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1. HNF1B deletions in patients with young-onset diabetes but no known renal disease [2013]

  • Oram, R. A., Ellard, S., Hattersley, A. T., Stals, K., Shepherd, M. H., and Edghill, E. L.
  • DIABETIC MEDICINE.

2. Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest [2020]

  • Sparks, Michael E., Bansal, Raman, Benoit, Joshua B., Blackburn, Michael B., Chao, Hsu, Chen, Mengyao, Cheng, Sammy, Childers, Christopher, Dinh, Huyen, Doddapaneni, Harsha V., Dugan, Shannon, Elpidina, Elena N., Farrow, David W., Friedrich, Markus, Gibbs, Richard A., Hall, Brantley, Han, Yi, Hardy, Richard W., Holmes, Christopher J., Hughes, Daniel S. T., Ioannidis, Panagiotis, Cheatle Jarvela, Alys M., Johnston, J. S., Jones, Jeffery W., Kronmiller, Brent A., Kung, Faith, Lee, Sandra L., Martynov, Alexander G., Masterson, Patrick, Maumus, Florian, Munoz-Torres, Monica, Murali, Shwetha C., Murphy, Terence D., Muzny, Donna M., Nelson, David R., Oppert, Brenda, Panfilio, Kristen A., Paula, Débora P., Pick, Leslie, Poelchau, Monica F., Qu, Jiaxin, Reding, Katie, Rhoades, Joshua H., Rhodes, Adelaide, Richards, Stephen, Richter, Rose, Robertson, Hugh M., Rosendale, Andrew J., Tu, Zhijian J., Velamuri, Arun S., Waterhouse, Robert M., Weirauch, Matthew T., Wells, Jackson T., Werren, John H., Worley, Kim C., Zdobnov, Evgeny M., and Gundersen-Rindal, Dawn E.
Abstract
Background Halyomorpha halys (Stål), the brown marmorated stink bug, is a highly invasive insect species due in part to its exceptionally high levels of polyphagy. This species is also a nuisance due to overwintering in human-made structures. It has caused significant agricultural losses in recent years along the Atlantic seaboard of North America and in continental Europe. Genomic resources will assist with determining the molecular basis for this species’ feeding and habitat traits, defining potential targets for pest management strategies. Results Analysis of the 1.15-Gb draft genome assembly has identified a wide variety of genetic elements underpinning the biological characteristics of this formidable pest species, encompassing the roles of sensory functions, digestion, immunity, detoxification and development, all of which likely support H. halys’ capacity for invasiveness. Many of the genes identified herein have potential for biomolecular pesticide applications. Conclusions Availability of the H. halys genome sequence will be useful for the development of environmentally friendly biomolecular pesticides to be applied in concert with more traditional, synthetic chemical-based controls.

3. Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest [2020]

  • Michael E. Sparks, Raman Bansal, Joshua B. Benoit, Michael B. Blackburn, Hsu Chao, Mengyao Chen, Sammy Cheng, Christopher Childers, Huyen Dinh, Harsha Vardhan Doddapaneni, Shannon Dugan, Elena N. Elpidina, David W. Farrow, Markus Friedrich, Richard A. Gibbs, Brantley Hall, Yi Han, Richard W. Hardy, Christopher J. Holmes, Daniel S. T. Hughes, Panagiotis Ioannidis, Alys M. Cheatle Jarvela, J. Spencer Johnston, Jeffery W. Jones, Brent A. Kronmiller, Faith Kung, Sandra L. Lee, Alexander G. Martynov, Patrick Masterson, Florian Maumus, Monica Munoz-Torres, Shwetha C. Murali, Terence D. Murphy, Donna M. Muzny, David R. Nelson, Brenda Oppert, Kristen A. Panfilio, Débora Pires Paula, Leslie Pick, Monica F. Poelchau, Jiaxin Qu, Katie Reding, Joshua H. Rhoades, Adelaide Rhodes, Stephen Richards, Rose Richter, Hugh M. Robertson, Andrew J. Rosendale, Zhijian Jake Tu, Arun S. Velamuri, Robert M. Waterhouse, Matthew T. Weirauch, Jackson T. Wells, John H. Werren, Kim C. Worley, Evgeny M. Zdobnov, and Dawn E. Gundersen-Rindal
  • BMC Genomics, Vol 21, Iss 1, Pp 1-26 (2020)
Subjects
Brown marmorated stink bug genome, Pentatomid genomics, polyphagy, chemoreceptors, odorant binding proteins, opsins, Biotechnology, TP248.13-248.65, Genetics, and QH426-470
Abstract
Background Halyomorpha halys (Stål), the brown marmorated stink bug, is a highly invasive insect species due in part to its exceptionally high levels of polyphagy. This species is also a nuisance due to overwintering in human-made structures. It has caused significant agricultural losses in recent years along the Atlantic seaboard of North America and in continental Europe. Genomic resources will assist with determining the molecular basis for this species’ feeding and habitat traits, defining potential targets for pest management strategies. Results Analysis of the 1.15-Gb draft genome assembly has identified a wide variety of genetic elements underpinning the biological characteristics of this formidable pest species, encompassing the roles of sensory functions, digestion, immunity, detoxification and development, all of which likely support H. halys’ capacity for invasiveness. Many of the genes identified herein have potential for biomolecular pesticide applications. Conclusions Availability of the H. halys genome sequence will be useful for the development of environmentally friendly biomolecular pesticides to be applied in concert with more traditional, synthetic chemical-based controls.

4. A restricted spectrum of missense KMT2D variants cause a multiple malformations disorder distinct from Kabuki syndrome. [2020]

  • Cuvertino, S, Hartill, V, Colyer, A, Garner, T, Nair, N, Al-Gazali, L, Canham, N, Faundes, V, Flinter, F, Hertecant, J, Holder-Espinasse, M, Jackson, B, Lynch, SA, Nadat, F, Narasimhan, VM, Peckham, M, Sellers, R, Seri, M, Montanari, F, Southgate, L, Squeo, GM, Trembath, R, van Heel, D, Venuto, S, Weisberg, D, Stals, K, Ellard, S, Genomics England Research Consortium, Barton, A, Kimber, SJ, Sheridan, E, Merla, G, Stevens, A, Johnson, CA, and Banka, S
Abstract
PURPOSE: To investigate if specific exon 38 or 39 KMT2D missense variants (MVs) cause a condition distinct from Kabuki syndrome type 1 (KS1). METHODS: Multiple individuals, with MVs in exons 38 or 39 of KMT2D that encode a highly conserved region of 54 amino acids flanked by Val3527 and Lys3583, were identified and phenotyped. Functional tests were performed to study their pathogenicity and understand the disease mechanism. RESULTS: The consistent clinical features of the affected individuals, from seven unrelated families, included choanal atresia, athelia or hypoplastic nipples, branchial sinus abnormalities, neck pits, lacrimal duct anomalies, hearing loss, external ear malformations, and thyroid abnormalities. None of the individuals had intellectual disability. The frequency of clinical features, objective software-based facial analysis metrics, and genome-wide peripheral blood DNA methylation patterns in these patients were significantly different from that of KS1. Circular dichroism spectroscopy indicated that these MVs perturb KMT2D secondary structure through an increased disordered to ɑ-helical transition. CONCLUSION: KMT2D MVs located in a specific region spanning exons 38 and 39 and affecting highly conserved residues cause a novel multiple malformations syndrome distinct from KS1. Unlike KMT2D haploinsufficiency in KS1, these MVs likely result in disease through a dominant negative mechanism.

