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Przemysław KRAKOWSKI, Józef JONAK, Robert KARPIŃSKI, and Łukasz JAWORSKI
- Applied Computer Science, Vol 15, Iss 3, Pp 65-72 (2019)
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Rapid Prototyping, surgery planning, fractures, Information technology, T58.5-58.64, Electronic computers. Computer science, and QA75.5-76.95
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Orthopaedic trauma surgery is a complex surgical speciality in which anatomy, physiology and physics are mixed. Proper diagnosing and based on that planning and performing surgery is of crucial matter. This article presents usefulness of 3D reconstruction in diagnostics and surgical planning. It focuses on utility of computed tomography reconstruction in trauma surgery. Moreover, two cases in which this technique was used is described. Complex 3D reconstruction proved its usefulness and in future it may become a modality of choice for planning complex trauma procedures in which standard implants and approaches are insufficient.
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Lorenzo Invidia, Silvio Lucio Oliva, Andrea Palmieri, Luigi Patrono, and Piercosimo Rametta
- Journal of Communications Software and Systems, Vol 15, Iss 2, Pp 138-149 (2019)
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BLE, Embedded System, Internet of Things, MQTT, Rapid Prototyping, STM32 ODE, Computer software, and QA76.75-76.765
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The Internet of Things (IoT) is characterized by many technologies, standards, tools and devices for a wide range of application fields and often, for the end-users (makers and developers), is hard to orientate in an equally wide range of offers from various manufacturers. In recent years, the Bluetooth Low Energy (BLE) communication protocol is achieving a large portion of the market, thanks to its low-power and low-cost orientation and its pervasiveness in mobile devices, like smartphones. For these reasons, BLE is increasingly used in IoT-oriented Wireless Personal Area Networks (WPAN), where a small set of devices arranged in star topology network and connected to a smartphone and a Wi-Fi gateway, can cover a large number of monitoring and controlling use case scenarios. This work presents the ST’s STM32 Open Development Environment (ODE), a complete suite of hardware and software tools representing a reference point for end-users willing to create BLE-based star topology networks for a wide range of applications. Through a simple use case in a smart home context, it is shown how all provided tools can be used to fast prototype applications addressing all user requirements.
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3. Translaminar facet joint screw insertion with a rapid prototyping guide template: a cadaver study [2019]
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Yuanwu Cao, Wenjun Zhang, Yun Liang, Zhenzhou Feng, Chun Jiang, Zixian Chen, and Xiaoxing Jiang
- Computer Assisted Surgery, Vol 24, Iss 1, Pp 1-6 (2019)
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Translaminar facet screw, rapid prototyping, guide template system, screw trajectory, tail angle, submergence angle, Computer applications to medicine. Medical informatics, R858-859.7, Surgery, and RD1-811
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It is technically demanding and requires rich experience to insert the translaminar facet screw(TFS) via the paramedian mini-incision approach. It seems that it is easy to place the TFS using computer-assisted design and rapid prototyping(RP) techniques. However, the accuracy and safety of these techniques is still unknown. The aim of this study is to assess the accuracy and safety of translaminar facet screw placement in multilevel unilateral transforaminal lumbar interbody fusion using a rapid prototyping drill guide template system. A patient-matched rapid prototyping translaminar facet screw guide was examined in fourteen cadaveric lumbar spine specimens. A three-dimensional (3D) preoperative screw trajectory was constructed using spinal computed tomography scans, from which individualized guides were developed for the placement of translaminar facet screws. Following bone tunnel establishment, the 3D positioning of the entry point and trajectory of the screws was compared to the preoperative plan as found in the Mimics software.Among 60 trajectories eligible for assessment, no cases of clinically significant laminar perforation were found. The mean deviation between the planned and the actual starting points on spinous process was 1.22 mm. The mean tail and submergence angle deviation was found to be 0.68°and 1.46°, respectively. Among all the deviations, none were found to have any statistical significance. These results indicate that translaminar facet screw placement using the guide system is both accurate and safe.
