298 results in SearchWorks articles

1. Consensus Statement on the definition and classification of metabolic hyperferritinaemia. [2023]

Valenti L, Corradini E, Adams LA, Aigner E, Alqahtani S, Arrese M, Bardou-Jacquet E, Bugianesi E, Fernandez-Real JM, Girelli D, Hagström H, Henninger B, Kowdley K, Ligabue G, McClain D, Lainé F, Miyanishi K, Muckenthaler MU, Pagani A, Pedrotti P, Pietrangelo A, Prati D, Ryan JD, Silvestri L, Spearman CW, Stål P, Tsochatzis EA, Vinchi F, Zheng MH, and Zoller H
Nature reviews. Endocrinology [Nat Rev Endocrinol] 2023 Feb 17. Date of Electronic Publication: 2023 Feb 17.

Abstract: Hyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron accumulation in the body and is associated with an increased risk of cardiometabolic and liver diseases. Genetic variants that modulate iron homeostasis and tissue levels of iron are the main determinants of serum levels of ferritin in individuals with metabolic dysfunction, raising the hypothesis that iron accumulation might be implicated in the pathogenesis of insulin resistance and the related organ damage. However, validated criteria for the non-invasive diagnosis of metabolic hyperferritinaemia and the staging of iron overload are still lacking, and there is no clear evidence of a benefit for iron depletion therapy. Here, we provide an overview of the literature on the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction, and on the associated clinical outcomes. We propose an updated definition and a provisional staging system for metabolic hyperferritinaemia, which has been agreed on by a multidisciplinary global panel of expert researchers. The goal is to foster studies into the epidemiology, genetics, pathophysiology, clinical relevance and treatment of metabolic hyperferritinaemia, for which we provide suggestions on the main unmet needs, optimal design and clinically relevant outcomes.
(© 2023. Springer Nature Limited.)

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2. Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans. [2023]

Guimier A, de Pontual L, Braddock SR, Torti E, Pérez-Jurado LA, Muñoz-Cabello P, Arumí M, Monaghan KG, Lee H, Wang LK, Pluym ID, Lynch SA, Stals K, Ellard S, Muller C, Houyel L, Cohen L, Lyonnet S, Bajolle F, Amiel J, and Gordon CT
Human molecular genetics [Hum Mol Genet] 2023 Jan 13; Vol. 32 (3), pp. 353-356.

Subjects: Humans, Heart Defects, Congenital, and Truncus Arteriosus, Persistent

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3. SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females. [2021]

Radio FC, Pang K, Ciolfi A, Levy MA, Hernández-García A, Pedace L, Pantaleoni F, Liu Z, de Boer E, Jackson A, Bruselles A, McConkey H, Stellacci E, Lo Cicero S, Motta M, Carrozzo R, Dentici ML, McWalter K, Desai M, Monaghan KG, Telegrafi A, Philippe C, Vitobello A, Au M, Grand K, Sanchez-Lara PA, Baez J, Lindstrom K, Kulch P, Sebastian J, Madan-Khetarpal S, Roadhouse C, MacKenzie JJ, Monteleone B, Saunders CJ, Jean Cuevas JK, Cross L, Zhou D, Hartley T, Sawyer SL, Monteiro FP, Secches TV, Kok F, Schultz-Rogers LE, Macke EL, Morava E, Klee EW, Kemppainen J, Iascone M, Selicorni A, Tenconi R, Amor DJ, Pais L, Gallacher L, Turnpenny PD, Stals K, Ellard S, Cabet S, Lesca G, Pascal J, Steindl K, Ravid S, Weiss K, Castle AMR, Carter MT, Kalsner L, de Vries BBA, van Bon BW, Wevers MR, Pfundt R, Stegmann APA, Kerr B, Kingston HM, Chandler KE, Sheehan W, Elias AF, Shinde DN, Towne MC, Robin NH, Goodloe D, Vanderver A, Sherbini O, Bluske K, Hagelstrom RT, Zanus C, Faletra F, Musante L, Kurtz-Nelson EC, Earl RK, Anderlid BM, Morin G, van Slegtenhorst M, Diderich KEM, Brooks AS, Gribnau J, Boers RG, Finestra TR, Carter LB, Rauch A, Gasparini P, Boycott KM, Barakat TS, Graham JM Jr, Faivre L, Banka S, Wang T, Eichler EE, Priolo M, Dallapiccola B, Vissers LELM, Sadikovic B, Scott DA, Holder JL Jr, and Tartaglia M
American journal of human genetics [Am J Hum Genet] 2021 Mar 04; Vol. 108 (3), pp. 502-516. Date of Electronic Publication: 2021 Feb 16.

Subjects: Adolescent, Autism Spectrum Disorder genetics, Autism Spectrum Disorder pathology, Child, Child, Preschool, Chromosome Deletion, Chromosome Disorders physiopathology, DNA Methylation genetics, Epigenesis, Genetic genetics, Female, Haploinsufficiency genetics, Humans, Intellectual Disability genetics, Intellectual Disability physiopathology, Male, Neurodevelopmental Disorders genetics, Neurodevelopmental Disorders physiopathology, Phenotype, Young Adult, Chromosome Disorders genetics, Chromosomes, Human, Pair 1 genetics, Chromosomes, Human, X genetics, DNA-Binding Proteins genetics, and RNA-Binding Proteins genetics
Abstract: Deletion 1p36 (del1p36) syndrome is the most common human disorder resulting from a terminal autosomal deletion. This condition is molecularly and clinically heterogeneous. Deletions involving two non-overlapping regions, known as the distal (telomeric) and proximal (centromeric) critical regions, are sufficient to cause the majority of the recurrent clinical features, although with different facial features and dysmorphisms. SPEN encodes a transcriptional repressor commonly deleted in proximal del1p36 syndrome and is located centromeric to the proximal 1p36 critical region. Here, we used clinical data from 34 individuals with truncating variants in SPEN to define a neurodevelopmental disorder presenting with features that overlap considerably with those of proximal del1p36 syndrome. The clinical profile of this disease includes developmental delay/intellectual disability, autism spectrum disorder, anxiety, aggressive behavior, attention deficit disorder, hypotonia, brain and spine anomalies, congenital heart defects, high/narrow palate, facial dysmorphisms, and obesity/increased BMI, especially in females. SPEN also emerges as a relevant gene for del1p36 syndrome by co-expression analyses. Finally, we show that haploinsufficiency of SPEN is associated with a distinctive DNA methylation episignature of the X chromosome in affected females, providing further evidence of a specific contribution of the protein to the epigenetic control of this chromosome, and a paradigm of an X chromosome-specific episignature that classifies syndromic traits. We conclude that SPEN is required for multiple developmental processes and SPEN haploinsufficiency is a major contributor to a disorder associated with deletions centromeric to the previously established 1p36 critical regions.
(Copyright © 2021 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)

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4. HNF1B deletions in patients with young-onset diabetes but no known renal disease [2013]

Edghill, E. L., Stals, K., Oram, R. A., Shepherd, M. H., Hattersley, A. T., and Ellard, S.
Diabetic Medicine. Jan 2013, Vol. 30 Issue 1, p114, 4 p.

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5. Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave [2021]

Kaptein, F.H.J., Stals, M.A.M., Grootenboers, M., Braken, S.J.E., Burggraaf, J.L.I., van Bussel, B.C.T., Cannegieter, S.C., ten Cate, H., Endeman, H., Gommers, D.A.M.P.J., van Guldener, C., de Jonge, E., Juffermans, N.P., Kant, K.M., Kevenaar, M.E., Koster, S., Kroft, L.J.M., Kruip, M.J.H.A., Leentjens, J., Marechal, C., Soei, Y.L., Tjepkema, L., Visser, C., Klok, F.A., and Huisman, M.V.
Thrombosis Research. March 2021, Vol. 199, 143

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6. Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome [2022]

Ismail, Vardha, Zachariassen, Linda G., Godwin, Annie, Sahakian, Mane, Ellard, Sian, Stals, Karen L., Baple, Emma, Brown, Kate Tatton, Foulds, Nicola, Wheway, Gabrielle, Parker, Matthew O., Lyngby, Signe M., Pedersen, Miriam G., Desir, Julie, Bayat, Allan, Musgaard, Maria, Guille, Matthew, Kristensen, Anders S., and Baralle, Diana
American Journal of Human Genetics. July 7, 2022, Vol. 109 Issue 7, 1217

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7. Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms [2002]

Yu, F., Stål, P., Thornell, L.-E., and Larsson, L.
Journal of Muscle Research and Cell Motility. August, 2002, Vol. 23 Issue 4, p317, 10 p.

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8. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study [2020]

Groeneweg, Stefan, van Geest, Ferdy S, Abaci, Ayhan, Alcantud, Alberto, Ambegaonkar, Gautam P, Armour, Christine M, Bakhtiani, Priyanka, Barca, Diana, Bertini, Enrico S, van Beynum, Ingrid M, Brunetti-Pierri, Nicola, Bugiani, Marianna, Cappa, Marco, Cappuccio, Gerarda, Castellotti, Barbara, Castiglioni, Claudia, Chatterjee, Krishna, de Coo, Irenaeus F M, Coutant, Régis, Craiu, Dana, Crock, Patricia, DeGoede, Christian, Demir, Korcan, Dica, Alice, Dimitri, Paul, Dolcetta-Capuzzo, Anna, Dremmen, Marjolein H G, Dubey, Rachana, Enderli, Anina, Fairchild, Jan, Gallichan, Jonathan, George, Belinda, Gevers, Evelien F, Hackenberg, Annette, Halász, Zita, Heinrich, Bianka, Huynh, Tony, Klosowska, Anna, van der Knaap, Marjo S, van der Knoop, Marieke M, Konrad, Daniel, Koolen, David A, Krude, Heiko, Lawson-Yuen, Amy, Lebl, Jan, Linder-Lucht, Michaela, Lorea, Cláudia F, Lourenço, Charles M, Lunsing, Roelineke J, Lyons, Greta, Malikova, Jana, Mancilla, Edna E, McGowan, Anne, Mericq, Veronica, Lora, Felipe M, Moran, Carla, Müller, Katalin E, Oliver-Petit, Isabelle, Paone, Laura, Paul, Praveen G, Polak, Michel, Porta, Francesco, Poswar, Fabiano O, Reinauer, Christina, Rozenkova, Klara, Menevse, Tuba S, Simm, Peter, Simon, Anna, Singh, Yogen, Spada, Marco, van der Spek, Jet, Stals, Milou A M, Stoupa, Athanasia, Subramanian, Gopinath M, Tonduti, Davide, Turan, Serap, den Uil, Corstiaan A, Vanderniet, Joel, van der Walt, Adri, Wémeau, Jean-Louis, Wierzba, Jolante, de Wit, Marie-Claire Y, Wolf, Nicole I, Wurm, Michael, Zibordi, Federica, Zung, Amnon, Zwaveling-Soonawala, Nitash, and Visser, W Edward
The Lancet Diabetes & Endocrinology. July, 2020, Vol. 8 Issue 7, p594.

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9. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior [2014]

Shrestha, Stal Saurav, Nelson, Eric E., Liow, Jeih-San, Gladding, Robert, Lyoo, Chul Hyoung, Noble, Pam L., Morse, Cheryl, Henter, Ioline D., Kruger, Jeremy, Zhang, Bo, Suomi, Stephen J., Svenningsson, Per, Pike, Victor W., Winslow, James T., Leibenluft, Ellen, Pine, Daniel S., and Innis, Robert B.
American Journal of Psychiatry. March 2014, Vol. 171 Issue 3, p323, 9 p.

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10. Evidence for low muscle capillary supply as a pathogenic factor in chronic compartment syndrome [2010]

Edmundsson, D., Toolanen, G., Thornell, L-E., and Stal, P.
Scandinavian Journal of Medicine and Science in Sports. Dec 2010, Vol. 20 Issue 6, p805, 9 p.

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11. Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial [2005]

Jirstrom, K., Ryden, L., Anagnostaki, L., Nordenskjold, B., Stal, O., Thorstenson, S., Chebil, G., Jonsson, P.-E., Ferno, M., and Landberg, G.
Journal of Clinical Pathology. Nov 2005, Vol. 58 Issue 11, p1135, 8 p.

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12. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. [2020]

Barish S, Barakat TS, Michel BC, Mashtalir N, Phillips JB, Valencia AM, Ugur B, Wegner J, Scott TM, Bostwick B, Murdock DR, Dai H, Perenthaler E, Nikoncuk A, van Slegtenhorst M, Brooks AS, Keren B, Nava C, Mignot C, Douglas J, Rodan L, Nowak C, Ellard S, Stals K, Lynch SA, Faoucher M, Lesca G, Edery P, Engleman KL, Zhou D, Thiffault I, Herriges J, Gass J, Louie RJ, Stolerman E, Washington C, Vetrini F, Otsubo A, Pratt VM, Conboy E, Treat K, Shannon N, Camacho J, Wakeling E, Yuan B, Chen CA, Rosenfeld JA, Westerfield M, Wangler M, Yamamoto S, Kadoch C, Scott DA, and Bellen HJ
American journal of human genetics [Am J Hum Genet] 2020 Dec 03; Vol. 107 (6), pp. 1096-1112. Date of Electronic Publication: 2020 Nov 23.

Subjects: Adolescent, Animals, Child, Child, Preschool, Drosophila Proteins genetics, Drosophila melanogaster, Female, Genes, Dominant, Genetic Variation, Haploinsufficiency, Humans, Infant, Male, Microscopy, Confocal, Neuroglia metabolism, Neurons metabolism, Protein Binding, Zebrafish, Zebrafish Proteins genetics, Chromosomal Proteins, Non-Histone genetics, Developmental Disabilities genetics, Mutation, Missense, Phenotype, and Tumor Suppressor Proteins genetics
Abstract: SWI/SNF-related intellectual disability disorders (SSRIDDs) are rare neurodevelopmental disorders characterized by developmental disability, coarse facial features, and fifth digit/nail hypoplasia that are caused by pathogenic variants in genes that encode for members of the SWI/SNF (or BAF) family of chromatin remodeling complexes. We have identified 12 individuals with rare variants (10 loss-of-function, 2 missense) in the BICRA (BRD4 interacting chromatin remodeling complex-associated protein) gene, also known as GLTSCR1, which encodes a subunit of the non-canonical BAF (ncBAF) complex. These individuals exhibited neurodevelopmental phenotypes that include developmental delay, intellectual disability, autism spectrum disorder, and behavioral abnormalities as well as dysmorphic features. Notably, the majority of individuals lack the fifth digit/nail hypoplasia phenotype, a hallmark of most SSRIDDs. To confirm the role of BICRA in the development of these phenotypes, we performed functional characterization of the zebrafish and Drosophila orthologs of BICRA. In zebrafish, a mutation of bicra that mimics one of the loss-of-function variants leads to craniofacial defects possibly akin to the dysmorphic facial features seen in individuals harboring putatively pathogenic BICRA variants. We further show that Bicra physically binds to other non-canonical ncBAF complex members, including the BRD9/7 ortholog, CG7154, and is the defining member of the ncBAF complex in flies. Like other SWI/SNF complex members, loss of Bicra function in flies acts as a dominant enhancer of position effect variegation but in a more context-specific manner. We conclude that haploinsufficiency of BICRA leads to a unique SSRIDD in humans whose phenotypes overlap with those previously reported.
(Copyright © 2020 American Society of Human Genetics. All rights reserved.)

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13. VAV3 mediates resistance to breast cancer endocrine therapy [2014]

Aguilar, Helena, Urruticoechea, Ander, Halonen, Pasi, Kiyotani, Kazuma, Mushiroda, Taisei, Barril, Xavier, Serra-Musach, Jordi, Islam, Abul, Caizzi, Livia, Di Croce, Luciano, Nevedomskaya, Ekaterina, Zwart, Wilbert, Bostner, Josefine, Karlsson, Elin, Pnrez Tenorio, Gizeh, Fornander, Tommy, Sgroi, Dennis C, Garcia-Mata, Rafael, Jansen, Maurice PHM, Garcia, Nadia, Bonifaci, Nuria, Climent, Fina, Soler, Maria Teresa, Rodriguez-Vida, Alejo, Gil, Miguel, Brunet, Joan, Martrat, Griselda, Gomez-Baldo, Laia, Extremera, Ana I, Figueras, Agnes, Balart, Josep, Clarke, Robert, Burnstein, Kerry L, Carlson, Kathryn E, Katzenellenbogen, John A, Vizoso, Miguel, Esteller, Manel, Villanueva, Alberto, Rodriguez-Peea, Ana B, Bustelo, Xosn R, Nakamura, Yusuke, Zembutsu, Hitoshi, Stal, Olle, Beijersbergen, Roderick L, and Pujana, Miguel Angel
Breast Cancer Research. May 28, 2014, Vol. 16 Issue 3

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14. Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial [2018]

Zhu, Andrew X, Finn, Richard S, Edeline, Julien, Cattan, Stephane, Ogasawara, Sadahisa, Palmer, Daniel, Verslype, Chris, Zagonel, Vittorina, Fartoux, Laetitia, Vogel, Arndt, Sarker, Debashis, Verset, Gontran, Chan, Stephen L, Knox, Jennifer, Daniele, Bruno, Webber, Andrea L, Ebbinghaus, Scot W, Ma, Junshui, Siegel, Abby B, Cheng, Ann-Lii, Kudo, Masatoshi, Alistar, Angela, Asselah, Jamil, Blanc, Jean-Frederic, Borbath, Ivan, Cannon, Timothy, Chung, Ki, Cohn, Allen, Cosgrove, David P, Damjanov, Nevena, Gupta, Mukul, Karino, Yoshivasu, Karwal, Mark, Kaubisch, Andreas, Kelley, Robin, Van Laethem, Jena-Luc, Larson, Timothy, Lee, James, Li, Daneng, Manhas, Atisha, Manji, Gulam Abbas, Numata, Kazushi, Parsons, Benjamin, Paulson, Andrew S., Pinto, Carmine, Ramirez, Robert, Ratnam, Suresh, Rizell, Magnus, Rosmorduc, Olivier, Sada, Yvonne, Sasaki, Yutaka, Stal, Per I, Strasser, Simone, Trojan, Joerg, Vaccaro, Gina, Van Vlierberghe, Hans, Weiss, Alan, Weiss, Karl-Heinz, and Yamashita, Tatsuya
Lancet Oncology. July, 2018, Vol. 19 Issue 7, p940.

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15. Taxonomy based on science is necessary for global conservation. [2018]

Thomson SA, Pyle RL, Ahyong ST, Alonso-Zarazaga M, Ammirati J, Araya JF, Ascher JS, Audisio TL, Azevedo-Santos VM, Bailly N, Baker WJ, Balke M, Barclay MVL, Barrett RL, Benine RC, Bickerstaff JRM, Bouchard P, Bour R, Bourgoin T, Boyko CB, Breure ASH, Brothers DJ, Byng JW, Campbell D, Ceríaco LMP, Cernák I, Cerretti P, Chang CH, Cho S, Copus JM, Costello MJ, Cseh A, Csuzdi C, Culham A, D'Elía G, d'Udekem d'Acoz C, Daneliya ME, Dekker R, Dickinson EC, Dickinson TA, van Dijk PP, Dijkstra KB, Dima B, Dmitriev DA, Duistermaat L, Dumbacher JP, Eiserhardt WL, Ekrem T, Evenhuis NL, Faille A, Fernández-Triana JL, Fiesler E, Fishbein M, Fordham BG, Freitas AVL, Friol NR, Fritz U, Frøslev T, Funk VA, Gaimari SD, Garbino GST, Garraffoni ARS, Geml J, Gill AC, Gray A, Grazziotin FG, Greenslade P, Gutiérrez EE, Harvey MS, Hazevoet CJ, He K, He X, Helfer S, Helgen KM, van Heteren AH, Hita Garcia F, Holstein N, Horváth MK, Hovenkamp PH, Hwang WS, Hyvönen J, Islam MB, Iverson JB, Ivie MA, Jaafar Z, Jackson MD, Jayat JP, Johnson NF, Kaiser H, Klitgård BB, Knapp DG, Kojima JI, Kõljalg U, Kontschán J, Krell FT, Krisai-Greilhuber I, Kullander S, Latella L, Lattke JE, Lencioni V, Lewis GP, Lhano MG, Lujan NK, Luksenburg JA, Mariaux J, Marinho-Filho J, Marshall CJ, Mate JF, McDonough MM, Michel E, Miranda VFO, Mitroiu MD, Molinari J, Monks S, Moore AJ, Moratelli R, Murányi D, Nakano T, Nikolaeva S, Noyes J, Ohl M, Oleas NH, Orrell T, Páll-Gergely B, Pape T, Papp V, Parenti LR, Patterson D, Pavlinov IY, Pine RH, Poczai P, Prado J, Prathapan D, Rabeler RK, Randall JE, Rheindt FE, Rhodin AGJ, Rodríguez SM, Rogers DC, Roque FO, Rowe KC, Ruedas LA, Salazar-Bravo J, Salvador RB, Sangster G, Sarmiento CE, Schigel DS, Schmidt S, Schueler FW, Segers H, Snow N, Souza-Dias PGB, Stals R, Stenroos S, Stone RD, Sturm CF, Štys P, Teta P, Thomas DC, Timm RM, Tindall BJ, Todd JA, Triebel D, Valdecasas AG, Vizzini A, Vorontsova MS, de Vos JM, Wagner P, Watling L, Weakley A, Welter-Schultes F, Whitmore D, Wilding N, Will K, Williams J, Wilson K, Winston JE, Wüster W, Yanega D, Yeates DK, Zaher H, Zhang G, Zhang ZQ, and Zhou HZ
PLoS biology [PLoS Biol] 2018 Mar 14; Vol. 16 (3), pp. e2005075. Date of Electronic Publication: 2018 Mar 14 (Print Publication: 2018).

Subjects: Biodiversity and Conservation of Natural Resources

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16. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial. [2019]

Younossi ZM, Ratziu V, Loomba R, Rinella M, Anstee QM, Goodman Z, Bedossa P, Geier A, Beckebaum S, Newsome PN, Sheridan D, Sheikh MY, Trotter J, Knapple W, Lawitz E, Abdelmalek MF, Kowdley KV, Montano-Loza AJ, Boursier J, Mathurin P, Bugianesi E, Mazzella G, Olveira A, Cortez-Pinto H, Graupera I, Orr D, Gluud LL, Dufour JF, Shapiro D, Campagna J, Zaru L, MacConell L, Shringarpure R, Harrison S, and Sanyal AJ
Lancet (London, England) [Lancet] 2019 Dec 14; Vol. 394 (10215), pp. 2184-2196. Date of Electronic Publication: 2019 Dec 05.

Subjects: Administration, Oral, Biomarkers analysis, Biopsy, Chenodeoxycholic Acid administration dosage, Chenodeoxycholic Acid therapeutic use, Double-Blind Method, Female, Humans, Liver Function Tests, Male, Middle Aged, Chenodeoxycholic Acid analogs derivatives, and Non-alcoholic Fatty Liver Disease drug therapy
Abstract: Background: Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH.
Methods: In this multicentre, randomised, double-blind, placebo-controlled study, adult patients with definite NASH, non-alcoholic fatty liver disease (NAFLD) activity score of at least 4, and fibrosis stages F2-F3, or F1 with at least one accompanying comorbidity, were randomly assigned using an interactive web response system in a 1:1:1 ratio to receive oral placebo, obeticholic acid 10 mg, or obeticholic acid 25 mg daily. Patients were excluded if cirrhosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were present. The primary endpoints for the month-18 interim analysis were fibrosis improvement (≥1 stage) with no worsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered successful if either primary endpoint was met. Primary analyses were done by intention to treat, in patients with fibrosis stage F2-F3 who received at least one dose of treatment and reached, or would have reached, the month 18 visit by the prespecified interim analysis cutoff date. The study also evaluated other histological and biochemical markers of NASH and fibrosis, and safety. This study is ongoing, and registered with ClinicalTrials.gov, NCT02548351, and EudraCT, 20150-025601-6.
Findings: Between Dec 9, 2015, and Oct 26, 2018, 1968 patients with stage F1-F3 fibrosis were enrolled and received at least one dose of study treatment; 931 patients with stage F2-F3 fibrosis were included in the primary analysis (311 in the placebo group, 312 in the obeticholic acid 10 mg group, and 308 in the obeticholic acid 25 mg group). The fibrosis improvement endpoint was achieved by 37 (12%) patients in the placebo group, 55 (18%) in the obeticholic acid 10 mg group (p=0·045), and 71 (23%) in the obeticholic acid 25 mg group (p=0·0002). The NASH resolution endpoint was not met (25 [8%] patients in the placebo group, 35 [11%] in the obeticholic acid 10 mg group [p=0·18], and 36 [12%] in the obeticholic acid 25 mg group [p=0·13]). In the safety population (1968 patients with fibrosis stages F1-F3), the most common adverse event was pruritus (123 [19%] in the placebo group, 183 [28%] in the obeticholic acid 10 mg group, and 336 [51%] in the obeticholic acid 25 mg group); incidence was generally mild to moderate in severity. The overall safety profile was similar to that in previous studies, and incidence of serious adverse events was similar across treatment groups (75 [11%] patients in the placebo group, 72 [11%] in the obeticholic acid 10 mg group, and 93 [14%] in the obeticholic acid 25 mg group).
Interpretation: Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH. The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes.
Funding: Intercept Pharmaceuticals.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)

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17. Muscle contractures in patients with cerebral palsy and acquired brain injury are associated with extracellular matrix expansion, pro-inflammatory gene expression, and reduced rRNA synthesis. [2018]

Von Walden F, Gantelius S, Liu C, Borgström H, Björk L, Gremark O, Stål P, Nader GA, and PontéN E
Muscle & nerve [Muscle Nerve] 2018 Aug; Vol. 58 (2), pp. 277-285. Date of Electronic Publication: 2018 May 24.