5. Taxonomy based on science is necessary for global conservation [2018]

  • Scott A., Thomson, Richard L., Pyle, Shane T., Ahyong, Miguel, Alonso-Zarazaga, Joe, Ammirati, Juan Francisco, Araya, John S., Ascher, Tracy Lynn, Audisio, Valter M., Azevedo-Santos, Nicolas, Bailly, William J., Baker, Michael, Balke, Maxwell V. L., Barclay, Russell L., Barrett, Ricardo C., Benine, James R. M., Bickerstaff, Patrice, Bouchard, Roger, Bour, Thierry, Bourgoin, Christopher B., Boyko, Abraham S. H., Breure, Denis J., Brothers, James W., Byng, David, Campbell, Luis M. P., Ceríaco, István, Cernák, Pierfilippo, Cerretti, Chih-Han, Chang, Soowon, Cho, Joshua M., Copus, Mark J., Costello, Andras, Cseh, Csaba, Csuzdi, Alastair, Culham, Guillermo, D’Elía, Cédric, d’Udekem d’Acoz, Mikhail E., Daneliya, René, Dekker, Edward C., Dickinson, Timothy A., Dickinson, Peter Paul, van Dijk, Klaas-Douwe B., Dijkstra, Bálint, Dima, Dmitry A., Dmitriev, Leni, Duistermaat, John P., Dumbacher, Wolf L., Eiserhardt, Torbjørn, Ekrem, Neal L., Evenhuis, Arnaud, Faille, José L., Fernández-Triana, Emile, Fiesler, Mark, Fishbein, Barry G., Fordham, André V. L., Freitas, Natália R., Friol, Uwe, Fritz, Tobias, Frøslev, Vicki A., Funk, Stephen D., Gaimari, Guilherme S. T., Garbino, André R. S., Garraffoni, József, Geml, Anthony C., Gill, Alan, Gray, Felipe G., Grazziotin, Penelope, Greenslade, Eliécer E., Gutiérrez, Mark S., Harvey, Cornelis J., Hazevoet, Kai, He, Xiaolan, He, Stephan, Helfer, Kristofer M., Helgen, Anneke H., van Heteren, Francisco, Hita Garcia, Norbert, Holstein, Margit K., Horváth, Peter H., Hovenkamp, Wei Song, Hwang, Jaakko, Hyvönen, Melissa B., Islam, John B., Iverson, Michael A., Ivie, Zeehan, Jaafar, Morgan D., Jackson, J. Pablo, Jayat, Norman F., Johnson, Hinrich, Kaiser, Bente B., Klitgård, Dániel G., Knapp, Jun-ichi, Kojima, Urmas, Kõljalg, Jenő, Kontschán, Frank-Thorsten, Krell, Irmgard, Krisai-Greilhuber, Sven, Kullander, Leonardo, Latella, John E., Lattke, Valeria, Lencioni, Gwilym P., Lewis, Marcos G., Lhano, Nathan K., Lujan, Jolanda A., Luksenburg, Jean, Mariaux, Jader, Marinho-Filho, Christopher J., Marshall, Jason F., Mate, Molly M., McDonough, Ellinor, Michel, Vitor F. O., Miranda, Mircea-Dan, Mitroiu, Jesús, Molinari, Scott, Monks, Abigail J., Moore, Ricardo, Moratelli, Dávid, Murányi, Takafumi, Nakano, Svetlana, Nikolaeva, John, Noyes, Michael, Ohl, Nora H., Oleas, Thomas, Orrell, Barna, Páll-Gergely, Thomas, Pape, Viktor, Papp, Lynne R., Parenti, David, Patterson, Igor Ya., Pavlinov, Ronald H., Pine, Péter, Poczai, Jefferson, Prado, Divakaran, Prathapan, Richard K., Rabeler, John E., Randall, Frank E., Rheindt, Anders G. J., Rhodin, Sara M., Rodríguez, D. Christopher, Rogers, Fabio de O., Roque, Kevin C., Rowe, Luis A., Ruedas, Jorge, Salazar-Bravo, Rodrigo B., Salvador, George, Sangster, Carlos E., Sarmiento, Dmitry S., Schigel, Stefan, Schmidt, Frederick W., Schueler, Hendrik, Segers, Neil, Snow, Pedro G. B., Souza-Dias, Riaan, Stals, Soili, Stenroos, R. Douglas, Stone, Charles F., Sturm, Pavel, Štys, Pablo, Teta, Daniel C., Thomas, Robert M., Timm, Brian J., Tindall, Jonathan A., Todd, Dagmar, Triebel, Antonio G., Valdecasas, Alfredo, Vizzini, Maria S., Vorontsova, Jurriaan M., de Vos, Philipp, Wagner, Les, Watling, Alan, Weakley, Francisco, Welter-Schultes, Daniel, Whitmore, Nicholas, Wilding, Kipling, Will, Jason, Williams, Karen, Wilson, Judith E., Winston, Wolfgang, Wüster, Douglas, Yanega, David K., Yeates, Hussam, Zaher, Guanyang, Zhang, Zhi-Qiang, Zhang, and Hong-Zhang, Zhou
  • PLOS Biology. 16

6. Taxonomy based on science is necessary for global conservation [2018]

  • Thomson, Scott, Pyle, Richard L., Ahyong, Shane T., Alonso-Zarazaga, Miguel, Ammirati, Joe, Araya, Juan Francisco, Ascher, John S., Audisio, Tracy Lynn, Azevedo-Santos, Valter M., Bailly, Nicolas, Baker, William J., Balke, Michael, Barclay, Maxwell V. L., Barrett, Russell, Benine, Ricardo, Bickerstaff, James R. M., Bouchard, Patrice, Bour, Roger, Bourgoin, Thierry, Boyko, Christopher B., Breure, Abraham S. H., Brothers, Denis J., Byng, James W., Campbell, David, Ceríaco, Luis M. P., Cernák, István, Cerretti, Pierfilippo, Chang, Chih-Han, Cho, Soowon, Copus, Joshua M., Costello, Mark J., Cseh, Andras, Csuzdi, Csaba, Culham, Alastair, D'Elía, Guillermo, d’Udekem d’Acoz, Cédric, Daneliya, Mikhail E., Dekker, René, Dickinson, Edward C., Dickinson, Timothy, van Dijk, Peter Paul, Dijkstra, Klaas-Douwe B., Dima, Bálint, Dmitriev, Dmitry A., Duistermaat, Leni, Dumbacher, John P., Eiserhardt, Wolf, Ekrem, Torbjørn, Evenhuis, Neal L., Faille, Arnaud, Fernández-Triana, José L., Fiesler, Emile, Fishbein, Mark, Fordham, Barry, Freitas, André V. L., Friol, Natália R., Fritz, Uwe, Frøslev, Tobias, Funk, Vicki A., Gaimari, Stephen, Garbino, Guilherme, Garraffoni, André Rinaldo Senna, Geml, József, Gill, Anthony C., Gray, Alan, Grazziotin, Felipe, Greenslade, Penelope, Gutiérrez, Eliécer, Harvey, Mark, Hazevoet, Cornelis J., He, Kai, He, Xiaolan, Helfer, Stephan, Helgen, Kristofer, van Heteren, Anneke H., Hita Garcia, Francisco, Holstein, Norbert, Horváth, Margit K., Hovenkamp, Peter, Hwang, Wei Song, Hyvönen, Jaakko, Islam, Melissa B., Iverson, John B., Ivie, Michael A., Jaafar, Zeehan, Jackson, Morgan D., Jayat, J. Pablo, Johnson, Norman F., Kaiser, Hinrich, Klitgård, Bente B., Knapp, Dániel G., Kojima, Jun-ichi, Kõljalg, Urmas, Kontschán, Jenő, Krell, Frank-Thorsten, Krisai-Greilhuber, Irmgard, Kullander, Sven, Latella, Leonardo, Lattke, John E., Lencioni, Valeria, Lewis, Gwilym P., Lhano, Marcos G., Lujan, Nathan K., Luksenburg, Jolanda A., Mariaux, Jean, Marinho-Filho, Jader, Marshall, Christopher J., Mate, Jason F., McDonough, Molly M., Michel, Ellinor, F. O. Miranda, Vitor, Mitroiu, Mircea-Dan, Molinari, Jesús, Monks, Scott, Moore, Abigail J., Moratelli, Ricardo, Murányi, Dávid, Nakano, Takafumi, Nikolaeva, Svetlana, Noyes, John, Ohl, Michael, Oleas, Nora H., Orrell, Thomas, Páll-Gergely, Barna, Pape, Thomas, Papp, Viktor, Parenti, Lynne R., Patterson, David, Pavlinov, Igor Ya., Pine, Ronald H., Poczai, Péter, Prado, Jefferson, Divakaran, Prathapan, Rabeler, Richard K., Randall, John E., Rheindt, Frank E., Rhodin, Anders G. J., Rodríguez, Sara M., Rogers, D. Christopher, Roque, Fabio de O., Rowe, Kevin C., Ruedas, Luis A., Salazar-Bravo, Jorge, Salvador, Rodrigo Brincalepe, Sangster, George, Sarmiento, Carlos E., Schigel, Dmitry, Schmidt, Stefan, Schueler, Frederick W., Segers, Hendrik, Snow, Neil, Souza-Dias, Pedro, Stals, Riaan, Stenroos, Soili, Stone, Robert Douglas, Sturm, Charles F., Štys, Pavel, Teta, Pablo, Thomas, Daniel C., Timm, Robert M., Tindall, Brian J., Todd, Jonathan, Triebel, Dagmar, Valdecasas, Antonio G, Vizzini, Alfredo, Vorontsova, Maria, de Vos, Jurriaan M., Wagner, Philipp, Watling, Les, Weakley, Alan, Welter-Schultes, Francisco, Whitmore, Daniel, Wilding, Nicholas, Will, Kipling, Williams, Jason, Wilson, Karen, Winston, Judith E., Wüster, Wolfgang, Yanega, Douglas, Yeates, David, Zaher, Hussam, Zhang, Guanyang, Zhang, Zhi-Qiang, and Zhou, Hong-Zhang
  • PLoS biology, 16(3):e2005075
Subjects
Taxonomy, Biodiversity, Controlled vocabularies, Species delimitation, Conservation science, Conservation biology, Endangered species, and Legislation

