Author ""Robin, Jacqueline,"" Database Gale Academic OneFile Database Supplemental Index Database Academic Search Premier

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1. The identification of the 3′terminus of the 70 S RNA of murine sarcoma virus (moloney) [1972]

  • Robin, Jacqueline, Larsen, Christian Jacques, Ravicovitch, Rodica Emanöil, Bazilier, Monique, Mauchauffe, Martine, and Boiron, Michel
  • FEBS Letters; October 1972, Vol. 27 Issue: 1 p58-62, 5p

2. Book Review: Art. [1978]

  • Hausman, Patricia R., Sisson, Jacqueline D., DeCandido, GraceAnne A., Bond, Randall I., Huemer, Christina, Kaplan, Robin, Pollard, Elizabeth B., Miller, Marjorie, von Khrum, Paul, and Reister, Willa
  • Library Journal. 6/1/1978, Vol. 103 Issue 11, p1162. 3p.

3. Immunological Comparison of Muscle Actins from Mammal, Bird and Fish [1979]

  • Benyamin, Yves, Roger, Michel, Gabrion, Jacqueline, Robin, Yvonne, and Van Thoai, Nguyen
  • FEBS Letters; June 1979, Vol. 102 Issue: 1 p69-74, 6p

4. Beach Bag Bingo. [1984]

  • McCaffrey, Robin, Gerber, Albert B., Boone, Cherry, Noguchi, Thomas, Briskin, Jacqueline, Cook, Robin, Kinder, Gary, Principal, Victoria, Simon, and Schuster
  • New York Native; 4/9/84, Issue 87, p37, 2p
Abstract
Presents information on several books on leisure reading. "The Book of Sex Lists," by Albert Gerber; "Coroner," by Thomas Noguchi; "The Godplayer," by Robin Cook; "The Body Principal," by Victoria Principal.

5. Effect of dietary cholesterol on plasma cholesterol concentration in subjects following reduced fat, high fibre diet. [1987]

  • Edington, Jacqueline, Geekie, Moira, Carter, Robin, Benfield, Lisa, Fisher, Karen, Ball, Madeleine, and Mann, Jim
  • British Medical Journal (Clinical Research Edition). 2/7/1987, Vol. 294 Issue 6568, p333-336. 4p. 1 Diagram, 4 Charts.
Subjects
LOW-fat diet and BLOOD cholesterol
Abstract
Examines the effect of dietary cholesterol on plasma cholesterol concentration in subjects following low fat diet in Great Britain. Ratio of polyunsaturated to saturated fatty acids; Comparison of the cholesterol concentration among subjects; Importance of dietary cholesterol for the reduction of saturated fats.

6. Shape Preferences for Simple Euclidian Forms in Three Age Groups [1989]

  • Silver, Annabelle, Combs, Allan, McConnellogue, Janet, Johnson, Robin, Pickering, John, and Hicks, Jacqueline
  • Perceptual & Motor Skills; April 1989, Vol. 68 Issue: 2 p522-522, 1p

7. Serum lipid response to dietary cholesterol in subjects fed a low-fat, high-fiber diet [1989]

  • Edington, Jacqueline D., Geekie, Moira, Carter, Robin, Benfield, Lisa, Ball, Madeleine, and Mann, Jim
  • American Journal of Clinical Nutrition. July 1989, Vol. 50 Issue 1, p58, 5 p.

8. AFTER THE LOVING, COUNTING THE COST Boy meets girl, boy loses girl, girl gets revenge: Some landmark cases in which famous ex-spouses gained millions from marital pain. [1989]

  • Schindehette, Susan, Micheli, Robin, Sheff, Vicki, Savaiano, Jacqueline, Knapp, Dan, Bacon, Doris, Demaret, Kent, McNeil, Liz, and Waggoner, Dianna
  • People. 8/7/89, Vol. 32 Issue 6, p68. 1p.

9. NEWS & Political Review. [1992]

  • Kingman, Sharon, Yamauchi, Masaya, Dorozynski, Alexander, Swan, Norman, McBride, Gail, Karcher, Helmut L., Godlee, Fiona, Annis, Jacqueline, Gloag, Daphne, Lowry, Stella, Warden, John, Dyer, Clare, Williams, Robin, Greenhill, Sally, and Greenhill, Richard
  • BMJ: British Medical Journal (International Edition). 3/7/92, Vol. 304 Issue 6827, p591. 6p. 4 Black and White Photographs, 1 Diagram.
Subjects
MEDICINE, FETAL tissue research, POPULATION & the environment, FETAL death, and POLITICAL science
Abstract
Presents global developments on the political aspects of medicine as of March 1992. Progress on fetal tissue research and transplants in Australia, Europe, and the United States; Increase in human population; Disposal of fetuses and fetus remains.

10. Excavation and Survey at Watchfield, Oxfordshire, 1983-92. [1992]

  • Scull, Christopher, Ager, Barry, Bourn, Robert, Cameron, Esther, Clogg, P. W., Creighton, John, Edwards, Glynis, Gelling, Margaret, Gilmour, Brian, Harman, Mary, Henry, Pippa, Holgate, Robin, Huntley, Jacqueline P., Johnson, Paul, Linford, Neil, Marlow, C. A., Mortimer, Catherine, Mudd, Andrew, Odenstedt, Bengt, and Page, R. I.
  • Archaeological Journal; 1992, Vol. 149, p124-281, 158p, 13 Black and White Photographs, 66 Diagrams, 12 Charts, 2 Graphs, 2 Maps
Abstract
Geophysical survey and excavation have demonstrated that iron age settlement features and early Anglo-Saxon burials discovered during road construction in 1983 were part o[ an extensive multi-period site, now a Scheduled Ancient Monument. This paper presents the results of the archaeological investigations. The bulk of the report is concerned with the early Anglo-Saxon burials, which included a grave containing a balance, weights and runic inscription. The evidence for late mesolithic, neolithic -- early bronze age, iron age and post-medieval activity is also discussed, and the site is considered in its regional and wider context. [ABSTRACT FROM AUTHOR]

11. Nonsteroidal signals originating in the gonads [1992]

  • Ackland, Jacqueline F., Schwartz, Neena B., Mayo, Kelly E., and Dodson, Robin E.
  • Physiological Reviews. July 1992, Vol. 72 Issue 3, p731, 57 p.

12. On Winning Friends and Influencing People: Action Identification and Self-Presentation Success [1992]

  • Vallacher, Robin R., Wegner, Daniel M., McMahan, Susan C., Cotter, Jacqueline, and Larsen, Kathleen A.
  • Social Cognition; Fall 1992, Vol. 10 Issue: 3 p335-355, 21p
Abstract
This study tested the performance optimality hypothesis of action identification theory in the context of self-presentation. Optimal performance is said to occur when a personally easy action is identified in relatively high level terms (i.e., the action's goals and likely effects) or a personally difficult action is identified in relatively low level terms (i.e., the action's mechanical details). To test this idea with respect to self-presentation, subjects were asked to describe themselves to either a difficult-to-impress or an easy-to-impress stranger in advance of a get-acquainted conversation with him or her. Subjects were induced to think about the self-description task in either high level terms (e.g., demonstrating their personality) or low level terms (e.g., smiling when appropriate). Support for the optimality hypothesis was obtained in subjects' self-reports of their self-presentation effectiveness and in observers' evaluations of subjects. Discussion centered on the manifestation of self-presentation nonoptimality in the early stages of relationship formation.