Subjects: Adolescent, Cell Count, Child, Collagen metabolism, Cytokines biosynthesis, Cytokines genetics, Female, Gene Expression Regulation, Humans, Male, Muscle Fibers, Skeletal pathology, RNA, Ribosomal genetics, Real-Time Polymerase Chain Reaction, Ribosomes genetics, Ribosomes pathology, Satellite Cells, Skeletal Muscle pathology, Brain Injuries pathology, Cerebral Palsy pathology, Extracellular Matrix pathology, Muscle, Skeletal pathology, and RNA, Ribosomal biosynthesis
Abstract: Introduction: Children with cerebral palsy (CP) and acquired brain injury (ABI) commonly develop muscle contractures with advancing age. An underlying growth defect contributing to skeletal muscle contracture formation in CP/ABI has been suggested.
Methods: The biceps muscles of children and adolescents with CP/ABI (n = 20) and typically developing controls (n = 10) were investigated. We used immunohistochemistry, quantitative real-time polymerase chain reaction, and Western blotting to assess gene expression relevant to growth and size homeostasis.
Results: Classical pro-inflammatory cytokines and genes involved in extracellular matrix (ECM) production were elevated in skeletal muscle of children with CP/ABI. Intramuscular collagen content was increased and satellite cell number decreased and this was associated with reduced levels of RNA polymerase I transcription factors, 45s pre-rRNA and 28S rRNA.
Discussion: The present study provides novel data suggesting a role for pro-inflammatory cytokines and reduced ribosomal production in the development/maintenance of muscle contractures, possibly underlying stunted growth and perimysial ECM expansion. Muscle Nerve 58: 277-285, 2018.
(© 2018 Wiley Periodicals, Inc.)

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18. Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing. [2018]

Stals KL, Wakeling M, Baptista J, Caswell R, Parrish A, Rankin J, Tysoe C, Jones G, Gunning AC, Lango Allen H, Bradley L, Brady AF, Carley H, Carmichael J, Castle B, Cilliers D, Cox H, Deshpande C, Dixit A, Eason J, Elmslie F, Fry AE, Fryer A, Holder M, Homfray T, Kivuva E, McKay V, Newbury-Ecob R, Parker M, Savarirayan R, Searle C, Shannon N, Shears D, Smithson S, Thomas E, Turnpenny PD, Varghese V, Vasudevan P, Wakeling E, Baple EL, and Ellard S
Prenatal diagnosis [Prenat Diagn] 2018 Jan; Vol. 38 (1), pp. 33-43. Date of Electronic Publication: 2017 Dec 03.

Subjects: Female, Genes, Recessive, Humans, Male, Pregnancy, Congenital Abnormalities genetics, Genetic Diseases, Inborn diagnosis, Parents, Prenatal Diagnosis methods, and Exome Sequencing
Abstract: Objective: Rare genetic disorders resulting in prenatal or neonatal death are genetically heterogeneous, but testing is often limited by the availability of fetal DNA, leaving couples without a potential prenatal test for future pregnancies. We describe our novel strategy of exome sequencing parental DNA samples to diagnose recessive monogenic disorders in an audit of the first 50 couples referred.
Method: Exome sequencing was carried out in a consecutive series of 50 couples who had 1 or more pregnancies affected with a lethal or prenatal-onset disorder. In all cases, there was insufficient DNA for exome sequencing of the affected fetus. Heterozygous rare variants (MAF < 0.001) in the same gene in both parents were selected for analysis. Likely, disease-causing variants were tested in fetal DNA to confirm co-segregation.
Results: Parental exome analysis identified heterozygous pathogenic (or likely pathogenic) variants in 24 different genes in 26/50 couples (52%). Where 2 or more fetuses were affected, a genetic diagnosis was obtained in 18/29 cases (62%). In most cases, the clinical features were typical of the disorder, but in others, they result from a hypomorphic variant or represent the most severe form of a variable phenotypic spectrum.
Conclusion: We conclude that exome sequencing of parental samples is a powerful strategy with high clinical utility for the genetic diagnosis of lethal or prenatal-onset recessive disorders. © 2017 The Authors Prenatal Diagnosis published by John Wiley & Sons Ltd.
(© 2017 The Authors Prenatal Diagnosis published by John Wiley & Sons Ltd.)

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19. The role of microRNA-200 in progression of human colorectal and breast cancer. [2013]

Bojmar L, Karlsson E, Ellegård S, Olsson H, Björnsson B, Hallböök O, Larsson M, Stål O, and Sandström P
PloS one [PLoS One] 2013 Dec 20; Vol. 8 (12), pp. e84815. Date of Electronic Publication: 2013 Dec 20 (Print Publication: 2013).

Subjects: Biomarkers, Tumor metabolism, Breast Neoplasms genetics, Breast Neoplasms metabolism, Cadherins metabolism, Colorectal Neoplasms genetics, Colorectal Neoplasms metabolism, Epithelial-Mesenchymal Transition genetics, Gene Expression Regulation, Neoplastic genetics, Homeodomain Proteins metabolism, Humans, Immunohistochemistry, In Situ Hybridization, Laser Capture Microdissection, Liver Neoplasms secondary, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Transcription Factors metabolism, Zinc Finger E-box-Binding Homeobox 1, Breast Neoplasms physiopathology, Colorectal Neoplasms physiopathology, Epithelial-Mesenchymal Transition physiology, Gene Expression Regulation, Neoplastic physiology, Liver Neoplasms metabolism, MicroRNAs metabolism, and Signal Transduction physiology
Abstract: The role of the epithelial-mesenchymal transition (EMT) in cancer has been studied extensively in vitro, but involvement of the EMT in tumorigenesis in vivo is largely unknown. We investigated the potential of microRNAs as clinical markers and analyzed participation of the EMT-associated microRNA-200-ZEB-E-cadherin pathway in cancer progression. Expression of the microRNA-200 family was quantified by real-time RT-PCR analysis of fresh-frozen and microdissected formalin-fixed paraffin-embedded primary colorectal tumors, normal colon mucosa, and matched liver metastases. MicroRNA expression was validated by in situ hybridization and after in vitro culture of the malignant cells. To assess EMT as a predictive marker, factors considered relevant in colorectal cancer were investigated in 98 primary breast tumors from a treatment-randomized study. Associations between the studied EMT-markers were found in primary breast tumors and in colorectal liver metastases. MicroRNA-200 expression in epithelial cells was lower in malignant mucosa than in normal mucosa, and was also decreased in metastatic compared to non-metastatic colorectal cancer. Low microRNA-200 expression in colorectal liver metastases was associated with bad prognosis. In breast cancer, low levels of microRNA-200 were related to reduced survival and high expression of microRNA-200 was predictive of benefit from radiotheraphy. MicroRNA-200 was associated with ER positive status, and inversely correlated to HER2 and overactivation of the PI3K/AKT pathway, that was associated with high ZEB1 mRNA expression. Our findings suggest that the stability of microRNAs makes them suitable as clinical markers and that the EMT-related microRNA-200-ZEB-E-cadherin signaling pathway is connected to established clinical characteristics and can give useful prognostic and treatment-predictive information in progressive breast and colorectal cancers.

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20. AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience. [2016]

Ramírez-Rentería C, Hernández-Ramírez LC, Portocarrero-Ortiz L, Vargas G, Melgar V, Espinosa E, Espinosa-de-Los-Monteros AL, Sosa E, González B, Zúñiga S, Unterländer M, Burger J, Stals K, Bussell AM, Ellard S, Dang M, Iacovazzo D, Kapur S, Gabrovska P, Radian S, Roncaroli F, Korbonits M, and Mercado M
Endocrine [Endocrine] 2016 Aug; Vol. 53 (2), pp. 402-11. Date of Electronic Publication: 2016 Mar 31.

Subjects: Adenoma genetics, Adolescent, Adult, Female, Gene Frequency, Growth Hormone-Secreting Pituitary Adenoma genetics, Humans, Male, Mexico, Mutation, Young Adult, Acromegaly genetics, Gigantism genetics, and Intracellular Signaling Peptides and Proteins genetics
Abstract: Although aryl hydrocarbon receptor-interacting protein (AIP) mutations are rare in sporadic acromegaly, their prevalence among young patients is nonnegligible. The objectives of this study were to evaluate the frequency of AIP mutations in a cohort of Mexican patients with acromegaly with disease onset before the age of 30 and to search for molecular abnormalities in the AIP gene in teeth obtained from the "Tampico Giant". Peripheral blood DNA from 71 patients with acromegaly (51 females) with disease onset <30 years was analysed (median age of disease onset of 23 years) and correlated with clinical, biochemical and imaging characteristics. Sequencing was also carried out in DNA extracted from teeth of the Tampico Giant. Five patients (7 %) harboured heterozygous, germline mutations of the AIP gene. In two of them (a 9-year-old girl with gigantism and a young man with symptoms of GH excess since age 14) the c.910C>T (p.Arg304Ter), well-known truncating mutation was identified; in one of these two cases and her identical twin sister, the mutation proved to be a de novo event, since neither of their parents were found to be carriers. In the remaining three patients, new mutations were identified: a frameshift mutation (c.976_977insC, p.Gly326AfsTer), an in-frame deletion (c.872_877del, p.Val291_Leu292del) and a nonsense mutation (c.868A > T, p.Lys290Ter), which are predicted to be pathogenic based on in silico analysis. Patients with AIP mutations tended to have an earlier onset of acromegaly and harboured larger and more invasive tumours. A previously described genetic variant of unknown significance (c.869C > T, p.Ala299Val) was identified in DNA from the Tampico Giant. The prevalence of AIP mutations in young Mexican patients with acromegaly is similar to that of European cohorts. Our results support the need for genetic evaluation of patients with early onset acromegaly.

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21. The effect of in utero and lactational exposure to chloroform on postnatal growth and glucose tolerance in male wistar rats [2004]

Lim, Gareth E., Stals, Sandra I., Petrik, James J., Foster, Warren G., and Holloway, Alison C.
Endocrine. Dec 2004, Vol. 25 Issue 3, p223, 6 p.

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22. Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors. [2020]

Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB, and Korbonits M
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Jun 01; Vol. 105 (6).

Subjects: Adolescent, Adult, Age of Onset, Female, Follow-Up Studies, Growth Hormone-Secreting Pituitary Adenoma genetics, Humans, Male, Pituitary Neoplasms genetics, Prognosis, Prospective Studies, Young Adult, Biomarkers analysis, Genetic Testing methods, Growth Hormone-Secreting Pituitary Adenoma diagnosis, Intracellular Signaling Peptides and Proteins genetics, Mass Screening methods, Mutation, and Pituitary Neoplasms diagnosis
Abstract: Context: Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).
Objective: To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.
Design: 12-year prospective, observational study.
Participants & Setting: We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases.
Interventions & Outcome: AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310).
Results: Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650).
Conclusions: Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course.
(© Endocrine Society 2020.)

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23. Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort. [2015]

Dénes J, Swords F, Rattenberry E, Stals K, Owens M, Cranston T, Xekouki P, Moran L, Kumar A, Wassif C, Fersht N, Baldeweg SE, Morris D, Lightman S, Agha A, Rees A, Grieve J, Powell M, Boguszewski CL, Dutta P, Thakker RV, Srirangalingam U, Thompson CJ, Druce M, Higham C, Davis J, Eeles R, Stevenson M, O'Sullivan B, Taniere P, Skordilis K, Gabrovska P, Barlier A, Webb SM, Aulinas A, Drake WM, Bevan JS, Preda C, Dalantaeva N, Ribeiro-Oliveira A Jr, Garcia IT, Yordanova G, Iotova V, Evanson J, Grossman AB, Trouillas J, Ellard S, Stratakis CA, Maher ER, Roncaroli F, and Korbonits M
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2015 Mar; Vol. 100 (3), pp. E531-41. Date of Electronic Publication: 2014 Dec 12.

Subjects: Adenoma epidemiology, Adrenal Gland Neoplasms epidemiology, Adult, Cohort Studies, Female, Genetic Association Studies, Genetic Testing, Humans, Male, Middle Aged, Paraganglioma epidemiology, Pheochromocytoma epidemiology, Pituitary Neoplasms epidemiology, Young Adult, Adenoma genetics, Adrenal Gland Neoplasms genetics, Genetic Heterogeneity, Genetic Predisposition to Disease, Paraganglioma genetics, Pheochromocytoma genetics, and Pituitary Neoplasms genetics
Abstract: Context: Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur in the same patient or in the same family. Coexistence of the two diseases could be due to either a common pathogenic mechanism or a coincidence.
Objective: The objective of the investigation was to study the possible coexistence of pituitary adenoma and pheo/PGL.
Design: Thirty-nine cases of sporadic or familial pheo/PGL and pituitary adenomas were investigated. Known pheo/PGL genes (SDHA-D, SDHAF2, RET, VHL, TMEM127, MAX, FH) and pituitary adenoma genes (MEN1, AIP, CDKN1B) were sequenced using next generation or Sanger sequencing. Loss of heterozygosity study and pathological studies were performed on the available tumor samples.
Setting: The study was conducted at university hospitals.
Patients: Thirty-nine patients with sporadic of familial pituitary adenoma and pheo/PGL participated in the study.
Outcome: Outcomes included genetic screening and clinical characteristics.
Results: Eleven germline mutations (five SDHB, one SDHC, one SDHD, two VHL, and two MEN1) and four variants of unknown significance (two SDHA, one SDHB, and one SDHAF2) were identified in the studied genes in our patient cohort. Tumor tissue analysis identified LOH at the SDHB locus in three pituitary adenomas and loss of heterozygosity at the MEN1 locus in two pheochromocytomas. All the pituitary adenomas of patients affected by SDHX alterations have a unique histological feature not previously described in this context.
Conclusions: Mutations in the genes known to cause pheo/PGL can rarely be associated with pituitary adenomas, whereas mutation in a gene predisposing to pituitary adenomas (MEN1) can be associated with pheo/PGL. Our findings suggest that genetic testing should be considered in all patients or families with the constellation of pheo/PGL and a pituitary adenoma.

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24. Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis. [2014]

Stickel F, Buch S, Zoller H, Hultcrantz R, Gallati S, Österreicher C, Finkenstedt A, Stadlmayr A, Aigner E, Sahinbegovic E, Sarrazin C, Schafmayer C, Braun F, Erhart W, Nothnagel M, Lerch MM, Mayerle J, Völzke H, Schaller A, Kratzer W, Boehm BO, Sipos B, D'Amato M, Torkvist L, Stal P, Arlt A, Franke A, Becker T, Krawczak M, Zwerina J, Berg T, Hinrichsen H, Krones E, Dejaco C, Strasser M, Datz C, and Hampe J
Human molecular genetics [Hum Mol Genet] 2014 Jul 15; Vol. 23 (14), pp. 3883-90. Date of Electronic Publication: 2014 Feb 20.

Subjects: Aged, Female, Genome, Human, Genome-Wide Association Study, Hemochromatosis complications, Hemochromatosis pathology, Hemochromatosis Protein, Homozygote, Humans, Iron metabolism, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Hemochromatosis genetics, Histocompatibility Antigens Class I genetics, Liver Cirrhosis genetics, Membrane Proteins genetics, and Subtilisins genetics
Abstract: Genome-wide association studies (GWAS) have revealed genetic determinants of iron metabolism, but correlation of these with clinical phenotypes is pending. Homozygosity for HFE C282Y is the predominant genetic risk factor for hereditary hemochromatosis (HH) and may cause liver cirrhosis. However, this genotype has a low penetrance. Thus, detection of yet unknown genetic markers that identify patients at risk of developing severe liver disease is necessary for better prevention. Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes. Replication of associations was sought in additional 499 Austrian/Swiss and 112 HFE C282Y homozygotes from Sweden. Only variant rs236918 in the PCSK7 gene (proprotein convertase subtilisin/kexin type 7) was associated with cirrhosis or advanced fibrosis (P = 1.02 × 10(-5)) in the German cohort with genotypic odds ratios of 3.56 (95% CI 1.29-9.77) for CG heterozygotes and 5.38 (95% CI 2.39-12.10) for C allele carriers. Association between rs236918 and cirrhosis was confirmed in Austrian/Swiss HFE C282Y homozygotes (P = 0.014; ORallelic = 1.82 (95% CI 1.12-2.95) but not in Swedish patients. Post hoc combined analyses of German/Swiss/Austrian patients with available liver histology (N = 244, P = 0.00014, ORallelic = 2.84) and of males only (N = 431, P = 2.17 × 10(-5), ORallelic = 2.54) were consistent with the premier finding. Association between rs236918 and cirrhosis was not confirmed in alcoholic cirrhotics, suggesting specificity of this genetic risk factor for HH. PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation.
(© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

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25. The Cyclin-Dependent Kinase Inhibitor KRP6 Induces Mitosis and Impairs Cytokinesis in Giant Cells Induced by Plant-Parasitic Nematodes in Arabidopsis. [2014]

Vieira P, De Clercq A, Stals H, Van Leene J, Van De Slijke E, Van Isterdael G, Eeckhout D, Persiau G, Van Damme D, Verkest A, Antonino de Souza JD, Júnior, Glab N, Abad P, Engler G, Inzé D, De Veylder L, De Jaeger G, and Engler JD
The Plant cell [Plant Cell] 2014 Jun; Vol. 26 (6), pp. 2633-2647. Date of Electronic Publication: 2014 Jun 24.

Abstract: In Arabidopsis thaliana, seven cyclin-dependent kinase (CDK) inhibitors have been identified, designated interactors of CDKs or Kip-related proteins (KRPs). Here, the function of KRP6 was investigated during cell cycle progression in roots infected by plant-parasitic root-knot nematodes. Contrary to expectations, analysis of Meloidogyne incognita-induced galls of KRP6-overexpressing lines revealed a role for this particular KRP as an activator of the mitotic cell cycle. In accordance, KRP6-overexpressing suspension cultures displayed accelerated entry into mitosis, but delayed mitotic progression. Likewise, phenotypic analysis of cultured cells and nematode-induced giant cells revealed a failure in mitotic exit, with the appearance of multinucleated cells as a consequence. Strong KRP6 expression upon nematode infection and the phenotypic resemblance between KRP6 overexpression cell cultures and root-knot morphology point toward the involvement of KRP6 in the multinucleate and acytokinetic state of giant cells. Along these lines, the parasite might have evolved to manipulate plant KRP6 transcription to the benefit of gall establishment.
(© 2014 American Society of Plant Biologists. All rights reserved.)

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26. Thermal Biology of Liorhyssus hyalinus (Hemiptera: Rhopalidae) and Nysius simulans (Hemiptera: Lygaeidae), Fed on the Milky Stage of Maize Grains. [2022]

Cruces L, de la Peña E, and De Clercq P
Journal of insect science (Online) [J Insect Sci] 2022 Jul 01; Vol. 22 (4).

Subjects: Animals, Biology, Diet, Female, Nymph growth development, Ovum, Heteroptera growth development, Temperature, and Zea mays
Abstract: When quinoa, Chenopodium quinoa Willd., is cultivated in South America outside of its Andean origin, the heteropterans Liorhyssus hyalinus (Fabricius) and Nysius simulans Stål may emerge as important pests. Here we studied the development and reproduction of both species at different constant temperatures in the laboratory. Egg and nymphal development were investigated at 18, 22, 26, 30, 34, and 36°C. For both species, egg incubation time significantly decreased as the temperature increased. Nymphs did not successfully develop at 18°C and the total nymphal time significantly decreased as the temperature increased from 22 to 36°C. Based on a linear day-degree (DD) model, the lower developmental threshold (LDT) temperatures for eggs and nymphs were estimated to be 16.0 and 17.9°C for L. hyalinus, and 16.1 and 19.7°C for N. simulans, respectively. Thermal requirements for egg and nymphal development were 68.6 and 114.8 DD for L. hyalinus, and 77.7 and 190.3 DD for N. simulans, respectively. Reproduction and adult longevity were studied at 22, 26, 30, and 34°C. For both species preoviposition time decreased as temperature increased, and the oviposition period was longest at 26°C. The highest fecundity and egg viability were observed at 30°C, whereas longevities were higher at 22-26°C than at 30-34°C. As the lowest tested temperatures were not suitable to both heteropterans and 30°C was found to be the optimal temperature for development and reproduction, peak densities are expected in warm areas and seasons.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Entomological Society of America.)

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27. Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units: A retrospective cohort study. [2022]

Noordermeer T, Schutgens REG, Visser C, Rademaker E, de Maat MPM, Jansen AJG, Limper M, Cremer OL, Kruip MJHA, Endeman H, Maas C, de Laat B, and Urbanus RT
Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2022 Sep 16; Vol. 6 (6), pp. e12809. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).

Abstract: Background: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients with COVID-19. Whether LA is associated with thrombosis in patients with severe COVID-19 is currently unclear.
Objective: To investigate if LA is associated with thrombosis in critically ill patients with COVID-19.
Patients/methods: The presence of LA and other antiphospholipid antibodies was assessed in patients with COVID-19 admitted to the ICU. LA was determined with dilute Russell's viper venom time (dRVVT) and LA-sensitive activated partial thromboplastin time (aPTT) reagents.
Results: Of 169 patients with COVID-19, 116 (69%) tested positive for at least one antiphospholipid antibody upon admission to the ICU. Forty (24%) patients tested positive for LA; of whom 29 (17%) tested positive with a dRVVT, 19 (11%) tested positive with an LA-sensitive aPTT, and 8 (5%) tested positive on both tests. Fifty-eight (34%) patients developed thrombosis after ICU admission. The odds ratio (OR) for thrombosis in patients with LA based on a dRVVT was 2.5 (95% confidence interval [CI], 1.1-5.7), which increased to 4.5 (95% CI, 1.4-14.3) in patients at or below the median age in this study (64 years). LA positivity based on a dRVVT or LA-sensitive aPTT was only associated with thrombosis in patients aged less than 65 years (OR, 3.8; 95% CI, 1.3-11.4) and disappeared after adjustment for C-reactive protein.
Conclusion: Lupus anticoagulant on admission is strongly associated with thrombosis in critically ill patients with COVID-19, especially in patients aged less than 65 years.
(© 2022 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis (ISTH).)

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28. An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant Staphylococcus aureus with additional resistance to fusidic acid, June 2018 to January 2020. [2022]

Vendrik KEW, Kuijper EJ, Dimmendaal M, Silvis W, Denie-Verhaegh E, de Boer A, Postma B, Schoffelen AF, Ruijs WLM, Koene FMHPA, Petrignani M, Hooiveld M, Witteveen S, Schouls LM, and Notermans DW
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2022 Dec; Vol. 27 (49).

