Communications research -- Methodology, Big data, Theory of knowledge, Machine learning, Ethnology methodology, Watson (Computer), and Artificial intelligence

"Big Data" and "artificial intelligence" have captured the public imagination and are profoundly shaping social, economic, and political spheres. Through an interrogation of the histories, perceptions, and practices that shape these technologies, we problematize the myths that animate the supposed "magic" of these systems. In the face of an increasingly widespread blind faith in data-driven technologies, we argue for grounding machine learning-based practices and untethering them from hype and fear cycles. One path forward is to develop a rich methodological framework for addressing the strengths and weaknesses of doing data analysis. Through provocatively reimagining machine learning as computational ethnography, we invite practitioners to prioritize methodological reflection and recognize that all knowledge work is situated practice. [ABSTRACT FROM AUTHOR]

Privacy, Journalists, Learning & scholarship, Surveillance detection, and Middle class -- United States

Although privacy and surveillance affect different populations in disparate ways, they are often treated as monolithic concepts by journalists, privacy advocates, and researchers. Achieving privacy is especially difficult for those who are marginalized in other areas of life. This special section interrogates what privacy looks like at the margins, investigating a broad spectrum of issues, methodologies, and contexts. Many make an intervention into mainstream theories of privacy and surveillance, showing how examining the experiences of individuals outside the normative White, American, middle-class subject often complicates assumptions about how privacy operates. Others examine the mundane and the banal to analyze how power relations play out in everyday life. By incorporating research outside the canon of privacy research, and by advocating for projects that discuss more diverse conceptualizations of "the user" or the subject, we can envision a future for privacy scholarship that incorporates a wider set of harms and needs and encompasses the concerns of a larger base of citizens. [ABSTRACT FROM AUTHOR]

Teachers -- Practice, Teacher centers -- Methods, Teacher centers -- Analysis, Teachers -- Training, Teachers -- Methods, and Teachers -- Analysis

Recently, a great amount of attention --both scholarly and popular--has been focused on implementing design thinking in schools (Norton Hathaway, 2015). A recent piece in The Atlantic, for example, notes [...]

Creative ability -- Analysis, Educators -- Evaluation, Schools -- Management, and Schools -- United States

Organic compounds -- Research, Cancer -- Care and treatment, and Cancer -- Research

Author(s): Danah S. Al-Shamary[sup.1], Monirah A. Al-Alshaikh[sup.1], Nabila Abdelshafy Kheder[sup.2,3], Yahia Nasser Mabkhot[sup.4] and Syed Lal Badshah[sup.5] Background The quinazoline moiety containing compounds is of considerable medicinal importance because of [...]
Background The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc. Results We evaluated the previously synthesized quinazoline derivatives 1-3 for their anticancer activities against three cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were found to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds had less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies were performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2, butyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking properties with the CDK2 as compared to the other two enzymes. Conclusions The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence of drug resistance, it is important to explore and develop more efficacious drugs. Keywords: Thioxoquinazolin-4(3H)-one, Anticancer activity, Antioxidant activity, Anticonvulsant activity, Molecular docking