7. Antibiotic Resistance and the Risk of Recurrent Bacteremia [2018]

  • Woudt, Sjoukje H. S., de Greeff, Sabine C., Schoffelen, Annelot F., Vlek, Anne L. M., Bonten, Marc J. M., Cohen Stuart, J. W. T., Weersink, A. J. L., Vandenbroucke-Grauls, C. M. J. E., Visser, C. E., van Ogtrop, M. L., Kaersenhout, D. J., Scholing, M., van Hees, B. C., van Keulen, P. H. J., Kluytmans, J. A. J. W., Kraan, E. M., Mattsson, E. E., Sebens, F. W., de Jong, E., Frénay, H. M. E., Maraha, B., van Griethuysen, A. J., Silvis, W., Demeulemeester, A., Wintermans, B. B., van Trijp, M., Ott, A., Arends, J. P., Kampinga, G. A., Veenendaal, D., Hol, C., de Brauwer, E. I. G. B., Stals, F. S., Bakker, L. J., Dorigo-Zetsma, J. W., Ridwan, B., van Zeijl, J. H., Bernards, A. T., Erkens-Hulshof, S., de Jongh, B. M., Vlaminckx, B. J. M., Nabuurs-Franssen, M. H., Kuipers, S., Diederen, B. M. W., Melles, D. C., van Rijn, M., Dinant, S., Pontesilli, O., de Man, P., Vaessen, N., Leversteijn-van Hall, M. A., van Elzakker, E. P. M., Muller, A. E., Renders, N. H., van Dam, D. W., Buiting, A. G. M., Vlek, A. L. M., Deege, M. P. D., Frakking, F. N. J., Overdevest, I. T. M. A., Bosboom, R. W., Trienekens, T., Voorn, G. P., Ruijs, G. J. H. M., Wolfhagen, M. J. H. M., Alblas, J., Altorf-van der Kuil, W., Blijboom, L., Groenendijk, S., van Heereveld, J., Hertroys, R., Monen, J. C., Notermans, D. W., Reuland, E. A., van Triest, M. I., Wielders, C. C. H., Amsterdam Infection & Immunity, and Medical Microbiology
  • Clinical infectious diseases, 66(11), 1651 - 1657. Oxford University Press
Subjects
bacterial infections and mycoses
Abstract
Background Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk of recurrent bacteremia associated with resistance. Methods We extracted antimicrobial susceptibility testing data on blood isolates from the Dutch surveillance system for antimicrobial resistance between 2008 and 2017. First and first recurrent (4-30 days) bacteremia episodes were categorized as susceptible, single nonsusceptible, or co-nonsusceptible to third-generation cephalosporins without or with carbapenems (Enterobacteriaceae), ceftazidime without or with carbapenems (Pseudomonas species), aminopenicillins without or with vancomycin (Enterococcus species), or as methicillin-sensitive/-resistant S. aureus (MSSA/MRSA). We calculated risks of recurrent bacteremia after nonsusceptible vs susceptible first bacteremia, estimated the crude population attributable effect of resistance for the Netherlands, and calculated risks of nonsusceptible recurrent bacteremia after a susceptible first episode. Results Risk ratios for recurrent bacteremia after a single- and co-nonsusceptible first episode, respectively, vs susceptible first episode, were 1.7 (95% confidence interval [CI], 1.5-2.0) and 5.2 (95% CI, 2.1-12.4) for Enterobacteriaceae, 1.3 (95% CI, 0.5-3.1) and 5.0 (95% CI, 2.9-8.5) for Pseudomonas species, 1.4 (95% CI, 1.2-1.7) and 1.6 (95% CI, 0.6-4.2) for Enterococcus species, and 1.6 (95% CI, 1.1-2.4) for MRSA vs MSSA. The estimated population annual number of recurrent bacteremias associated with nonsusceptibility was 40. The risk of nonsusceptible recurrent bacteremia after a susceptible first episode was at most 0.4% (Pseudomonas species). Conclusions Although antibiotic nonsusceptibility was consistently associated with higher risks of recurrent bacteremia, the estimated annual number of additional recurrent episodes in the Netherlands (40) was rather limited.

8. National laboratory-based surveillance system for antimicrobial resistance: a successful tool to support the control of antimicrobial resistance in the Netherlands [2017]