Subjects: Child, Humans, Fusidic Acid therapeutic use, Fusidic Acid pharmacology, Methicillin, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Netherlands epidemiology, Staphylococcus aureus, Disease Outbreaks, Microbial Sensitivity Tests, Methicillin-Resistant Staphylococcus aureus, Impetigo drug therapy, Impetigo epidemiology, Staphylococcal Infections drug therapy, and Staphylococcal Infections epidemiology
Abstract: In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin-resistant Staphylococcus aureus (MRSA), with additional resistance to fusidic acid (first-line treatment). The outbreak occurred between June 2018 and January 2020 in the eastern part of the Netherlands with an epidemiological link to three cases from the north-western part. Forty nine impetigo cases and eight carrier cases were identified, including 47 children. All but one impetigo case had community-onset of symptoms. Pharmacy prescription data for topical mupirocin and fusidic acid and GP questionnaires suggested an underestimated outbreak size. The 57 outbreak isolates were identified by the Dutch MRSA surveillance as MLVA-type MT4627 and sequence type 121, previously reported only once in 2014. Next-generation sequencing revealed they contained a fusidic acid resistance gene, exfoliative toxin genes and an epidermal cell differentiation inhibitor gene. Whole-genome multilocus sequence typing revealed genetic clustering of all 19 sequenced isolates from the outbreak region and isolates from the three north-western cases. The allelic distances between these Dutch isolates and international isolates were high. This outbreak shows the appearance of community-onset MRSA strains with additional drug resistance and virulence factors in a country with a low prevalence of antimicrobial resistance.

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29. Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation. [1999]

Wang GS, Eriksson LC, Xia L, Olsson J, and Stål P
Journal of hepatology [J Hepatol] 1999 Apr; Vol. 30 (4), pp. 689-98.

Subjects: Animals, Antioxidants metabolism, Apoptosis drug effects, Body Weight drug effects, Carbon Tetrachloride antagonists inhibitors, Carcinogens toxicity, Cell Division drug effects, Diet, Diethylnitrosamine toxicity, Iron administration dosage, Iron metabolism, Kupffer Cells drug effects, Kupffer Cells pathology, Liver metabolism, Liver pathology, Liver Neoplasms, Experimental chemically induced, Liver Neoplasms, Experimental pathology, Male, Necrosis, Organ Size drug effects, Rats, Rats, Wistar, Ubiquinone metabolism, Vitamin E metabolism, Carbon Tetrachloride toxicity, Iron pharmacology, Liver drug effects, and Liver Neoplasms, Experimental prevention control
Abstract: Background/aims: The aim of this study was to investigate if feeding with carbonyl iron would facilitate the development of preneoplastic lesions initiated by diethylnitrosamine (DEN) and promoted by CCl4-induced liver cirrhosis.
Methods: Male Wistar rats were fed a diet with 1.25%-2.5% carbonyl iron for 23 weeks and received intragastric injections of CCl4 (1.0 or 2.0 ml/kg per week) for 13 weeks, followed by one i.p. injection of DEN (200 mg/kg), after which CCl4 was administered for 8 additional weeks. Animals were killed 48 h after the first CCl4 injection to evaluate liver necrosis, 8 weeks later to evaluate fibrosis, and 9 weeks after DEN to determine formation of glutathione S-transferase 7,7 (GST-7,7) positive foci.
Results: Treatment with iron counteracted the increased serum alanine aminotransferase levels and liver necrosis following CCl4 administration. Hepatic levels of reduced Q9 and alpha-tocopherol were elevated in rats treated with CCl4 and decreased in rats treated with iron compared to the controls. Fibrogenesis was not altered by iron treatment. Nine weeks after DEN initiation, the number and volume density of GST-7,7-positive foci in rats treated with CCl4 were significantly increased as compared with controls, but co-treatment with iron inhibited this increase. Apoptotic index was increased in iron-loaded livers, and labelling index (the fraction of S-phase hepatocytes) was decreased by co-treatment with iron in livers exposed to CCl4.
Conclusion: Carbonyl iron depleted hepatic levels of antioxidants, it decreased CCl4-induced necrosis and cell proliferation, it enhanced apoptosis and did not facilitate fibrogenesis. These effects together may explain the suppression of CCl4-induced promotion after DEN initiation exerted by carbonyl iron in the present study.

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30. Development, Predation, and Prey Preference of Chrysoperla externa on Liorhyssus hyalinus and Nysius simulans, Two Emerging Pests of Quinoa. [2022]

Cruces L, de la Peña E, Livia C, and De Clercq P
Neotropical entomology [Neotrop Entomol] 2022 Jun 21. Date of Electronic Publication: 2022 Jun 21.

Abstract: In recent years, Liorhyssus hyalinus (Fabricius) (Hemiptera: Rhopalidae) and Nysius simulans Stål (Hemiptera: Lygaeidae) have emerged as important pests of quinoa in Peru, when the crop started to be cultivated at relatively low elevations. The potential of the native lacewing Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) was evaluated as a biological control agent of these two pest species. Prey consumption on all immature stages of L. hyalinus and N. simulans was assessed, as well as development on first instars of these heteropterans and eggs of Sitotroga cerealella (Olivier) (Lepidoptera: Pyralidae) as a factitious prey. In addition, prey preference was examined in the absence and presence of a preferred prey, Macrosiphum euphorbiae (Thomas) (Hemiptera: Aphididae). Larvae of the predator were not able to feed on L. hyalinus eggs, but they effectively did on N. simulans eggs as well as on all nymphal instars of both species. Nymphs of L. hyalinus were less suitable prey for larval development of C. externa than eggs of S. cerealella, whereas N. simulans was overall an unsuitable prey. There was a clear prey preference of C. externa for aphids over the two heteropteran species, as well as a preference for N. simulans over L. hyalinus. The predation rates in this study indicate the potential of C. externa as a predator of these heteropteran pests that can play a role in both conservation and augmentation biological control programs.
(© 2022. Sociedade Entomológica do Brasil.)

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31. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. [2010]

Van Leene J, Hollunder J, Eeckhout D, Persiau G, Van De Slijke E, Stals H, Van Isterdael G, Verkest A, Neirynck S, Buffel Y, De Bodt S, Maere S, Laukens K, Pharazyn A, Ferreira PC, Eloy N, Renne C, Meyer C, Faure JD, Steinbrenner J, Beynon J, Larkin JC, Van de Peer Y, Hilson P, Kuiper M, De Veylder L, Van Onckelen H, Inzé D, Witters E, and De Jaeger G
Molecular systems biology [Mol Syst Biol] 2010 Aug 10; Vol. 6, pp. 397.

Subjects: Computational Biology, Cyclin-Dependent Kinases metabolism, Cyclins metabolism, DNA Replication, Luciferases metabolism, Mitosis, Models, Biological, Multiprotein Complexes metabolism, Protein Binding, Protein Interaction Mapping, Reproducibility of Results, Arabidopsis cytology, Arabidopsis metabolism, Arabidopsis Proteins metabolism, Cell Cycle, and Cell Cycle Proteins metabolism
Abstract: Cell proliferation is the main driving force for plant growth. Although genome sequence analysis revealed a high number of cell cycle genes in plants, little is known about the molecular complexes steering cell division. In a targeted proteomics approach, we mapped the core complex machinery at the heart of the Arabidopsis thaliana cell cycle control. Besides a central regulatory network of core complexes, we distinguished a peripheral network that links the core machinery to up- and downstream pathways. Over 100 new candidate cell cycle proteins were predicted and an in-depth biological interpretation demonstrated the hypothesis-generating power of the interaction data. The data set provided a comprehensive view on heterodimeric cyclin-dependent kinase (CDK)-cyclin complexes in plants. For the first time, inhibitory proteins of plant-specific B-type CDKs were discovered and the anaphase-promoting complex was characterized and extended. Important conclusions were that mitotic A- and B-type cyclins form complexes with the plant-specific B-type CDKs and not with CDKA;1, and that D-type cyclins and S-phase-specific A-type cyclins seem to be associated exclusively with CDKA;1. Furthermore, we could show that plants have evolved a combinatorial toolkit consisting of at least 92 different CDK-cyclin complex variants, which strongly underscores the functional diversification among the large family of cyclins and reflects the pivotal role of cell cycle regulation in the developmental plasticity of plants.

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32. Role of hydroperoxide lyase in white-backed planthopper (Sogatella furcifera Horvath)-induced resistance to bacterial blight in rice, Oryza sativa L [2010]

Plant Journal. Jan 2010, Vol. 61 Issue 1, p46, 12 p.

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33. A technology platform for the fast production of monoclonal recombinant antibodies against plant proteins and peptides. [2004]

Eeckhout D, De Clercq A, Van De Slijke E, Van Leene J, Stals H, Casteels P, Persiau G, Vercammen D, Van Breusegem F, Zabeau M, Inzé D, Jespers L, Depicker A, and De Jaeger G
Journal of immunological methods [J Immunol Methods] 2004 Nov; Vol. 294 (1-2), pp. 181-7.

Subjects: Antibodies, Monoclonal immunology, Antibody Affinity immunology, Carrier Proteins genetics, Gene Expression, Humans, Immunoglobulin Variable Region immunology, Immunoglobulin Variable Region isolation purification, Immunoglobulin kappa-Chains genetics, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins immunology, Recombinant Fusion Proteins isolation purification, Substrate Specificity genetics, Substrate Specificity immunology, Antibodies, Monoclonal genetics, Antibody Affinity genetics, Gene Library, Immunoglobulin Variable Region genetics, Peptides immunology, and Plant Proteins immunology
Abstract: The application of recombinant antibodies in plant biology research is limited because plant researchers have minimal access to high-quality phage display libraries. Therefore, we constructed a library of 1.3 x 10(10) clones displaying human single-chain variable fragments (scFvs) that is available to the academic community. The scFvs selected from the library against a diverse set of plant proteins showed moderate to high antigen-binding affinity together with high specificity. Moreover, to optimize an scFv as immunodetection agent, two expression systems that allow efficient production and purification of bivalent scFv-Fc and scFv-CkappaZIP fusion proteins were integrated. We are convinced that this antibody platform will further stimulate applications of recombinant antibodies such as the diagnostic detection or immunomodulation of specific antigens in plants.

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34. Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. [2010]

Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, and Korbonits M
Human mutation [Hum Mutat] 2010 Aug; Vol. 31 (8), pp. 950-60.

Subjects: Adult, Alternative Splicing genetics, Amino Acid Sequence, Animals, Cell Line, Cyclic AMP metabolism, Cyclic AMP-Dependent Protein Kinases metabolism, Family, Female, Gene Expression Regulation, Neoplastic, Humans, Intracellular Signaling Peptides and Proteins chemistry, Intracellular Signaling Peptides and Proteins metabolism, Male, Middle Aged, Molecular Sequence Data, Mutant Proteins genetics, Mutant Proteins metabolism, Mutation, Missense genetics, Pedigree, Pituitary Neoplasms enzymology, Promoter Regions, Genetic genetics, RNA Splice Sites genetics, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Signal Transduction, Intracellular Signaling Peptides and Proteins genetics, Mutation genetics, and Pituitary Neoplasms genetics
Abstract: Familial isolated pituitary adenoma (FIPA) is an autosomal dominant condition with variable genetic background and incomplete penetrance. Germline mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene have been reported in 15-40% of FIPA patients. Limited data are available on the functional consequences of the mutations or regarding the regulation of the AIP gene. We describe a large cohort of FIPA families and characterize missense and silent mutations using minigene constructs, luciferase and beta-galactosidase assays, as well as in silico predictions. Patients with AIP mutations had a lower mean age at diagnosis (23.6+/-11.2 years) than AIP mutation-negative patients (40.4+/-14.5 years). A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples. Stimulation of the protein kinase A-pathway positively regulates the AIP promoter. Silent mutations led to abnormal splicing resulting in truncated protein or reduced AIP expression. A two-hybrid assay of protein-protein interaction of all missense variants showed variable disruption of AIP-phosphodiesterase-4A5 binding. In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort. Functional characterization of AIP changes is important to identify the functional impact of gene sequence variants.

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35. Leafhoppers (Homoptera: Cicadellidae) Associated with Potatoes in Alaska: Species Composition, Seasonal Abundance, and Potential Phytoplasma Vectors [2009]

Pantoja, Alberto, Hagerty, Aaron M., Emmert, Susan Y., and Munyaneza, Joseph E.
American Journal of Potato Research. Feb 2009, Vol. 86 Issue 1, p68, 8 p.

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36. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers. [2015]

Hernández-Ramírez LC, Gabrovska P, Dénes J, Stals K, Trivellin G, Tilley D, Ferrau F, Evanson J, Ellard S, Grossman AB, Roncaroli F, Gadelha MR, and Korbonits M
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2015 Sep; Vol. 100 (9), pp. E1242-54.

Subjects: Adenoma genetics, Adenoma pathology, Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Genetic Testing, Germ-Line Mutation, Growth Hormone-Secreting Pituitary Adenoma genetics, Growth Hormone-Secreting Pituitary Adenoma pathology, Humans, Longitudinal Studies, Male, Middle Aged, Mutation, Pituitary Neoplasms genetics, Pituitary Neoplasms pathology, Prospective Studies, Young Adult, Adenoma diagnosis, Growth Hormone-Secreting Pituitary Adenoma diagnosis, Intracellular Signaling Peptides and Proteins genetics, and Pituitary Neoplasms diagnosis
Abstract: Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease.
Objective: To determine the AIP mutational status of FIPA and young pituitary adenoma patients, analyzing their clinical characteristics, and to perform clinical screening of apparently unaffected AIPmut carrier family members.
Design: This was an observational, longitudinal study conducted over 7 years.
Setting: International collaborative study conducted at referral centers for pituitary diseases.
Participants: FIPA families (n 216) and sporadic young-onset (30 y) pituitary adenoma patients (n 404) participated in the study.
Interventions: We performed genetic screening of patients for AIPmuts, clinical assessment of their family members, and genetic screening for somatic GNAS1 mutations and the germline FGFR4 p.G388R variant.
Main Outcome Measure(s): We assessed clinical disease in mutation carriers, comparison of characteristics of AIPmut positive and negative patients, results of GNAS1, and FGFR4 analysis.
Results: Thirty-seven FIPA families and 34 sporadic patients had AIPmuts. Patients with truncating AIPmuts had a younger age at disease onset and diagnosis, compared with patients with nontruncating AIPmuts. Somatic GNAS1 mutations were absent in tumors from AIPmut-positive patients, and the studied FGFR4 variant did not modify the disease behavior or penetrance in AIPmut-positive individuals. A total of 164 AIPmut-positive unaffected family members were identified; pituitary disease was detected in 18 of those who underwent clinical screening.
Conclusions: A quarter of the AIPmut carriers screened were diagnosed with pituitary disease, justifying this screening and suggesting a variable clinical course for AIPmut-positive pituitary adenomas.

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37. Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer. [2021]

Berger K, Rhost S, Rafnsdóttir S, Hughes É, Magnusson Y, Ekholm M, Stål O, Rydén L, and Landberg G
BMC cancer [BMC Cancer] 2021 Feb 22; Vol. 21 (1), pp. 185. Date of Electronic Publication: 2021 Feb 22.

Subjects: Adult, Antineoplastic Agents, Hormonal therapeutic use, Biomarkers, Tumor metabolism, Breast Neoplasms drug therapy, Female, Humans, Lymphatic Metastasis, Middle Aged, Neoplastic Stem Cells pathology, Prognosis, Randomized Controlled Trials as Topic, Retrospective Studies, Survival Rate, Adaptor Proteins, Vesicular Transport metabolism, Breast Neoplasms metabolism, Breast Neoplasms pathology, Neoplastic Stem Cells metabolism, Progranulins metabolism, and Tamoxifen therapeutic use
Abstract: Background: The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranulin, via its receptor sortilin, drives breast cancer stem cell propagation in vitro and increases metastasis formation in an in vivo breast cancer xenograft model. In this retrospective biomarker analysis, we aimed to determine whether tumor co-expression of progranulin and sortilin has prognostic and treatment predictive values for breast cancer patients.
Methods: We explored how co-expression of progranulin and sortilin was associated with established clinical markers by analyzing a tissue microarray including 560 randomized premenopausal breast cancer patients receiving either 2 years of tamoxifen treatment or no adjuvant treatment, with a median follow-up time of 28 years. Breast cancer-specific survival was analyzed using Kaplan-Meier and Cox Proportional Hazards regression models to assess the prognostic and predictive value of progranulin and sortilin in relation to known clinical markers.
Results: Co-expression of progranulin and sortilin was observed in 20% of the breast cancer samples. In untreated patients, prognostic considerations could be detailed separately from treatment prediction and the high progranulin and sortilin expressing subgroup was significantly associated with breast cancer-specific death in multivariable analyses (HR=2.188, CI: 1.317-3.637, p=0.003) along with tumor size, high tumor grade and lymph node positivity. When comparing the untreated patients with tamoxifen treated patients in the ERα positive subgroup, co-expression of progranulin and sortilin was not linked to tamoxifen resistance.
Conclusion: Data suggest that co-expression of progranulin and its receptor sortilin is a novel prognostic biomarker combination identifying a highly malignant subgroup of breast cancer. Importantly, this subpopulation could potentially be targeted with anti-sortilin based therapies.

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38. Thyanta custator subsp. accerra McAtee 1919 [2021]

Rider, David A. and Swanson, Daniel R.

Subjects: Biodiversity, Taxonomy, Animalia, Arthropoda, Insecta, Hemiptera, Pentatomidae, Thyanta, Thyanta custator, and Thyanta custator accerra mcatee, 1919
Abstract: Thyanta custator accerra McAtee, 1919 Distribution: Canada: MB (Maw et al. 2000), ON (Maw et al. 2000, Roch 2020), QC, SK (Scudder 2013). United States: AL, AR, AZ, CA (Van Duzee 1917, Johnson & Ledig 1918, Norland 1931, Goeden 1971, Rider & Chapin 1992), CO, CT (Van Duzee 1917, Parshley 1923 a, O’Donnell & Schaefer 2012), DE (Rider & Chapin 1992), DC (Rider & Chapin 1992), FL, GA, IA (Osborn, 1892, Stoner 1915, Van Duzee 1917, Hendrickson 1930, Knight 1936, Rider & Chapin 1992), IL, IN, KS, KY (Rider & Chapin 1992), LA (Rider & Chapin 1992, Temple, Davis, Micinski et al. 2013), MA (Uhler 1878, Parshley 1917, Van Duzee 1917), MD (Rider & Chapin 1992), ME (Phipps 1930, Rider & Chapin 1992, Roch 2020), MI, MN (Rider & Chapin 1992, Koch et al. 2014), MO, MS, MT, NC, ND, NE (Uhler 1872, 1876; Van Duzee 1917; Rider & Chapin 1992), NH (Rider & Chapin 1992, Roch 2020), NJ (Van Duzee 1917, Rider & Chapin 1992), NM, NV, NY, OH (Osborn 1900, Adkins 1917, Balduf 1923, Furth 1974, Rider & Chapin 1992), OK (Ortenburger 1927; Carpenter 1937; Smith 1940a, b; Fenton & Howell 1957; Stoner et al. 1962; Arnold & Drew 1988; Rider & Chapin 1992; Kondratieff et al. 2005), PA (Van Duzee 1917, Rider & Chapin 1992), SC (Jones & Sullivan 1981, Rider & Chapin 1992), SD, TN (Stål 1872, Van Duzee 1917, Howden & Crossley 1961, Rider & Chapin 1992, Lambdin et al. 2003), TX, UT, VA (Hoffman 1971; Allen & Hoffman 1975, 1976; Rider & Chapin 1992; Basnet et al. 2014), WV (Rider & Chapin 1992), WI (Rider & Chapin 1992), WY. (Mexico, Guatemala, Hawaii) Comments: At the time of the Froeschner (1988) catalog, the status of the different U.S. forms within Thyanta was confused. Rider & Chapin (1992) determined that Thyanta custator is composed of two subspecies - the nominate subspecies occurs along the Atlantic and Gulf coasts, whereas Thyanta custator accerra occurs throughout the rest of the U.S., except it is replaced by Thyanta pallidovirens in the western U.S. This form was listed in Froeschner (1988) as Thyanta accerra and also the records for Thyanta pallidovirens spinosa Ruckes refer to this form. Additionally, most records of Thyanta perditor from the desert southwestern states should be referred here. The Idaho record for this species should be referred to Thyanta pallidovirens.
Published as part of Rider, David A. & Swanson, Daniel R., 2021, A distributional synopsis of the Pentatomidae (Heteroptera) north of Mexico, including new state and provincial records, pp. 1-69 in Zootaxa 5015 (1) on pages 38-39, DOI: 10.11646/zootaxa.5015.1.1, http://zenodo.org/record/5159085
{"references":["McAtee, W. L. (1919) Notes on Nearctic Hemiptera. Bulletin of the Brooklyn Entomological Society, 14, 8 - 16.","Maw, H. E. L., Foottit, R. G., Hamilton, K. G. A. & Scudder, G. G. E. (2000) Checklist of the Hemiptera of Canada and Alaska. National Research Council of Canada, NRC Research Press, Ottawa, 220 pp. Canada,","Roch, J-F. (2020) Entomofaune du Quebec. Liste des Punaises du Quebec et des Regions Adjacentes (Hemiptera: Heteroptera). Document Faunique 27. Version 2.3. Entomofaune du Quebec Inc., Saguenay, 41 pp.","Scudder, G. G. E. (2013) Additional provincial and state records for Heteroptera (Hemiptera) in Canada and the United States. Journal of the Entomological Society of British Columbia, 109, 55 - 69.","Van Duzee, E. P. (1917) Catalogue of the Hemiptera of America North of Mexico, Excepting the Aphididae, Coccidae and Aleurodidae. University of California Publications Entomology 2. 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Connecticut State Geological and Natural History Survey Bulletin, 34, pp. 753 - 783, pls. XVIII - XX","Wheeler, A. G. Jr. & Krimmel, B. A. (2012) Banasa sordida (Uhler) (Hemiptera: Pentatomidae): Monterey cypress and Gowen cyprus (Cupressus macrocarpa, C. goveniana; Cupressaceae) as host plants in coastal California. Proceedings of the Entomological Society of Washington, 114 (2), 263 - 268. https: // doi. org / 10.4289 / 0013 - 8797.114.2.263","Osborn, H. (1892) Catalogue of the Hemiptera of Iowa. Proceedings of the Iowa Academy of Sciences, 1 (2), 120 - 131.","Stoner, D. (1915) Preliminary notes on Iowa Pentatomoidea (Heterop.). Entomological News, 26, 353 - 355.","Hendrickson, G. O. (1930) Studies on the insect fauna of Iowa praries. Iowa State College Journal of Science, 4 (2), 49 - 179.","Knight, H. H. (1936) Records of southern insect species moving northward during the drouth years of 1930 and 1934. 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(2014) Stink bugs (Hemiptera: Heteroptera: Pentatomidae) of Minnesota: An annotated checklist and new state records. The Great Lakes Entomologist, 47 (3 - 4), 171 - 185.","Uhler, P. R. (1872) Notices of the Hemiptera of the Western Territories of the United States, chiefly from the surveys of Dr. F. V. Hayden. In: Hayden, F. V. (Ed.), Preliminary Report of the United States Geological Survey of Montana and Portions of Adjacent Territories, Being a Fifth Annual Report of Progress. Government Printing Office, Washington, D. C, pp. 392 - 423.","Uhler, P. R. (1876) List of the Hemiptera of the region west of the Mississippi River, including those collected during the Hayden explorations of 1873. Bulletin of the United States Geological and Geographical Survey of the Territories, 1, 267 - 361.","Osborn, H. (1900) Remarks on the hemipterous fauna of Ohio with a preliminary record of species. Annual Report of the Ohio State Academy of Science, 8, 60 - 79.","Adkins, W. S. (1917) Some Ohio Heteroptera records. Ohio Journal of Science, 18 (2), 58 - 61.","Balduf, W. V. (1923) The insects of the soybean in Ohio. Bulletin of the Ohio Agricultural Experiment Station, 366, 147 - 181.","Furth, D. G. (1974) The stink bugs of Ohio (Hemiptera: Pentatomidae). Bulletin of the Ohio Biological Survey, 5 (1), 1 - 62.","Ortenburger, A. I. (1927) Some Oklahoma Hemiptera. Proceedings of the Oklahoma Academy of Science, 6, 184 - 192.","Carpenter, J. R. (1937) Fluctuations in biotic communities, III. Aspection in a ravine sere in central Oklahoma. Ecology, 18 (1), 80 - 92. https: // doi. org / 10.2307 / 1932704","Smith, C. C. (1940 a) Biotic and physiographic succession on abandoned eroded farmland. Ecological Monographs, 10 (3), 421 - 484. https: // doi. org / 10.2307 / 1948513","Fenton, F. A. & Howell, D. E. (1957) A comparison of five methods of sampling alfalfa fields for arthropod populations. 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Shield Bugs (Hemiptera; Scutelleroidea, Corimelaenidae, Cydnidae, Pentatomidae). Virginia Polytechnic Institute and State University, Research Division Bulletin, 67, i - v + 1 - 61, 7 maps, 1 pl.","Allen, W. A. & Hoffman, R. L. (1975) Distribution records of several Virginia shield bugs (Hemiptera: Scutelleridae, Corimelaenidae, Cydnidae, Pentatomidae). USDA Cooperative Economic Insect Report, 25 (12), 233 - 236.","Allen, W. A. & Hoffman, R. L. (1976) New geographical and seasonal distribution records for thiry-one species of Virginia shield bugs (Hemiptera: Scutelleridae, Cydnidae, and Pentatomidae. USDA Cooperative Plant Pest Report, 1 (41), 747 - 751.","Basnet, S., Maxey, L. M., Laub, C. A., Kuhar, T. P. & Pfeiffer, D. G. (2014) Stink bugs (Hemiptera: Pentatomidae) in primocanebearing raspberries in southwestern Virginia. Journal of Entomological Science, 49 (3), 304 - 312. https: // doi. org / 10.18474 / 0749 - 8004 - 49.3.304","Froeschner, R. C. (1988) Family Pentatomidae Leach, 1815. The stink bugs. In: Henry, T. J. & Froeschner, R. C. (Eds.), Catalog of the Heteroptera, or True Bugs, of Canada and the Continental United States. E. J. Brill, Leiden, New York, pp. 544 - 607. https: // doi. org / 10.1201 / 9781351070447 - 30"]}

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39. A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. [2021]

Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal AJ, Sejling AS, and Harrison SA
The New England journal of medicine [N Engl J Med] 2021 Mar 25; Vol. 384 (12), pp. 1113-1124. Date of Electronic Publication: 2020 Nov 13.

