AMIA ... Annual Symposium Proceedings. AMIA Symposium [AMIA Annu Symp Proc] 2007 Oct 11, pp. 986. Date of Electronic Publication: 2007 Oct 11.
Female, Fractures, Bone, Humans, Medical Records Systems, Computerized, Middle Aged, Quality Assurance, Health Care, Computer Graphics, Decision Support Techniques, Hypercholesterolemia therapy, Osteoporosis therapy, and Quality Indicators, Health Care
We describe the application of the RetroGuide analytical toolset to quality improvement in osteoporosis and cholesterol management. Our graphical executable scenarios enable user-friendly modeling of temporal processes and retrospective prototyping of decision support on real EHR data. The graphical format is well understood by clinicians and improves the analyst-clinician collaboration.
Borah B, Gross GJ, Dufresne TE, Smith TS, Cockman MD, Chmielewski PA, Lundy MW, Hartke JR, and Sod EW
The Anatomical Record [Anat Rec] 2001 Apr; Vol. 265 (2), pp. 101-10.
Aged, Animals, Biomechanical Phenomena, Bone and Bones diagnostic imaging, Bone and Bones physiopathology, Female, Finite Element Analysis, Humans, Male, Middle Aged, Rats, Bone and Bones pathology, Imaging, Three-Dimensional, Magnetic Resonance Imaging methods, Osteoporosis diagnosis, and Tomography, X-Ray Computed methods
With the proportion of elderly people increasing in many countries, osteoporosis has become a growing public health problem, with rising medical, social, and economic consequences. It is well recognized that a combination of low bone mass and the deterioration of the trabecular architecture underlies osteoporotic fractures. A comprehensive understanding of the relationships between bone mass, the three-dimensional (3D) architecture of bone and bone function is fundamental to the study of new and existing therapies for osteoporosis. Detailed analysis of 3D trabecular architecture, using high-resolution digital imaging techniques such as magnetic resonance microimaging (MRmicroI), micro-computed tomography (microCT), and direct image analysis, has become feasible only recently. Rapid prototyping technology is used to replicate the complex trabecular architecture on a macroscopic scale for visual or biomechanical analysis. Further, a complete set of 3D image data provides a basis for finite element modeling (FEM) to predict mechanical properties. The goal of this paper is to describe how we can integrate three-dimensional microimaging and image analysis techniques for quantitation of trabecular bone architecture, FEM for virtual biomechanics, and rapid prototyping for enhanced visualization. The integration of these techniques provide us with an unique ability to investigate the role of bone architecture in osteoporotic fractures and to support the development of new therapies. (Copyright 2001 Wiley-Liss, Inc.)