  • Altorf-van der Kuil, Wieke, Schoffelen, A.F. (Annelot F.), de Greeff, Sabine C., Thijsen, Steven, Alblas, H.J. (H. Jeroen), Notermans, Daan, Vlek, Anne L.M., Sande, Marianne, Leenstra, T. (Tjalling), Cohen Stuart, James, Weersink, A.J.L. (A. J.L.), Visser, C.E., Vandenbroucke-Grauls, Christina, van Ogtrop, M.L. (M. L.), Soeltan-Kaersenhout, D.J. (D. J.), Scholing, M. (M.), Hees, Babette, Keulen, Peter, Blijboom, L. (L.), Frakking, Florine N., Groenendijk, S. (S.), van Heereveld, J. (J.), Hertroys, R. (R.), Monen, J.C. (J. C.), van Triest, M.I. (M. I.), Wielders, Cornelia, Woudt, S.H.S. (S. H.S.), Kluytmans, Jan, Lundblad-Mattsson, E.E. (E. E.), Sebens, Fré, de Jong, E. (E.), Frénay, H.M.E. (H. M.E.), Maraha, Boulos, Griethuysen, Arjanne, Silvis, W. (W.), Demeulemeester, A. (A.), Wintermans, B.B. (B. B.), Trijp, Marijke, Hendrix, Marijke, Ott, Alewijn, Arends, Jan, Kampinga, Greetje, Veenendaal, Dick, Brauwer, E. I G B, Stals, F.S. (F. S.), Bakker, L.J. (L. J.), Dorigo-Zetsma, J.W., Ridwan, B. (B.), Zeijl, J., Bernards, Alexandra, Erkens-Hulshof, Sandra, Jongh, Bartelt, Nabuurs-Franssen, M.H. (M. H.), Kuipers, S. (S.), Diederen, Bram, Melles, Damian, Melles, D.C. (D. C.), van Rijn, M. (M.), de Man, P. (P.), Vaessen, Norbert, Leverstein-Van Hall, Maurine, Elzakker, E., Muller, Anouk, Renders, Nicole, van Dam, D.W. (D. W.), Hendrickx, B.G.A. (B. G.A.), Buiting, Anton, Deege, M.P.D. (M. P.D.), Overdevest, Ilse, Bosboom, R.W. (R. W.), Trienekens, T.A.M. (T. A.M.), Voorn, G., Ruijs, G., Wolfhagen, M.J.H.M., and Department of Medical Microbiology and Infectious Diseases
Abstract
textabstractAn important cornerstone in the control of antimicrobial resistance (AMR) is a well-designed quantitative system for the surveillance of spread and temporal trends in AMR. Since 2008, the Dutch national AMR surveillance system, based on routine data from medical microbiological laboratories (MMLs), has developed into a successful tool to support the control of AMR in the Netherlands. It provides background information for policy making in public health and healthcare services, supports development of empirical antibiotic therapy guidelines and facilitates in-depth research. In addition, participation of the MMLs in the national AMR surveillance network has contributed to sharing of knowledge and quality improvement. A future improvement will be the implementation of a new semantic standard together with standardised data transfer, which will reduce errors in data handling and enable a more real-time surveillance. Furthermore, the s

9. National laboratory-based surveillance system for antimicrobial resistance: a successful tool to support the control of antimicrobial resistance in the Netherlands [2017]

  • Altorf-van der Kuil, Wieke, Schoffelen, Annelot F., de Greeff, Sabine C., Thijsen, Steven F.T., Alblas, H. Jeroen, Notermans, Daan W., Vlek, Anne L.M., van der Sande, Marianne A.B., Leenstra, Tjalling, Cohen-Stuart, J. W.T., Weersink, A. J.L., Visser, C. E., Vandenbroucke-Grauls, C. M.J.E., van Ogtrop, M. L., Soeltan-Kaersenhout, D. J., Scholing, M., van Hees, B. C., van Keulen, P. H.J., Blijboom, L., Frakking, F. N.J., Groenendijk, S., van Heereveld, J., Hertroys, R., Monen, J. C., van Triest, M. I., Wielders, C. C.H., Woudt, S. H.S., Kluytmans, J. A.J.W., Lundblad-Mattsson, E. E., Sebens, F. W., de Jong, E., Frénay, H. M.E., Maraha, B., van Griethuysen, A. J., Silvis, W., Demeulemeester, A., Wintermans, B. B., van Trijp, M. J.C.A., Hendrix, M. G.R., Ott, A., Arends, J. P., Kampinga, G. A., Veenendaal, D., de Brauwer, E. I.G.B., Stals, F. S., Bakker, L. J., Dorigo-Zetsma, J. W., Ridwan, B., van Zeijl, J. H., Overdevest, I. T.M.A., Medical Microbiology and Infection Control, I&I - Infection diseases, and AG&M - Digestive immunity
  • Eurosurveillance, 22(46). Centre Europeen pour la Surveillance Epidemiologique du SIDA
Subjects
Epidemiology, Public Health, Environmental and Occupational Health, Virology, and no
Abstract
An important cornerstone in the control of antimicrobial resistance (AMR) is a well-designed quantitative system for the surveillance of spread and temporal trends in AMR. Since 2008, the Dutch national AMR surveillance system, based on routine data from medical microbiological laboratories (MMLs), has developed into a successful tool to support the control of AMR in the Netherlands. It provides background information for policy making in public health and healthcare services, supports development of empirical antibiotic therapy guidelines and facilitates in-depth research. In addition, participation of the MMLs in the national AMR surveillance network has contributed to sharing of knowledge and quality improvement. A future improvement will be the implementation of a new semantic standard together with standardised data transfer, which will reduce errors in data handling and enable a more real-time surveillance. Furthermore, the scientific impact and the possibility of detecting outbreaks may be amplified by merging the AMR surveillance database with databases from selected pathogen-based surveillance programmes containing patient data and genotypic typing data.

10. Physics at the e(+) e(-) linear collider [2015]

  • Moortgat-Pick, G., Baer, H., Battaglia, M., Belanger, G., Fujii, K., Kalinowski, J., Heinemeyer, S., Kiyo, Y., Olive, K., Simon, F., Uwer, P., Wackeroth, D., Zerwas, P. M., Arbey, A., Asano, M., Bagger, J., Bechtle, P., Bharucha, A., Brau, J., Bruemmer, F., Choi, S. Y., Denner, A., Desch, K., Dittmaier, S., Ellwanger, U., Englert, C., Freitas, A., Ginzburg, I., Godfrey, S., Greiner, N., Grojean, C., Gruenewald, M., Heisig, J., Hoecker, A., Kanemura, S., Kawagoe, K., Kogler, R., Krawczyk, M., Kronfeld, A. S., Kroseberg, J., Liebler, S., List, J., Mahmoudi, F., Mambrini, Y., Matsumoto, S., Mnich, J., Moenig, K., Muehlleitner, M. M., Poschl, R., Porod, W., Porto, S., Rolbiecki, K., Schmitt, M., Serpico, P., Stanitzki, M., Stal, O., Stoecfaniak, T., Stockinger, D., Weiglein, G., Wilson, G. W., Zeune, L., Moortgat, F., Xella, S., Ellis, J. d, Komamiya, S., Peskin, M., Schlatter, D., Wagner, A., and Yamamoto, H.
  • Moortgat-Pick, G, Baer, H, Battaglia, M, Belanger, G, Fujii, K, Kalinowski, J, Heinemeyer, S, Kiyo, Y, Olive, K, Simon, F, Uwer, P, Wackeroth, D, Zerwas, P M, Arbey, A, Asano, M, Bagger, J, Bechtle, P, Bharucha, A, Brau, J, Bruemmer, F, Choi, S Y, Denner, A, Desch, K, Dittmaier, S, Ellwanger, U, Englert, C, Freitas, A, Ginzburg, I, Godfrey, S, Greiner, N, Grojean, C, Gruenewald, M, Heisig, J, Hoecker, A, Kanemura, S, Kawagoe, K, Kogler, R, Krawczyk, M, Kronfeld, A S, Kroseberg, J, Liebler, S, List, J, Mahmoudi, F, Mambrini, Y, Matsumoto, S, Mnich, J, Moenig, K, Muehlleitner, M M, Poschl, R, Porod, W, Porto, S, Rolbiecki, K, Schmitt, M, Serpico, P, Stanitzki, M, Stal, O, Stoecfaniak, T, Stockinger, D, Weiglein, G, Wilson, G W, Zeune, L, Moortgat, F, Xella, S, Bagger, J, Brau, J, Ellis, J D, Kawagoe, K, Komamiya, S, Kronfeld, A S, Mnich, J, Peskin, M, Schlatter, D, Wagner, A & Yamamoto, H 2015, ' Physics at the e(+) e(-) linear collider ', The European Physical Journal C: Particles and Fields, vol. 75, no. 8, 371 . https://doi.org/10.1140/epjc/s10052-015-3511-9