Subjects: Adolescent, Adult, Aged, Amylases blood, Biopsy, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 drug therapy, Dose-Response Relationship, Drug, Double-Blind Method, Female, Glucagon-Like Peptides adverse effects, Humans, Injections, Subcutaneous, Lipase blood, Liver pathology, Liver Cirrhosis drug therapy, Liver Cirrhosis etiology, Liver Cirrhosis pathology, Male, Middle Aged, Non-alcoholic Fatty Liver Disease blood, Non-alcoholic Fatty Liver Disease complications, Non-alcoholic Fatty Liver Disease pathology, Young Adult, Glucagon-Like Peptides administration dosage, and Non-alcoholic Fatty Liver Disease drug therapy
Abstract: Background: Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited. The efficacy and safety of the glucagon-like peptide-1 receptor agonist semaglutide in patients with NASH is not known.
Methods: We conducted a 72-week, double-blind phase 2 trial involving patients with biopsy-confirmed NASH and liver fibrosis of stage F1, F2, or F3. Patients were randomly assigned, in a 3:3:3:1:1:1 ratio, to receive once-daily subcutaneous semaglutide at a dose of 0.1, 0.2, or 0.4 mg or corresponding placebo. The primary end point was resolution of NASH with no worsening of fibrosis. The confirmatory secondary end point was an improvement of at least one fibrosis stage with no worsening of NASH. The analyses of these end points were performed only in patients with stage F2 or F3 fibrosis; other analyses were performed in all the patients.
Results: In total, 320 patients (of whom 230 had stage F2 or F3 fibrosis) were randomly assigned to receive semaglutide at a dose of 0.1 mg (80 patients), 0.2 mg (78 patients), or 0.4 mg (82 patients) or to receive placebo (80 patients). The percentage of patients in whom NASH resolution was achieved with no worsening of fibrosis was 40% in the 0.1-mg group, 36% in the 0.2-mg group, 59% in the 0.4-mg group, and 17% in the placebo group (P<0.001 for semaglutide 0.4 mg vs. placebo). An improvement in fibrosis stage occurred in 43% of the patients in the 0.4-mg group and in 33% of the patients in the placebo group (P = 0.48). The mean percent weight loss was 13% in the 0.4-mg group and 1% in the placebo group. The incidence of nausea, constipation, and vomiting was higher in the 0.4-mg group than in the placebo group (nausea, 42% vs. 11%; constipation, 22% vs. 12%; and vomiting, 15% vs. 2%). Malignant neoplasms were reported in 3 patients who received semaglutide (1%) and in no patients who received placebo. Overall, neoplasms (benign, malignant, or unspecified) were reported in 15% of the patients in the semaglutide groups and in 8% in the placebo group; no pattern of occurrence in specific organs was observed.
Conclusions: This phase 2 trial involving patients with NASH showed that treatment with semaglutide resulted in a significantly higher percentage of patients with NASH resolution than placebo. However, the trial did not show a significant between-group difference in the percentage of patients with an improvement in fibrosis stage. (Funded by Novo Nordisk; ClinicalTrials.gov number, NCT02970942.).
(Copyright © 2020 Massachusetts Medical Society.)

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40. National surveillance pilot study unveils a multicenter, clonal outbreak of VIM-2-producing Pseudomonas aeruginosa ST111 in the Netherlands between 2015 and 2017. [2021]

Pirzadian J, Persoon MC, Severin JA, Klaassen CHW, de Greeff SC, Mennen MG, Schoffelen AF, Wielders CCH, Witteveen S, van Santen-Verheuvel M, Schouls LM, and Vos MC
Scientific reports [Sci Rep] 2021 Oct 25; Vol. 11 (1), pp. 21015. Date of Electronic Publication: 2021 Oct 25.

Subjects: Anti-Bacterial Agents pharmacology, Geography, Medical, History, 21st Century, Humans, Microbial Sensitivity Tests, Multilocus Sequence Typing, Netherlands epidemiology, Phylogeny, Pilot Projects, Pseudomonas Infections history, Pseudomonas aeruginosa classification, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa isolation purification, Public Health Surveillance, beta-Lactam Resistance, beta-Lactamases biosynthesis, Disease Outbreaks, Pseudomonas Infections epidemiology, Pseudomonas Infections microbiology, Pseudomonas aeruginosa genetics, and beta-Lactamases genetics
Abstract: Verona Integron-encoded Metallo-beta-lactamase (VIM) is the most frequently-encountered carbapenemase in the healthcare-related pathogen Pseudomonas aeruginosa. In the Netherlands, a low-endemic country for antibiotic-resistant bacteria, no national surveillance data on the prevalence of carbapenemase-producing P. aeruginosa (CPPA) was available. Therefore, in 2016, a national surveillance pilot study was initiated to investigate the occurrence, molecular epidemiology, genetic characterization, and resistomes of CPPA among P. aeruginosa isolates submitted by medical microbiology laboratories (MMLs) throughout the country. From 1221 isolates included in the study, 124 (10%) produced carbapenemase (CIM-positive); of these, the majority (95, 77%) were positive for the bla VIM gene using PCR. Sequencing was performed on 112 CIM-positive and 56 CIM-negative isolates (n = 168), and genetic clustering revealed that 75/168 (45%) isolates were highly similar. This genetic cluster, designated Group 1, comprised isolates that belonged to high-risk sequence type ST111/serotype O12, had similar resistomes, and all but two carried the bla VIM-2 allele on an identical class 1 integron. Additionally, Group 1 isolates originated from around the country (i.e. seven provinces) and from multiple MMLs. In conclusion, the Netherlands had experienced a nationwide, inter-institutional, clonal outbreak of VIM-2-producing P. aeruginosa for at least three years, which this pilot study was crucial in identifying. A structured, national surveillance program is strongly advised to monitor the spread of Group 1 CPPA, to identify emerging clones/carbapenemase genes, and to detect transmission in and especially between hospitals in order to control current and future outbreaks.
(© 2021. The Author(s).)

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41. Outcomes of patients with myelofibrosis treated with compassionate use pacritinib: a sponsor-independent international study. [2018]

Mascarenhas J, Virtgaym E, Stal M, Blacklock H, Gerds AT, Mesa R, Ganly P, Snyder D, Tabbara I, Tremblay D, and Moshier E
Annals of hematology [Ann Hematol] 2018 Aug; Vol. 97 (8), pp. 1369-1374. Date of Electronic Publication: 2018 Apr 03.

Subjects: Aged, Biomarkers, Bridged-Ring Compounds administration dosage, Bridged-Ring Compounds adverse effects, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Molecular Targeted Therapy, Mutation, Primary Myelofibrosis diagnosis, Primary Myelofibrosis genetics, Primary Myelofibrosis mortality, Protein Kinase Inhibitors administration dosage, Protein Kinase Inhibitors adverse effects, Pyrimidines administration dosage, Pyrimidines adverse effects, Treatment Outcome, Bridged-Ring Compounds therapeutic use, Primary Myelofibrosis drug therapy, Protein Kinase Inhibitors therapeutic use, and Pyrimidines therapeutic use
Abstract: Myelofibrosis (MF) is a chronic yet progressive myeloid neoplasm in which only a minority of patients undergo curative therapy, hematopoietic stem cell transplantation. Ruxolitinib, a JAK1/2 inhibitor, is the lone therapy approved for MF, offering a clear symptom and spleen benefit at the expense of treatment-related cytopenias. Pacritinib (PAC), a multi-kinase inhibitor with specificity for JAK2, FLT3, and IRAK1 but sparing JAK1, has demonstrated clinical activity in MF with minimal myelosuppression. Due to an FDA-mandated full clinical hold, the randomized phase 3 PERSIST trials were abruptly stopped and PAC was immediately discontinued for all patients. Thirty-three patients benefitting from PAC on clinical trial prior to the hold were allowed to resume therapy on an individual, compassionate-use basis. This study reports the detailed outcomes of 19 of these PAC retreatment patients with a median follow-up of 8 months. Despite a median platelet count of 49 × 10 9 /L at restart of PAC, no significant change in hematologic profile was observed. Grade 3/4 adverse events of epistaxis (n = 1), asymptomatic QT prolongation (n = 1), and bradycardia (n = 1) occurred in three patients within the first 3 months of retreatment. One death due to catheter-associated sepsis occurred. The median time to discontinuation of PAC therapy on compassionate use for all 33 patients was 12.2 (95% CI 8.3-NR) months. PAC retreatment was associated with modest improvement in splenomegaly without progressive myelosuppression and supports the continued development of this agent for the treatment of MF second line to ruxolitinib or in the setting of treatment-limiting thrombocytopenia.

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42. Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data. [2018]

Zardavas D, Te Marvelde L, Milne RL, Fumagalli D, Fountzilas G, Kotoula V, Razis E, Papaxoinis G, Joensuu H, Moynahan ME, Hennessy BT, Bieche I, Saal LH, Stal O, Iacopetta B, Jensen JD, O'Toole S, Lopez-Knowles E, Barbaraeschi M, Noguchi S, Azim HA Jr, Lerma E, Bachelot T, Wang Q, Perez-Tenorio G, Can de Velde CJH, Rea DW, Sabine V, Bartlett JMS, Sotiriou C, Michiels S, and Loi S
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2018 Apr 01; Vol. 36 (10), pp. 981-990. Date of Electronic Publication: 2018 Feb 22.

Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Breast Neoplasms mortality, Breast Neoplasms pathology, Breast Neoplasms therapy, Disease-Free Survival, Female, Genotype, Humans, Middle Aged, Mutation, Neoplasm Staging, Prognosis, Proportional Hazards Models, Receptor, ErbB-2 metabolism, Receptors, Estrogen metabolism, Survival Rate, Young Adult, Breast Neoplasms genetics, and Class I Phosphatidylinositol 3-Kinases genetics
Abstract: Purpose Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data. Patients and Methods Associations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted for age, tumor size, nodes, grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, treatment, and study. Invasive disease-free survival (IDFS) was the primary end point; distant disease-free survival (DDFS) and overall survival (OS) were also assessed, overall and by breast cancer subtypes. Results Data from 10,319 patients from 19 studies were included (median OS follow-up, 6.9 years); 1,787 patients (17%) received chemotherapy, 4,036 (39%) received endocrine monotherapy, 3,583 (35%) received both, and 913 (9%) received none or their treatment was unknown. PIK3CA mutations occurred in 32% of patients, with significant associations with ER positivity, increasing age, lower grade, and smaller size (all P < .001). Prevalence of PIK3CA mutations was 18%, 22%, and 37% in the ER-negative/HER2-negative, HER2-positive, and ER-positive/HER2-negative subtypes, respectively. In univariable analysis, PIK3CA mutations were associated with better IDFS (HR, 0.77; 95% CI, 0.71 to 0.84; P < .001), with evidence for a stronger effect in the first years of follow-up (0 to 5 years: HR, 0.73; 95% CI, 0.66 to 0.81; P < .001; 5 to 10 years: HR, 0.82; 95% CI, 0.68 to 0.99; P = .037); > 10 years: (HR, 1.15; 95% CI, 0.84 to 1.58; P = .38; P heterogeneity = .02). In multivariable analysis, PIK3CA genotype remained significant for improved IDFS ( P = .043), but not for the DDFS and OS end points. Conclusion In this large pooled analysis, PIK3CA mutations were significantly associated with a better IDFS, DDFS, and OS, but had a lesser prognostic effect after adjustment for other prognostic factors.

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43. Plasmid diversity among genetically related Klebsiella pneumoniae bla KPC-2 and bla KPC-3 isolates collected in the Dutch national surveillance. [2020]

Hendrickx APA, Landman F, de Haan A, Borst D, Witteveen S, van Santen-Verheuvel MG, van der Heide HGJ, and Schouls LM
Scientific reports [Sci Rep] 2020 Oct 08; Vol. 10 (1), pp. 16778. Date of Electronic Publication: 2020 Oct 08.

Subjects: High-Throughput Nucleotide Sequencing, Humans, Klebsiella pneumoniae isolation purification, Netherlands, DNA, Bacterial genetics, Klebsiella Infections microbiology, Klebsiella pneumoniae genetics, and beta-Lactamases genetics
Abstract: Carbapenemase-producing Klebsiella pneumoniae emerged as a nosocomial pathogen causing morbidity and mortality in patients. For infection prevention it is important to track the spread of K. pneumoniae and its plasmids between patients. Therefore, the major aim was to recapitulate the contents and diversity of the plasmids of genetically related K. pneumoniae strains harboring the beta-lactamase gene bla KPC-2 or bla KPC-3 to determine their dissemination in the Netherlands and the former Dutch Caribbean islands from 2014 to 2019. Next-generation sequencing was combined with long-read third-generation sequencing to reconstruct 22 plasmids. wgMLST revealed five genetic clusters comprised of K. pneumoniae bla KPC-2 isolates and four clusters consisted of bla KPC-3 isolates. KpnCluster-019 bla KPC-2 isolates were found both in the Netherlands and the Caribbean islands, while bla KPC-3 cluster isolates only in the Netherlands. Each K. pneumoniae bla KPC-2 or bla KPC-3 cluster was characterized by a distinct resistome and plasmidome. However, the large and medium plasmids contained a variety of antibiotic resistance genes, conjugation machinery, cation transport systems, transposons, toxin/antitoxins, insertion sequences and prophage-related elements. The small plasmids carried genes implicated in virulence. Thus, implementing long-read plasmid sequencing analysis for K. pneumoniae surveillance provided important insights in the transmission of a KpnCluster-019 bla KPC-2 strain between the Netherlands and the Caribbean.

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44. Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial. [2015]

Zhu AX, Park JO, Ryoo BY, Yen CJ, Poon R, Pastorelli D, Blanc JF, Chung HC, Baron AD, Pfiffer TE, Okusaka T, Kubackova K, Trojan J, Sastre J, Chau I, Chang SC, Abada PB, Yang L, Schwartz JD, and Kudo M
The Lancet. Oncology [Lancet Oncol] 2015 Jul; Vol. 16 (7), pp. 859-70. Date of Electronic Publication: 2015 Jun 18.

Subjects: Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Carcinoma, Hepatocellular mortality, Carcinoma, Hepatocellular pathology, Confidence Intervals, Disease-Free Survival, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Liver Neoplasms mortality, Liver Neoplasms pathology, Male, Middle Aged, Niacinamide therapeutic use, Patient Selection, Proportional Hazards Models, Remission Induction, Sorafenib, Survival Analysis, Time Factors, Treatment Outcome, Antibodies, Monoclonal therapeutic use, Carcinoma, Hepatocellular drug therapy, Liver Neoplasms drug therapy, Niacinamide analogs derivatives, and Phenylurea Compounds therapeutic use
Abstract: Background: VEGF and VEGF receptor-2-mediated angiogenesis contribute to hepatocellular carcinoma pathogenesis. Ramucirumab is a recombinant IgG1 monoclonal antibody and VEGF receptor-2 antagonist. We aimed to assess the safety and efficacy of ramucirumab in advanced hepatocellular carcinoma following first-line therapy with sorafenib.
Methods: In this randomised, placebo-controlled, double-blind, multicentre, phase 3 trial (REACH), patients were enrolled from 154 centres in 27 countries. Eligible patients were aged 18 years or older, had hepatocellular carcinoma with Barcelona Clinic Liver Cancer stage C disease or stage B disease that was refractory or not amenable to locoregional therapy, had Child-Pugh A liver disease, an Eastern Cooperative Oncology Group performance status of 0 or 1, had previously received sorafenib (stopped because of progression or intolerance), and had adequate haematological and biochemical parameters. Patients were randomly assigned (1:1) to receive intravenous ramucirumab (8 mg/kg) or placebo every 2 weeks, plus best supportive care, until disease progression, unacceptable toxicity, or death. Randomisation was stratified by geographic region and cause of liver disease with a stratified permuted block method. Patients, medical staff, investigators, and the funder were masked to treatment assignment. The primary endpoint was overall survival in the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT01140347.
Findings: Between Nov 4, 2010, and April 18, 2013, 565 patients were enrolled, of whom 283 were assigned to ramucirumab and 282 were assigned to placebo. Median overall survival for the ramucirumab group was 9·2 months (95% CI 8·0-10·6) versus 7·6 months (6·0-9·3) for the placebo group (HR 0·87 [95% CI 0·72-1·05]; p=0·14). Grade 3 or greater adverse events occurring in 5% or more of patients in either treatment group were ascites (13 [5%] of 277 patients treated with ramucirumab vs 11 [4%] of 276 patients treated with placebo), hypertension (34 [12%] vs ten [4%]), asthenia (14 [5%] vs five [2%]), malignant neoplasm progression (18 [6%] vs 11 [4%]), increased aspartate aminotransferase concentration (15 [5%] vs 23 [8%]), thrombocytopenia (13 [5%] vs one [<1%]), hyperbilirubinaemia (three [1%] vs 13 [5%]), and increased blood bilirubin (five [2%] vs 14 [5%]). The most frequently reported (≥1%) treatment-emergent serious adverse event of any grade or grade 3 or more was malignant neoplasm progression.
Interpretation: Second-line treatment with ramucirumab did not significantly improve survival over placebo in patients with advanced hepatocellular carcinoma. No new safety signals were noted in eligible patients and the safety profile is manageable.
Funding: Eli Lilly and Co.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)

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45. Behavioral Response of the Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) to Semiochemicals Deployed Inside and Outside Anthropogenic Structures During the Overwintering Period. [2017]

Morrison WR 3rd, Acebes-Doria A, Ogburn E, Kuhar TP, Walgenbach JF, Bergh JC, Nottingham L, Dimeglio A, Hipkins P, and Leskey TC
Journal of economic entomology [J Econ Entomol] 2017 Jun 01; Vol. 110 (3), pp. 1002-1009.

Subjects: Animals, Housing, Seasons, Chemotaxis, Heteroptera physiology, Insect Control, and Pheromones pharmacology
Abstract: The brown marmorated stink bug, Halyomorpha halys (Stål), is an invasive species from Asia capable of causing severe agricultural damage. It can also be a nuisance pest when it enters and exits anthropogenic overwintering sites. In recent years, pheromone lures and traps for H. halys have been developed and used to monitor populations in field studies. To date, no study has investigated the applicability of these monitoring tools for use indoors by building residents during the overwintering period. Herein, we 1) assessed when in late winter (diapause) and spring (postdiapause) H. halys begins to respond to its pheromone (10,11-epoxy-1-bisabolen-3-ol), 2) evaluated whether pheromone-based tools can be used reliably for monitoring H. halys adults in unheated and heated buildings, and 3) elucidated the potential for indoor management using pheromone-baited traps. A 2-yr trapping study suggested that H. halys began to respond reliably to pheromone-baited traps after a critical photoperiod of 13.5 h in the spring. Captures before that point were not correlated with visual counts of bugs in buildings despite robust populations, suggesting currently available pheromone-baited traps were ineffective for surveillance of diapausing H. halys. Finally, because baited traps captured only 8-20% of the adult H. halys known to be present per location, they were not an effective indoor management tool for overwintering H. halys. Our study contributes important knowledge about the capacity of H. halys to perceive its pheromone during overwintering, and the ramifications thereof for building residents with nuisance problems.
(Published by Oxford University Press on behalf of Entomological Society of America 2017. This work is written by US Government employees and is in the public domain in the US.)

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46. Histological grade provides significant prognostic information in addition to breast cancer subtypes defined according to St Gallen 2013. [2017]

Ehinger A, Malmström P, Bendahl PO, Elston CW, Falck AK, Forsare C, Grabau D, Rydén L, Stål O, and Fernö M
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2017 Jan; Vol. 56 (1), pp. 68-74. Date of Electronic Publication: 2016 Oct 20.

Subjects: Adult, Aged, Aged, 80 and over, Breast Neoplasms drug therapy, Breast Neoplasms metabolism, Cohort Studies, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Lymphatic Metastasis, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local metabolism, Neoplasm Staging, Prognosis, Receptor, ErbB-2 metabolism, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, Survival Rate, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor metabolism, Breast Neoplasms classification, Breast Neoplasms pathology, and Neoplasm Recurrence, Local pathology
Abstract: Background: The St Gallen surrogate definition of the intrinsic subtypes of breast cancer consist of five subgroups based on estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor type 2 (HER2), and Ki-67. PgR and Ki-67 are used for discriminating between the 'Luminal A-like' and 'Luminal B-like (HER2-negative)' subtypes. Histological grade (G) has prognostic value in breast cancer; however, its relationship to the St Gallen subtypes is not clear. Based on a previous pilot study, we hypothesized that G could be a primary discriminator for ER-positive/HER2-negative breast cancers that were G1 or G3, whereas Ki-67 and PgR could provide additional prognostic information specifically for patients with G2 tumors. To test this hypothesis, a larger patient cohort was examined.
Patients and Methods: Six hundred seventy-one patients (≥35 years of age, pT1-2, pN0-1) with ER-positive/HER2-negative breast cancer and complete data for PgR, Ki-67, G, lymph node status, tumor size, age, and distant disease-free survival (DDFS; median follow-up 9.2 years) were included.
Results: 'Luminal A-like' tumors were mostly G1 or G2 (90%) whereas 'Luminal B-like' tumors were mostly G2 or G3 (87%) and corresponded with good and poor DDFS, respectively. In 'Luminal B-like' tumors that were G1 (n = 23), no metastasis occurred, whereas 14 of 40 'Luminal A-like' tumors that were G3 metastasized. In the G2 subgroup, low PgR and high Ki-67 were associated with an increased risk of distant metastases, hazard ratio (HR) and 95% confidence interval (CI) 1.8 (0.95-3.4) and 1.5 (0.80-2.8), respectively.
Conclusions: Patients with ER-positive/HER2-negative/G1 breast cancer have a good prognosis, similar to that of 'Luminal A-like', while those with ER-positive/HER2-negative/G3 breast cancer have a worse prognosis, similar to that of 'Luminal B-like', when assessed independently of PgR and Ki-67. Therapy decisions based on Ki-67 and PgR might thus be restricted to the subgroup G2.

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47. Môrewind oor die Karasberge: 'n Kultuurhistoriese Verkenning van die Karasstreek van die Laat Negentiende Eeu. [2011]

Groenewald, Gerald
Historia; Nov2011, Vol. 56 Issue 2, p203-206, 4p

Subjects: NAMIBIAN history and NONFICTION
Abstract: The article presents a book review of "Môrewind oor die Karasberge: ’n Kultuurhistoriese Verkenning van die Karasstreek van die Laat Negentiende Eeu," by E. L. P. Stals.