13. Characteristics Relating to Ovarian Cancer Risk Collaborative Analysis of 12 U.S. Case-Control Studies. VI. Nonepithelial Cancers among Adults [1992]

  • Horn-Ross, Pamela L., Whittemore, Alice S., Harris, Robin, and Itnyre, Jacqueline
  • Epidemiology; November 1992, Vol. 3 Issue: 6 p490-495, 6p
Abstract
Nonepithelial ovarian cancers are rare, and little is known about their etiology. Of particular interest are the effects of oral contraceptive use and pregnancy, both of which are associated with large decreases in risk for epithelial ovarian cancer. We examined the risk factors for nonepithelial ovarian tumors by combining data from four case-control studies conducted in the United States. We compared personal characteristics of 38 germ cell cases and 45 stromal cases, respectively, with 1,142 and 2,617 general population controls. All subjects were over age 18 years. For germ cell tumors, there was a weak negative association with parity but no consistent pattern of decreasing risk with increasing parity. In contrast, relative to nulligravid women, gravid nulliparous women were at increased risk of developing a germ cell cancer odds ratio (OR) 4.8, 95 confidence interval (CI) 1.2-18.61. The use of oral contraceptives was also associated with elevated risk (OR 2.0,95 CI 0.77- 5.1); however, no clear trends in risk were observed. For stromal tumors, oral contraceptive use was associated with decreased risk (OR 0.37, 95 CI 0.16-0.83), whereas pregnancy was associated with a small elevation in risk. A trend of increasing risk with increasing age at first term pregnancy was observed, with an odds ratio of 3.6 (95 CI 1.0-12.5) for a first birth after age 29 years. Risk factors for nonepithelial ovarian cancers do not appear to parallel each other or those for epithelial ovarian cancer. (Epidemiology 1992;3490-495)

14. Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case-Control Studies: I. Methods [1992]

  • Whittemore, Alice S., Harris, Robin, Itnyre, Jacqueline, Halpern, Jerry, and Group, the Collaborative Ovarian Cancer
  • American Journal of Epidemiology; November 1992, Vol. 136 Issue: 10 p1175-1175, 1p
Abstract
Data from 12 US case-control studies of ovarian cancer, conducted during the period 1956–1986 and representing some 3, 000 cases and 10,000 controls, were pooled and reanalyzed. Separate analyses were conducted for four subgroups of the pooled data: invasive epithelial ovarian cancers in white women; epithelial ovarian cancers of low malignant potential in white women, epithelial ovarian cancers in black women, and nonepithelial ovarian cancers. This paper gives a brief description of the participating studies and describes the methods used in the collaborative analysis. Am J Epidemiol1992; 136: 1175–83

15. Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case -Control Studies: II. Invasive Epithelial Ovarian Cancers in White Women [1992]

  • Whittmore, Alice S., Harris, Robin, Itnyre, Jacqueline, and Group, the Collaborative Ovarian Cancer
  • American Journal of Epidemiology; November 1992, Vol. 136 Issue: 10 p1184-1184, 1p
Abstract
Data collected from 2,197 white ovarian cancer patients and 8,893 white controls in 12 US case-control studies conducted in the period 1956–1986 were used to evaluate the relation of invasive epithelial ovarian cancer to reproductive and menstrual characteristics, exogenous estrogen use, and prior pelvic surgeries. Clear trends of decreasing risk were evident with increasing number of pregnancies (regardless of outcome) and increasing duration of breast feeding and oral contraceptive use. Ovarian dysfunction leading to both infertility and malignancy is an unlikely explanation for these trends for several reasons: 1) The trends were evident even among the highly parous; 2) risk among nulliparous women did not vary by marital status or gravidity; and 3) risk among ever-married women showed little relation to length of longest pregnancy attempt or history of clinically diagnosed infertility. Risk was increased among women who had used fertility drugs and among women with long total duration of premenopausal sexual activity without birth control; these associations were particularly strong among the nulligravid. No consistent trends in risk were seen with age at menarche, age at menopause, or duration of estrogen replacement therapy. A history of tubal ligation or of hystereclomy with ovarian conservation was associated with reduced ovarian cancer risk. These observations suggest that pregnancy, breast feeding, and oral contraceptive use induce biological changes that protect against ovarian malignancy, that, at most, a small fraction of the excess ovarian cancer risk among nulliparous women is due to infertility, and that any increased risk associated with infertility may be due to the use of fertility drugs. Am J Epidemiol 1992; 136: 1184–1203

16. Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of 12 US Case-Control Studies: III. Epithelial Tumors of Low Malignant Potential in White Women [1992]

  • Harris, Robin, Whittemore, Alice S., Itnyre, Jacqueline, and Group, the Collaborative Ovarian Cancer
  • American Journal of Epidemiology; November 1992, Vol. 136 Issue: 10 p1204-1204, 1p
Abstract
Epithelial ovarian neoplasms of low malignant potential, also called borderline ovarian tumors, have various features of malignancy, but they do not invade the ovarian stroma. Women with these tumors usually are younger when diagnosed and have better prognoses than do women with invasive tumors. There have been few epidemiologic studies of borderline tumors, and it is unclear whether there are etiologic differences between the two types of tumor behavior. Combined data from nine case-control studies, conducted from 1974 to 1986 and representing 327 white women with tumors of low malignant potential and 4, 144 white controls, were used to evaluate the relation between these tumors and personal characteristics related to invasive ovarian cancer. The risk profile for tumors of low malignant potential was found to be similar to that for invasive tumors, with two exceptions: Compared with that of invasive tumors, risk of borderline tumors was less clearly reduced among women who had used oral contraceptives and more clearly elevated among women with a history of Infertility. Am J Epidemiol 1992; 136: 1204–11

17. Characteristics Relating to ovarian Cancer Risk: Collaborative Analysis of 12 US case-Control Studies: IV. The Pathogenesis of Epithlial Ovarian Cancer [1992]

  • Whittemore, Alice S., Harris, Robin, ltnyre, Jacqueline, and Group, the Collaborative Ovarian Cancer
  • American Journal of Epidemiology; November 1992, Vol. 136 Issue: 10 p1212-1212, 1p
Abstract
Two hypotheses have been proposed to explain the reduced risk of epithelial ovarian cancer associated with pregnancy and oral contraceptive use. The first states that some sequelae of ovulation increase the likelihood of malignancy and that pregnancies and oral contraceptives protect by suppressing ovulation. The second hypothesis states that circulating levels of pituitary gonadotropins increase the risk of malignancy and that pregnancies and oral contraceptives protect by suppressing secretion of these hormones. The authors evaluate the two hypotheses in light of combined data from 12 United States case-oxitrol studies of epithelial ovarian cancer in white women conducted from 1956 to 1986. While a number of observations support both hypotheses, there are exceptions. Differential risk reduction associated with pregnancy and oral contraceptive use (pregnancy being the more effective in young women and the less effective in older women) conflicts with the first “ovulation” hypothesis, while reduced risk associated with breast feeding and absence of altered risk associated with estrogen replacement therapy conflicts with the second “gonadotropin” hypothesis. Several findings would not have been predicted by either hypothesis, e.g., only weak trends relate cancer risk to age at menarche, and, among older women, no clear trends relate risk to age at menopause. Odds ratio attenuation due to errors in reporting personal characteristics may be responsible for some of these inconsistencies. Multidisciplinary research is needed to clarify the etkrfogic roles of ovulation and gonadotropin stimulation, both of which may enhance carcinogenesis in the ovarian epithelium. Am J Epidemiol 1992: 136: 1212–20