11. Physics at the e+ e- Linear Collider [2015]

  • Moortgat-Pick, G., Baer, H., Battaglia, M., Belanger, G., Fujii, K., Kalinowski, J., Heinemeyer, S., Kiyo, Y., Olive, K., Simon, F., Uwer, P., Wackeroth, D., Zerwas, P. M., Arbey, A., Asano, M., Bagger, J., Bechtle, P., Bharucha, Aoife, Brau, J., Brümmer, Felix, Choi, S. Y., Denner, A., Desch, K., Dittmaier, S., Ellwanger, U., Englert, C., Freitas, A., Ginzburg, I., Godfrey, S., Greiner, N., Grojean, C., Grünewald, M., Heisig, J., Höcker, A., Kanemura, S., Kawagoe, K., Kogler, R., Krawczyk, M., Kronfeld, A. S., Kroseberg, J., Liebler, S., List, J., Mahmoudi, F., Mambrini, Y., Matsumoto, S., Mnich, J., Mönig, K., Mühlleitner, M. M., Pöschl, R., Porod, W., Porto, S., Rolbiecki, K., Schmitt, M., Serpico, P., Stanitzki, M., Stål, O., Stefaniak, T., Stöckinger, D., Weiglein, G., Wilson, G. W., Zeune, L., Moortgat, F., Xella, S., Ellis, J., Komamiya, S., Peskin, M., Schlatter, D., Wagner, A., Yamamoto, H., Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH) ; Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), CPT - E1 Physique des particules ; Centre de Physique Théorique - UMR 7332 (CPT) ; Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique Théorique - UMR 7332 (CPT) ; Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM) ; Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT) ; Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) ; Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), European Organization for Nuclear Research (CERN), Laboratoire de l'Accélérateur Linéaire (LAL) ; Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Deutsches Elektronen-Synchrotron [Hamburg] (DESY)
  • European Physical Journal C: Particles and Fields
    European Physical Journal C: Particles and Fields, Springer Verlag (Germany), 2015, 75 (8), pp.371. ⟨10.1140/epjc/s10052-015-3511-9⟩
Subjects
[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Phenomenology, and High Energy Physics::Experiment
Abstract
International audience; A comprehensive review of physics at an e+e- Linear Collider in the energy range of sqrt{s}=92 GeV--3 TeV is presented in view of recent and expected LHC results, experiments from low energy as well as astroparticle physics.The report focuses in particular on Higgs boson, Top quark and electroweak precision physics, but also discusses several models of beyond the Standard Model physics such as Supersymmetry, little Higgs models and extra gauge bosons. The connection to cosmology has been analyzed as well.

12. Physics at the $e^+ e^-$ linear collider [2015]

  • Moortgat-Pick, G., Baer, H., Uwer, P., Wackeroth, D., Zerwas, P. M., Arbey, A., Asano, M., Bagger, J., Bechtle, P., Bharucha, A., Brau, J., Brümmer, F., Battaglia, M., Choi, S. Y., Denner, A., Desch, K., Dittmaier, S., Ellwanger, U., Englert, C., Freitas, A., Ginzburg, I., Godfrey, S., Greiner, N., Belanger, G., Grojean, C., Grünewald, M., Heisig, J., Höcker, A., Kanemura, S., Kawagoe, K., Kogler, R., Krawczyk, M., Kronfeld, A. S., Kroseberg, J., Fujii, K., Liebler, S., List, J., Mahmoudi, F., Mambrini, Y., Matsumoto, S., Mnich, J., Mönig, K., Mühlleitner, M. M., Pöschl, R., Porod, W., Kalinowski, J., Porto, S., Rolbiecki, K., Schmitt, M., Serpico, P., Stanitzki, M., Stål, O., Stefaniak, T., Stöckinger, D., Weiglein, G., Wilson, G. W., Heinemeyer, S., Zeune, L., Moortgat, F., Xella, S., Ellis, J., Komamiya, S., Kiyo, Y., Peskin, M., Schlatter, D., Wagner, A., Yamamoto, H., Olive, K., and Simon, F.
  • The European physical journal / C 75(8), 371 (2015). doi:10.1140/epjc/s10052-015-3511-9
Subjects
High Energy Physics::Phenomenology, ddc:530, and High Energy Physics::Experiment
Abstract
A comprehensive review of physics at an e$^+$e$^−$ linear collider in the energy range of $\sqrt s$=92 GeV–3 TeV is presented in view of recent and expected LHC results, experiments from low-energy as well as astroparticle physics. The report focusses in particular on Higgs-boson, top-quark and electroweak precision physics, but also discusses several models of beyond the standard model physics such as supersymmetry, little Higgs models and extra gauge bosons. The connection to cosmology has been analysed as well.

13. Prospects for charged Higgs searches at the LHC [2017]

  • Akeroyd, A. G., Aoki, M., Arhrib, A., Basso, L., Ginzburg, I. F., Guedes, R., Hernandez-Sanchez, J., Huitu, K., Hurth, T., Kadastik, M., Kanemura, S., Kannike, K., Khater, W., Krawczyk, M., Mahmoudi, F., Moretti, S., Najjari, S., Osland, P., Pruna, G. M., Purmohammadi, M., Racioppi, A., Raidal, M., Santos, R., Sharma, P., Sokołowska, D., Stål, O., Yagyu, K., and Yildirim, E.
  • EPJC.
Subjects
High Energy Physics::Phenomenology
Abstract
The goal of this report is to summarize the current situation and discuss possible search strategies for charged scalars, in non-supersymmetric extensions of the Standard Model at the LHC. Such scalars appear in Multi-Higgs-Doublet models, in particular in the popular Two-Higgs-Doublet model, allowing for charged and additional neutral Higgs bosons. These models have the attractive property that electroweak precision observables are automatically in agreement with the Standard Model at the tree level. For the most popular version of this framework, Model II, a discovery of a charged Higgs boson remains challenging, since the parameter space is becoming very constrained, and the QCD background is very high. We also briefly comment on models with dark matter which constrain the corresponding charged scalars that occur in these models. The stakes of a possible discovery of an extended scalar sector are very high, and these searches should be pursued in all conceivable channels, at the LHC and at future colliders.

14. Prospects for charged Higgs searches at the LHC [2017]

  • Akeroyd, A. G., Aoki, M., Arhrib, A., Basso, L., Ginzburg, I. F., Guedes, R., Hernandez-Sanchez, J., Huitu, K., Hurth, T., Kadastik, M., Kanemura, S., Kannike, K., Khater, W., Krawczyk, M., Mahmoudi, F., Moretti, S., Najjari, S., Osland, P., Pruna, G. M., Purmohammadi, M., Racioppi, A., Raidal, M., Santos, R., Sharma, P., Sokolowska, D., Stål, O., Yagyu, K., Yildirim, E., and University of Helsinki, Department of Physics
Subjects
X-S-GAMMA, 2-HIGGS DOUBLET MODEL, STANDARD MODEL, BOSON PAIR PRODUCTION, High Energy Physics::Phenomenology, LARGE HADRON COLLIDER, GLUON-GLUON COLLISIONS, 114 Physical sciences, TOP-QUARK, QUARK MASS-DEPENDENCE, ELECTRIC-DIPOLE MOMENT, and 2-LOOP QCD CORRECTIONS
Abstract
The goal of this report is to summarize the current situation and discuss possible search strategies for charged scalars, in non-supersymmetric extensions of the Standard Model at the LHC. Such scalars appear in Multi-HiggsDoublet models, in particular in the popular Two-HiggsDoublet model, allowing for charged and additional neutral Higgs bosons. These models have the attractive property that electroweak precision observables are automatically in agreement with the Standard Model at the tree level. For the most popular version of this framework, Model II, a discovery of a charged Higgs boson remains challenging, since the parameter space is becoming very constrained, and the QCD background is very high. We also briefly comment on models with dark matter which constrain the corresponding charged scalars that occur in these models. The stakes of a possible discovery of an extended scalar sector are very high, and these searches should be pursued in all conceivable channels, at the LHC and at future colliders.