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Batsch Michał
- Journal of KONBiN, Vol 49, Iss 1, Pp 369-382 (2019)
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tooth contact analysis, eccentric cycloid gear engagement, rapid prototyping, Industrial safety. Industrial accident prevention, and T55-55.3
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This paper presents a mathematical model and tooth contact analysis of eccentric cycloid gear mesh. Numerical simulations aimed at generating contact pattern for a sample gear pair were performed. Contact pattern was also determined for gear wheels made by additive fabrication from transparent light-activated resin.
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Brittany Pousett, Aimee Lizcano, and Silvia Ursula Raschke
- Canadian Prosthetics & Orthotics Journal (2019)
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Prostheses, Rapid Prototyping, Prosthesis Design, 3D Printing, Three Dimensional Printing, Transtibial, Socket Strength, Transtibial Socket, Thermoplastic, Lamination, Rapid Additive Manufacturing, Lower-limb Prostheses, Medical technology, R855-855.5, Orthopedic surgery, and RD701-811
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BACKGROUND: Rapid Prototyping is becoming an accessible manufacturing method but before clinical adoption can occur, the safety of treatments needs to be established. Previous studies have evaluated the static strength of traditional sockets using ultimate strength testing protocols outlined by the International Organization for Standardization (ISO). OBJECTIVE: To carry out a pilot test in which 3D printed sockets will be compared to traditionally fabricated sockets, by applying a static ultimate strength test. METHODOLOGY: 36 sockets were made from a mold of a transtibial socket shape,18 for cushion liners with a distal socket attachment block and 18 for locking liners with a distal 4-hole pattern. Of the 18 sockets, 6 were thermoplastic, 6 laminated composites & 6 3D printed Polylactic Acid. Sockets were aligned in standard bench alignment and placed in a testing jig that applied forces simulating individuals of different weight putting force through the socket both early and late in the stance phase. Ultimate strength tests were conducted in these conditions. If a setup passed the ultimate strength test, load was applied until failure. FINDINGS: All sockets made for cushion liners passed the strength tests, however failure levels and methods varied. For early stance, thermoplastic sockets yielded, laminated sockets cracked posteriorly, and 3D printed socket broke circumferen-tially. For late stance, 2/3 of the sockets failed at the pylon. Sockets made for locking liners passed the ultimate strength tests early in stance phase, however, none of the sockets passed for forces late in stance phase, all broke around the lock mechanism. CONCLUSION: Thermoplastic, laminated and 3D printed sockets made for cushion liners passed the ultimate strength test protocol outlined by the ISO for forces applied statically in gait. This provides initial evidence that 3D printed sockets are statically safe to use on patients and quantifies the static strength of laminated and thermoplastic sockets. However, all set-ups of sockets made for locking liners failed at terminal stance. While further work is needed, this suggests that the distal reinforcement for thermoplastic, laminated and 3D printed sockets with distal cylindrical locks may need to be reconsidered. Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/31008/24937 LAYMAN’S ABSTRACT 3D printing is a new manufacturing method that could be used to make prosthetic sockets (the part of the prosthesis connected to the individual). However, very little is known about the strength of 3D printed sockets and if they are safe to use. As Prosthetists are responsible for providing patients with safe treatments, the strength of 3D printed sockets needs to be established before they can be used in clinical practice. The strength of sockets made using current manufacturing methods was compared to those made using 3D printing. Strength was tested using the static portion of the ISO standard most applicable for this situation which outlines the forces a socket must take at 2 points in walking–when the foot is placed on the ground (early stance) and when the foot pushed off the ground (late stance). Sockets made for two prosthetic designs (cushion and locking) were tested to determine if one is safer than the other. All sockets made for cushion liners passed the standard for forces applied statically. However, different materials failed in different ways. At early stance, thermoplastic sockets yielded, laminated composite sockets cracked and 3D printed sockets broke circumferentially. At late stance other components failed 2/3 of the time before the sockets were affected. This provides initial evidence that sockets made for cushion liners are statically safe to use on patients. Sockets made for locking liners failed around the end, showing that 3D printing should not be used to create sockets with the design tested in this study. How to Cite: Pousett B, Lizcano A, Raschke S.U. An investigation of the structural strength of transtibial sockets fabricated using conventional methods and rapid prototyping techniques. Canadian Prosthetics & Orthotics Journal. 2019; Volume2, Issue1, No.2. DOI: https://doi.org/10.33137/cpoj.v2i1.31008