18. Characteristics Relating to Ovarian Cancer Risk: Collaborative Analysis of Seven U.S. Case-Control Studies. Epithelial Ovarian Cancer in Black Women [1993]

  • John, Esther M., Whittemore, Alice S., Harris, Robin, Itnyre, Jacqueline, and Group, Collaborative Ovarian Cancer
  • JNCI Journal of the National Cancer Institute; January 1993, Vol. 85 Issue: 2 p142-142, 1p
Abstract
Background Previous epidemiologic studies of ovarian cancer have focused chiefly on White women, who have a higher incidence of ovarian cancer than Black women. No study has previously examined risk factors for ovarian cancer among Black women. Purpose This study was designed to evaluate the risk of epithelial ovarian cancer in Black women in relation to reproductive characteristics such as pregnancy, oral contraceptive use, and breast-feeding, and to determine whether differences in reproductive factors between Black and White women account for differences in ovarian cancer incidence. Methods Combining interview data from seven case-control studies, we compared reproductive characteristics of 110 Black case subjects with a diagnosis of epithelial ovarian cancer between 1971 and 1986 with characteristics of 251 Black population control subjects and 114 Black hospital control subjects. We also compared the prevalence of reproductive factors in 246 Black population control subjects and 4378 White population control subjects and estimated the fraction of Black-White differences in ovarian cancer incidence attributable to racial differences in prevalence of these characteristics. Results Decreased risks of epithelial ovarian cancer in Black women were associated with parity of four or higher (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.25–1.1), breast-feeding for 6 months or longer (OR=0.85; 95% CI=0.36–2.0), and use of oral contraceptives for 6 years or longer (OR=0.62; 95% CI=0.24–1.6). A greater proportion of Black women (48%) than White women (27%) reported four or more term pregnancies, and Black women (62%) were more likely than White women (53%) to have breast-fed their children. Oral contraceptive use was more common among White women (59%) than Black women (51%). Conclusions Differences in the prevalence of other factors related to ovarian cancer risk or differences in genetic susceptibility must explain most of the Black-White differences in incidence of ovarian cancer. [J Natl Cancer Inst 85:142–147, 1993]

19. Public health interests in trade agreements on alcoholic beverages in North America [1993]

  • Ferris, Jacqueline, Room, Robin, and Giesbrecht, Norman
  • Alcohol Health & Research World. Summer 1993, Vol. 17 Issue 3, p235, 7 p.

20. New barriers to ventricular invasion in paraglottic laryngeal cancer [1994]

  • Beitler, Jonathan J., Mahadevia, Panna S., Silver, Carl E., Wadler, Scott, Rubin, John S., Bello, Jacqueline A., Mitnick, Robin J., and Vikram, Bhadrasain
  • Cancer. May 15, 1994, Vol. 73 Issue 10, p2648, 5 p.

21. Developmental Expression of the Sea Urchin Egg Receptor for Sperm [1994]

  • Ohlendieck, Kay, Partin, Jacqueline S., Stears, Robin L., and Lennarz, William J.
  • Developmental Biology; September 1994, Vol. 165 Issue: 1 p53-62, 10p
Abstract
Little is known about the biochemical changes underlying the morphological differentiation of the sea urchin egg during oogenesis. Because of this and the essential role of gamete recognition in fertilization, we studied the developmental expression of the recently identified egg surface receptor for sperm during oogenesis. Consecutive stages of ovaries undergoing oogenesis over a 4-month time course were examined morphologically and assessed with respect to content of sperm receptor mRNA, as well as the content and subcellular distribution of the sperm receptor glycoprotein. Although in early oocyte stages neither mRNA encoding for the receptor nor receptor glycoprotein was detectable, at the last two stages of development the level of receptor mRNA accumulation increased dramatically. This finding correlated well with immunoblot analyses which established that sperm receptor protein was only detectable at the last two stages of egg maturation. Interestingly, immunocytochemistry showed that the formation of the receptor correlated temporally and spatially with the formation of cortical granules. In the earlier of these two stages of maturation, the receptor population identified by immunoblotting was found by immunocytochemistry to be restricted to the cortical granules and small vesicles in the cytoplasm. In contrast, at the last stage of egg maturation, sperm receptor was also detected at the surface of the oocyte, localized predominantly to the microvilli. Two receptor populations appear to exist, one in cortical granules and a second at the cell surface that may be formed via secretory vesicles. The late appearance of the receptor on the plasma membrane during oogenesis is consistent with its biological role in binding sperm to the mature egg cell surface.

22. The meaning of illness questionnaire: Further evidence for its reliability and validity [1994]

  • Weir, Robin, Browne, Gina, Roberts, Jacqueline, Tunks, Eldon, and Gafni, Amiram
  • Pain. September 1, 1994, Vol. 58 Issue 3, p377, 10 p.

23. The risk of harm to oneself from drinking, Canada 1989. [1995]

  • Room, Robin, Bondy, Susan J., and Ferris, Jacqueline
  • Addiction. Apr1995, Vol. 90 Issue 4, p499-513. 16p. 4 Charts, 5 Graphs.
Subjects
ALCOHOL drinking
Abstract
In a national sample of 11 634 Canadians aged 15 years and above, risk curves for harm to six life-areas from one's own drinking and for assault by another drinker rose steadily with the respondent's volume of alcohol consumption. While drinking five or more drinks on an occasion at least once a month substantially raised the risk at a given volume of drinking, the risk rose with volume even among those not regularly drinking five or more drinks. These relationships remained in logistic regressions which controlled for gender, age and educational level. Younger respondents, those without higher education and men reported more harm for a given level of their own drinking although differences by gender disappeared above one-third of one drink per day. Three sets of guidelines for low-risk drinking-two from Canada, and one generally used in Britain-were compared in terms of the proportions of respondents reporting harm from their own drinking among those who had kept within the guideline in the previous 7 days' drinking. More restrictiveness in the guidelines was associated with substantial reductions in reported drinking-related harm. [ABSTRACT FROM AUTHOR]

24. Ambiguity and underwriter decision processes [1995]

  • Kunreuther, Howard, Meszaros, Jacqueline, Hogarth, Robin M., and Spranca, Mark
  • Journal of Economic Behavior & Organization. May 1995, Vol. 26 Issue 3, p337, 1 p.

25. Three tips for saving mice. [1995]

  • Seewald, Jacqueline and Harris, Robin
  • Technology Connection. Oct95, Vol. 2 Issue 6, p8. 1/2p.
Subjects
MICE (Computers)
Abstract
Offers advice on how to prevent removal of a computer mouse's trackball. Dabbing super glue on the inside lid; Locking the trackball retaining ring into the mouse.