15. A comprehensive overview of urogenital, anorectal and oropharyngeal Neisseria gonorrhoeae testing and diagnoses among different STI care providers: a cross-sectional study [2017]

  • Casper D. J. den Heijer, Christian J. P. A. Hoebe, Geneviève A. F. S. van Liere, Jan E. A. M. van Bergen, Jochen W. L. Cals, Frans S. Stals, Nicole H. T. M. Dukers-Muijrers, Promovendi PHPC, Medische Microbiologie, RS: CAPHRI - R4 - Inequity, Participation and Globalisation, Huisartsgeneeskunde, and RS: CAPHRI - R5 - Optimising Patient Care
  • BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-10 (2017)
    BMC Infectious Diseases, 17. BioMed Central Ltd
Subjects
Research Article, Sexually Transmitted Infection, Social Economic Status, SEX, NETHERLANDS, Chlamydia Trachomatis, Patient Visit, Neisseria Gonorrhoeae, RC109-216, GENERAL PRACTICES, MEN, Infectious and parasitic diseases, INFECTIONS, CHLAMYDIA-TRACHOMATIS, and WOMEN
Abstract
Background Gonorrhoea, caused by Neisseria gonorrhoeae (NG), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and is frequently asymptomatic, which shows the essential role of NG test practice. In this study we wanted to compare NG diagnostic testing procedures between different STI care providers serving a defined geographic Dutch region (280,000 inhabitants). Methods Data on laboratory testing and diagnosis of urogenital and extragenital (i.e. anorectal and oropharyngeal) NG were retrieved from general practitioners (GPs), an STI clinic, and gynaecologists (2006–2010). Per provider, we assessed their contribution regarding the total number of tests performed and type of populations tested, the proportion of NG positives re-tested (3–12 months after treatment) and test-of-cure (TOC, within 3 months post treatment). Results Overall, 17,702 NG tests (48.7% STI clinic, 38.2% GPs, 13.1% gynaecologists) were performed during 15,458 patient visits. From this total number of tests, 2257 (12.7%) were extragenital, of which 99.4% were performed by the STI clinic. Men were mostly tested at the STI clinic (71%) and women by their GP (43%). NG positivity per visit was 1.6%; GP 1.9% (n = 111), STI clinic 1.7% (n = 131) and gynaecology 0.2% (n = 5). NG positivity was associated with Chlamydia trachomatis positivity (OR: 2.06, 95% confidence interval: 1.46–2.92). Per anatomical location, the proportion of NG positives re-tested were: urogenital 20.3% (n = 36), anorectal 43.6% (n = 17) and oropharyngeal 57.1% (n = 20). NG positivity among re-tests was 16.9%. Proportions of NG positives with TOC by anatomical location were: urogenital 10.2% (n = 18), anorectal 17.9% (n = 7) and oropharyngeal 17.1% (n = 6). Conclusions To achieve best practice in relation to NG testing, we recommend that: 1) GPs test at extragenital sites, especially men who have sex with men (MSM), 2) all care providers consider re-testing 3 to 12 months after NG diagnosis and 3) TOC is performed following oropharyngeal NG diagnosis in settings which provide services to higher-risk men and women (such as STI clinics).