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Xiaopeng Wen, Shan Gao, Jinteng Feng, Shuo Li, Rui Gao, and Guangjian Zhang
- Journal of Cardiothoracic Surgery, Vol 13, Iss 1, Pp 1-7 (2018)
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3D printing, Titanium-alloy prosthesis, Chest-wall bony defect, Rapid prototyping, Surgery, RD1-811, Anesthesiology, and RD78.3-87.3
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Abstract Background As 3D printing technology emerge, there is increasing demand for a more customizable implant in the repair of chest-wall bony defects. This article aims to present a custom design and fabrication method for repairing bony defects of the chest wall following tumour resection, which utilizes three-dimensional (3D) printing and rapid-prototyping technology. Methods A 3D model of the bony defect was generated after acquiring helical CT data. A customized prosthesis was then designed using computer-aided design (CAD) and mirroring technology, and fabricated using titanium-alloy powder. The mechanical properties of the printed prosthesis were investigated using ANSYS software. Results The yield strength of the titanium-alloy prosthesis was 950 ± 14 MPa (mean ± SD), and its ultimate strength was 1005 ± 26 MPa. The 3D finite element analyses revealed that the equivalent stress distribution of each prosthesis was unifrom. The symmetry and reconstruction quality contour of the repaired chest wall was satisfactory. No rejection or infection occurred during the 6-month follow-up period. Conclusion Chest-wall reconstruction with a customized titanium-alloy prosthesis is a reliable technique for repairing bony defects.
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Harušinec Jozef, Suchánek Andrej, and Loulová Mária
- MATEC Web of Conferences, Vol 254, p 01013 (2019)
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rapid prototyping, FDM, prototype, Engineering (General). Civil engineering (General), and TA1-2040
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The article deals with creating 3D models using RAPID PROTOTYPING technology. At present, we are witnessing the integration of new technologies into ordinary life. A good example is the use of FDM (fused deposition modeling) technology that primarily uses thermoplastics to create 3D models. A few years ago, the use of rapid prototyping technology was a prerogative of companies, research institutes and a narrow group of universities. Technologies such as FDM and STL (Stereolithography) have become affordable in the past few years for smaller businesses and individuals. The specific segment is the replicating rapid prototype RepRap (replicating rapid prototype), the extended version of which is the Prusa i3 printer.
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Shakeba Quadri, Bhumika Kapoor, Gaurav Singh, and Rajendra Kumar Tewari
- Journal of Oral Research and Review, Vol 9, Iss 2, Pp 96-102 (2017)
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Prosthesis, rapid prototyping, stereolithography, three-dimensional, Dentistry, and RK1-715
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Emergence of advanced digital technology has opened up new perspectives for design and production in the field of dentistry. Rapid prototyping (RP) is a technique to quickly and automatically construct a three-dimensional (3D) model of a part or product using 3D printers or stereolithography machines. RP has various dental applications, such as fabrication of implant surgical guides, zirconia prosthesis and molds for metal castings, maxillofacial prosthesis and frameworks for fixed and removable partial dentures, wax patterns for the dental prosthesis and complete denture. Rapid prototyping presents fascinating opportunities, but the process is difficult as it demands a high level of artistic skill, which means that the dental technicians should be able to work with the models obtained after impression to form a mirror image and achieve good esthetics. This review aims to focus on various RP methods and its application in dentistry.