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48. Diversification patterns of the grasshopper genus Zoniopoda Stål (Romaleidae, Acridoidea, Orthoptera) in open vegetation biomes of South America. [2018]

POCCO, M. A. R. T. I. N. A. E., GUZMÁN, N. O. E. L. I. A., PLISCHUK, S. A. N. T. I. A. G. O., CONFALONIERI, V. I. V. I. A. N. A., LANGE, C. A. R. L. O. S. E., and CIGLIANO, MARÍA M. A. R. T. A.
Systematic Entomology; Apr2018, Vol. 43 Issue 2, p290-307, 18p

Subjects: BIODIVERSITY, GRASSHOPPER behavior, BIOMES, PHYLOGENY, and SPECIES distribution
Abstract: Abstract: The open vegetation biomes, within the limits of the Chacoan subregion, occur along a diagonal in eastern South America covering a large range of environmental conditions. In order to contribute to the knowledge on the biodiversity of these open biomes, we analysed the phylogenetic relationships of the grasshopper genus Zoniopoda to the remaining South American Romaleinae, and examined the biogeographical patterns of diversification of the genus. The study is based on morphological and molecular (COI and H3) evidence, including 12 species of Zoniopoda and 17 species of four tribes of South American Romaleinae. We describe a new species of Zoniopoda, and test its taxonomic placement within the group. Results of our phylogenetic analyses recovered Zoniopoda as a monophyletic group with high support values. According to the dispersion–vicariance analysis, the ancestor of Zoniopoda may have been distributed in an area corresponding to the Chacoan and Cerrado provinces. A vicariant event, that could be explained by the uplift of the Brazilian Plateau and the subsidence of the Chaco, is hypothesized to have occurred splitting the ancestral distribution of Zoniopoda, resulting in the independent evolution of the Tarsata group within the Cerrado and the Iheringi group in the Chacoan subregion. This published work has been registered in ZooBank, http://zoobank.org/urn:lsid:zoobank.org:act:FCFB4C5D-1741-46F1-8E25-B37ED2B9D872. [ABSTRACT FROM AUTHOR]

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49. Ethyl formate dilution in carbon dioxide for fumigation control of the brown marmorated stink bug Halyomorpha halys, Stål (Hemiptera: Pentatomidae). [2022]

Kawagoe, James C, Abrams, Adelaine E, Lourie, Austin P, and Walse, Spencer S
Pest Management Science; Jul2022, Vol. 78 Issue 7, p3090-3097, 8p

Subjects: STINKBUGS, BROWN marmorated stink bug, CARBON dioxide, FUMIGATION, ATMOSPHERIC carbon dioxide, HEMIPTERA, and DILUTION
Abstract: BACKGROUND: The brown marmorated stink bug (BMSB), Halyomorpha halys, has caused significant agricultural damage to numerous hosts, so agricultural producers seek to limit its spread. Where established, BMSB can also cause substantial urban and commercial disturbance, as overwintering adults may seek refuge inside dwellings, covered spaces, vehicles, and consignments. Phytosanitary authorities are most concerned with the importation of 'hitchhiking' adults in this refugia, with certain countries requiring a quarantine treatment to mitigate risk. This study explores fumigation with ethyl formate, applied as 16.7% by mass dilution in carbon dioxide, for control of adult BMSB. RESULTS: The induction of diapause, to simulate overwintering physiology, resulted in 2‐ and 3‐fold increases in the tolerance of adults toward this ethyl formate fumigation at 10 ± 0.5 °C (x¯±2s) lasting for 8 and 12 h, respectively. However, a decreased tolerance (0.7‐fold) of diapausing specimens was observed for a 4‐h duration. Diapausing and nondiapausing adult BMSB can be controlled at the probit 9 level if the headspace concentration of ethyl formate, [EF], in the carbon dioxide mixture is maintained ≥7.68 mg L−1 for 12 h at 10 ± 0.5 °C (x¯±2s). If the duration is shortened to 4 h, [EF] must be maintained ≥14.73 mg L−1 over the course of fumigation. CONCLUSION: The toxicity of ethyl formate in this mixture can be distinct for different physiological states of the same life stage, as evidenced by a ca. 3‐fold increase in the Haber's z parameter for adult BMSB when in diapause. Respective to the physiological state of adults, this study identifies how the applied dose and/or treatment duration can be modulated (i.e. tuned) to ensure adequate toxicological efficacy toward BMSB infesting hosts or refuge at temperatures ca. >10 °C. Published 2022. This article is a U.S. Government work and is in the public domain in the USA. [ABSTRACT FROM AUTHOR]

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50. Inventory of some families of Hemiptera, Coleoptera (Curculionidae) and Hymenoptera associated with horticultural production of the Alto Valle de Río Negro and Neuquén provinces (Argentina). [2021]

ÁLVAREZ, Leopoldo J., BERNARDIS, Adela M., DEFEA, Bárbara S., DELLAPÉ, Pablo M., DEL RÍO, María G., GITTINS LÓPEZ, Cecilia G., LANTERI, Analía A., LÓPEZ ARMENGOL, María F., MARINO DE REMES LENICOV, Ana M., MINGHETTI, Eugenia, PARADELL, Susana L., and RIZZO, María E.
Revista de la Sociedad Entomológica Argentina; 2021, Vol. 80 Issue 1, p48-69, 22p

Subjects: HYMENOPTERA, CURCULIONIDAE, HOMOPTERA, PEST control, INSECT collection & preservation, BEETLES, and HEMIPTERA
Abstract: Copyright of Revista de la Sociedad Entomológica Argentina is the property of Sociedad Entomologica Argentina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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51. Identification of a novel locus, BPH38(t), conferring resistance to brown planthopper (Nilaparvata lugens Stal.) using early backcross population in rice (Oryza sativa L.). [2019]

Balachiranjeevi, C. H., Prahalada, G. D., Mahender, A., Jamaloddin, Md., Sevilla, M. A. L., Marfori-Nazarea, C. M., Vinarao, R., Sushanto, U., Baehaki, S. E., Li, Z. K., and Ali, J.
Euphytica; 2019, p1-14, 14p

Subjects: NILAPARVATA lugens, SINGLE nucleotide polymorphisms, LOCUS (Genetics), GENOTYPES, INSECT pests, and RICE
Abstract: Rice is the most important staple food crop, and it feeds more than half of the world population. Brown planthopper (BPH) is a major insect pest of rice that causes 20–80% yield loss through direct and indirect damage. The identification and use of BPH resistance genes can efficiently manage BPH. A molecular marker-based genetic analysis of BPH resistance was carried out using 101 BC1F5 mapping population derived from a cross between a BPH-resistant indica variety Khazar and an elite BPH-susceptible line Huang–Huan–Zhan. The genetic analysis indicated the existence of Mendelian segregation for BPH resistance. A total of 702 high-quality polymorphic single nucleotide polymorphism (SNP) markers, genotypic data, and precisely estimated BPH scores were used for molecular mapping, which resulted in the identification of the BPH38(t) locus on the long arm of chromosome 1 between SNP markers 693,369 and id 10,112,165 of 496.2 kb in size with LOD of 20.53 and phenotypic variation explained of 35.91%. A total of 71 candidate genes were predicted in the detected locus. Among these candidate genes, LOC_Os01g37260 was found to belong to the FBXL class of F-box protein possessing the LRR domain, which is reported to be involved in biotic stress resistance. Furthermore, background analysis and phenotypic selection resulted in the identification of introgression lines (ILs) possessing at least 90% recurrent parent genome recovery and showing superior performance for several agro-morphological traits. The BPH resistance locus and ILs identified in the present study will be useful in marker-assisted BPH resistance breeding programs. [ABSTRACT FROM AUTHOR]

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52. MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit. [2021]

Løkkegaard, Sanne, Elias, Daniel, Alves, Carla L., Bennetzen, Martin V., Lænkholm, Anne-Vibeke, Bak, Martin, Gjerstorff, Morten F., Johansen, Lene E., Vever, Henriette, Bjerre, Christina, Kirkegaard, Tove, Nordenskjöld, Bo, Fornander, Tommy, Stål, Olle, Lindström, Linda S., Esserman, Laura J., Lykkesfeldt, Anne E., Andersen, Jens S., Leth-Larsen, Rikke, and Ditzel, Henrik J.
NPJ Breast Cancer; 1/4/2021, Vol. 7 Issue 1, p1-15, 15p

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53. First Detection of the Adventive Egg Parasitoid of Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) Trissolcus mitsukurii (Ashmead) (Hymenoptera: Scelionidae) in France. [2021]

Bout A, Tortorici F, Hamidi R, Warot S, Tavella L, and Thomas M
Insects [Insects] 2021 Aug 24; Vol. 12 (9). Date of Electronic Publication: 2021 Aug 24.

Abstract: We report the first detection of Trissolcus mitsukurii in France. More than 1860 sentinel egg masses of Halyomorpha halys (BMSB) were exposed in the field during the 2018-2020 period, and 12 specimens of T. mitsukurii emerged from one egg mass. Their taxonomic identification was confirmed both by morphological and molecular analysis. Trissolcus mitsukurii , similar to T. japonicus , is an egg parasitoid of BMSB in its area of origin in Asia, and both species are considered to be candidates for a classical biological control strategy against BMSB. Trissolcus mitsukurii was previously recorded in Italy where it is well established and widespread, and this may be the source of the French population. Possible permanent establishment and dispersion of T. mitsukurii in France should be monitored with emphasis on its potential effect on BMSB populations.

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54. INSECTICIDAL ACTIVITY OF SESAME LEAF AND STEM EXTRACTS ON Clavigralla tomentosicollis Stal (Hemiptera: Coreidae). [2020]

Negbenebor, H. E., Abdullahi, R. I., Nura, S., and Sharif, U.
Bayero Journal of Pure & Applied Sciences; Jun2020, Vol. 13 Issue 1, p145-151, 7p

Subjects: SESAME, BOTANICAL insecticides, INSECTICIDES, CARDIAC glycosides, INSECT mortality, HEMIPTERA, and EXTRACTS
Abstract: A study was conducted to investigate the insecticidal potency of leaf and stem ethanolic extracts of white sesame (Sesamum indicum L.) on the pod-sucking bug (Clavigralla tomentosicollis Stal.) under laboratory conditions. Four different concentrations of the extracts (5.00, 10.00, 15.00 and 20.00 mg/l) of ethanolic extracts were prepared from the leaf and stem parts of the Sesame plant. Water and Cypermethrin were used as negative and positive controls. Fresh cowpea pods were treated with the various concentrations of the stem and leaf ethanolic extracts and the pod-sucking bugs were introduced into the jars containing the pods. The result obtained revealed significant differences (P≤0.05) in the effect of various concentrations in inducing mortality of the insects at different instars. The extracts were more effective in the first (1st) instars against the pod-sucking bugs. The activity is concentration dependent as it increases with increase in concentration of the extract. However, leaf ethanolic extract proved to be more effective. More so, the percentages of pods infested by the bugs were found to be lower among the 20.00 mg/l treated pods in both stem and leaf ethanolic extracts. The phytochemical result indicated the presence of certain phytochemicals such as alkaloids, carbohydrates, cardiac glycosides, diterpenoids, flavonoids, proteins, saponins, steroids, tannins and triterpenoids that were proved to be vital in the insecticidal activity of the extracts. Thus, the stem and leaf ethanolic extracts of sesame are effective botanical insecticides against C. tomentosicollis especially at 20.00 mg/l of the leaf extract. [ABSTRACT FROM AUTHOR]

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55. Validation of a competitive ELISA assay for the quantification of human serum hepcidin. [2015]

Dahlfors G, Stål P, Hansson EC, Bàràny P, Sisowath C, Onelöv L, Nelson D, Eggertsen G, Marmur J, and Beshara S
Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2015; Vol. 75 (8), pp. 652-8. Date of Electronic Publication: 2015 Aug 12.

Subjects: Adult, Aged, Blood Chemical Analysis, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Hepcidins genetics, Humans, Kidney Failure, Chronic blood, Limit of Detection, Liver metabolism, Liver Diseases blood, Male, Middle Aged, RNA, Messenger metabolism, Tandem Mass Spectrometry, Young Adult, and Hepcidins blood
Abstract: Background: Hepcidin-25 is a potential marker for iron disorders with a demand for accessible assays. This study aimed to evaluate a commercial competitive enzyme-linked immunosorbent assay (cELISA) for hepcidin quantitation.
Methods: Serum samples; 95 healthy subjects (HS), six patients with iron deficiency (ID), 84 patients with liver disorders (LD) and 220 hemodialysis patients (HD), were analyzed. Controls were used for imprecision, while accuracy was evaluated by quantitating hepcidin-25 with LC-MS/MS in 149 samples. Cross-reactivity for hepcidin-20 and hepcidin-22 was tested. Hepcidin-mRNA expression in 37 liver biopsies was measured.
Results: S-hepcidin ranged from 8-76 and 2-31 μg/L in healthy men and women. Levels in ID, LD and HD significantly differed from HS. Total coefficients of variation (CV) for controls were 24% and 22%. Within-sample CV was 10%. Despite a good correlation with LC-MS/MS (r = 0.89), the cELISA showed higher values and detected hepcidin-20 and hepcidin-22. Hepcidin-mRNA correlated well with S-hepcidin using cELISA and LC-MS/MS (r = 0.69 and 0.64).
Conclusions: The correlation with LC-MS/MS is good and the examined kit can differentiate between patient groups although it is not specific for hepcidin-25. Considering ELISA's capacity to readily be set up, the investigated kit can be applied. Specific reference ranges are required.

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56. Lantana camara L. and its biocontrol agent, Teleonemia scrupulosa Stål, in Botswana. [2015]

Assefa, Yoseph, Tiroesele, Bamphitlhi, Segwagwe, Amogelang, and Madisa, Mogapi E.
African Journal of Ecology; Sep2015, Vol. 53 Issue 3, p381-384, 4p

Subjects: LANTANA camara, ORNAMENTAL plants, BIOSAFETY, QUARANTINE, ECOSYSTEM dynamics, NATURALIZATION, and WEEDS
Abstract: The article presents a research focused on analyzing the status of ornamental plant lantana camara that grows in the urban areas and also discusses its implication on the biosafety and quarantine of the region. Various topics discussed in the research includes natural enemies of lantana, natural ecosystem of Botswana and impact of naturalization on weed removal.

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57. Real-time PCR assay to detect brown marmorated stink bug, Halyomorpha halys (Stål), in environmental DNA. [2016]

Valentin, Rafael E, Maslo, Brooke, Lockwood, Julie L, Pote, John, and Fonseca, Dina M
Pest Management Science; Oct2016, Vol. 72 Issue 10, p1854-1861, 8p

Subjects: POLYMERASE chain reaction, BIOLOGICAL assay, STINKBUGS, PREDATORY animals, INTRODUCED organisms, and NONINDIGENOUS pests
Abstract: BACKGROUND Early detection before establishment and identification of key predators are time-honored strategies towards effective eradication or control of invasive species. The brown marmorated stink bug (BMSB), Halyomorpha halys, is a recent exotic pest of several important crops in North America and Europe. Resulting widespread applications of insecticides have countered years of careful integrated pest management and are leading to the resurgence of other agricultural pests. Environmental DNA (eDNA) has been used effectively to detect aquatic invasives. RESULTS We developed a real-time PCR (qPCR) assay for BMSB in a conserved region of the ribosomal DNA interspacer 1 (ITS1). We validated this assay on worldwide populations of BMSB and tested its specificity and sensitivity against other US Pentatomidae species and on guano of big brown bat, Eptesicus fuscus, which we confirmed is a BMSB predator in New Jersey. We also detected BMSB DNA after rapid (and inexpensive) HotSHOT DNA extractions of soiled paper from cages briefly holding BMSB, as well as from discarded exuviae. CONCLUSION Given the high sensitivity of our assay to BMSB environmental DNA (eDNA) in terrestrial samples, this tool should become a cost-effective approach for using eDNA to detect terrestrial invasive species and their key predators. © 2016 Society of Chemical Industry [ABSTRACT FROM AUTHOR]

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58. The overlooked role of weed plants affecting pest stink bug (Hemiptera: Heteroptera: Pentatomidae) bioecology in the Neotropics. [2022]

Panizzi, A. R. and Lucini, T. L.
Arthropod-Plant Interactions; Feb2022, Vol. 16 Issue 1, p1-14, 14p

Abstract: Most stink bugs (Pentatomidae) are polyphagous and feed on an array of cultivated and non-cultivated plants. Among the last, weed plants play an important role in their bioecology and pest status, particularly in the Neotropics, in where stink bugs are active during most of the year. In spite of this, the weeds role is, in general, underestimated. In this review article we present and discuss the importance of weed plants present in row crops and pasture lands, affecting stink bugs pests of major commodities in the Neotropics. We surveyed the literature and other sources (unpublished records) on the presence of stink bugs on weed plants. These plants were ranked as hosts (allowing nymph development and/or adult reproduction) or as associated plants (providing some nutrients/water/shelter, but not allowing nymph and/or adult performance). The following stink bug pest species were covered: The green-bellied stink bugs, Diceraeus furcatus (F.) and D. melacanthus Dallas; the Neotropical brown sink bug, Euschistus heros (F.); the brown-winged stink bug, Edessa meditabunda (F.); the southern green stink bug, Nezara viridula (L.); the rice stink bugs, Oebalus poecilus (Dallas) and O. ypsilongriseus (De Geer); the red-banded stink bug, Piezodorus guildinii (Westwood); the rice stalk stink bug, Tibraca limbativentris Stål; and the red-shouldered stink bug, Thyanta perditor (F.). The survey showed plants from 16 different families interacting with the 10 species of pest pentatomids analyzed, with the greater number of species of Fabaceae (16+), Poaceae (14+), and Asteraceae (7). Data demonstrated that, in the modern landscape scenario of agricultural areas in the Neotropics, highly polyphagous species, such as N. viridula, tend to suffer greater impact, while the oligophagous species, E. heros, D. furcatus, and D. melacanthus, in contrast, tend to be favored. The management of weed plants through the increase use of herbicides, multiple cropping, and the non-tillage cultivation systems seems to be the major factors influencing the interactions of stink bugs and weeds, changing the population dynamics of pest stink bugs in the Neotropics, and, consequently their pest status. [ABSTRACT FROM AUTHOR]

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59. Predicting Rice Stem Stink Bug Population Dynamics Based on GAMLSS Models. [2020]

Seidel, E J, Pazini, J B, Tomazella, V L D, Vieira, A M C, Silva, F F, Martins, J F S, and Barrigossi, J A F
Environmental Entomology; Oct2020, Vol. 49 Issue 5, p1145-1154, 10p

Subjects: STINKBUGS, POPULATION dynamics, RICE, PEST control, and PADDY fields
Abstract: The rice stem stink bug, Tibraca limbativentris Stål (Hemiptera: Pentatomidae), is one of the most harmful insects for Brazilian rice fields. Aiming to define the most appropriate time and place for pest management measures in commercial paddy fields, we adjusted regression models (Poisson, Zero Inflated Poisson, reparametrized Zero Inflated Poisson, Negative Binomial and Zero Inflated Negative Binomial) for modeling the population variation of T. limbativentris along the phenological cycle of the flooded rice cultivation. We hypothesize that the rice stem stink bug population's size is influenced by the rice cycle (time) and geographical positions within the crop. It was possible to predict the occurrence of the rice stem stink bug in the commercial flooded rice crop. The population of the rice stem stink bug increased significantly with the time or phenological evolution of rice. Our results indicated that the start of T. limbativentris monitoring should occur up to 45 d After Plant Emergence (DAE), from the regions along the edges of the rice paddies, which are the points of entry and higher concentration of the insect. In addition, 45 and 60 DAE were considered the crucial times for T. limbativentris control decision making in flooded rice paddies. [ABSTRACT FROM AUTHOR]

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60. Greenhouse Rearing Methods for Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) on Live Cowpea Plants. [2021]

Abrams, Adelaine E, Alvarez, Alfredo, Rodriguez, Matthew S, Kron, Cindy R, Bellamy, Dave E, and Walse, Spencer S
Journal of Economic Entomology; Dec2021, Vol. 114 Issue 6, p2297-2306, 10p

Subjects: BROWN marmorated stink bug, STINKBUGS, HEMIPTERA, GREENHOUSES, ADULTS, and COWPEA
Abstract: Brown marmorated stink bug (BMSB), Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is a pest of concern that must be controlled for market access of host material and regulated articles to certain countries. This work outlines a rearing system for BMSB on live cowpea plants, Vigna unguiculata (L.) Walp. (Fabales: Fabaceae), including methods to induce adults to both enter and exit diapause. This scalable system affords continuous access to >600 specimens per week of each life stage and/or age group, which is particularly advantageous when developing treatment efficacy data. [ABSTRACT FROM AUTHOR]

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61. Prospects for charged Higgs searches at the LHC. [2017]

Arhrib, A., Hernandez-Sanchez, J., Mahmoudi, F., Santos, R., Akeroyd, A., Moretti, S., Yagyu, K., Yildirim, E., Khater, W., Krawczyk, M., Najjari, S., Sokołowska, D., Osland, P., Purmohammadi, M., Pruna, G., Sharma, P., Stål, O., Aoki, M., Basso, L., and Ginzburg, I.
European Physical Journal C -- Particles & Fields; May2017, Vol. 77 Issue 5, p1-33, 33p

Subjects: HIGGS bosons, SCALAR field theory, SUPERSYMMETRY, STANDARD model (Nuclear physics), DARK matter, and MATHEMATICAL models
Abstract: The goal of this report is to summarize the current situation and discuss possible search strategies for charged scalars, in non-supersymmetric extensions of the Standard Model at the LHC. Such scalars appear in Multi-Higgs-Doublet models, in particular in the popular Two-Higgs-Doublet model, allowing for charged and additional neutral Higgs bosons. These models have the attractive property that electroweak precision observables are automatically in agreement with the Standard Model at the tree level. For the most popular version of this framework, Model II, a discovery of a charged Higgs boson remains challenging, since the parameter space is becoming very constrained, and the QCD background is very high. We also briefly comment on models with dark matter which constrain the corresponding charged scalars that occur in these models. The stakes of a possible discovery of an extended scalar sector are very high, and these searches should be pursued in all conceivable channels, at the LHC and at future colliders. [ABSTRACT FROM AUTHOR]

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62. A comprehensive overview of urogenital, anorectal and oropharyngeal Neisseria gonorrhoeae testing and diagnoses among different STI care providers: a cross-sectional study. [2017]

den Heijer, Casper D. J., Hoebe, Christian J. P. A., van Liere, Geneviève A. F. S., van Bergen, Jan E. A. M., Cals, Jochen W. L., Stals, Frans S., and Dukers-Muijrers, Nicole H. T. M.
BMC Infectious Diseases; 4/20/2017, Vol. 17, p1-10, 10p, 1 Diagram, 3 Charts, 1 Graph