16. Handbook of LHC Higgs Cross Sections: 4. Deciphering the Nature of the Higgs Sector [2016]

  • Florian, D. de, Grojean, C., Maltoni, F., Mariotti, C., Nikitenko, A., Pieri, M., Savard, P., Schumacher, M., Tanaka, R., Aggleton, R., Ahmad, M.A., Allanach, B., Anastasiou, C., Astill, W., Badger, S.A., Badziak, M., Baglio, J., Bagnaschi, E., Ballestrero, A., Banfi, A., Barducci, D., Beckingham, M., Becot, C., Bélanger, G., Bellm, J., Belyaev, N., Bernlochner, F. U., Beskidt, C., Biekötter, A., Bishara, Fady, Bizon, W., Bomark, N. E., Bonvini, Marco, Borowka, S., Bortolotto, V., Boselli, S., Botella, F. J., Boughezal, R., Branco, G. C., Brehmer, J., Brenner, L., Bressler, S., Brivio, I., Broggio, A., Brun, V.H., Buchalla, G., Burgard, C. D., Calandri, A., Caminada, L., Armadans, R. Caminal, Campanario, F., Campbell, J., Caola, Fabrizio, Calame, C. M. Carloni, Carrazza, Stefano, Carvalho, A., Casolino, M., Cata, O., Celis, A., Cerutti, Francesco, Chanon, N., Chen, M., Chen, X., Nejad, B. Chokoufé, Christensen, N., Ciuchini, M., Contino, R., Corbett, T., Costa, S.R., Curtin, D.M., Dall'Osso, M., David, A., Dawson, S.J., Blas, J. de, Boer, W. de, Manzano, P. de Castro, Degrande, C., Rueda-Delgado, L.M., Demartin, Federico, Denner, A., Micco, B. Di, Nardo, R. Di, Dittmaier, S., Dobado, A., Dorigo, T., Dreyer, F. A., Dührssen, M., Duhr, C., Dulat, F., Ecker, K., Ellis, K.A., Ellwanger, U., Englert, C., Espriu, D., Falkowski, A., Fayard, L., Feger, R., Ferrera, G., Ferroglia, A., Fidanza, N., Figy, T., Flechl, M., Fontes, J.D., Forte, Stefano, Francavilla, P., Franco, E, Frederix, R., Freitas, A., Freitas, F., Frensch, F., Frixione, S., Fuks, B., Furlan, E., Gadatsch, S., Gao, J., Gao, Y., Garzelli, M. V., Gehrmann, T., Gerosa, R., Ghezzi, M., Ghosh, D., Gieseke, S., Gillberg, D., Giudice, G. F., Glover, E. W. N., Goertz, F., Gonçalves, D., Gonzalez-Fraile, J., Gorbahn, M., Gori, S., Gottardo, C. A., Gouzevitch, Maxime, Govoni, P., Gray, D., Grazzini, M., Greiner, N., Greljo, A., Grigo, J., Gritsan, A. V., Gröber, R., Guindon, S., Haber, H. E., Han, C., Han, T.S., Harlander, R., Harrendorf, M. A., Hartanto, H. B., Hays, C., Heinemeyer, S., Heinrich, G., Herrero, M., Herzog, F., Hespel, B., Hirschi, V., Hoeche, S., Honeywell, S., Huber, S. J., Hugonie, C., Huston, Joey, Ilnicka, A., Isidori, G., Jäger, B., Jaquier, M., Jones, S. P., Juste, A., Kallweit, S., Kaluza, A., Kardos, A., Karlberg, A.T., Kassabov, Zahari, Kauer, N., Kazakov, D. I., Kerner, M., Kilian, W., Kling, M.F., Köneke, K., Kogler, R., Konoplich, R., Kortner, S., Kraml, S., Krause, C., Krauss, F., Krawczyk, P.M., Kulesza, Anna, Kuttimalai, S., Lane, R., Lazopoulos, A., Lee, W.G., Lenzi, P., Lewis, I. M., Li, Y., Liebler, S., van Lindert, E.J., Liu, X., Liu, Z., Llanes-Estrada, F. J., Logan, H. E., Lopez-Val, D., Low, I., Luisoni, G., Maierhöfer, P., Maina, E., Mansoulié, B., Mantler, H., Mantoani, M., Marini, A. C., Outschoorn, V. I. Martinez, Marzani, Simone, Marzocca, D., Massironi, A., Mawatari, K., Mazzitelli, J., McCarn, A., Mellado, B., Melnikov, K., Menari, S. B., Merlo, L., Meyer, C., Milenovic, P., Mimasu, K., Mishima, S., Mistlberger, B., Moch, S. O., Mohammadi, A., Monni, P. F., Montagna, G., Llácer, M. Moreno, Moretti, N., Moretti, S., Motyka, L., Mück, A., Mühlleitner, M., Munir, S., Musella, P., Nadolsky, Pavel, Napoletano, D., Nebot, M., Neu, C., Neubert, R.E.M., Nevzorov, R., Nicrosini, O., Nielsen, J., Nikolopoulos, K., No, J. M., O'Brien, C., Ohl, T., Oleari, C., Orimoto, T. J., Pagani, D., Pandini, C. E., Papaefstathiou, A., Papanastasiou, A. S., Passarino, G., Pecjak, B. D., Pelliccioni, M., Perez, J.G., Perrozzi, Luca, Petriello, F., Petrucciani, G., Pianori, E., Piccinini, F., Pierini, M., Pilkington, A., Plätzer, S., Plehn, T., Podskubka, R., Potter, C. T., Pozzorini, S., Prokofiev, K., Pukhov, A., Puljak, I., Queitsch-Maitland, M., Quevillon, J., Rathlev, D., Rauch, S.A.M., Re, E., Rebelo, M. N., Rebuzzi, D., Reina, L., Reuschle, C., Reuter, J., Riembau, M., Riva, F., Rizzi, A., Robens, T., Röntsch, R., Rojo, J., Romão, J. C., Rompotis, N., Roskes, J., Roth, R., Salam, Gavin P., Salerno, R., Sampaio, M. O. P., Santos, R., Sanz-Nebot, V., Sanz-Cillero, J. J., Sargsyan, H., Sarica, U., Schichtel, P., Schlenk, J., Schmidt, T., Schmitt, C., Schönherr, M., Schubert, U., Schulze, M., Sekula, S. J., Sekulla, M., Shabalina, E., Shao, H. -S., Shelton, J., Shepherd-Themistocleous, C. H., Shim, S. Y., Siegert, F., Signer, A., Da Silva, J.P., Silvestrini, L., Sjodahl, M., Slavich, P., Slawinska, M., Soffi, L., Spannowsky, M., Speckner, C., Sperka, D. M., Spira, M., Stål, O., Staub, F., Stebel, T., Stefaniak, T., Steinhauser, M., Stewart, I. W., Strassler, M. J., Streicher, J., Strom, D. M., Su, S., Sun, X., Tackmann, F. J., Tackmann, K., Teixeira, A. M., Lima, R. Teixeira de, Theeuwes, V., Thorne, R., Tommasini, D., Torrielli, P., Tosi, M., Tramontano, F., Trócsányi, Z., Trott, M., Tsinikos, I., Ubiali, Maria, Vanlaer, P., Verkerke, W., Vicini, A., Viliani, L., Vryonidou, E., Wackeroth, D., Wagner, C. E. M., Wang, J., Wayand, S., Weiglein, G., Weiss, C., Wiesemann, M., Williams, C., Winter, J., Winterbottom, D., Wolf, R., Xiao, S.M., Yang, L. L., Yohay, R., Yuen, S. P. Y., Zanderighi, G., Zaro, M., Zeppenfeld, D., Ziegler, R., Zirke, T., Zupan, J., and (Astro)-Particles Physics
Subjects
High Energy Physics::Phenomenology, hep-ex, hep-ph, and High Energy Physics::Experiment
Abstract
This Report summarizes the results of the activities of the LHC Higgs Cross Section Working Group in the period 2014-2016. The main goal of the working group was to present the state-of-the-art of Higgs physics at the LHC, integrating all new results that have appeared in the last few years. The first part compiles the most up-to-date predictions of Higgs boson production cross sections and decay branching ratios, parton distribution functions, and off-shell Higgs boson production and interference effects. The second part discusses the recent progress in Higgs effective field theory predictions, followed by the third part on pseudo-observables, simplified template cross section and fiducial cross section measurements, which give the baseline framework for Higgs boson property measurements. The fourth part deals with the beyond the Standard Model predictions of various benchmark scenarios of Minimal Supersymmetric Standard Model, extended scalar sector, Next-to-Minimal Supersymmetric Standard Model and exotic Higgs boson decays. This report follows three previous working-group reports: Handbook of LHC Higgs Cross Sections: 1. Inclusive Observables (CERN-2011-002), Handbook of LHC Higgs Cross Sections: 2. Differential Distributions (CERN-2012-002), and Handbook of LHC Higgs Cross Sections: 3. Higgs properties (CERN-2013-004). The current report serves as the baseline reference for Higgs physics in LHC Run 2 and beyond.

17. The harlequin ladybird, Harmonia axyridis: global perspectives on invasion history and ecology [2016]

  • Roy, Helen E., Brown, Peter M.J., Adriaens, Tim, Berkvens, Nick, Borges, Isabel, Clusella-Trullas, Susana, Comont, Richard F., De Clercq, Patrick, Eschen, Rene, Estoup, Arnaud, Evans, Edward W., Facon, Benoit, Gardiner, Mary M., Gil, Artur, Grez, Audrey A., Guillemaud, Thomas, Haelewaters, Danny, Herz, Annette, Honek, Alois, Howe, Andy G., Hui, Cang, Hutchison, William D., Kenis, Marc, Koch, Robert L., Kulfan, Jan, Lawson Handley, Lori, Lombaert, Eric, Loomans, Antoon, Losey, John, Lukashuk, Alexander O., Maes, Dirk, Magro, Alexandra, Murray, Katie M., San Martin, Gilles, Martinkova, Zdenka, Minnaar, Ingrid A., Nedved, Oldřich, Orlova-Bienkowskaja, Marina J., Osawa, Naoya, Rabitsch, Wolfgang, Ravn, Hans Peter, Rondoni, Gabriele, Rorke, Steph L., Ryndevich, Sergey K., Saethre, May-Guri, Sloggett, John J., Soares, Antonio Onofre, Stals, Riaan, Tinsley, Matthew C., Vandereycken, Axel, van Wielink, Paul, Viglášová, Sandra, Zach, Peter, Zakharov, Ilya A., Zaviezo, Tania, Zhao, Zihua, Sobell Department of Motor Neuroscience and Movement Disorders ; Institute of Neurology, Research Institute for Nature and Forest, Centre de Biologie pour la Gestion des Populations (UMR CBGP) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut Sophia Agrobiotech [Sophia Antipolis] (ISA) ; Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS) ; Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Julius Kühn Institute (JKI), Stellenbosch University, CABI Europe Switzerland, Universität der Bundeswehr München [Neubiberg] = Bundeswehr University, Evolution et Diversité Biologique (EDB) ; Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3) ; Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Grad Sch Agr, Lab Forest Ecol ; Kyoto University [Kyoto], Department of Biodiversity and Nature Conservation ; Environment Agency Austria, NEMOD Biotherapeutics GmbH & Co. KG ; NEMOD Biotherapeutics GmbH & Co. KG, and Facultad de Agronomía e Ingeniería Forestal ; Pontificia Universidad Católica de Chile (UC)
  • Biological Invasions, Springer Verlag, 2016, 18 (4), pp.997-1044. ⟨10.1007/s10530-016-1077-6⟩
Subjects
Invasion history, Biology and Life Sciences, Coccinellidae, Species traits, Competitive interactions, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Biocontrol, and Ecology and Environment
Abstract
The harlequin ladybird, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), is native to Asia but has been intentionally introduced to many countries as a biological control agent of pest insects. In numerous countries, however, it has been introduced unintentionally. The dramatic spread of H. axyridis within many countries has been met with considerable trepidation. It is a generalist top predator, able to thrive in many habitats and across wide climatic conditions. It poses a threat to biodiversity, particularly aphidophagous insects, through competition and predation, and in many countries adverse effects have been reported on other species, particularly coccinellids. However, the patterns are not consistent around the world and seem to be affected by many factors including landscape and climate. Research on H. axyridis has provided detailed insights into invasion biology from broad patterns and processes to approaches in surveillance and monitoring. An impressive number of studies on this alien species have provided mechanistic evidence alongside models explaining large-scale patterns and processes. The involvement of citizens in monitoring this species in a number of countries around the world is inspiring and has provided data on scales that would be otherwise unachievable. Harmonia axyridis has successfully been used as a model invasive alien species and has been the inspiration for global collaborations at various scales. There is considerable scope to expand the research and associated collaborations, particularly to increase the breadth of parallel studies conducted in the native and invaded regions. Indeed a qualitative comparison of biological traits across the native and invaded range suggests that there are differences which ultimately could influence the population dynamics of this invader. Here we provide an overview of the invasion history and ecology of H. axyridis globally with consideration of future research perspectives. We reflect broadly on the contributions of such research to our understanding of invasion biology while also informing policy and people.

