BRAIN, CEREBRAL ventricles, CENTRAL nervous system tumors, CEREBELLUM, HEMANGIOMAS, HOSPITALS, RESEARCH methodology, CASE studies, SEX distribution, MENINGES, CANCER of unknown primary origin, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, and TUMORS
Objectives Hemangioblastoma refers to a benign vascular neoplasm that comprises stromal and capillary cells. Based on the classification of nervous system tumors proposed by WHO, hemangioblastomas are classified as Grade I meningeal tumors of uncertain origin. These tumors are found almost exclusively in the central nervous system (CNS) and account for 0.9% to 2.1% of all primary CNS tumors. Materials & Methods In this descriptive retrospective study, the archives of pathology reports were reviewed in the Department of Pathology of Shohada-e-Tajrish Hospital, Tehran, Iran and patients with definite diagnosis of hemangioblastoma made through histopathological examinations during 2004-2014 were identified. Age, gender and the location of tumor were extracted from the medical records and entered into SPSS statistical software v.22 for analysis. Results Thirty patients including 16 males (53.3%) and 14 females (46.7%) were identified. The mean age of the patients was calculated to be 41.2±13.47 yr, ranging from 19 to 62 yr old. The majority of lesions had been found in the cerebellum of the patients (93.3%); only one had occurred in the cerebrum (3.3%) and another in the fourth ventricle (3.3%). Conclusion Cerebellum is the most commonly affected location in patients with CNS hemangioblastomas, and a male preponderance is observed in these cases. [ABSTRACT FROM AUTHOR]
SAINT Bernard dog, ATAXIA, AUTOPSY, BRAIN, GLIAL fibrillary acidic protein, and VIMENTIN
Summary: A 6-year-old, neutered male Saint Bernard dog was presented with a 1-month history of ataxia, hypermetria and head tilt. High-field magnetic resonance imaging revealed a mass in the cerebellar vermis. During necropsy examination, a cream-coloured irregular area was observed in the cerebellar white matter. Microscopically, the mass comprised a diffuse neoplastic proliferation of spindle cells with oval pleomorphic nuclei in the white and grey matter of the cerebellum and pons and in the subpial area. Neoplastic infiltration was not found in the cerebrum. Immunohistochemistry revealed that the neoplastic cells were positive for vimentin and partially positive for glial fibrillary acidic protein. Based on these findings, the neoplastic lesion was diagnosed as gliomatosis cerebelli, without involvement of the cerebrum. [ABSTRACT FROM AUTHOR]
The article discusses a study which investigated the clinical and pathological features of coenurosis diagnosed in calves during slaughterhouse inspection. The infected animals have exhibited depression, uncontrolled movements, inability to swallow and impaired vision. Degenerative changes in neurons were also reported in the calves. Findings revealed a non purulent meningoencephalitis in the cerebellum of the first animal and in the cerebrum of the two other calves. Severe hyperaemia and perivascular cuffing were also found in the vessels of the calves, along with infiltrates with mononuclear cells and thickening of meninges.
BRAIN, RADIOGRAPHY, GENETIC disorder diagnosis, BRAIN stem, CEREBELLUM, GENES, GENETIC counseling, GENETIC disorders, MAGNETIC resonance imaging, NURSE practitioners, NURSING specialties, PHYSICAL diagnosis, PRENATAL diagnosis, WORLD Wide Web, INFORMATION resources, PHENOTYPES, SYMPTOMS, and PROGNOSIS
Abstract: Joubert syndrome (JS) and related disorders (JSRD) are rare autosomal recessive disorders typified by a distinctive cerebellar and brainstem malformation. The diagnosis of JSRD requires the neuroradiological “molar tooth sign” found on magnetic resonance imaging. Many children affected with the disorder die in infancy before diagnosis. Rare diseases or syndromes can pose unique challenges for primary care providers who participate in the day-to-day care of chronically ill and physically and mentally challenged children. This article discusses JS and JSRD to provide insight for primary care providers caring for these special children and adults. [Copyright &y& Elsevier]
SHIH tzu, MAMMARY gland cancer, CANCER in animals, AUTOPSY, BRAIN, CEREBELLUM, and DISEASES
The article discusses a study which describes the case of a 10-year-old female spayed Shih Tzu dog, diagnosed with inflammatory mammary carcinoma (IMC). IMC is a specific type of rare, very aggressive, and highly metastatic mammary cancer that affects both human beings and dogs. The necropsy revealed brain metastasis of mammary neoplastic cells in tissues of the dog's cerebrum and cerebellum.