26. The Use of Magnetic Resonance Angiography prior to Pharyngeal Flap Surgery in Patients with Velocardiofacial Syndrome [1996]

  • Mitnick, Robin J., Bello, Jacqueline A., GoldingKushner, Karen J., Argamaso, Ravelo V., and Shprintzen, Robert J.
  • Plastic and Reconstructive Surgery; April 1996, Vol. 97 Issue: 5 p908-919, 12p
Abstract
Twenty consecutive patients with velocardiofacial syndrome underwent magnetic resonance angiography MRA to determine if abnormalities of the neck arteries would contraindicate pharyngeal flap surgery. All 20 patients were found to have anomalies of the carotid arteries, vertebral arteries, or both. Anomalies included tortuous or kinked vertebral arteries, medially placed internal carotids, low carotid bifurcations, and tortuous or kinked internal carotids. The internal carotids were found to be almost directly under the mucous membrane of the pharynx in two patients. In these two patients, the arteries were close to the pharyngeal midline at the base of the first cervical vertebra and might easily be severed during the raising of a pharyngeal flap. Hypoplastic vertebral arteries also were found. One patient had an extra neck vessel. The anomalies of the internal carotids did not have a strong correlation with endoscopically observed pulsations in the posterior pharyngeal wall. It also was found that head position affected the location of the internal carotid arteries when they were located close to the pharyngeal mucous membrane. The information provided in the MRA studies allowed assessment of the arterial anomalies in relation to the flap donor site so that the patients in the sample who underwent pharyngeal flap surgery using a short superiorly based flap had no major bleeding complications. Plast. Reconstr. Surg. 97 908, 1996.

27. Internal medicine student clubs in U.S. medical schools [1996]

  • Albritton, T., Fincher, Ruth-Marie, Mutha, Sunita, Womeodu, Robin, Kirk, Lynne, Peterson, Jacqueline, and Carson, Jeffrey
  • Journal of General Internal Medicine; July 1996, Vol. 11 Issue: 7 p440-440, 1p

28. HIV Continuum of Care: Challenges in Management [1996]

  • Goldenberg, Robin I., Bell, Stefanie H., Wright, Jacqueline, Brodeur, Sharon E., Turjanica, Mary Ann, Beckman, Loretta, and Warker, Nancy
  • Home Health Care Management and Practice; October 1996, Vol. 8 Issue: 6 p1-10, 10p
Abstract
The human immunodeficiency virus (HIV) continuum of care within the Inova Health System (IHS) has three levels of management: individual case management, linkage management, and disease-state management. Individual case management takes place at each operating unit— physician's office, hospital, home health care setting, or hospice—and has a multidisciplinary team that addresses treatment, education, therapy, and counseling. Inova Home Health and Hospice of Northern Virginia developed a staging tool to objectively determine the appropriate level of care and to provide a seamless transition between home health care and hospice. Inova's HIV Services provides the disease management component, incorporating proactive and cost-effective management of patients through the disease life cycle and across all settings.

29. Uncertainties in field-line tracing in the magnetosphere. Part I: the axisymmetric part of the internal geomagnetic field [1997]

  • Willis, D. M., Singh, J. Robin, and Comer, Jacqueline
  • Annales Geophysicae; February 1997, Vol. 15 Issue: 2 p165-180, 16p
Abstract
The technique of tracing along magnetic field lines is widely used in magnetospheric physics to provide a “magnetic frame of reference” that facilitates both the planning of experiments and the interpretation of observations. The precision of any such magnetic frame of reference depends critically on the accurate representation of the various sources of magnetic field in the magnetosphere. In order to consider this important problem systematically, a study is initiated to estimate first the uncertainties in magnetic-field-line tracing in the magnetosphere that arise solely from the published (standard) errors in the specification of the geomagnetic field of internal origin. Because of the complexity in computing these uncertainties for the complete geomagnetic field of internal origin, attention is focused in this preliminary paper on the uncertainties in magnetic-field-line tracing that result from the standard errors in just the axisymmetric part of the internal geomagnetic field. An exact analytic equation exists for the magnetic field lines of an arbitrary linear combination of axisymmetric multipoles. This equation is used to derive numerical estimates of the uncertainties in magnetic-field-line tracing that are due to the published standard errors in the axisymmetric spherical harmonic coefficients (i.e. gn0 ± dgn0). Numerical results determined from the analytic equation are compared with computational results based on stepwise numerical integration along magnetic field lines. Excellent agreement is obtained between the analytical and computational methods in the axisymmetric case, which provides great confidence in the accuracy of the computer program used for stepwise numerical integration along magnetic field lines. This computer program is then used in the following paper to estimate the uncertainties in magnetic-field-line tracing in the magnetosphere that arise from the published standard errors in the full set of spherical harmonic coefficients, which define the complete (non-axisymmetric) geomagnetic field of internal origin. Numerical estimates of the uncertainties in magnetic-field-line tracing in the magnetosphere, calculated here for the axisymmetric part of the internal geomagnetic filed, should be regarded as “first approximations” in the sense that such estimates are only as accurate as the published standard errors in the set of axisymmetric spherical harmonic coefficients. However, all procedures developed in this preliminary paper can be applied to the derivation of more realistic estimates of the uncertainties in magnetic-field-line tracing in the magnetosphere, following further progress in the determination of more accurate standard errors in the spherical harmonic coefficients.

30. Ki-67 Antigen Staining as an Adjunct to Identifying Cervical Intraepithelial Neoplasia [1997]

  • Dunton, Charles J., van Hoeven, Karen H., Kovatich, Al J., Oliver, Robin E., Scacheri, Robert Q., Cater, Jacqueline R., and Carlson, John A.
  • Gynecologic Oncology; March 1997, Vol. 64 Issue: 3 p451-455, 5p
Abstract
The purpose of the work was to determine the feasibility and predictive value of Ki-67 immunostaining of cervical cytology and the detection of cervical dysplasia. Air-dried cervical smears were stained with MIB-1 antibody to identify the Ki-67 antigen. Nuclear decoration in abnormal squamous nuclei determined immunoreactivity. One hundred twenty-four nonpregnant patients underwent colposcopy and directed biopsies for abnormal cytology. Sensitivity (0.89), specificity (0.65), positive predictive value (0.60), and negative predictive value (0.91) were found for Ki-67 immunostaining in detection of high-grade cervical intraepithelial neoplasia (CIN) in 124 patients and positive Ki-67 staining was a significant predictor of high-grade CIN in both univariate (odds ratio 15.5 (95% CI 5.5–43.8) and multivariable (odds ratio 21.5 (95% CI 5.0–92.0) analysis. In 101 patients with ASCUS and LGSIL, Ki-67 immunostaining demonstrated the following in detection of high-grade CIN: sensitivity (0.96), specificity (0.67), positive predictive value (0.49), and negative predictive value (0.98). Ki-67 immunostaining of cervical cytology is a predictor of significant cervical pathology with high sensitivity and negative predictive value. Ki-67 immunostaining of cervical cytology may represent a new and cost-effective triage tool for patients with minor abnormalities on cytology.

31. The Efficacy and Effectiveness of Process Consultation in Improving Staff Morale and Absenteeism [1997]

  • Weir*, Robin, †, Stewart*, Larry, †, ‡, Browne*, Gina, †, §, ¶, Roberts*, Jacqueline, §, ¶, Gafni§, Amiram, ¶, Easton*, Sandra, †, ‡, and Seymour‡, Louise
  • Medical Care; April 1997, Vol. 35 Issue: 4 p334-353, 20p
Abstract
The purpose of this randomized controlled trial was to test the efficacy and effectiveness of process consultation consisting of a series of nurse manager-consultant problem-solving meetings for leadership development that would lead to their staff's improved morale, quality of care, and reduced absenteeism.