Subjects: NEISSERIA gonorrhoeae, SEXUALLY transmitted diseases, ANTIBIOTICS, CHLAMYDIA trachomatis, GYNECOLOGISTS, DIAGNOSIS, CHLAMYDIA infection diagnosis, GENITOURINARY disease diagnosis, GONORRHEA diagnosis, CLINICS, GENITOURINARY diseases, GONORRHEA, DISEASES in men, NEISSERIA, PHARYNGEAL diseases, PHYSICIANS, GENERAL practitioners, CROSS-sectional method, and RECTAL diseases
Abstract: Background: Gonorrhoea, caused by Neisseria gonorrhoeae (NG), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and is frequently asymptomatic, which shows the essential role of NG test practice. In this study we wanted to compare NG diagnostic testing procedures between different STI care providers serving a defined geographic Dutch region (280,000 inhabitants).Methods: Data on laboratory testing and diagnosis of urogenital and extragenital (i.e. anorectal and oropharyngeal) NG were retrieved from general practitioners (GPs), an STI clinic, and gynaecologists (2006-2010). Per provider, we assessed their contribution regarding the total number of tests performed and type of populations tested, the proportion of NG positives re-tested (3-12 months after treatment) and test-of-cure (TOC, within 3 months post treatment).Results: Overall, 17,702 NG tests (48.7% STI clinic, 38.2% GPs, 13.1% gynaecologists) were performed during 15,458 patient visits. From this total number of tests, 2257 (12.7%) were extragenital, of which 99.4% were performed by the STI clinic. Men were mostly tested at the STI clinic (71%) and women by their GP (43%). NG positivity per visit was 1.6%; GP 1.9% (n = 111), STI clinic 1.7% (n = 131) and gynaecology 0.2% (n = 5). NG positivity was associated with Chlamydia trachomatis positivity (OR: 2.06, 95% confidence interval: 1.46-2.92). Per anatomical location, the proportion of NG positives re-tested were: urogenital 20.3% (n = 36), anorectal 43.6% (n = 17) and oropharyngeal 57.1% (n = 20). NG positivity among re-tests was 16.9%. Proportions of NG positives with TOC by anatomical location were: urogenital 10.2% (n = 18), anorectal 17.9% (n = 7) and oropharyngeal 17.1% (n = 6).Conclusions: To achieve best practice in relation to NG testing, we recommend that: 1) GPs test at extragenital sites, especially men who have sex with men (MSM), 2) all care providers consider re-testing 3 to 12 months after NG diagnosis and 3) TOC is performed following oropharyngeal NG diagnosis in settings which provide services to higher-risk men and women (such as STI clinics). [ABSTRACT FROM AUTHOR]

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63. Parasitism and Predation on Sentinel Egg Masses of Three Stink Bug Species (Hemiptera: Pentatomidae) in Native and Exotic Ornamental Landscapes. [2021]

Cornelius, Mary L, Herlihy, Megan V, Vinyard, Bryan T, Weber, Donald C, and Greenstone, Matthew H
Journal of Economic Entomology; Apr2021, Vol. 114 Issue 2, p590-596, 7p

Subjects: STINKBUGS, BROWN marmorated stink bug, PREDATION, HEMIPTERA, SPECIES, and LANDSCAPES
Abstract: This study evaluated parasitism and predation on sentinel egg masses of three stink bug species, the spined soldier bug, Podisus maculiventris (Say), the brown stink bug, Euschistus servus (Say), and the invasive brown marmorated stink bug (BMSB), Halyomorpha halys (Stål), in ornamental landscapes composed of either native or exotic plants. This study also compared the species composition of parasitoids attacking two native stink bug species (P. maculiventris and E. servus) with those attacking the invasive BMSB on the same tree species in the same habitat. Overall, egg parasitism and predation were much higher on the two native stink bug species compared with BMSB, with an average parasitism rate of 20.6% for E. servus , 12.7% for P. maculiventris , and only 4.2% for H. halys and an average predation rate of 8.2% for E. servus, 17.7% for P. maculiventris, and 2.3% for H. halys. Egg predation was also significantly higher on P. maculiventris than on E. servus eggs. Eight parasitoid species attacked sentinel stink bug eggs in the ornamental landscaped plots. Trissolcus euschisti (Ashmead) (Hymenoptera: Scelionidae) was the predominant parasitoid for all three stink bug species. There were no significant differences in parasitism and predation rates on any of the stink bug species between native and exotic plots. Therefore, there is no evidence that ornamental landscapes composed of native plants increased parasitism or predation rates of sentinel egg masses of two native stink bug species or the invasive BMSB, compared with those composed entirely of exotic plants. [ABSTRACT FROM AUTHOR]

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64. Permanent genetic resources added to Molecular Ecology Resources Database 1 December 2011-31 January 2012. [2012]

Arias MC, Arnoux E, Bell JJ, Bernadou A, Bino G, Blatrix R, Bourguet D, Carrea C, Clamens AL, Cunha HA, d'Alençon E, Ding Y, Djieto-Lordon C, Dubois MP, Dumas P, Eraud C, Faivre B, Francisco FO, Françoso E, Garcia M, Gardner JP, Garnier S, Gimenez S, Gold JR, Harris DJ, He G, Hellemans B, Hollenbeck CM, Jing S, Kergoat GJ, Liu B, McDowell JR, McKey D, Miller TL, Newton E, Pagenkopp Lohan KM, Papetti C, Paterson I, Peccoud J, Peng X, Piatscheck F, Ponsard S, Reece KS, Reisser CM, Renshaw MA, Ruzzante DE, Sauve M, Shields JD, Solé-Cava A, Souche EL, Van Houdt JK, Vasconcellos A, Volckaert FA, Wang S, Xiao J, Yu H, Zane L, Zannato B, Zemlak TS, Zhang C, Zhao Y, Zhou X, and Zhu L
Molecular ecology resources [Mol Ecol Resour] 2012 May; Vol. 12 (3), pp. 570-2. Date of Electronic Publication: 2012 Mar 26.

Subjects: Biota, DNA Primers genetics, Databases, Genetic, Ecology methods, Microsatellite Repeats, and Polymorphism, Single Nucleotide
Abstract: This article documents the addition of 473 microsatellite marker loci and 71 pairs of single-nucleotide polymorphism (SNP) sequencing primers to the Molecular Ecology Resources Database. Loci were developed for the following species: Barteria fistulosa, Bombus morio, Galaxias platei, Hematodinium perezi, Macrocentrus cingulum Brischke (a.k.a. M. abdominalis Fab., M. grandii Goidanich or M. gifuensis Ashmead), Micropogonias furnieri, Nerita melanotragus, Nilaparvata lugens Stål, Sciaenops ocellatus, Scomber scombrus, Spodoptera frugiperda and Turdus lherminieri. These loci were cross-tested on the following species: Barteria dewevrei, Barteria nigritana, Barteria solida, Cynoscion acoupa, Cynoscion jamaicensis, Cynoscion leiarchus, Cynoscion nebulosus, Cynoscion striatus, Cynoscion virescens, Macrodon ancylodon, Menticirrhus americanus, Nilaparvata muiri and Umbrina canosai. This article also documents the addition of 116 sequencing primer pairs for Dicentrarchus labrax.
(© 2012 Blackwell Publishing Ltd.)

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65. Assessment of chemical resistance of wild and cultivated Vigna species to the brown pod-bugClavigralla tomentosicollis Stal (Hem., Coreidae). [2003]

Koona, P., Osisanya, E. O., Lajide, L., Jackai, L. E. N., and Tamo, M.
Journal of Applied Entomology; Jun2003, Vol. 127 Issue 5, p293, 6p

Subjects: PLANT chemical defenses, VIGNA, and COREIDAE
Abstract: The effects of secondary metabolites in different Vigna species on the development of Clavigralla tomentosicollis were investigated in an artificial seed system using different fractions of crude pod extracts, while the orientation response of this pod-bug to volatile extracts was studied using a dual-choice olfactometer. Feeding on the neutral fraction extracts, in contrast to the basic and acidic fractions, resulted in significantly higher mortalities, longer total developmental time, and lower growth index of the insects in comparison with controls. All volatile extracts elicited an avoidance reaction by C. tomentosicollis, except the volatile from the susceptible genotype IT84S-2246 which generally attracted as many insects as controls. Extracts from wild Vigna species showed higher activity than those from their cultivated relatives. The present study which has established that most secondary metabolites in cowpea pods were localized in the neutral fraction of the crude extract, could facilitate experiments on the separation and characterization of the toxic factors involved. [ABSTRACT FROM AUTHOR]

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66. A Revision of Myrocheine Genus Ennius St l With Special Reference to Redescription of E. monteironis Distant (Hemiptera: Pentatomidae Pentatominae) and Their Phylogenetic Relationships. [2011]

Zahid, Muhammad and Ahmad, Imtiaz
Pakistan Journal of Zoology; 2011, Vol. 43 Issue 3, p549-554, 6p

Abstract: The article highlights a study which examined the characteristics and phylogenetic relationships of the myrocheine stink bug genus Ennius Stål, with special reference to its species Ennius monteironis Distant. The bug's metathoracic scent auricle, female genitalia and male genitalia including inflated aedeagus were investigated. The Ennius species belonged to the Myrochea Stål subclade, under the Myrocheini Stål genus and Kyrtalus genera. The Ennius was found to be predominantly Ethiopian in distribution.

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67. Observations of parasitoid behaviour in both no‐choice and choice tests are consistent with proposed ecological host range. [2021]

Withers, Toni M., Allen, Geoff R., Todoroki, Christine L., Pugh, Andrew R., and Gresham, Belinda A.
Entomologia Experimentalis et Applicata; Jan2021, Vol. 169 Issue 1, p97-110, 14p

Subjects: BIOLOGICAL weed control, BIOLOGICAL pest control agents, CHRYSOMELIDAE, BEETLES, HYMENOPTERA, and EUCALYPTUS
Abstract: The solitary larval endoparasitoid Eadya daenerys Ridenbaugh (Hymenoptera: Braconidae) is a proposed biocontrol agent of Paropsis charybdis Stål (Coleoptera: Chrysomelidae, Chrysomelinae), a pest of eucalypts in New Zealand. Eadya daenerys oviposition behaviour was examined in two assay types during host range testing, with the aim of improving ecological host range prediction. No‐choice sequential and two‐choice behavioural observations were undertaken against nine closely related species of New Zealand non‐target beetle larvae, including a native beetle, introduced weed biocontrol agents, and invasive paropsine beetles. No behavioural measure was significantly different between no‐choice and two‐choice tests. In sequential no‐choice assays the order of first presentation (target–non‐target) had no significant effect on the median number of attacks or the attack rate while on the plant. Beetle species was the most important factor. Parasitoids expressed significantly lower on‐plant attack rates against non‐targets compared to target P. charybdis larvae. The median number of attacks was always higher towards target larvae than towards non‐target larvae, except for the phylogenetically closest related non‐target Trachymela sloanei (Blackburn) (Coleoptera: Chrysomelidae, Chrysomelinae). Most non‐target larvae were disregarded upon contact, which suggests that the infrequent attack behaviour observed by two individual E. daenerys against Allocharis nr. tarsalis larvae in two‐choice tests and the frass of Chrysolina abchasica (Weise) was probably abnormal host selection behaviour. Results indicate that E. daenerys is unlikely to attack non‐target species apart from Eucalyptus‐feeding invasive paropsines (Chrysomelinae). Non‐lethal negative impacts upon less preferred non‐target larvae are possible if E. daenerys does attack them in the field; however, this is likely to be rare. [ABSTRACT FROM AUTHOR]

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68. Community Composition, Abundance, and Phenology of Stink Bugs (Hemiptera: Pentatomidae) in Soybean in the North Central Region of the United States. [2019]

Pezzini, Daniela T, DiFonzo, Christina D, Finke, Deborah L, Hunt, Thomas E, Knodel, Janet J, Krupke, Christian H, McCornack, Brian, Michel, Andrew P, Philips, Christopher R, Varenhorst, Adam J, Wright, Robert J, and Koch, Robert L
Journal of Economic Entomology; Aug2019, Vol. 112 Issue 4, p1722-1731, 10p

Subjects: PLANT phenology, STINKBUGS, SOYBEAN farming, SOYBEAN diseases & pests, and HEMIPTERA
Abstract: Stink bugs (Hemiptera: Pentatomidae) are an increasing threat to soybean (Fabales: Fabaceae) production in the North Central Region of the United States, which accounts for 80% of the country's total soybean production. Characterization of the stink bug community is essential for development of management programs for these pests. However, the composition of the stink bug community in the region is not well defined. This study aimed to address this gap with a 2-yr, 9-state survey. Specifically, we characterized the relative abundance, richness, and diversity of taxa in this community, and assessed phenological differences in abundance of herbivorous and predatory stink bugs. Overall, the stink bug community was dominated by Euschistus spp. (Hemiptera: Pentatomidae) and Chinavia hilaris (Say) (Hemiptera: Pentatomidae). Euschistus variolarius (Palisot de Beauvois) (Hemiptera: Pentatomidae), C. hilaris and Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) were more abundant in the northwestern, southeastern and eastern parts, respectively, of the North Central Region of the United States. Economically significant infestations of herbivorous species occurred in fields in southern parts of the region. Species richness differed across states, while diversity was the same across the region. Herbivorous and predatory species were more abundant during later soybean growth stages. Our results represent the first regional characterization of the stink bug community in soybean fields and will be fundamental for the development of state- and region-specific management programs for these pests in the North Central Region of the United States. [ABSTRACT FROM AUTHOR]

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69. Comparative suitability of soybean and cowpea as host plants for the brown cowpea coreid bug, Clavigralla tomentosicollis Stal. (Hem., Coreidae). [1996]

Ntonifor, N. N. and Jackai, L. E. N.
Journal of Applied Entomology; Jan1996, Vol. 120 Issue 1-5, p439-443, 5p, 3 Charts, 4 Graphs

Subjects: INSECT host plants, SOYBEAN diseases & pests, COWPEA, COREIDAE, LEGUME diseases & pests, SEED pods, and INSECT food
Abstract: Suitability of the pods of cowpea ( Vigna unguiculata (L.) Walp) and soybean ( Glycine max (L.) Merrill) as food for Clavigralla tomentosicollis was determined in the laboratory using development, food substitution and host switch experiments. On soybean pods, nymphs survived for 8 days and adults for 12 days; on cowpea, all nymphal instars developed into adults and lived for 80-100 days. Teneral adults that were switched from cowpea to soybean lost weight, while adults that were moved from soybean to cowpea gained weight with slight differences between the sexes. The shortest critical survival threshold (duration with at least 50% survival) of adults on cowpea was greater than the longest on soybean. The likelihood of C. tomentosicollis exploiting soybean as a trophic niche in areas of tropical Africa where production of this crop is on the increase and usually contiguous with cowpea production, is discussed. [ABSTRACT FROM AUTHOR]

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70. P14.01 Incidence and impact of venous thromboembolism and major bleeding in patients with glioblastoma. [2021]

Kaptein, F H J, Stals, M A M, Klaase, E, Kapteijn, M Y, Cannegieter, S C, Taphoorn, M J B, Dirven, L, Huisman, M V, Koekkoek, J A F, and Klok, F A
Neuro-Oncology; 2021 Supplement, Vol. 23, pii38-ii38, 1p

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71. De novo SETD5 nonsense mutation associated with diaphragmatic hernia and severe cerebral cortical dysplasia. [2017]

Rawlins, Lettie E., Stals, Karen L., Eason, Julian D., and Turnpenny, Peter D.
Clinical Dysmorphology; Apr2017, Vol. 26 Issue 2, p95-97, 3p, 1 Black and White Photograph

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72. New record of Trissolcus solocis (Hymenoptera: Scelionidae) parasitising Halyomorpha halys (Hemiptera: Pentatomidae) in the United States of America. [2019]

Balusu, Rammohan R., Cottrell, Ted E., Talamas, Elijah J., Toews, Michael D., Blaauw, Brett R., Sial, Ashfaq A., Buntin, David G., Vinson, Edgar L., Fadamiro, Henry Y., and Tillman, Glynn P.
Biodiversity Data Journal; 2019, p1-6, 6p

Subjects: TRISSOLCUS, BROWN marmorated stink bug, PARASITOIDS, SCELIONIDAE, and WASPS
Abstract: Background A parasitoid wasp, Trissolcus solocis Johnson, was recorded parasitising eggs of the invasive stink bug Halyomorpha halys (Stål), in the United States. This is the first record of this species parasitising eggs of H. halys. New information First record of Trissolcus solocis parasitising Halyomorpha halys eggs in the United States and first record of T. solocis in Alabama. [ABSTRACT FROM AUTHOR]

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73. Biogeography and diversification of Holarctic water striders: Cenozoic temperature variation, habitat shifting and multiple intercontinental dispersals. [2018]

YE, Z. H. E. N., ZHEN, Y. A. H. U. I., DAMGAARD, J. A. K. O. B., CHEN, P. I. N. G. P. I. N. G., ZHU, L. I. N., ZHENG, C. H. E. N. G. U. A. N. G., and BU, W. E. N. J. U. N.
Systematic Entomology; Jan2018, Vol. 43 Issue 1, p19-30, 12p

Subjects: BIODIVERSITY, VERTEBRATES, HABITATS, GLACIATION, and PLIOCENE Epoch
Abstract: It is now rare to find a semi-aquatic organism group with which to vigorously test whether their diversification model and distribution pattern are closely related to the Cenozoic temperature variation. This hypothesis is explored for water striders of the genera Aquarius Schellenberg, Gerris Fabricius and Limnoporus Stål, which comprise a monophyletic clade with primarily Holarctic distribution. We sample almost 90% of the currently recognized Aquarius, Gerris and Limnoporus species. Five DNA fragments from 62 species are used to reconstruct a phylogram. Divergence time is estimated using Bayesian relaxed-clock method and three fossil calibrations. We investigate diversification dynamics, biogeography and ancestral state reconstruction by using maximum-likelihood, Bayesian and parsimony approaches. Our results showed that the crown of the three genera originated and underwent an initial diversification in Asia at 72 Ma (HPD: 59-86 Ma) in the Late Cretaceous, subsequently expanding into other regions via dispersal. The Bering Land Bridge was the major migration route between Eurasia and North America but was interrupted before the early Oligocene (34 Ma). Ancestors most likely used lentic habitats, and a minimum of two independent shifts to lotic habitats occurred in the initial diversification. Cenozoic temperature variation regulated the evolutionary history of Holarctic water striders of the genera Aquarius, Gerris and Limnoporus. Temperature warming during Stage I (52-66 Ma) was associated with the disappearance of shallow lentic habitats; this phenomenon forced certain lentic lineages to colonize new lotic habitats and promoted the diversification of lineages. Temperature cooling during Stage II (after 34 Ma) was associated with the fragmentation of water habitats of the 'mixed-mesophytic' belt, resulting in the extinction of historical taxa and influencing close lineages that shaped the present disjunct Eurasian-North American distribution. [ABSTRACT FROM AUTHOR]

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74. Susceptibility of ESBL Escherichia coli and Klebsiella pneumoniae to fosfomycin in the Netherlands and comparison of several testing methods including Etest, MIC test strip, Vitek2, Phoenix and disc diffusion. [2018]

van den Bijllaardt, Wouter, Schijffelen, Maarten J, Bosboom, Ron W, Stuart, James Cohen, Diederen, Bram, Kampinga, Greetje, Le, Thuy-Nga, Overdevest, Ilse, Stals, Frans, and Voorn, Paul
Journal of Antimicrobial Chemotherapy (JAC); Sep2018, Vol. 73 Issue 9, p2380-2387, 8p

Subjects: FOSFOMYCIN, INFECTION, ESCHERICHIA coli, EPIDEMIOLOGY, and TEST methods
Abstract: Objectives Fosfomycin susceptibility testing is complicated and prone to error. Before using fosfomycin widely in patients with serious infections, acquisition of WT distribution data and reliable susceptibility testing methods are crucial. In this study, the performance of five methods for fosfomycin testing in the routine laboratory against the reference method was evaluated. Methods Ten laboratories collected up to 100 ESBL-producing isolates each (80 Escherichia coli and 20 Klebsiella pneumoniae). Isolates were tested using Etest, MIC test strip (MTS), Vitek2, Phoenix and disc diffusion. Agar dilution was performed as the reference method in a central laboratory. Epidemiological cut-off values (ECOFFs) were determined for each species and susceptibility and error rates were calculated. Results In total, 775 E. coli and 201 K. pneumoniae isolates were tested by agar dilution. The ECOFF was 2 mg/L for E. coli and 64 mg/L for K. pneumoniae. Susceptibility rates based on the EUCAST breakpoint of ≤32 mg/L were 95.9% for E. coli and 87.6% for K. pneumoniae. Despite high categorical agreement rates for all methods, notably in E. coli, none of the alternative antimicrobial susceptibility testing methods performed satisfactorily. Due to poor detection of resistant isolates, very high error rates of 23.3% (Etest), 18.5% (MTS), 18.8% (Vitek2), 12.5% (Phoenix) and 12.9% (disc diffusion) for E. coli and 22.7% (Etest and MTS), 16.0% (Vitek2) and 12% (Phoenix) for K. pneumoniae were found. None of the methods adequately differentiated between WT and non-WT populations. Conclusions Overall, it was concluded that none of the test methods is suitable as an alternative to agar dilution in the routine laboratory. [ABSTRACT FROM AUTHOR]

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75. Pod wall trichomes and resistance of two wild cowpea, Vigna vexillata, accessions to Maruca testualis (Geyer) (Lepidoptera: Pyralidae) and Clavigralla tomentosicollis Stål (Hemiptera: Coreidae). [1989]

Jackai, L. E. N. and Oghiakhe, S.
Bulletin of Entomological Research; Oct1989, Vol. 79 Issue 4, p595-605, 11p

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76. Activation of Akt, mTOR, and the estrogen receptor as a signature to predict tamoxifen treatment benefit. [2013]

Bostner J, Karlsson E, Pandiyan MJ, Westman H, Skoog L, Fornander T, Nordenskjöld B, and Stål O
Breast cancer research and treatment [Breast Cancer Res Treat] 2013 Jan; Vol. 137 (2), pp. 397-406. Date of Electronic Publication: 2012 Dec 15.

Subjects: Biomarkers, Tumor metabolism, Female, Humans, Middle Aged, Phosphorylation, Postmenopause, Predictive Value of Tests, Receptors, Estrogen metabolism, Retrospective Studies, Serine metabolism, Treatment Outcome, Antineoplastic Agents, Hormonal pharmacology, Breast Neoplasms drug therapy, Breast Neoplasms metabolism, Proto-Oncogene Proteins c-akt metabolism, TOR Serine-Threonine Kinases metabolism, and Tamoxifen pharmacology
Abstract: The frequent alterations of the PI3K/Akt/mTOR-growth signaling pathway are proposed mechanisms for resistance to endocrine therapy in breast cancer, partly through regulation of estrogen receptor α (ER) activity. Reliable biomarkers for treatment prediction are required for improved individualized treatment. We performed a retrospective immunohistochemical analysis of primary tumors from 912 postmenopausal patients with node-negative breast cancer, randomized to either tamoxifen or no adjuvant treatment. Phosphorylated (p) Akt-serine (s) 473, p-mTOR-s2448, and ER phosphorylations-s167 and -s305 were evaluated as potential biomarkers of prognosis and tamoxifen treatment efficacy. High expression of p-mTOR indicated a reduced response to tamoxifen, most pronounced in the ER+/progesterone receptor (PgR) + subgroup (tamoxifen vs. no tamoxifen: hazard ratio (HR), 0.86; 95 % confidence interval (CI), 0.31-2.38; P = 0.78), whereas low p-mTOR expression predicted tamoxifen benefit (HR, 0.29; 95 % CI, 0.18-0.49; P = 0.000002). In addition, nuclear p-Akt-s473 as well as p-ER at -s167 and/or -s305 showed interaction with tamoxifen efficacy with borderline statistical significance. A combination score of positive pathway markers including p-Akt, p-mTOR, and p-ER showed significant association with tamoxifen benefit (test for interaction; P = 0.029). Cross-talk between growth signaling pathways and ER-signaling has been proposed to affect tamoxifen response in hormone receptor-positive breast cancer. The results support this hypothesis, as an overactive pathway was significantly associated with reduced response to tamoxifen. A clinical pre-treatment test for cross-talk markers would be a step toward individualized adjuvant endocrine treatment with or without the addition of PI3K/Akt/mTOR pathway inhibitors.