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Lubis Sobron and David Sutanto
- Jurnal Ilmiah SINERGI, Vol 20, Iss 3, Pp 229-238 (2016)
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Rapid prototyping, fused deposition modeling, orientasi objek, 3D printer, Engineering (General). Civil engineering (General), and TA1-2040
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Pembuatan prototipe pada industri manufaktur berkembang dengan pesat, berawal dari pembuatan secara konvensional, kemudian dilakukan dengan menggunakan mesin-mesin perkakas, dan berkembang dengan pemanfaatan komputer sebagai alat kontrol pada mesin tersebut sehingga dikenal dengan istilah CNC (computer numerically control). Pada awalnya, pembuatan prototipe dilakukan menggunakan mesin perkakas yang membentuk kontur permukaan dengan melakukan pemotongan pada benda kerja, tentunya dalam hal ini terdapat bahan tersisa yang dikenal dengan chip. Dewasa ini perkembangan dalam pembuatan prototipe maju dengan pesat yang dikenal dengan pembuatan prototipe cepat (rapid prorotyping). Keunggulan dari rapid prototyping dalam bidang manufaktur adalah kemudahannya dalam menghasilkan suatu produk yang kompleks dengan tepat dan efisien. Proses rapid prototyping mampu merealisasikan hasil permodelan 3D software dalam bentuk nyata tanpa intervensi apapun. Dalam penelitian ini, dikaji tentang pengaruh penentuan posisi orientasi secara vertical dan horizontal terhadap kekuatan Tarik material polymer yang digunakan. Penelitian dilakukan dengan dengan menggunakan perangkat rapid prototyping tipe fused deposition modeling yakni 3D printing. Bahan filament yang digunakan jenis polymer PLA dan ABS. Proses printing dilakukan terhadap bentuk objek uji Tarik ASTM D638. Proses 3D printing dilakukan dengan memvariasikan posisi orientasi objek secara vertikal dan horizontal. Spesimen yang dihasilkan selanjutnya dilakukan uji tarik. Berdasarkan hasil pengujian yang dilakukan dapat diketahui bahwa penentuan orientasi posisi objek spesimen memberi pengaruh terhadap tegangan tarik spesimen.
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Byung Kyu Park, David J. Hwang, Dong Eui Kwon, Tae Jun Yoon, and Youn-Woo Lee
- Nanomaterials, Vol 8, Iss 8, p 575 (2018)
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multiscale structure, rapid prototyping, nanofoam, gas foaming, polylactic acid, Chemistry, and QD1-999
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Multiscale structured polymers have been considered as a promising category of functional materials with unique properties. We combined rapid prototyping and gas foaming technologies to fabricate multiscale functional materials of superior mechanical and thermal insulation properties. Through scanning electron microscope based morphological characterization, formation of multiscale porous structure with nanoscale cellular pores was confirmed. Improvement in mechanical strength is attributed to rearrangement of crystals within CO2 saturated grid sample. It is also shown that a post-foaming temperature higher than the glass transition temperature deteriorates mechanical strength, providing process guidelines. Thermal decomposition of filament material sets the upper limit of temperature for 3D printed features, characterized by simultaneous differential scanning calorimetry and thermogravimetric analysis. Porosity of the fabricated 3D structured polylactic acid (PLA) foam is controllable by suitable tuning of foaming conditions. The fabricated multiscale 3D structures have potential for thermal insulation applications with lightweight and reasonable mechanical strength.
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Verjans Mark, Asseln Malte, and Radermacher Klaus
- Current Directions in Biomedical Engineering, Vol 2, Iss 1, Pp 553-556 (2016)
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biomechanics, knee simulator, rapid prototyping, total knee arthroplasty, and Medicine
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The understanding of the complex biomechanics of the knee is a key for an optimal implant design. To easily investigate the influence of prosthetic designs on knee biomechanics a rapid prototyping workflow for knee implants has been developed and evaluated. Therefore, different manufacturing technologies and post-treatment methods have been examined and overall seven different replica knee implants were manufactured. For evaluation, the manufacturing properties such as surface accuracy and roughness were determined and kinematic behaviour was investigated in a novel knee testing rig. It was carried out that PolyJet-Modelling with a sanded surface resulted in changed kinematic patterns compared to a usual CoCr-UHMWPE implant. However, fused deposition modelling using ABS and subsequent surface smoothening with acetone vapor showed the lowest roughness of the manufactured implants and only minor kinematic differences. For this reason this method constitutes a promising approach towards an optimal implant design for improved patient-satisfaction and long lifetime of the implant. Finally the workflow is not only limited to the knee.