32. CD4-Independent Infection by HIV-2 (ROD/B): Use of the 7-Transmembrane Receptors CXCR-4, CCR-3, and V28 for Entry [1997]

  • Reeves, Jacqueline D., McKnight, ÁINE, Potempa, Sandra, Simmons, Graham, Gray, Patrick W., Power, Christine A., Wells, Timothy, Weiss, Robin A., and Talbot, Simon J.
  • Virology; April 1997, Vol. 231 Issue: 1 p130-134, 5p
Abstract
We have assayed a variety of 7tm chemokine receptors (CCR-2b, CCR-3, CCR-4, CCR-5, CXCR-1, CXCR-4) and two orphan 7tm receptors (V28 and EBI.1) for their ability to allow infection of CD4-negative feline kidney CCC cells by the HIV-2 strains ROD/A and ROD/B. We found that ROD/B was able to use CXCR-4 transiently expressed in CCC cells, and infection by ROD/A was enhanced 15-fold in the presence of sCD4. Feline CCC cells also became permissive to ROD/B and ROD/A entry when transiently transfected with the chemokine receptor CCR-3 or the orphan 7tm receptor V28, when cultured in the presence of sCD4. Entry of ROD/A into CCC cells expressing CCR-3 could be blocked by 800 ng/ml eotaxin, the natural ligand for CCR-3.

33. An evaluation of peer and professional trainers in a union-based occupational health and safety training program [1997]

  • Kurtz, Jacqueline R., Robins, Thomas G., and Schork, M. Anthony
  • Journal of Occupational and Environmental Medicine. July 1997, Vol. 39 Issue 7, p661, 11 p.

34. Lifeline. [1997]

  • DeRosa, Robin and Blais, Jacqueline
  • USA Today (Front Page); 09/18/97, Vol. 16 Issue 4, p1D, 2 Color Photographs
Abstract
Presents interest and entertainment-related news briefs as of September 18, 1997. The `X-Files' pinball machine from Nieman Marcus; The song `You Light Up My Life,' by LeAnn Rimes; The popularity of films from the United States; More.

35. Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines [1997]

  • Boshoff, Chris, Endo, Yoshio, Collins, Paul D., Takeuchi, Yasuhiro, Reeves, Jacqueline D., Schweickart, Vicki L., Siani, Michael A., Sasaki, Takuma, Williams, Timothy J., Gray, Patrick W., Moore, Patrick S., Chang, Yuan, and Weiss, Robin A.
  • Science. Oct 10, 1997, Vol. 278 Issue 5336, p290, 5 p.

36. Reactivity of carbanions of Fischer-type carbene complexes with pyrylium salts. Synthesis of new γ-methylenepyran carbene complexes via an addition-oxidation-deprotonation process [1998]

  • Caro, Bertrand, Le Poul, Pascal, Robin-Le Guen, Françoise, Sénéchal-Tocquer, Marie-Claude, and Vaisserman, Jacqueline
  • Tetrahedron Letters; January 1998, Vol. 39 Issue: 7 p557-560, 4p
Abstract
The condensation reaction between γ-unsubstituted pyrylium salts and carbanions of Fischer-type carbene complexes allowed the synthesis of new γ-methylenepyran carbene complexes. 13C NMR data and single cristal X-ray analysis suggest a delocalisation of the oxygene lone pair of the heterocycle.

37. Randomised trial of isoniazid versus rifampicin and pyrazinamide for prevention of tuberculosis in HIV-1 infection. [1998]

  • Halsey, Neal A., Coberly, Jacqueline S., Desormeaux, Julio, Atkinson, Joan, Moulton, Lawrence H., Contave, Mireil, Johnson, Michael, Davis, Homer, Geiter, Lawrence, Johnson, Erica, Huebner, Robin, Boulos, Reginald, and Chaisson, Richard E.
  • Lancet. 3/14/1998, Vol. 351 Issue 9105, p786. 7p. 1 Diagram, 5 Charts, 3 Graphs.
Subjects
TUBERCULOSIS prevention, MEDICAL care of HIV-positive persons, ISONIAZID, PTERIDINES, and DRUG efficacy
Abstract
Studies the effectiveness of isoniazid versus rifampicin with pyrazinamide for prevention of tuberculosis in HIV-1 positive individuals. Methods for comparing efficacy of the chemoprophylaxis regimens; Findings; Interpretation. INSET: Disease categories.

38. Latanoprost treatment for glaucoma: effects of treating for 1 year and of switching from timolol [1998]

  • Camras, Carl B., Wax, Martin B., Ritch, Robert, Weinreb, Robert, Robin, Alan L., Higginbotham, Eve J., Lustgarten, Jacqueline, Stewart, William C., Sherwood, Mark, Krupin, Theodore, Wilensky, Jacob, Cioffi, George A., Katz, L. Jay, Schumer, Robert A., Kaufman, Paul L., Minckler, Don, Zimmerman, Thom, and Stjernschantz, Johan
  • American Journal of Ophthalmology. Sept 1998, Vol. 126 Issue 3, p390, 10 p.

39. Anger-related traits and response to interpersonal conflict among New York City traffic agents [1998]

  • Brondolo, Elizabeth, Masheb, Robin, Stores, Jacqueline, Stockhammer, Tanya, Tunick, Wendy, Melhado, Elizabeth, Karlin, William A., Schwartz, Joseph, Harburg, Ernest, and Contrada, Richard J.
  • Journal of Applied Social Psychology. Nov 16, 1998, Vol. 28 Issue 22, p2089, 3 p. 3

40. Enterocytic differentiation of the human Caco-2 cell line correlates with alterations in integrin signaling [1998]

  • Lévy, Peggy, Robin, Hélène, Kornprobst, Michel, Capeau, Jacqueline, and Cherqui, Gisèle
  • Journal of Cellular Physiology; December 1998, Vol. 177 Issue: 4 p618-627, 10p
Abstract
We previously reported that the enterocytic differentiation of human colonic Caco-2 cells correlated with down-regulation of fibronectin (FN) and laminin (LN), two extracellular matrix components interacting with cell surface integrin receptors. We now investigated whether Caco-2 cell differentiation was associated with alterations in integrin signaling with special interest in the expression and activity of focal adhesion kinase (FAK) and mitogen-activated protein (MAP) kinase. The differentiation of Caco-2 cells was associated with: 1) down-regulation of β1 integrin expression at the mRNA and protein levels; 2) increased FAK expression together with decreased FAK autophosphorylation; 3) decreased FAK's ability to associate with PI3-kinase and pp60c-src; and 4) increased MAP kinase expression along with decreased MAP activity. In addition, we show that FAK and MAP kinase belong to distinct integrin signaling pathways and that both pathways remain functional during Caco-2 cell differentiation since the coating of differentiating cells on FN and LN but not on polylysine increased the tyrosine phosphorylation of FAK and of its endogenous substrate paxillin, and stimulated MAP kinase activity. In conclusion, our results provide evidence that FAK and MAP kinase, two signaling molecules activated independently by β1 integrins in Caco-2 cells, undergo alterations of both expression and activity during the enterocytic differentiation of this cell line. J Cell Physiol 177:618627, 1998. © 1998 Wiley-Liss, Inc.

41. LETTERS. [1999]

  • Brand, William, Rudnick, David, Dunphy, Brendan, Moen, Gerald, Rutelli, Francesco, Fadiman, Jeffrey, Sivasubramanian, M. N., Desmond, Marc, Harris, Robin, Lamont, Lord, Talekar, N. S., Mounteer, Carl, Fitzpatrick, Maurice, Richards, Ian, Teo, Jacqueline, Sass, Edgar, and Dussolier, Maurice
  • Economist. 2/13/1999, Vol. 350 Issue 8106, p6-8. 2p.
Subjects
LETTERS to the editor, DAY trading (Securities), BUBBLE gum, ECONOMICS, and ECONOMIC policy
Abstract
Several letters to the editor are presented in response to articles in previous issues including "When the Bubble Bursts," in the January 30, 1999 issue, "Blame It on the Bubbles," in the January 23, 1999 issue, and "A Nervous Shuffle in Malaysia," in the January 16, 1999 issue.