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77. Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial. [2005]

Jirström, K., Rydén, L., Anagnostaki, L., Nordenskjöld, B., Stål, O., Thorstenson, S., Chebil, G., Jönsson, P.-E., Fernö, M., and Landberg, G.
Journal of Clinical Pathology; Nov2005, Vol. 58 Issue 11, p1135-1142, 8p, 6 Charts, 3 Graphs

Subjects: BREAST cancer, CANCER in women, CANCER treatment, THERAPEUTICS, TAMOXIFEN, TUMOR growth, and ESTROGEN
Abstract: Background: Subgroups of breast cancer that have an impaired response to endocrine treatment, despite hormone receptor positivily, are still poorly defined. Breast cancer can be subdivided according to standard pathological parameters including histological type, grade, and assessment of proliferation. These parameters are the net result of combinations of genetic alterations effecting tumour behaviour and could potentially reflect subtypes that respond differently to endocrine treatment. Aims: To investigate the usefulness of these parameters as predictors of the response to tamoxifen in premenopausal women with breast cancer. Materials/methods: Clinically established pathological parameters were assessed and related to the tamoxifen response in 500 available tumour specimens from 564 premenopausal patients with breast cancer randomised to either two years of tamoxifen or no treatment with 14 years of follow up. Proliferation was further evaluated by immunohistochemical Ki-67 expression. Results: Oestrogen receptor positive ductal carcinomas responded as expected to tamoxifen, whereas the difference in recurrence free survival between control and tamoxifen treated patients was less apparent in the relatively few lobular carcinomas. For histological grade, there was no obvious difference in treatment response between the groups. The relation between proliferation and tamoxifen response seemed to be more complex, with a clear response in tumours with high and low proliferation, whereas tumours with intermediate proliferation defined by Ki-67 responded more poorly. Conclusions: Clinically established pathology parameters seem to mirror the endocrine treatment response and could potentially be valuable in future treatment decisions for patients with breast cancer. [ABSTRACT FROM AUTHOR]

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78. Diazotrophic microbial community of coastal microbial mats of the southern North Sea. [2011]

BAUERSACHS, T., COMPAORÉ, J., SEVERIN, I., HOPMANS, E. C., SCHOUTEN, S., STAL, L. J., and DAMSTÉ, J. S. SINNINGHE
Geobiology; Jul2011, Vol. 9 Issue 4, p349-359, 11p, 2 Color Photographs, 1 Chart, 2 Graphs, 1 Map

Subjects: MICROBIAL mats, MICROBIAL aggregation, BIOMARKERS, GENE libraries, RECOMBINANT DNA, and MICROBIAL ecology
Abstract: The diazotrophic community in microbial mats growing along the shore of the North Sea barrier island Schiermonnikoog (The Netherlands) was studied using microscopy, lipid biomarkers, stable carbon (δC) and nitrogen (δN) isotopes as well as by constructing and analyzing 16S rRNA gene libraries. Depending on their position on the littoral gradient, two types of mats were identified, which showed distinct differences regarding the structure, development and composition of the microbial community. Intertidal microbial mats showed a low species diversity with filamentous non-heterocystous Cyanobacteria providing the main mat structure. In contrast, supratidal microbial mats showed a distinct vertical zonation and a high degree of species diversity. Morphotypes of non-heterocystous Cyanobacteria were recognized as the main structural component in these mats. In addition, unicellular Cyanobacteria were frequently observed, whereas filamentous heterocystous Cyanobacteria occurred only in low numbers. Besides the apparent visual dominance of cyanobacterial morphotpyes, 16S rRNA gene libraries indicated that both microbial mat types also included members of the Proteobacteria and the Cytophaga-Flavobacterium-Bacteroides group as well as diatoms. Bulk δN isotopes of the microbial mats ranged from +6.1‰ in the lower intertidal to −1.2‰ in the supratidal zone, indicating a shift from predominantly nitrate utilization to nitrogen fixation along the littoral gradient. This conclusion was supported by the presence of heterocyst glycolipids, representing lipid biomarkers for nitrogen-fixing heterocystous Cyanobacteria, in supratidal but not in intertidal microbial mats. The availability of combined nitrogen species might thus be a key factor in controlling and regulating the distribution of the diazotrophic microbial community of Schiermonnikoog. [ABSTRACT FROM AUTHOR]

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79. Double strand RNA delivery system for plant-sap-feeding insects. [2017]

Ghosh, Saikat Kumar B., Hunter, Wayne B., Park, Alexis L., and Gundersen-Rindal, Dawn E.
PLoS ONE; 2/9/2017, Vol. 12 Issue 2, p1-19, 19p

Subjects: DOUBLE-stranded RNA, SAP (Plant), INSECT-plant relationships, INSECT pests, and GENE silencing
Abstract: Double-stranded RNA (dsRNA)-mediated gene silencing, also known as RNA interference (RNAi), has been a breakthrough technology for functional genomic studies and represents a potential tool for the management of insect pests. Since the inception of RNAi numerous studies documented successful introduction of exogenously synthesized dsRNA or siRNA into an organism triggering highly efficient gene silencing through the degradation of endogenous RNA homologous to the presented siRNA. Managing hemipteran insect pests, especially Halyomorpha halys (Stål) (Heteroptera: Pentatomidae), the brown marmorated stink bug (BMSB), is critical to food productivity. BMSB was recently introduced into North America where it is both an invasive agricultural pest of high value specialty, row, and staple crops, as well as an indoor nuisance pest. RNAi technology may serve as a viable tool to manage this voracious pest, but delivery of dsRNA to piercing-sucking insects has posed a tremendous challenge. Effective and practical use of RNAi as molecular biopesticides for biocontrol of insects like BMSB in the environment requires that dsRNAs be delivered in vivo through ingestion. Therefore, the key challenge for molecular biologists in developing insect-specific molecular biopesticides is to find effective and reliable methods for practical delivery of stable dsRNAs such as through oral ingestion. Here demonstrated is a reliable delivery system of effective insect-specific dsRNAs through oral feeding through a new delivery system to induce a significant decrease in expression of targeted genes such as JHAMT and Vg. This state-of-the-art delivery method overcomes environmental delivery challenges so that RNAi is induced through insect-specific dsRNAs orally delivered to hemipteran and other insect pests. [ABSTRACT FROM AUTHOR]

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80. Identification, Biology, Impacts, and Management of Stink Bugs (Hemiptera: Heteroptera: Pentatomidae) of Soybean and Corn in the Midwestern United States. [2017]

Koch, Robert L., Pezzini, Daniela T., Michel, Andrew P., and Hunt, Thomas E.
Journal of Integrated Pest Management; 2017, Vol. 8 Issue 1, p1-14, 14p

Subjects: BROWN marmorated stink bug, PODISUS, and INSECT pest control
Abstract: Stink bugs (Hemiptera: Heteroptera: Pentatomidae) are an emerging threat to soybean and corn production in the midwestern United States. An invasive species, the brown marmorated stink bug, Halyomorpha halys (Stål), is spreading through the region. However, little is known about the complex of stink bug species associated with corn and soybean in the midwestern United States. In this region, particularly in the more northern states, stink bugs have historically caused only infrequent impacts to these crops. To prepare growers and agricultural professionals to contend with this new threat, we provide a review of stink bugs associated with soybean and corn in the midwestern United States. Descriptions and images of common stink bug species are provided as a diagnostic aid. The biologies and impacts of stink bugs to crops are discussed, with particular attention to differences among species. Based primarily on information from southern states, scouting, thresholds, and insecticide-based management of these pests are discussed. It is hoped that this review will provide stakeholders sufficient information for management of these pests, until more region-specific research can be performed on stink bugs in soybean and corn in the midwestern United States. [ABSTRACT FROM AUTHOR]

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81. Comparison of Two Sampling Methods for Assessing Halyomorpha halys (Hemiptera: Pentatomidae) Numbers in Soybean Fields. [2016]

Aigner, B. L., Herbert, D. A., Dively, G. P., Venugopal, D., Whalen, J., Cissel, B., Kuhar, T. P., Brewster, C. C., Hogue, J. W., and Seymore, E.
Journal of Economic Entomology; Dec2016, Vol. 109 Issue 6, p2586-2589, 4p

Subjects: SOYBEAN diseases & pests, BROWN marmorated stink bug, and STINKBUGS
Abstract: Sampling soybean fields for the brown marmorated stink bug, Halyomorpha halys Stål (Hemiptera: Pentatomidae), can be challenging. Both adults and nymphs have a "startle response" and drop to the ground with even the slightest disturbance. This behavior could reduce the effectiveness of the traditional sweep net and ground cloth sampling methods. In 2013 and 2014, in Virginia, Delaware, and Maryland, we evaluated a visual plant inspection method that consisted of counting the number of brown marmorated stink bug nymphs and adults seen on soybean plants in a 2-min inspection period while walking carefully between two rows. After a 30-min interval, which allowed the stink bugs to reposition in the canopy, the area was resampled using 15 sweeps with a 38-cm-diameter sweep net. In total, 76 soybean fields and 2,042 paired comparisons were used to determine a strong linear relationship between sampling methods (y = 0.984x + 0.4359, R2 = 0.6934, where y = brown marmorated stink bugs/2-min visual count and x = brown marmorated stink bugs/15 sweeps). An average visual count of 5.4 brown marmorated stink bugs in 2 min was estimated as being equivalent to the current economic threshold of 5 stink bugs per 15 sweeps. Visual inspection appears to be an effective method for assessing brown marmorated stink bug populations in soybeans. [ABSTRACT FROM AUTHOR]

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82. A Modular Approach to Introduce Function into Single-Chain Polymeric Nanoparticles. [2014]

Huerta, Elisa, van Genabeek, Bas, Stals, Patrick J. M., Meijer, E. W., and Palmans, Anja R. A.
Macromolecular Rapid Communications; Aug2014, Vol. 35 Issue 15, p1320-1325, 6p

Subjects: ORGANOCATALYSIS, AMPHIPHILES, NAPHTHALIMIDES, STEREOSELECTIVE reactions, ALDOL condensation, and CYCLOHEXANONES
Abstract: Here, a modular approach is reported to introduce a specific function into single-chain polymeric nanoparticles (SCPNs). Hereto, an amphiphilic polymer with pendant benzene-1,3,5-tricarboxamide (BTA) units is mixed with a 'free' BTA that contains a functional group, either a fluorescent naphthalimide or a catalytically active l-proline. Taking advantage of hydrophobic interactions and self-recognition properties of the BTA units, the 'free' BTAs are captured into the interior of the SCPN in water as evidenced by fluorescence studies. To illustrate that function can be readily introduced using a modular approach, l-proline-based BTAs are incorporated to procure a catalytically active SCPN in water. The aldol reaction between p-nitrobenzaldehyde and cyclohexanone shows good conversions at low catalyst loadings and substrate concentrations, and high stereoselectivities are obtained ( de = 91% and ee = 98%). [ABSTRACT FROM AUTHOR]

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83. Studies on probing stimulants for the green rice leafhopper, Nephotettix nigropictus (Stål) (Hemiptera: Cicadellidae), in the rice plant ( Oryza sativa L.). [2016]

Zhan ZH, Matsuo A, and Kim CS
Journal of pesticide science [J Pestic Sci] 2016 Nov 20; Vol. 41 (4), pp. 163-166.

Abstract: A crude rice extract caused a higher probing response than did the control in the green rice leafhopper, Nephotettix nigropictus . Bioassay-guided separation led to the isolation of four active compounds, isoscoparin 2″- O -glucoside, isoscoparin 2″- O -(6‴-( E )-feruloyl)glucoside, isoscoparin 2″- O -(6‴-( E )- p -coumaroyl)glucoside, and isovitexin 2″- O -(6‴-( E )-feruloyl)glucoside from ODS 40% methanol in water faction. Each of the compounds, or any combination without one of the four compounds, caused weaker probing responses than the crude rice extract. The activity was recovered only when all the compounds were combined.

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84. Biogenic Stabilization of Intertidal Sediments: The Importance of Extracellular Polymeric Substances Produced by Benthic Diatoms. [2005]

De Brouwer, J. F. C., Wolfstein, K., Ruddy, G. K., Jones, T. E. R., and Stal, L. J.
Microbial Ecology; May2005, Vol. 49 Issue 4, p501-512, 12p, 5 Charts, 7 Graphs

Subjects: INTERTIDAL ecology, SEDIMENTATION & deposition, POLYMERIC composites, DIATOMS, and ALGAE
Abstract: The sediment-stabilizing effect of benthic diatoms was investigated in a laboratory setting. Axenic cultures of the benthic diatoms Nitzschia cf. brevissima and Cylindrotheca closterium were inoculated in Petri dishes containing sand and incubated under axenic conditions. By ensuring aseptic routines throughout the experiments, interference from other organisms occurring with diatoms in natural photothrophic biofilms was avoided. This allowed the examination of the role of benthic diatoms in sediment stabilization. Increases in the critical erosion shear stress of the sediment were observed in the presence of both diatom taxa relative to sterile sediment. However, N. cf. brevissima was more effective than C. closterium. Values of critical shear stress in the experimental system were in the same range as those observed in natural biofilms, which indicates that diatoms are important agents for biogenic stabilization. Extracellular carbohydrate contents in the microcosms were similar for both diatom species. However, in the presence of N cf. brevissima, extracellular carbohydrate correlated significantly to critical shear stress, explaining up to 80% of the variation, whereas this was not the case for C. closterium. Therefore, it was concluded that the quantity of extracellular polymeric substances (EPS) alone did not explain the biogenic stabilization. Observed adsorption of EPS to sediment particles depended on the relative amount of uronic acids in the exopolymers. Using fluorescently labeled lectins, confocal laser scanning microscopy showed that EPS secretion by N. cf. brevissima resulted in ordered three-dimensional matrix structures. It is suggested that the structuring of EPS plays an prominent role in the process of biostabilization, and that diatoms such as N. cf. brevissima are actively involved in producing the structure of EPS, whereas others such as C. closterium do not do so to the same extent. [ABSTRACT FROM AUTHOR]

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85. Fibre Composition of Human Intrinsic Tongue Muscles. [2003]

Stål, P., Marklund, S., Thornell, L.-E., De Paul, R., and Eriksson, P.-O.
Cells Tissues Organs; 2003, Vol. 173 Issue 3, p147-161, 15p, 4 Black and White Photographs, 2 Diagrams, 5 Charts, 5 Graphs

Subjects: TONGUE, MORPHOLOGY, COMPARATIVE anatomy, MUSCLES, and MOUTH
Abstract: The muscle fibre composition of three human intrinsic tongue muscles, the longitudinalis, verticalis and transversus, was investigated in four anterior to posterior regions of the tongue using morphological and enzyme- and immunohistochemical techniques. All three muscles typically contained type I, IIA and IM/IIC fibres. Type I fibres expressed slow myosin heavy chain (MyHC), type II fibres fast MyHC, mainly fast A MyHC, whereas type IM/IIC coexpressed slow and fast MyHCs. Type II fibres were in the majority (60%), but regional differences in proportion and diameter of fibre types were obvious. The anterior region of the tongue contained a predominance of relatively small type II fibres (71%), in contrast to the posterior region which instead showed a majority of larger type I and type IM/IIC fibres (66%). In general, the fibre diameter was larger in the posterior region. This muscle fibre composition of the tongue differs from those of limb, orofacial and masticatory muscles, probably reflecting genotypic as well as phenotypic functional specialization in oral function. The predominance of type II fibres and the regional differences in fibre composition, together with intricate muscle structure, suggest generally fast and flexible actions in positioning and shaping the tongue, during vital tasks such as mastication, swallowing, respiration and speech.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

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86. Dinitrogen fixation in the world's oceans. [2002]

Karl, D., Michaels, A., Bergman, B., Capone, D., Carpenter, E., Letelier, R., Lipschultz, F., Paerl, H., Sigman, D., and Stal, L.
Biogeochemistry; Apr2002, Vol. 57/58, p47, 52p, 2 Color Photographs, 6 Graphs, 1 Map

Subjects: NITROGEN fixation and OCEAN
Abstract: Explores the ecological aspects of dinitrogen fixation in the world's oceans. Diversity of dinitrogen-fixing microorganisms; Major controls on rates of oceanic dinitrogen fixation; Significance of dinitrogen fixation for the global carbon cycle; Role of human activities in the alteration of oceanic dinitrogen fixation.

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87. Tumour characteristics and survival in patients with invasive interval breast cancer classified according to mammographic findings at the latest screening: a comparison of true interval and missed interval cancers. [1999]

Vitak, B., Olsen, K. E., Månson, J. C., Arnesson, L. G., Stål, O., Månson, J C, and Stål, O
European Radiology; Mar1999, Vol. 9 Issue 3, p460-469, 10p

Abstract: The aim of this study was to investigate whether different mammographic categories of interval cancer classified according to findings at the latest screening are associated with different distributions of prognostic factors or with different survival rates. The series consisted of all patients with invasive interval cancer detected from May 1978 to August 1995 (n = 544). The tumours were evaluated with regard to age, radiological category, interval between the latest screen and diagnosis and tumour characteristics at the time of diagnosis. We investigated possible relationships between the survival rate of patients with interval cancer and the interval between the latest screen and diagnosis, tumour characteristics and radiological category of the interval tumours. The study focused on comparison of patients with true interval and missed interval cancer. Women with mammographically occult tumours were younger than those in the other radiological categories. Comparisons of true interval cancers with overlooked or misinterpreted tumours showed equal distributions of age, tumour size, TNM stage and lymph node status. The overlooked or misinterpreted tumours showed significantly higher proportions of grade-I tumours (22 vs 11 %), tumours with low S-phase fraction (SPF; 44 vs 24 %) and oestrogen receptor (ER) positive tumours (72 vs 57 %). However, analyses of survival rates disclosed no clear differences between the two radiological categories. Radiological category and interval between the latest screen and diagnosis were not genuine predictors of the prognosis in patients with invasive interval breast cancer. No certain prognostic difference existed between true interval cancers and overlooked or misinterpreted interval breast cancers, despite higher proportions of grade-I tumours, ER positive tumours and tumours with low SPF in the latter group. [ABSTRACT FROM AUTHOR]

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88. Herbivory-induced plant volatiles from Oryza sativa and their influence on chemotaxis behaviour of Tibraca limbativentris stal. (Hemiptera: Pentatomidae) and egg parasitoids. [2014]

Melo Machado, R.C., Sant'Ana, J., Blassioli-Moraes, M.C., Laumann, R.A., and Borges, M.
Bulletin of Entomological Research; Jun2014, Vol. 104 Issue 3, p347-356, 10p

Subjects: HEMIPTERA, ORYZA, PARASITOIDS, RICE, PLANTING, STINKBUGS, and PARASITES
Abstract: The rice stem bug, Tibraca limbativentris Stal. (Hemiptera: Pentatomidae) is one of the most important pests of rice crops, especially irrigated crops. Plant defence strategies against these bugs may involve the emission of chemical compounds, which are released following herbivore attacks, directly or indirectly harming pest performance. The aim of this study was to evaluate the influence of constitutive and herbivory-induced volatiles from rice plants (Oryza sativa L.) on the behavioural responses of T. limbativentris adults and egg parasitoids Trissolcus basalis (Wollaston) and Telenomus podisi (Ashmead) (Hymenoptera, Platygastridae). Plant volatiles were collected from undamaged plants of the rice cultivar IRGA 424 and from plants that suffered herbivory by five males or five females of T. limbativentris. Air-entrainment extracts were analysed by GC–flame ionization detector and GC–MS, and insect responses evaluated in a ‘Y’ olfactometer. T. limbativentris feeding damaged on rice plants induced the release of 16 volatiles compounds in a higher amounts compared to undamaged plants The main compounds induced were (E)-2-hexenal, (E)-2-octen-1-ol, methyl salicylate and α-muurolene. Female bugs were significantly attracted to air-entrainment extracts containing volatiles from undamaged plants compared with air-entrainment extracts containing volatiles emitted from plants damaged by T. limbativentris, whereas males showed no preference. Telenomus podisi females were significantly attracted to volatiles from air-entrainment extracts of plants damaged by females, whereas T. basalis showed no preference. These results suggest that rice plants may be emitting defence compounds, which could be avoided by T. limbativentris females and also acted indirectly by attracting natural enemies. [ABSTRACT FROM AUTHOR]

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89. Pest kill rate as aggregate evaluation criterion to rank biological control agents: a case study with Neotropical predators of Tuta absoluta on tomato. [2019]

van Lenteren, J.C., Bueno, V.H.P., Burgio, G., Lanzoni, A., Montes, F.C., Silva, D.B., de Jong, P.W., and Hemerik, L.
Bulletin of Entomological Research; Dec2019, Vol. 109 Issue 6, p812-820, 9p

Subjects: BIOLOGICAL pest control agents, BIOLOGICAL pest control, PEST control, PESTS, TOMATOES, and SPECIES pools
Abstract: Tuta absoluta (Meyrick), a key pest of tomato, is quickly spreading over the world and biological control is considered as one of the control options. Worldwide more than 160 species of natural enemies are associated with this pest, and an important challenge is to quickly find an effective biocontrol agent from this pool of candidate species. Evaluation criteria for control agents are presented, with the advantages they offer for separating potentially useful natural enemies from less promising ones. Next, an aggregate parameter for ranking agents is proposed: the pest kill rate k m. We explain why the predator's intrinsic rate of increase cannot be used for comparing the control potential of predators or parasitoids, while k m can be used to compare both types of natural enemies. As an example, kill rates for males, females and both sexes combined of three Neotropical mirid species (Campyloneuropsis infumatus (Carvalho), Engytatus varians (Distant) and Macrolophus basicornis (Stål)) were determined, taking all life-history data (developmental times, survival rates, total nymphal and adult predation, sex ratios and adult lifespan) into account. Based on the value for the intrinsic rate of increase (r m) for T. absoluta and for the kill rate k m of the predators, we predict that all three predators are potentially able to control the pest, because their k m values are all higher than the r m of the pest. Using only k m values, we conclude that E. varians is the best candidate for control of T. absoluta on tomato, with C. infumatus ranking second and M. basicornis last. [ABSTRACT FROM AUTHOR]

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90. ACCELERATED AGEING WITH IN SITU ELECTRICAL TESTING: A POWERFUL TOOL FOR THE BUILDING-IN APPROACH TO QUALITY AND RELIABILITY IN ELECTRONICS. [1994]

Schepper, L. De, Ceuninck, W. De, Lekens, G., Stals, L., Vanhecke, B., Roggen, J., Beyne, E., and Tielemans, L.
Quality & Reliability Engineering International; Jan/Feb94, Vol. 10 Issue 1, p15-26, 12p

Subjects: TESTING, QUALITY, ELECTRONICS, RELIABILITY in engineering, MATHEMATICAL optimization, and MAINTAINABILITY (Engineering)
Abstract: A new technique for reliability and quality optimization of electronic components and assemblies, the so called in situ accelerated ageing technique with electrical testing, is presented. This technique is extremely useful for the building-in approach to quality and reliability. First, it can be used to optimize an electronic component or assembly with respect to its quality and reliability performance at a very early stage, i.e. at the design level, at the level of materials selection, and at the level of identifying production techniques and defining production parameters. The typical test time is of the order of 24 hours, which is sufficiently short to allow a design of experiments type approach to quality and reliability optimization. Furthermore, the technique is also very useful for obtaining a deeper understanding of the physico-chemical processes which lead to failure. A number of practical examples where the technique has been successfully applied are discussed. [ABSTRACT FROM AUTHOR]

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91. Total evidence phylogenetic analysis and reclassification of Euschistus Dallas within Carpocorini (Hemiptera: Pentatomidae: Pentatominae). [2017]

BIANCHI, FILIPE M., DEPRÁ, MARÍNDIA, FERRARI, AUGUSTO, GRAZIA, JOCELIA, VALENTE, VERA L. S., and CAMPOS, LUIZ A.
Systematic Entomology; Apr2017, Vol. 42 Issue 2, p399-409, 11p

Subjects: PHYLOGENY, MORPHOGENESIS, EVOLUTIONARY developmental biology, ORGANISMS, MICROBIAL ecology, and TAXONOMY
Abstract: Robust phylogenetic hypotheses have become key for studies addressing the evolutionary biology and ecology of various groups of organisms. In the species-rich heteropteran superfamily Pentatomoidea, phylogenies at lower taxonomic levels are still scarce and mostly employ exclusively morphological data. In this study, we conducted a total evidence phylogeny focusing on the tribe Carpocorini (Pentatomidae), using morphological data and four DNA markers ( COI, Cytb, 16S and 28S rDNA; ∼2330 bp; 32 taxa) in order to investigate the relationships within Euschistus Dallas, one of the most speciose pentatomid genera, and between Euschistus and related genera. Our hypotheses generated by maximum likelihood and Bayesian inference show that the current taxonomic composition and classification of Euschistus and allied genera are in need of revision. Euschistus was recovered as nonmonophyletic, with the subgenera forming four independent lineages: Euschistus ( Euschistus) and Euschistus ( Lycipta) Stål are sister groups; Euschistus ( Euschistomorphus) Jensen-Haarup is more closely related to Dichelops Spinola and Agroecus Dallas; and Mitripus Rolston is divided into two clades closely related to Sibaria Stål and Ladeaschistus Rolston. We chose not to change the classification of E. ( Euschistomorphus) until further data become available, and propose to split Euschistus into three genera with the exclusion of Euschistus ( Mitripus) and all of its species. Here we elevate Mitripus to genus rank to include M. acutus comb.n., M. convergens comb.n. and M. legionarius comb.n., and propose Adustonotus Bianchi gen.n. to include A. anticus comb.n., A. latus comb.n., A. tauricornis comb.n., A. grandis comb.n., A. hansi comb.n., A. paranticus comb.n., A. irroratus comb.n. and A. saramagoi comb.n. We also provide identification keys to the genera Adustonotus gen.n., Ladeaschistus, Mitripus n. rank and Sibaria, here defined as the Mitripus genus group, and to the species of Mitripus and Adustonotus gen.n. Our results provide insights into the current status of the classification of the Pentatomidae, suggesting the need for phylogenetic analyses at different taxonomic levels within stink bugs. This published work has been registered in ZooBank, . [ABSTRACT FROM AUTHOR]

