The discovery and development of effective chemotherapeutic agents in the past few decadeshave immensely enhanced the treatment and management of human cancer. However, becausethese drugs are associated with adverse side effects, high genotoxicity, risk for secondary cancersand devastating effects on the patients’ immune system; the need for developing more effectiveanticancer agents remains. A priority Research shows that 9-aminoacridine (9AA) derivativeshave substantial anticancer properties. The pharmacological properties of this agent are wellcharacterized and this scaffold has been widely used to treat different diseases for decades.Quinacrine is a 9AA derivative, which was first discovered as an antimalarial compound in1930’s and since then had been widely used in treating a variety of parasitic infections anddemonstrated potential for cancer treatment. Importantly, the polypharmacology of Quinacrinemakes it an attractive drug to treat a variety of cancers. Quinacrine acts by specifically targetingcellular signaling pathways that play an important role in cell survival. Given the distinctivecancer treating abilities of Quinacrine by specifically targeting cellular signaling pathways, itwas the objective of this study to develop a compound that has similar properties as Quinacrinebut has better efficacy and selectivity in targeting tumor cells. Therefore, for this project wecreated derivatives of 9AA compound using hybrid pharmapore approach and examined one ofthe derivatives of Quinacrine compound named VR118. After performing a series of experimentsto test the efficacy and selectivity of the Quinacrine derivative VR118, I came to the conclusionthat VR118 is highly effective in treating cancer cells and have the potential to selectively targetcancer cells without causing severe harm to normal cells at concentrations applicable formalignant cell lines. This report discusses the efficacy and selectivity of VR118 compound intargeting cellular signaling pathways and the mechanisms through which VR118 kills cancercells.
Behavioral Coaching, Skill Acquisition, Sport, and Behavioral Disciplines and Activities
Behavioral coaching procedures have been evaluated and enhanced over the years to find the most effective interventions for athletic performance in a variety of sports settings. Different types of feedback have been evaluated for effectiveness in teaching and improving skills. The purpose of this study was to examine the effects of video modeling and video feedback to improve technique for three novice individuals in a fitness program incorporating Olympic weightlifting. Two weightlifting events, the clean and jerk and snatch, were targeted for intervention. Each lift was broken down into a task analysis, and trainers used the task analysis to score each lift. Video modeling and video feedback was effective in improving all three participant's lifts from baseline. Annie's lifts improved from 37% in baseline to 79% in intervention for the clean and jerk, and 24% to 75% for the snatch. Rich's lifts improved from 79% in baseline to 95% following intervention for clean and jerk, and 58% to 89% for the snatch. Fran improved from 60% to 87% on the clean and jerk, and from 51% to 84% on the snatch.