42. The quick response initiative in the emergency department: who benefits? [1999]

  • Weir, Robin, Browne, Gina, Byrne, Carolyn, Roberts, Jacqueline, Gafni, Amiram, Thompson, Arlene, Walsh, Marian, and McColl, Lynda
  • Health Care Management Science. Sept 1999, Vol. 2 Issue 3, 137

43. Insulin Antiapoptotic Signaling Involves Insulin Activation of the Nuclear Factor κB-dependent Survival Genes Encoding Tumor Necrosis Factor Receptor-associated Factor 2 and Manganese-superoxide Dismutase* [1999]

  • Bertrand, France, Desbois-Mouthon, Christèle, Cadoret, Axelle, Prunier, Céline, Robin, Hélène, Capeau, Jacqueline, Atfi, Azeddine, and Cherqui, Gisèle
  • Journal of Biological Chemistry; October 1999, Vol. 274 Issue: 43 p30596-30602, 7p
Abstract
We recently showed that the antiapoptotic function of insulin requires nuclear factor κB (NF-κB) activation (Bertrand, F., Atfi, A., Cadoret, A., L'Allemain, G., Robin, H., Lascols, O., Capeau, J., and Cherqui, G. (1998) J. Biol. Chem.273, 2931–2938). Here we sought to identify the NF-κB-dependent survival genes that are activated by insulin to mediate this function. Insulin increased the expression of tumor necrosis factor receptor-associated factor 2 (TRAF2) mRNA and protein in Chinese hamster ovary cells overexpressing insulin receptors (IRs). This effect required (i) IR activation since it was abrogated by IR mutation at tyrosines 1162 and 1163 and (ii) NF-κB activation since it was abolished by overexpression of dominant-negative IκB-α(A32/36) and mimicked by overexpression of the NF-κB c-Rel subunit. TRAF2 contributed to insulin protection against serum withdrawal-induced apoptosis since TRAF2 overexpression mimicked insulin protection, whereas overexpression of dominant-negative TRAF2-(87–501) reduced this process. Along with its protective effect, overexpressed TRAF2 increased basal and insulin-stimulated NF-κB activities. All effects were inhibited by IκB-α(A32/36), suggesting that an amplification loop involving TRAF2 activation of NF-κB is implicated in insulin antiapoptotic signaling. We also show that insulin increased manganese-superoxide dismutase (Mn-SOD) mRNA expression through NF-κB activation and that Mn-SOD contributed to insulin antiapoptotic signaling since expression of antisense Mn-SOD RNA decreased this process. This study provides the first evidence that insulin activates the NF-κB-dependent survival genes encoding TRAF2 and Mn-SOD and thereby clarifies the role of NF-κB in the antiapoptotic function of insulin.

44. Economic evaluations of community-based care: lessons from twelve studies in Ontario. [1999]

  • Browne, Gina, Roberts, Jacqueline, Gafni, Amiram, Byrne, Carolyn, Weir, Robin, Majumdar, Basanti, and Watt, Susan
  • Journal of Evaluation in Clinical Practice. Dec1999, Vol. 5 Issue 4, p367-385. 19p.
Subjects
COMMUNITY health services, NATIONAL health insurance, and MEDICAL care
Abstract
A series of 12 studies (five historic cohort and seven randomized trials) examined clients in community settings in Southern Ontario suffering from a variety of chronic physical and mental health conditions. These studies are appraised using a framework for evaluating possible outcomes of economic evaluation. In the 12 studies, sample composition and size varied. Each study was designed to quantify the well-being outcomes and expenditures associated with different community-based approaches to care provided in the context of a system of national health insurance. As a collective, these studies represent increasing methodological rigour. Multiple-perspective client well-being outcome measures were used. In two studies, caregiver burden also was analysed. A common approach to quantification and evaluation of expenditures for service consumption was used in all 12 studies. The nature of community-based health services (health vs. disease care orientation) was found to have direct and measurable impact on total expenditures for health service utilization and client well-being outcomes. In most cases, a recurring pattern of equal or better client outcomes, yet lower expenditures for use of community based health services, was associated with well-integrated health oriented services. Integrated services aimed at factors which determine health are superior when compared to individual, fragmented, disease oriented, and focused approaches to care. The main lessons from the 12 studies are that it is as or more effective and as or less expensive to offer complete, proactive, community health services to persons living with chronic circumstance than to provide focused, on-demand, piecemeal services. Complete services would have a psychosocial and mental health focus included with the physical care approach. Furthermore, people with coexisting risk factors (age, living arrangements, mental distress and problem-solving ability) are the ones who most benefit at lower expense... [ABSTRACT FROM AUTHOR]

45. Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. [1999]

  • Toomes, Carmel, James, Jacqueline, Wood, A. Joseph, Wu, Chu Lee, McCormick, Derek, Lench, Nicholas, Hewitt, Chelsee, Moynihan, Leanne, Roberts, Emma, Woods, C. Geoffrey, Markham, Alexander, Wong, Melanie, Widmer, Richard, Ghaffar, Khaled Abdul, Pemberton, Michael, Hussein, Ibtessam Ramzy, Temtamy, Samia A., Davies, Robin, and Read, Andrew P.
  • Nature Genetics. Dec99, Vol. 23 Issue 4, p421. 4p.
Subjects
PERIODONTAL disease and KERATOSIS
Abstract
Papillon-Lefèvre syndrome, or keratosis palmoplantaris with periodontopathia (PLS, MIM 245000), is an autosomal recessive disorder that is mainly ascertained by dentists because of the severe periodontitis that afflicts patients. Both the deciduous and permanent dentitions are affected, resulting in premature tooth loss. Palmoplantar keratosis, varying from mild psoriasiform scaly skin to overt hyperkeratosis, typically develops within the first three years of life. Keratosis also affects other sites such as elbows and knees. Most PLS patients display both periodontitis and hyperkeratosis. Some patients have only palmoplantar keratosis or periodontitis, and in rare individuals the periodontitis is mild and of late onset. The PLS locus has been mapped to chromosome 11q14-q21 (refs 7-9). Using homozygosity mapping in eight small consanguineous families, we have narrowed the candidate region to a 1.2-cM interval between DllS4082 and D11S931. The gene (CTSC) encoding the lysosomal protease cathepsin C (or dipeptidyl aminopeptidase I) lies within this interval. We defined the genomic structure of CTSC and found mutations in all eight families. In two of these families we used a functional assay to demonstrate an almost total loss of cathepsin C activity in PLS patients and reduced activity in obligate carriers. [ABSTRACT FROM AUTHOR]

46. The Darwin Space Interferometer. [2000]

  • Bergeron, Jacqueline, Renzini, Alvio, Penny, Alan, Leger, Alain, Laurance, Robin, and Fridlund, Malcolm
  • From Extrasolar Planets to Cosmology: The VLT Opening Symposium; 2000, p535-538, 4p
Abstract
Darwin is a mid-IR(5-30 micron) interferometry observatory with baselines greater than 50 metres. As a long-duration general purpose observatory, ESA is studying it as part of its Horizons 2000 programme for a possible launch in the 2009 - 2016 timeframe. This paper describes some of the technical, scientific and programmatic aspects of the Darwin mission as presently conceived by the ESTEC study, the Alcatel industrial study and by the members of the Darwin Team. [ABSTRACT FROM AUTHOR]

47. Book reviews and notices [2000]

  • Trasi, Nitin, Clooney, Francis X., Hibbets, Maria, Cronk, George, Hatcher, Brian A., Rinehart, Robin, Prentiss, Karen Pechilis, French, Hal W., Bellantoni, Lisa, Korom, Frank J., Menzies, Robert, Bailly, Constantina Rhodes, Flood, Gavin, Manring, Rebecca J., Biernacki, Loriliai, Pennington, Brian K., Grimes, John, MacPhail, Richard D., Wallis, Glenn, Thatamanil, John J., Forsthoefel, Thomas, Cush, Denise, Saikia, Yasmin, Bracken, Joseph A., Vail, Lise F., Hirst, Jacqueline Suthren, Trapnell, Judson B., Findly, Ellison Banks, Waldau, Paul, and Johnson, D. L.
  • International Journal of Hindu Studies. April, 2000, Vol. 4 Issue 1, p61, 47 p.