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92. Effects of Aggregation Lure and Tree Species on Halyomorpha halys (Hemiptera: Pentatomidae) Seasonal Oviposition. [2020]

Formella, Adam, Dorman, Seth J, Taylor, Sally V, and Kuhar, Thomas P
Journal of Economic Entomology; Feb2020, Vol. 113 Issue 1, p203-210, 8p

Subjects: BROWN marmorated stink bug, STINKBUGS, HEMIPTERA, ORNAMENTAL trees, and FARM produce
Abstract: The brown marmorated stink bug, Halyomorpha halys (Stål), is a polyphagous pest that feeds on a wide variety of agricultural commodities including tree fruits, berries, vegetables, field crops, and ornamental trees and shrubs. Accurate knowledge of where H. halys lays eggs is critical to optimize the potential release of Trissolcus japonicus (Ashmead), a scelionid egg parasitoid native to the same host region as H. halys. Ideally, parasitoids should be released in and around areas with high host density. In southwestern Virginia in 2017 and 2018, we searched trees for egg masses in an urban environment and nonmanaged wooded border environment. We also evaluated the effects of a commercial aggregation lure on the number of eggs being deposited. This aggregation lure, when combined with methyl (E , E , Z)-2,4,6-decatrienoate (MDT), has been shown to attract both adult and nymph H. halys and its effects on egg laying were not known. Results of this study showed no difference between the number of eggs laid on trees with and without lures. Catalpa trees, Catalpa bignonioides Walter, had the most egg masses throughout the course of the study; however, the redbud, Cercis canadensis L., had similar numbers in the late July and August. There was an overall trend with more eggs masses found on trees with fruiting structures present. This information can provide insight on where and when to make augmentative releases of egg parasitoids for H. halys. [ABSTRACT FROM AUTHOR]

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93. The influence of ethylene glycol chains on the thermodynamics of hydrogen-bonded supramolecular assemblies in apolar solvents. [2008]

de Greef, Tom F. A., Nieuwenhuizen, Marko M. L., Stals, Patrick J. M., Fitié, Carel F. C., Palmans, Anja R. A., Sijbesma, Rint P., and Meijer, E. W.
Chemical Communications; Sep2008, Vol. 2008 Issue 36, p4306-4308, 3p

Subjects: ETHYLENE glycol, THERMODYNAMICS, HYDROGEN bonding, SUPRAMOLECULAR chemistry, SOLVENTS, and CHEMICAL reduction
Abstract: Substitution of hydrogen bond directed supramolecular assemblies with ethylene glycol chains leads to a reduction in the association constant in apolar solvents, where the reduction of the association constant is dependent on the length of the aliphatic spacer connecting the hydrogen bonds and the ethylene glycol chain. [ABSTRACT FROM AUTHOR]

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94. Role of hydroperoxide lyase in white-backed planthopper ( Sogatella furcifera Horváth)-induced resistance to bacterial blight in rice, Oryza sativa L. [2010]

Gomi, Kenji, Satoh, Masaru, Ozawa, Rika, Shinonaga, Yumi, Sanada, Sachiyo, Sasaki, Katsutomo, Matsumura, Masaya, Ohashi, Yuko, Kanno, Hiroo, Akimitsu, Kazuya, and Takabayashi, Junji
Plant Journal; Jan2010, Vol. 61 Issue 1, p46-57, 12p, 2 Color Photographs, 1 Black and White Photograph, 1 Chart, 4 Graphs

Subjects: LYASES, PLANTHOPPERS, RICE, GENES, and XANTHOMONAS
Abstract: A pre-infestation of the white-backed planthopper (WBPH), Sogatella furcifera Horváth, conferred resistance to bacterial blight caused by Xanthomonas oryzae pv. oryzae ( Xoo) in rice ( Oryza sativa L.) under both laboratory and field conditions. The infestation of another planthopper species, the brown planthopper (BPH) Nilaparvata lugens Stål, did not significantly reduce the incidence of bacterial blight symptoms. A large-scale screening using a rice DNA microarray and quantitative RT-PCR revealed that WBPH infestation caused the upregulation of more defence-related genes than did BPH infestation. Hydroperoxide lyase 2 ( OsHPL2), an enzyme for producing C6 volatiles, was upregulated by WBPH infestation, but not by BPH infestation. One C6 volatile, ( E)-2-hexenal, accumulated in rice after WBPH infestation, but not after BPH infestation. A direct application of ( E)-2-hexenal to a liquid culture of Xoo inhibited the growth of the bacterium. Furthermore, a vapour treatment of rice plants with ( E)-2-hexenal induced resistance to bacterial blight. OsHPL2-overexpressing transgenic rice plants exhibited increased resistance to bacterial blight. Based on these data, we conclude that OsHPL2 and its derived ( E)-2-hexenal play some role in WBPH-induced resistance in rice. [ABSTRACT FROM AUTHOR]

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95. Developmental profiles of two cowpea pests on resistant and susceptible Vigna genotypes under constant temperatures. [1992]

Jackai, L. E. N. and Inang, E. E.
Journal of Applied Entomology; Jan1992, Vol. 113 Issue 1-5, p217-227, 11p, 2 Charts, 4 Graphs

Subjects: COWPEA, VIGNA, HEMIPTERA, INSECT development, CULTIVARS, DISEASE resistance of plants, and EFFECT of temperature on plants
Abstract: The growth and development of Clavigralla tomentosicollis Stäl (Hemiptera: Coreidae) and Maruca testulalis Geyer (Lepidoptera: Pyralidae) were studied under laboratory conditions using three cultivated Vigna varieties (IT84E-124, TVu 1890, MRx 10-85S) and one wild variety (TVNu 72) under a range of temperatures: 19°C, 22°C, 25°C, 28°C, 31°C, 34°C, 37°C, 40°C and 43°C. IT84E-124 served as the susceptible and TVNu 72 as the resistant control for both insects. Development time of C. tomentosicollis ranged between 7 days at 37°C to 26 days at 19°C, and decreased with increasing temperature up to an upper temperature threshold of 37°C. The lower temperature threshold for development of C. tomentosicollis was estimated from regression curves to be ca 18.5°C, while the upper threshold was between 34°C and 37°C, the point where nymphal survivorship started to decline. Although 19°C and 22°C gave 90% and 80% survival, respectively, the duration of development at these temperatures was almost twice that reported under field conditions. Adult weights followed an inverse relationship with temperature. Third instar larvae of M. testulalis, obtained after rearing on artificial diet for 7 days prior to feeding on the plants, began to pupate 3 days after infestation at 28, 31 and 34°C. However, adults were obtained only at 22°C and 28°C. Temperatures above 34°C were lethal to the larvae which dried out prior to pupating. The lower temperature threshold determined by regression for pupae was 15.6°-17.8°C on both IT84E-124 and MRx 10-85S. Upper temperature threshold was estimated to be between 28 and 34°C at which no adult emergence was obtained. Female pupae were larger than males and temperature did not appear to influence sex ratio. Thermal requirements, expressed in degree days (DD), increased with temperature for C. tomentosicollis up to 31°C on all varieties. Degree days for M. testulalis pupae were of a lower magnitude than those computed for C. tomentosicollis. Zusammenfassung Entwicklungsprofile zweier Schädlinge an resistenten und empfindlichen Vigna-Genotypen bei konstanten Temperaturen Es wurden Wachstum und Entwicklung von Clavigralla tomentosicollis Stäl (Hem., Coreidae) und Maruca testulalis Geyer (Lep., Pyralidae) unter Laborbedingungen bei Verwendung von 3 kultivierten Vigna-Varietäten (IT84E-124, TVu 1890, MRx 10-85S) und einer Wildwuchs-Varietät (TVNu 72) bei konstanten Temperaturen von 19, 22, 25, 28, 31, 34, 37, 40 und 43°C untersucht. IT84E-124 diente als empfindliche und TVNu 72 als resistente Kontrolle für die beiden Insekten. Die Entwicklungszeit von C. tomentosicollis betrug zwischen 7 Tagen bei 37°C bis 26 Tagen bei 19°C und nahm mit ansteigender Temperatur ab bis zur oberen Temperaturgrenze von 37°C. Die untere Temperaturgrenze ergab sich aus den Regressionskurven zu 18,5°C, die obere lag zwischen 34 und 37°C. Bei letzterer Temperatur begann die Überlebensfähigkeit der Nymphen zu sinken. Obgleich bei 19 und 27°C die Überlebensquoten noch bei 90% und 80% lagen, war die Entwicklungsdauer bei diesen Temperaturen doppelt so lang wie unter Freilandverhältnissen. Die Gewichte der Adulten folgten einer inversen Beziehung zur Temperatur. Die Drittlarven von M. testulalis, die aus der Zucht mit künstlicher Diät 7 Tage früher als bei normaler Pflanzenernährung gewonnen wurden, begannen mit der Verpuppung 3 Tage nach Beeinflussung durch Temperaturen zwischen 28 und 34°C. Jedoch wurden Adulte nur aus Zuchten bei 22 und 28°C gewonnen. Temperaturen über 34°C waren für die Larven letal; diese starben vor der Verpuppung ab. Die untere Temperaturgrenze lag (It. Regressionskurven) zwischen 15,6 und 17,8°C bei beiden Varietäten IT84E-124 und MRx 10-85S. Die obere Temperaturgrenze wurde zwischen 28 und 34°C ermittelt. Die weiblichen Puppen waren größer als die männlichen. Die Temperatur beeinflußte das Geschlechterverhältnis nicht. Die Temperaturbedingungen, ausgedrückt in Tages-Graden (degree days DD) nahmen mit ansteigender Temperatur für C. tomentosicollis bis zu 31°C auf allen Varietäten zu. Die DD-Werte für M. testulalis-Puppen waren geringer als jene von C. tomentosicollis. [ABSTRACT FROM AUTHOR]

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96. Improvement in sintering efficiency by surfactant pelletization of the batch. [2016]

Maistrenko, N., Ovchinnikova, E., Shapovalov, A., and Bersenev, I.
Steel in Translation; Jan2016, Vol. 46 Issue 1, p45-48, 4p

Abstract: In the sintering shop at OAO Ural'skaya Stal', industrial trials are conducted with a view to improving the pelletization by wetting the sintering batch with water-soluble organic surfactants. The use of surfactants improves the granulometric composition of the batch, its gas permeability, and hence the sintering efficiency. The use of surfactant is most effective with optimal wetting of the batch (7-8%), with consumption of the experimental binder at a rate of 1.2-1.6 L/h. (The surfactant concentration in aqueous solution is 0.3⎯0.4 mL/L.) [ABSTRACT FROM AUTHOR]

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97. Salivary glands and their digestive enzymes in pod-sucking bugs (Hemiptera: Coreoidea) associated with cowpea Vigna unguiculata ssp. unguiculata in Nigeria. [2007]

Soyelu, O. L., Akingbohungbe, A. E., and Okonji, R. E.
International Journal of Tropical Insect Science; Mar2007, Vol. 27 Issue 1, p40-47, 8p, 5 Diagrams, 1 Chart

Subjects: SALIVARY glands, DIGESTIVE enzymes, HEMIPTERA, PLANT parasites, and COWPEA
Abstract: The salivary glands of the cowpea pod-sucking bugs Anoplocnemis curvipes (Fabricius), Clavigralla tomentosicollis Stål, Clavigralla shadabi Dolling, Riptortus dentipes (Fabricius) and Mirperus jaculus (Thunberg) are described and illustrated. Extracts of the glands were assayed for the presence of proteinases, α-amylase, β-amylase and amyloglucosidase. The salivary glands consist of four-lobed principal glands and a tubular accessory gland, and they differ in shape and size among the different species except for the median lobe, which is more or less spherical. The sickle-shaped nature of the posterior lobe reported before for Riptortus linearis (Linnaeus) was also observed in R. dentipes, suggestive of a probable generic characteristic. Anoplocnemis curvipes has the biggest salivary gland, and it is followed by R. dentipes, M. jaculus, C. tomentosicollis and C. shadabi in descending order. Assays of the gland extracts revealed that the four digestive enzymes tested are present in the five coreoid species. Proteinases were preponderant (1.4-94.9 µg/ml), while amylases were detected in traces [(0.5-11.0) x 10-3 µg/ml]. Proteinases may be largely responsible for the feeding damage caused by the coreoid species and their concentration in the glands of the different species correlates well with their known capacity to inflict pod damage and yield reduction in cowpea. Fourth instar nymphs of the different species also had higher concentrations of the digestive enzymes compared with their respective adults; and this correlates with the known ability of the nymphs to cause greater pod damage and yield reduction than adults. [ABSTRACT FROM AUTHOR]

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98. Blistering of rhenium irradiated with 21keV helium ions. [1978]

Guysse, J., Nandedkar, R., Stals, L., and Deruytter, A.
Applied Physics; 1978, Vol. 17 Issue 1, p89-97, 9p

Abstract: This paper describes blistering of rhenium following 21 keV He-ion irradiation at temperatures between 300 K and 1200 K. Blistering starts at 300 K at a dose of 3×10 ions/cm. The most probable blister diameter varies from 4400 Å at 300 K to 10100 Å at 1200 K. The blister depth τ, the blister diameter φ and the blister height h show a distribution. From the observations one could derive the following relationships: h = 0.35φ; τ=3.43φ. The erosion yield E due to blistering is function of dose E =0.51 atoms/ion at 3×10 ions/cm, E =0.56 atoms/ion at 6×10 ions/cm and E =0.14 atoms/ion at 3×10 ions/cm. The sputtering yield S (21 keV) is estimated to be ∼0.1 atom/ion. The corresponding surface regression is 44Å at 3×10 ions/cm and 1323 Å at 9×10 ions/cm. Surface regression has therefore little influence on the observations at low doses. [ABSTRACT FROM AUTHOR]

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99. New data on the subfamily Epilamprinae (Dictyoptera, Blaberidae) of the New World, with description of a new genus and a new species from Ecuador. [2016]

Anisyutkin, L.
Entomological Review; Apr2016, Vol. 96 Issue 2, p199-217, 19p

Abstract: Detailed morphological redescriptions of cockroaches of the subfamily Epilamprinae Brunner von Wattenwyl, 1865 from the New World based on the collection of the Zoological Institute of the Russian Academy of Sciences are given. Poeciloderrhis verticalis (Burmeister, 1838), the type species of the genus Poeciloderrhis Stål, 1874; Phoraspis picta (Drury, 1782), the type species of the genus Phoraspis Serville, 1831; Epilampra mexicana Saussure, 1862 and E. sodalis Walker, 1868, the members of the ' mexicana' and ' sodalis' species-groups, respectively, are redescribed. Parapoeciloderrhis dilatatus Anisyutkin, gen. et sp. n. is described from Ecuador. The paper pays special attention to the structures of the male and female genitalia. The hypothetical relationships between the taxa studied are briefly considered. The possible synapomorphies of the group [ Poeciloderrhis, Epilampra, and Phoraspis] are considered. The genus Epilampra is possibly artificial and needs division into several genera. [ABSTRACT FROM AUTHOR]

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100. Spatial complexity and the fitness of the kissing bug, Rhodnius prolixus. [2006]

Sulbaran, J. E. and Chaves, L. F.
Journal of Applied Entomology; Feb2006, Vol. 130 Issue 1, p51-55, 5p, 1 Diagram, 3 Charts, 3 Graphs

Subjects: CHAGAS' disease, RHODNIUS prolixus, RHODNIUS, CONENOSES, TRYPANOSOMIASIS, LIFE expectancy, LIFE spans, and LIFE (Biology)
Abstract: Rhodnius prolixus Stål (Reduviidae: Rhodninii) is one of the most important vectors of Chagas disease. As a result of its medical importance, several life history studies have been carried out, but in general with a restricted demographical scope, without assessing the potential tradeoffs in the life history of this insect. In this study, individuals of R. prolixus were kept in two spatially different habitats and several fitness components were measured. The results show that life expectancy in adults is negatively correlated with gross fecundity, indicating a cost of reproduction. Life expectancy is shorter for males and longer for individuals of the same sex in the more complex habitat, where the fitness is lower compared with that of the simpler habitat. [ABSTRACT FROM AUTHOR]

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1. Consensus Statement on the definition and classification of metabolic hyperferritinaemia. [2023]

2. Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans. [2023]

3. SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females. [2021]

4. HNF1B deletions in patients with young-onset diabetes but no known renal disease [2013]

5. Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave [2021]

6. Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome [2022]

7. Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms [2002]

8. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study [2020]

9. Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior [2014]

10. Evidence for low muscle capillary supply as a pathogenic factor in chronic compartment syndrome [2010]

11. Pathology parameters and adjuvant tamoxifen response in a randomised premenopausal breast cancer trial [2005]

12. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. [2020]

13. VAV3 mediates resistance to breast cancer endocrine therapy [2014]

14. Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial [2018]

15. Taxonomy based on science is necessary for global conservation. [2018]

16. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial. [2019]

17. Muscle contractures in patients with cerebral palsy and acquired brain injury are associated with extracellular matrix expansion, pro-inflammatory gene expression, and reduced rRNA synthesis. [2018]

18. Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing. [2018]

19. The role of microRNA-200 in progression of human colorectal and breast cancer. [2013]

20. AIP mutations in young patients with acromegaly and the Tampico Giant: the Mexican experience. [2016]

21. The effect of in utero and lactational exposure to chloroform on postnatal growth and glucose tolerance in male wistar rats [2004]

22. Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors. [2020]

23. Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort. [2015]

24. Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis. [2014]

25. The Cyclin-Dependent Kinase Inhibitor KRP6 Induces Mitosis and Impairs Cytokinesis in Giant Cells Induced by Plant-Parasitic Nematodes in Arabidopsis. [2014]

26. Thermal Biology of Liorhyssus hyalinus (Hemiptera: Rhopalidae) and Nysius simulans (Hemiptera: Lygaeidae), Fed on the Milky Stage of Maize Grains. [2022]

27. Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units: A retrospective cohort study. [2022]

28. An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant Staphylococcus aureus with additional resistance to fusidic acid, June 2018 to January 2020. [2022]

29. Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation. [1999]

30. Development, Predation, and Prey Preference of Chrysoperla externa on Liorhyssus hyalinus and Nysius simulans, Two Emerging Pests of Quinoa. [2022]

31. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. [2010]

32. Role of hydroperoxide lyase in white-backed planthopper (Sogatella furcifera Horvath)-induced resistance to bacterial blight in rice, Oryza sativa L [2010]

33. A technology platform for the fast production of monoclonal recombinant antibodies against plant proteins and peptides. [2004]

34. Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. [2010]

35. Leafhoppers (Homoptera: Cicadellidae) Associated with Potatoes in Alaska: Species Composition, Seasonal Abundance, and Potential Phytoplasma Vectors [2009]

36. Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers. [2015]

37. Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer. [2021]

38. Thyanta custator subsp. accerra McAtee 1919 [2021]

39. A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. [2021]

40. National surveillance pilot study unveils a multicenter, clonal outbreak of VIM-2-producing Pseudomonas aeruginosa ST111 in the Netherlands between 2015 and 2017. [2021]

41. Outcomes of patients with myelofibrosis treated with compassionate use pacritinib: a sponsor-independent international study. [2018]

42. Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data. [2018]

43. Plasmid diversity among genetically related Klebsiella pneumoniae bla KPC-2 and bla KPC-3 isolates collected in the Dutch national surveillance. [2020]

44. Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial. [2015]

45. Behavioral Response of the Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) to Semiochemicals Deployed Inside and Outside Anthropogenic Structures During the Overwintering Period. [2017]

46. Histological grade provides significant prognostic information in addition to breast cancer subtypes defined according to St Gallen 2013. [2017]

47. Môrewind oor die Karasberge: 'n Kultuurhistoriese Verkenning van die Karasstreek van die Laat Negentiende Eeu. [2011]

48. Diversification patterns of the grasshopper genus Zoniopoda Stål (Romaleidae, Acridoidea, Orthoptera) in open vegetation biomes of South America. [2018]

49. Ethyl formate dilution in carbon dioxide for fumigation control of the brown marmorated stink bug Halyomorpha halys, Stål (Hemiptera: Pentatomidae). [2022]

50. Inventory of some families of Hemiptera, Coleoptera (Curculionidae) and Hymenoptera associated with horticultural production of the Alto Valle de Río Negro and Neuquén provinces (Argentina). [2021]

51. Identification of a novel locus, BPH38(t), conferring resistance to brown planthopper (Nilaparvata lugens Stal.) using early backcross population in rice (Oryza sativa L.). [2019]

52. MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit. [2021]

53. First Detection of the Adventive Egg Parasitoid of Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) Trissolcus mitsukurii (Ashmead) (Hymenoptera: Scelionidae) in France. [2021]

54. INSECTICIDAL ACTIVITY OF SESAME LEAF AND STEM EXTRACTS ON Clavigralla tomentosicollis Stal (Hemiptera: Coreidae). [2020]

55. Validation of a competitive ELISA assay for the quantification of human serum hepcidin. [2015]

56. Lantana camara L. and its biocontrol agent, Teleonemia scrupulosa Stål, in Botswana. [2015]

57. Real-time PCR assay to detect brown marmorated stink bug, Halyomorpha halys (Stål), in environmental DNA. [2016]

58. The overlooked role of weed plants affecting pest stink bug (Hemiptera: Heteroptera: Pentatomidae) bioecology in the Neotropics. [2022]

59. Predicting Rice Stem Stink Bug Population Dynamics Based on GAMLSS Models. [2020]

60. Greenhouse Rearing Methods for Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) on Live Cowpea Plants. [2021]

61. Prospects for charged Higgs searches at the LHC. [2017]

62. A comprehensive overview of urogenital, anorectal and oropharyngeal Neisseria gonorrhoeae testing and diagnoses among different STI care providers: a cross-sectional study. [2017]

63. Parasitism and Predation on Sentinel Egg Masses of Three Stink Bug Species (Hemiptera: Pentatomidae) in Native and Exotic Ornamental Landscapes. [2021]

64. Permanent genetic resources added to Molecular Ecology Resources Database 1 December 2011-31 January 2012. [2012]

65. Assessment of chemical resistance of wild and cultivated Vigna species to the brown pod-bugClavigralla tomentosicollis Stal (Hem., Coreidae). [2003]

66. A Revision of Myrocheine Genus Ennius St l With Special Reference to Redescription of E. monteironis Distant (Hemiptera: Pentatomidae Pentatominae) and Their Phylogenetic Relationships. [2011]

67. Observations of parasitoid behaviour in both no‐choice and choice tests are consistent with proposed ecological host range. [2021]

68. Community Composition, Abundance, and Phenology of Stink Bugs (Hemiptera: Pentatomidae) in Soybean in the North Central Region of the United States. [2019]

69. Comparative suitability of soybean and cowpea as host plants for the brown cowpea coreid bug, Clavigralla tomentosicollis Stal. (Hem., Coreidae). [1996]

70. P14.01 Incidence and impact of venous thromboembolism and major bleeding in patients with glioblastoma. [2021]

71. De novo SETD5 nonsense mutation associated with diaphragmatic hernia and severe cerebral cortical dysplasia. [2017]

72. New record of Trissolcus solocis (Hymenoptera: Scelionidae) parasitising Halyomorpha halys (Hemiptera: Pentatomidae) in the United States of America. [2019]

73. Biogeography and diversification of Holarctic water striders: Cenozoic temperature variation, habitat shifting and multiple intercontinental dispersals. [2018]

74. Susceptibility of ESBL Escherichia coli and Klebsiella pneumoniae to fosfomycin in the Netherlands and comparison of several testing methods including Etest, MIC test strip, Vitek2, Phoenix and disc diffusion. [2018]