Social Research. Summer, 2019, Vol. 86 Issue 2, p449, 28 p.
Company personnel management, High technology industry -- Human resource management, High technology industry -- Ethical aspects, High technology industry -- Industry forecasts, Business ethics -- Methods, and Silicon Valley -- Social aspects
Recently, a great amount of attention --both scholarly and popular--has been focused on implementing design thinking in schools (Norton Hathaway, 2015). A recent piece in The Atlantic, for example, notes [...]
Al-Shamary, Danah S., Al-Alshaikh, Monirah A., Kheder, Nabila Abdelshafy, Mabkhot, Yahia Nasser, and Badshah, Syed Lal
Chemistry Central Journal. May 31, 2017, Vol. 11 Issue 1
Organic compounds -- Research, Cancer -- Care and treatment, and Cancer -- Research
Author(s): Danah S. Al-Shamary[sup.1], Monirah A. Al-Alshaikh[sup.1], Nabila Abdelshafy Kheder[sup.2,3], Yahia Nasser Mabkhot[sup.4] and Syed Lal Badshah[sup.5] Background The quinazoline moiety containing compounds is of considerable medicinal importance because of [...] Background The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc. Results We evaluated the previously synthesized quinazoline derivatives 1-3 for their anticancer activities against three cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were found to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds had less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies were performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2, butyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking properties with the CDK2 as compared to the other two enzymes. Conclusions The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence of drug resistance, it is important to explore and develop more efficacious drugs. Keywords: Thioxoquinazolin-4(3H)-one, Anticancer activity, Antioxidant activity, Anticonvulsant activity, Molecular docking
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