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Claudia Zanabria, Filip Pröstl Andrén, Johannes Kathan, and Thomas I. Strasser
- Applied Sciences, Vol 8, Iss 8, p 1326 (2018)
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battery energy storage systems, rapid prototyping, conflicts identification, power utility automation, power distribution grid, semantic web technologies, ontology, description logics, model-driven engineering, smart grid architecture model, IEC 61850, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, and QD1-999
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Battery Energy Storage Systems (BESS) are starting to play an important role in today’s power distribution networks. They provide a manifold of services for fulfilling demands and requests from diverse stakeholders, such as distribution system operators, energy market operators, aggregators but also end-users. Such services are usually provided by corresponding Energy Management Systems (EMS). This paper analyzes the complexity of the EMS development process resulting from an evolving power utility automation.
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Dudek P. and Rapacz-Kmita A.
- Archives of Metallurgy and Materials, Vol 61, Iss 2, Pp 891-896 (2016)
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Rapid prototyping, Additive manufacturing, Composites, Mining engineering. Metallurgy, TN1-997, Materials of engineering and construction. Mechanics of materials, and TA401-492
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In the context of product development, the term rapid prototyping (RP) is widely used to describe technologies which create physical prototypes directly from digital data. Recently, this technology has become one of the fastest-growing methods of manufacturing parts. The paper provides brief notes on the creation of composites using RP methods, such as stereolithography, selective laser sintering or melting, laminated object modelling, fused deposition modelling or three-dimensional printing. The emphasis of this work is on the methodology of composite fabrication and the variety of materials used in these technologies.
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MIN LIANG, NG, Wei-Ren, KIHUN CHANG, GBELE, Kokou, GEHM, Michael E, and HAO XIN
- IEEE transactions on antennas and propagation. 62(4):1799-1807
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Telecommunications, Télécommunications, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Telecommunications et theorie de l'information, Telecommunications and information theory, Télécommunications, Telecommunications, Radiocommunications, Antennes, Antennas, Alimentation antenne, Antenna feeds, Antenne lentille, Lens antenna, Antena lentiforme, Application spatiale, Space application, Aplicación espacial, Bande X, X band, Banda X, Constante diélectrique, Permittivity, Constante dieléctrica, Gradient indice, Gradient index, Gradiente indicativo, Guide onde, Waveguide, Guía onda, Implémentation, Implementation, Implementación, Lobe latéral, Lateral lobe, Lóbulo lateral, Matière plastique, Plastics, Material plástico, Méthode élément fini, Finite element method, Método elemento finito, Onde centimétrique, Centimetric wave, Onda centimétrica, Prototypage rapide, Rapid prototyping, Prototipificación rápida, Simulation, Simulación, Luneburg lens, lens antenna, and rapid prototyping
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In this work, we designed, built, and tested a low-gain 20 dBi Luneburg Lens antenna using a rapid prototyping machine as a proof of concept demonstrator. The required continuously varying relative permittivity profile was implemented by changing the size of plastic blocks centered on the junctions of a plastic rod space frame. A 12-cm (4λ0 at 10 GHz) diameter lens is designed to work at X-band. The effective permittivity of the unit cell is calculated by effective medium theory and simulated by full-wave finite-element simulations. The fabrication is implemented by a polymer jetting rapid prototyping method. In the measurement, the lens antenna is fed by an X-band waveguide. The measured gain of the antenna at X-band is from 17.3 to 20.3 dB. The measured half-power beam width is from 19° to 12.7° while the side lobes are about 25 dB below the main peak. Good agreement between simulation and experimental results is obtained.