18. Susceptibility of ESBL Escherichia coli and Klebsiella pneumoniae to fosfomycin in the Netherlands and comparison of several testing methods including Etest, MIC test strip, Vitek2, Phoenix and disc diffusion [2018]

  • van den Bijllaardt, Wouter, Schijffelen, Maarten J., Bosboom, Ron W., Stuart, James Cohen, Diederen, Bram, Kampinga, Greetje, Thuy-Nga Le, Overdevest, Ilse, Stals, Frans, Voorn, Paul, Waar, Karola, Mouton, Johan W., Muller, Anouk E., and MEDISCHE MICROBIOLOGIE
  • Journal of Antimicrobial Chemotherapy, 73(9), 2380 - 2387. Oxford University Press
Subjects
GRAM-NEGATIVE PATHOGENS, ANTIMICROBIAL RESISTANCE, INTRAVENOUS FOSFOMYCIN, MECHANISMS, INFECTIONS, ENTEROBACTERIACEAE, and BACTERIA
Abstract
Objectives: Fosfomycin susceptibility testing is complicated and prone to error. Before using fosfomycin widely in patients with serious infections, acquisition of WT distribution data and reliable susceptibility testing methods are crucial. In this study, the performance of five methods for fosfomycin testing in the routine laboratory against the reference method was evaluated. Methods: Ten laboratories collected up to 100 ESBL-producing isolates each (80 Escherichia coli and 20 Klebsiella pneumoniae). Isolates were tested using Etest, MIC test strip (MTS), Vitek2, Phoenix and disc diffusion. Agar dilution was performed as the reference method in a central laboratory. Epidemiological cut-off values (ECOFFs) were determined for each species and susceptibility and error rates were calculated. Results: In total, 775 E. coli and 201 K. pneumoniae isolates were tested by agar dilution. The ECOFF was 2 mg/L for E. coli and 64 mg/L for K. pneumoniae. Susceptibility rates based on the EUCAST breakpoint of Conclusions: Overall, it was concluded that none of the test methods is suitable as an alternative to agar dilution in the routine laboratory.

19. Insights into the Physiology and Ecology of the Brackish-Water-Adapted Cyanobacterium Nodularia spumigena CCY9414 Based on a Genome-Transcriptome Analysis [2013]

  • Voss, B., Bolhuis, H., Fewer, D., Kopf, M., Moke, F., Haas, F., El-Shehawy, R., Hayes, Paul, Bergman, B., Sivonen, K., Dittmann, E., Scanlan, D., Hagemann, M., Stal, L., Hess, W., and University of Helsinki, Department of Food and Nutrition
  • Voss, B, Bolhuis, H, Fewer, D, Kopf, M, Moke, F, Haas, F, El-Shehawy, R, Hayes, P, Bergman, B, Sivonen, K, Dittmann, E, Scanlan, D, Hagemann, M, Stal, L & Hess, W 2013, ' Insights into the physiology and ecology of the brackish-water-adapted cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome analysis ', PLoS One, vol. 8, no. 3, pp. e60224 . https://doi.org/10.1371/journal.pone.0060224
    PLoS ONE, Vol 8, Iss 3, p e60224 (2013)
Subjects
CHLOROPHYLL-BINDING PROTEIN, Earth Sciences, Research Article, 1181 Ecology, evolutionary biology, STRAIN PCC 7120, ESCHERICHIA-COLI, Genome Expression Analysis, Microbial Ecology, Marine Biology, Ecology, Bacteriology, GENE-PRODUCT, 1184 Genetics, developmental biology, physiology, Genomics, BALTIC SEA, QR, Biology, ANABAENA-SP PCC-7120, NITROGEN-FIXATION, Microbiology, Medicine, Ecophysiology, Marine Ecology, EVOLUTIONARY IMPLICATIONS, 1183 Plant biology, microbiology, virology, SYNECHOCOCCUS-SP, Biochemistry, Science, Genome Sequencing, Small Molecules, and HETEROCYST-FORMING CYANOBACTERIUM
Abstract
Nodularia spumigena is a filamentous diazotrophic cyanobacterium that dominates the annual late summer cyanobacterial blooms in the Baltic Sea. But N. spumigena also is common in brackish water bodies worldwide, suggesting special adaptation allowing it to thrive at moderate salinities. A draft genome analysis of N. spumigena sp. CCY9414 yielded a single scaffold of 5,462,271 nucleotides in length on which genes for 5,294 proteins were annotated. A subsequent strand-specific transcriptome analysis identified more than 6,000 putative transcriptional start sites (TSS). Orphan TSSs located in intergenic regions led us to predict 764 non-coding RNAs, among them 70 copies of a possible retrotransposon and several potential RNA regulators, some of which are also present in other N2-fixing cyanobacteria. Approximately 4% of the total coding capacity is devoted to the production of secondary metabolites, among them the potent hepatotoxin nodularin, the linear spumigin and the cyclic nodulapeptin. The transcriptional complexity associated with genes involved in nitrogen fixation and heterocyst differentiation is considerably smaller compared to other Nostocales. In contrast, sophisticated systems exist for the uptake and assimilation of iron and phosphorus compounds, for the synthesis of compatible solutes, and for the formation of gas vesicles, required for the active control of buoyancy. Hence, the annotation and interpretation of this sequence provides a vast array of clues into the genomic underpinnings of the physiology of this cyanobacterium and indicates in particular a competitive edge of N. spumigena in nutrient-limited brackish water ecosystems.

20. New records and update on the geographic distribution of fifteen species of Lincus Stål, 1867 (Insecta: Hemiptera: Pentatomidae) associated with palms and coconut trees in the Neotropics [2017]

  • Roell, Talita, Winter, Ingrid, Asipuela, René, and Campos, Luiz Alexandre
  • Check List.
Subjects
Amazonia, Phytomonas, Elaeis guineensis, Cocos nucifera, hartrot, Marchitez, and Ochlerini
Abstract
The Neotropical genus Lincus Stål, 1867 is frequently associated with the transmission of diseases to palms and coconut trees (Elaeis guineensis and Cocos nucifera) in commercial plantations in South America. Here we update the geographical distribution of 15 species of Lincus collected in E. guineensis and C. nucifera in the Neotropics. The geographical range of five species is expanded with new countries recorded for L. malevolus and L. styliger, and detailed geographic information is given for the first time for L. lobuliger and L. securiger.

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