which may mimic OAB, including infections, were excluded. Only unobstructed patients were considered and were given CAM twice daily for 12 weeks. After treatment, symptoms were re-evaluated repeating previous questionnaires and PGI-I was given to evaluate perceived improvement. Results: A total of 41 patients were evaluated and 35 respected inclusion criteria and were enrolled. All subjects had a full compliance and adherence with CAM medication intake. The median patient's age was 65 (56–73). Male were 8 (22.9%) while females were 27 (77.1%). Median baseline OAB-q SF and ICIQ-SF scores were 18 (15–25) and 9 (6–13), respectively. After treatment, 85.7% patients had a clinical benefit, with a significant reduction of OAB symptoms, also according to USS (p < 0.01). The median OAB-q SF and ICIQ-SF scores were 10 (7–15) and 6 (0–8) (p < 0.01). CAM was successful with an improvement in subjective patient's satisfaction, with a median PGI-I score of 2 (1–3). Patients (men and women) who still had UUI after 3 months CAM medication were eight (22.8%), and among them, those who did not refer any therapeutic benefit were five (14.3%) Conclusions: According to our study, CAM may be useful medication for a first line treatment of uncomplicated idiopathic OAB cases, providing a nonnegligible effects on symptoms. However, further studies are mandatory to draw definitive conclusions [ABSTRACT FROM AUTHOR]

SOLAR energy, LIGHT absorption, CONDUCTION bands, CHARGE exchange, ELECTRIC fields, and SOLAR cells

[Display omitted] • The maximum PCE of the novel 2D Sc 2 CCl 2 /SiS 2 heterostructure can reach 23.20%. • Strain and interlayer distance deviation must be avoided because they weaken PCEs. • Small CBO and favorable bandgap are the reasons for high PCEs of the heterostructure. Two-dimensional (2D) heterostructures are effective devices for converting solar energy into electrical energy. However, the highly efficient ones are difficult to screen. Here, we construct four configurations of 2D heterostructures by using Sc 2 CCl 2 and SiS 2 monolayers. On the basis of the first-principles calculations, we optimize geometrical structures, confirm the energy and thermal stabilities, calculate the electronic properties and optical absorptions, determine the solar power conversion efficiency (PCE), and explore the effect of strain engineering. The results indicate that the four configurations exhibit similar type-II band alignments with direct bandgaps, and the built-in electric fields support the electron transfer from the Sc 2 CCl 2 monolayer to the SiS 2 one. In addition, the highest predicted PCE of the configurations can reach 23.20%, which can be attributed to the small conduction band offset with a favorable bandgap of 1.49 eV that leads to excellent optical absorption in the range of visible and ultraviolet lights. These findings provide theoretical support for developing efficient solar cells and photodetectors by employing the Sc 2 CCl 2 /SiS 2 heterostructure. [ABSTRACT FROM AUTHOR]