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Zachary Strike, Kamyar Ghofrani, and Chris Backhouse
- Micromachines, Vol 9, Iss 5, p 215 (2018)
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micropumps, microvalves, rapid prototyping, CO2 laser ablation, microdroplets, Mechanical engineering and machinery, and TJ1-1570
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The fabrication of microdevices for fluidic control often requires the use of flexible diaphragms in a way that requires cleanroom equipment and compromises performance. We use a CO 2 laser to perform the standard ablative techniques of cutting and engraving materials, but we also apply a method that we call laser placement. This allows us to fabricate precisely-positioned and precisely-sized, isolated diaphragms. This in turn enables the rapid prototyping of integrated multilayer microfluidic devices to form complex structures without the need for manual positioning or cleanroom equipment. The fabrication process is also remarkably rapid and capable of being scaled to manufacturing levels of production. We explore the use of these devices to construct a compact system of peristaltic pumps that can form water in oil droplets without the use of the non-pulsatile pumping systems typically required. Many devices can be fabricated at a time on a sheet by sheet basis with a fabrication process that, to our knowledge, is the fastest reported to date for devices of this type (requiring only 3 h). Moreover, this system is unusually compact and self-contained.
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KIM, Oleksiy S
- IEEE transactions on antennas and propagation. 62(7):3839-3842
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Telecommunications, Télécommunications, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Telecommunications et theorie de l'information, Telecommunications and information theory, Télécommunications, Telecommunications, Radiocommunications, Antennes, Antennas, Antenne fil, Wire antenna, Antena hilo, Antenne hélicoïdale, Helical antenna, Antena helicoidal, Antenne sphérique, Spherical antenna, Antena esférica, Impression, Printing, Impresión, Prototypage rapide, Rapid prototyping, Prototipificación rápida, Stratification, Estratificación, 3D printing, electrically small antennas, nanocrystalline copper, rapid prototyping, selective laser sintering, and spherical antennas
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It is shown how modern rapid prototyping technologies can be applied for quick and inexpensive, but still accurate, fabrication of electrically small wire antennas. A well known folded spherical helix antenna and a novel spherical zigzag antenna have been fabricated and tested, exhibiting the impedance and radiation characteristics in close agreement with those predicted numerically.
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HSIAO, Chun-Feng and CHU, Chih-Ping
- Journal of information science and engineering. 30(1):125-139
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Computer science, Informatique, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Informatique; automatique theorique; systemes, Computer science; control theory; systems, Logiciel, Software, Systèmes informatiques et systèmes répartis. Interface utilisateur, Computer systems and distributed systems. User interface, Génie logiciel, Software engineering, Arbre graphe, Tree(graph), Arbol grafo, Calculateur embarqué, Boarded computer, Calculador embarque, Composant logiciel, Software component, Componente logicial, Entrée sortie, Input output, Entrada salida, Flux donnée, Data flow, Flujo datos, Internet, Langage JAVA, JAVA language, Lenguaje JAVA, Logiciel patrimonial, Legacy software, Logicial herencia, Programmation automatique, Automatic programming, Programación automática, Prototypage rapide, Rapid prototyping, Prototipificación rápida, Réseau web, World wide web, Red WWW, Traitement flux donnée, Data flow processing, Téléenseignement, Remote teaching, Teleensenanza, Réutilisation logiciel, Software reusability, Reutilización de logicial, CASE, automatic programming, input-output tree, rapid prototyping, and software reuse
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A prototyping tool which facilitates the design of Java applets based on existing Java classes in the repository is developed and embedded into an eLearning platform. An input-output tree is proposed to graphically show the data flow from the input to output of a specific application. In the future, the possible direction of using such similar application as the proposed tool will assist the programmer to assemble the reusable software components from the repository, in which the source codes are generated automatically by means of automatic programming.
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18. Rapid prototyping in medical sciences [2015]
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Ákos Márk Horváth and Péter Ficzere
- Production Engineering Archives, Vol 8/3(2015), Pp 28-31 (2015)
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Rapid Prototyping, 3D printing methods, 3D printed medicines, Machine design and drawing, TJ227-240, Engineering machinery, tools, and implements, and TA213-215
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Even if it sound a bit incredible rapid prototyping (RPT) as production method has been used for decades in other professions. Nevertheless medical science just started discover the possibilities of this technology and use the offered benefits of 3D printing. In this paper authors have investigated the pharmaceutical usage of rapid prototyping.
