Social Research. Summer, 2019, Vol. 86 Issue 2, p449, 28 p.
Company personnel management, High technology industry -- Human resource management, High technology industry -- Ethical aspects, High technology industry -- Industry forecasts, Business ethics -- Methods, and Silicon Valley -- Social aspects
Recently, a great amount of attention --both scholarly and popular--has been focused on implementing design thinking in schools (Norton Hathaway, 2015). A recent piece in The Atlantic, for example, notes [...]
Al-Shamary, Danah S., Al-Alshaikh, Monirah A., Kheder, Nabila Abdelshafy, Mabkhot, Yahia Nasser, and Badshah, Syed Lal
Chemistry Central Journal. May 31, 2017, Vol. 11 Issue 1
Organic compounds -- Research, Cancer -- Care and treatment, and Cancer -- Research
Author(s): Danah S. Al-Shamary[sup.1], Monirah A. Al-Alshaikh[sup.1], Nabila Abdelshafy Kheder[sup.2,3], Yahia Nasser Mabkhot[sup.4] and Syed Lal Badshah[sup.5] Background The quinazoline moiety containing compounds is of considerable medicinal importance because of [...] Background The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc. Results We evaluated the previously synthesized quinazoline derivatives 1-3 for their anticancer activities against three cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were found to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds had less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies were performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2, butyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking properties with the CDK2 as compared to the other two enzymes. Conclusions The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence of drug resistance, it is important to explore and develop more efficacious drugs. Keywords: Thioxoquinazolin-4(3H)-one, Anticancer activity, Antioxidant activity, Anticonvulsant activity, Molecular docking
I/S: A Journal of Law and Policy for the Information Society, 2011/01/01, Vol: 7, p1
communications law, computer internet law, criminal law procedure, and governments
I. Introduction As a platform for user-generated content, the Internet has made it possible for people around the world to converse, share information, create communities, and mobilize around shared interests. Those who celebrate the Internet often revel in the moments where networked technology has enhanced political action, transformed information flow, or empowered communities of interest to generate new cultural artifacts. Critics often see flaws in the very same features, pointing to the potential for terrorism, crimes against minors, and the spread of problematic content. Anxieties about the Internet are particularly acute in relation to youth, who are seen as both uncontrollable deviants who must be punished and an impressionable population who must be protected. As a result, the Internet is often criticized as a sinister world where na ve teens fall prey to various assorted malevolent forces, or teens are vilified for using the Internet to indulge their darkest and wildest impulses, below the radar of parental authority. 1 Societal anxiety about youth online safety has historically focused on three core areas of concern: (1) sexual solicitation and sex crimes against minors; (2) bullying and harassment; and (3) access to illegal or problematic content. 2 More recently, the increased public discourse around user- generated content has introduced a new area of concern: youth-generated problematic content. This is not to say that teens were not contributing problematic content to the Internet throughout the 1990s and 2000s or that it was not of concern to adults, but rather that emergent ...