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Samir Kumta, Monica Kumta, Leena Jain, Shrirang Purohit, and Rani Ummul
- Indian Journal of Plastic Surgery, Vol 48, Iss 3, Pp 263-273 (2015)
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Rapid prototyping, stereolithography, three dimensional (3D) template, Surgery, and RD1-811
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Introduction: Replication of the exact three-dimensional (3D) structure of the maxilla and mandible is now a priority whilst attempting reconstruction of these bones to attain a complete functional and aesthetic rehabilitation. We hereby present the process of rapid prototyping using stereolithography to produce templates for modelling bone grafts and implants for maxilla/mandible reconstructions, its applications in tumour/trauma, and outcomes for primary and secondary reconstruction. Materials and Methods: Stereolithographic template-assisted reconstruction was used on 11 patients for the reconstruction of the mandible/maxilla primarily following tumour excision and secondarily for the realignment of post-traumatic malunited fractures or deformity corrections. Data obtained from the computed tomography (CT) scans with 1-mm resolution were converted into a computer-aided design (CAD) using the CT Digital Imaging and Communications in Medicine (DICOM) data. Once a CAD model was constructed, it was converted into a stereolithographic format and then processed by the rapid prototyping technology to produce the physical anatomical model using a resin. This resin model replicates the native mandible, which can be thus used off table as a guide for modelling the bone grafts. Discussion: This conversion of two-dimensional (2D) data from CT scan into 3D models is a very precise guide to shaping the bone grafts. Further, this CAD can reconstruct the defective half of the mandible using the mirror image principle, and the normal anatomical model can be created to aid secondary reconstructions. Conclusion: This novel approach allows a precise translation of the treatment plan directly to the surgical field. It is also an important teaching tool for implant moulding and fixation, and helps in patient counselling.
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TU, Ting-Yuan, ZHE WANG, JING BAI, WEI SUN, WENG KUNG PENG, HUANG, Ruby Yun-Ju, THIERY, Jean-Paul, and KAMM, Roger D
- Advanced healthcare materials (Print). 3(4):609-616
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Biomedical engineering, Génie biomédical, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Tumeurs, Tumors, Tumeurs multiples. Tumeurs solides. Tumeurs chez l'enfant (généralités), Multiple tumors. Solid tumors. Tumors in childhood (general aspects), Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons, Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases, Technologie. Biomatériaux. Equipements, Technology. Biomaterials. Equipments, Cancer, Cáncer, Agrégat, Aggregate, Agregado, Criblage, Screening, Cernido, Dépistage, Medical screening, Descubrimiento, Médicament, Drug, Medicamento, Prototypage rapide, Rapid prototyping, Prototipificación rápida, Tumeur maligne, Malignant tumor, and Tumor maligno
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Microwell technology has revolutionized many aspects of in vitro cellular studies from 2D traditional cultures to 3D in vivo-like functional assays. However, existing lithography-based approaches are often costly and time-consuming. This study presents a rapid, low-cost prototyping method of CO2 laser ablation of a conventional untreated culture dish to create concave microwells used for generating multicellular aggregates, which can be readily available for general laboratories. Polymethylmethacrylate (PMMA), polydimethylsiloxane (PDMS), and polystyrene (PS) microwells are investigated, and each produces distinctive microwell features. Among these three materials, PS cell culture dishes produce the optimal surface smoothness and roundness. A549 lung cancer cells are grown to form cancer aggregates of controllable size from ≈40 to ≈80 μm in PS microwells. Functional assays of spheroids are performed to study migration on 2D substrates and in 3D hydrogel conditions as a step towards recapitulating the dissemination of cancer cells. Preclinical anti-cancer drug screening is investigated and reveals considerable differences between 2D and 3D conditions, indicating the importance of assay type as well as the utility of the present approach.
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