48. Cultural sensitivity in substance use prevention. [2000]

  • Resnicow, Ken, Soler, Robin, Braithwaite, Ronald L., Ahluwalia, Jasjit S., and Butler, Jacqueline
  • Journal of Community Psychology. May2000, Vol. 28 Issue 3, p271-290. 20p.
Subjects
SUBSTANCE abuse prevention, ETHNICITY, MEDICAL communication, ETHNIC groups, PATHOLOGICAL psychology, and SOCIAL psychology
Abstract
The rationale for targeted and tailored substance use prevention programs derives from essentially three observations: 1) differences in substance use prevalence rates across racial/ethnic groups; 2) differences in the prevalence of the risk factors for substance use across racial/ethnic groups; and 3) differences in the predictors of substance use across groups. This article provides a model for understanding cultural sensitivity as it pertains to substance use prevention. Cultural sensitivity is defined by two dimensions, surface and deep structure. Surface structure involves matching intervention materials and messages to observable, “superficial” characteristics of a target population. This may involve using people, places, language, product brands, music, food, locations, and clothing familiar to, and preferred by, the target audience. Surface structure refers to how well interventions fit within a specific culture. Deep structure involves incorporating the cultural, social, historical, environmental, and psychologic forces that influence the target health behavior in the proposed target population. For example, peer influences may exert a greater influence on substance use initiation among White and Hispanic than among African American youth, while parental influences may be stronger among African Americans. Whereas surface structure generally increases the "receptivity" or "acceptance" of messages, deep structure conveys salience. Techniques for developing culturally sensitive interventions, borrowed from social marketing and health communication theory, are described. © 2000 John Wiley & Sons, Inc. [ABSTRACT FROM AUTHOR]

49. Telangiectasia macularis eruptiva perstans and multiple myeloma [2000]

  • Bachmeyer, Claude, Guillemette, Jacqueline, Blum, Laurent, Turc, Yves, DhA[acute accent]te, Robin, Fermand, Jean-Paul, and Aractingi, Selim
  • Journal of the American Academy of Dermatology. Nov 2000, Vol. 43 Issue 5, p972, 3 p.

50. Reviews. [2001]

  • Young, Robin Darling, Marina, Jacqueline, Rae, Murray, Wainwright, Geoffrey, Lipton, Diana, Griffiths, Paul J., Collinge, William J., Fowl, Stephen, Valliere, Paul, and Tanner, Kathryn
  • Modern Theology. Jul2001, Vol. 17 Issue 3.
Subjects
DYING for God (Book), KANT the Problem of God (Book), and SUFFERING Divine Things (Book)
Abstract
Books reviewed: Daniel Boyarin Dying for God: Martyrdom and the Making of Christianity and Judaism . Gordon E. Michalson, Jr. Kant and the Problem of God . Reinhard Hütter Suffering Divine Things: Theology as Church Practice . Boris Bobrinskoy The Mystery of the Trinity: Trinitarian Experience and Vision in the Biblical and Patristic Tradition . Tod Linafelt Surviving Lamentations: Catastrophe, Lament and Protest in the Afterlife of a Biblical Book . F. Samuel Brainard Reality and Mystical Experience . Sandra Lee Dixon Augustine: The Scattered and Gathered Self . Elisabeth Schüssler Fiorenza Rhetoric and Ethic: The Politics of Biblical Studies . Vladimir Wozniuk (Ed.) Politics, Law, and Morality: Essays by V. S. Soloviev . Rowan Williams Lost Icons: Reflections on Cultural Bereavement [ABSTRACT FROM AUTHOR]

51. Linkage and association analysis of chromosome 19q13 in multiple sclerosis [2001]

  • Pericak-Vance, Margaret, Rimmler, Jacqueline, Martin, Eden, Haines, Jonathan, Garcia, Melissa, Oksenberg, Jorge, Barcellos, Lisa, Lincoln, Robin, Goodkin, Donald, and Hauser, Stephen
  • neurogenetics; 20011001, Vol. 3 Issue: 4 p195-201, 7p
Abstract
Abstract.: Multiple sclerosis (MS) is an autoimmune neurological disorder with a complex etiology. Sibling risk, twin, and adoption studies have demonstrated that genes play a vital role in susceptibility to MS. Numerous association and linkage studies have implicated the major histocompatibility complex (MHC) as one component of the genetic etiology, but additional loci remain to be identified. Genomic screens have suggested over 50 regions that might harbor these genes, but there has been little agreement between studies. The one region suggested by all four screens resides within chromosome 19q13. Allelic associations with several markers in this region have also been described. This region has now been examined in detail in an expanded dataset of MS families from the United States. Genetic linkage and association were tested with multiple markers in this region using both parametric and non-parametric analyses. Additional support for an MS susceptibility locus was observed, primarily in families with the MS-associated HLA-DR2 allele. While consistent, this effect appears to be modest with a maximum λS=1.47, probably representing no more than 10% of the overall genetic effect in MS.

52. Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis [2002]

  • Schmidt, Silke, Barcellos, Lisa F., DeSombre, Karen, Rimmler, Jacqueline B., Lincoln, Robin R., Bucher, Patricia, Saunders, Ann M., Lai, Eric, Martin, Eden R., Vance, Jeffery M., Oksenberg, Jorge R., Hauser, Stephen L., Pericak-Vance, Margaret A., and Haines, Jonathan L.
  • American Journal of Human Genetics. March 2002, Vol. 70 Issue 3, p708, 10 p.

53. Toxic equivalency factors for PAH and their applicability in shellfish pollution monitoring studies [2002]

  • Law, Robin J., Kelly, Carole, Baker, Kerry, Jones, Jacqueline, McIntosh, Alistair D., and Moffat, Colin F.
  • Journal of Environmental Monitoring; May 24, 2002, Vol. 4 Issue: 3 p383-388, 6p
Abstract
Fish and shellfish are exposed to a wide range of polycyclic aromatic hydrocarbons (PAH) following oil spills at sea, and can become contaminated as a result. Finfish have a more effective mixed-function oxidase enzyme system than shellfish, and are therefore able to metabolise and excrete PAH more effectively than the invertebrates. Thus, contamination by high-molecular weight PAH, including those with carcinogenic potential and so of concern with regard to human consumers, is therefore usually observed in shellfish, and particularly in bivalve molluscs. Oil spills are not the sole source of PAH, however, as parent compounds are also generated by a wide range of combustion processes. In this paper, consideration is given to monitoring data gathered following recent oil spills (both of crude oil and diesel fuel), alongside data from other studies. These include studies conducted around a former gasworks site and downstream of an aluminium smelter in the UK, and from mussel monitoring studies undertaken in the UK and the USA (including the Exxon Valdez oil spill and the National Status and Trends programme), and in other countries in Europe. For comparative purposes the PAH concentrations are summed and also expressed as benzo[a]pyrene equivalents, their relative concentrations being weighted in relation to the carcinogenic potential of individual PAH compounds using toxic equivalency factors (TEF). Our aim was to assess the utility of this approach in fishery resource monitoring and control following oil spills. Certainly this approach seems useful from the data assessed in this study, and the relative ranking of the various studies seems to reflect the relative degree of concern for human consumers due to the differing contamination sources. As a simple tool for control purposes it is equally applicable to PAH derived from oil spills, and from industrial and combustion sources.

54. Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats [2002]

  • Novak, Jacqueline, Ramirez, Rolando J.J., Gandley, Robin E., Sherwood, O. David, and Conrad, Kirk P.
  • American Journal of Physiology (Consolidated). August 2002, Vol. 283 Issue 2, pR349, 7 p.

55. Myogenic reactivity is reduced in small renal arteries isolate from relaxin-treated rats. [2002]

  • Novak, Jacqueline, Ramirez, Rolando J.J., Gandley, Robin E., Sherwood, O. David, and Conrad, Kirk P.
  • American Journal of Physiology: Regulatory, Integrative & Comparative Physiology. Aug2002, Vol. 52 Issue 2, pR349. 7p. 5 Graphs.
Subjects
RELAXIN, RAT physiology, RENAL artery, MYOGENESIS, and MESENTERIC artery
Abstract
Presents information on a study which investigated whether myogenic reactivity of small renal and mesenteric arteries is reduced in relaxin-treated rats. Methodology; Impact of relaxin on myogenic reactivity; Link between denudation of endothelium and myogenic reactivity; Role of nitric oxide in the reduction of myogenic activity.

56. Antithrombin ‘DREUX’ (Lys114Glu): A Variant with Complete Loss of Heparin Affinity [2002]

  • Mushunje, Alec, Zhou, Aiwu, Huntington, James A., Conard, Jacqueline, and Carrell, Robin W.
  • Thrombosis and Haemostasis; September 2002, Vol. 88 Issue: 3 p436-443, 8p

57. Reactivity of carbanions of Fischer-type carbene complexes with pyrylium salts. Synthesis and characterization of new γ-methylenepyran carbene complexes via an addition–oxidation–deprotonation process [2002]

  • Caro, Bertrand, Le Poul, Pascal, Robin-Le Guen, Françoise, Saillard, Jean-Yves, Kahlal, Samia, Moinet, Claude, Le Poul, Nicolas, and Vaissermann, Jacqueline
  • Tetrahedron. Sep2002, Vol. 58 Issue 37, p7519. 12p.
Subjects
CONDENSATION, PYRYLIUM compounds, and CARBANIONS
Abstract
The condensation reaction between γ-unsubstituted pyrylium salts and carbanions of Fischer-type carbene complexes allowed the synthesis of new γ-methylenepyran carbene complexes. NMR data, single crystal X-ray analysis, and DFT calculations suggest that these complexes have a partial pyrylium character due to the π electron-accepting ability of the carbenic fragment and to the electron-releasing properties of the methylenepyran part. [Copyright &y& Elsevier]

58. The wages of sin: will the Vice Fund lead down the road to perdition? [2002]

  • Blumenthal, Robin Goldwyn and Doherty, Jacqueline
  • Barron's. Oct 7, 2002, Vol. 82 Issue 40, p12, 1 p.

59. Letters. [2002]

  • Atkinson, Jacqueline M, Wells, Frank O, Oliver, James, Webb, David J, Patole, Sanjay, Travadi, Javeed, von Kaehne, Peter, Jones, Graham A, Mathy, Robin M, Rushton, D Hugh, Dover, Robin, Sainsbury, Anthony W, Norris, Michael J, Gilkes, Jeremy J H, Ramsay, Ian D, Navein, John F, Simey, Piers W, Skelton, Dawn, and Dinan, Susie
  • BMJ: British Medical Journal (International Edition). 11/16/2002, Vol. 325 Issue 7373, p1174. 4p. 1 Chart, 1 Graph.
Subjects
LETTERS to the editor, MEDICAL personnel, CLINICAL medicine, and PHYSICIANS' correspondence
Abstract
Presents letters to the editor and correspondence between medical practitioners as of November 16, 2002. Undisclosed payments in research; Use of sildenafil for so-called blue babies; Making the best of health advocates and interpreters; Homosexual-related legislation and suicidal intent among sexual minority groups; Iron deficiency in women's health; Others.

60. Health effects of World Trade Center site workers [2002]

  • Levin, Stephen, Herbert, Robin, Skloot, Gwen, Szeinuk, Jaime, Teirstein, Alvin, Fischler, David, Milek, Debra, Piligian, George, Wilk‐Rivard, Elizabeth, and Moline, Jacqueline
  • American Journal of Industrial Medicine; December 2002, Vol. 42 Issue: 6 p545-547, 3p

61. Efficient production of Arthromyces ramosus peroxidase by Aspergillus awamori [2003]

  • Lokman, B. Christien, Joosten, Vivi, Hovenkamp, Jacqueline, Gouka, Robin J., Verrips, C. Theo, and van den Hondel, Cees A.M.J.J.
  • Journal of Biotechnology. Jun2003, Vol. 103 Issue 2, p183. 8p.
Subjects
XYLANASES and ASPERGILLUS
Abstract
The heterologous production of Arthromyces ramosus peroxidase (ARP) was analysed in the filamentous fungus Aspergillus awamori under control of the inducible endoxylanase promoter. Secretion of active ARP was achieved up to 800 mg l−1 in shake flask cultures. Western blot analysis showed that an rARP product of the correct molecular weight was produced. In contrast to several other studies about heterologous production of heme containing peroxidases, our results suggest that in A. awamori no heme limitation exists during overproduction of ARP. [Copyright &y& Elsevier]

62. Butyrate-treated colonic Caco-2 cells exhibit defective integrin-mediated signaling together with increased apoptosis and differentiation. [2003]

  • Peggy Lévy, Hélène Robin, France Bertrand, Michel Kornprobst, and Jacqueline Capeau
  • Journal of Cellular Physiology. Dec2003, Vol. 197 Issue 3, p336. 12p.
Subjects
CELL differentiation, APOPTOSIS, FATTY acids, and PROTEINS
Abstract
We previously reported that the enterocytic differentiation of human colonic Caco-2 cells correlated with alterations in integrin signaling. We now investigated whether differentiation and apoptosis of Caco-2 cells induced by the short-chain fatty acid butyrate (NaBT) was associated with alterations in the integrin-mediated signaling pathway with special interest in the expression and activity of focal adhesion kinase (FAK), of the downstream phosphatidylinositol 3'-kinase (PI 3-kinase)Akt pathway and in the role of the nuclear factor κB (NF-κB). NaBT increased the level of sucrase. It induced apoptosis as shown by: (1) decreased Bcl-2 and Bcl-XL proteins and increased Bax protein; (2) activation of caspase-3; and (3) increased shedding of apoptotic cells in the medium. This effect was associated with defective integrin-mediated signaling as shown by: (1) down-regulation of β1 integrin expression; 2) decreased FAK expression and tyrosine phosphorylation; (3) concerted alterations in cytoskeletal and structural focal adhesions proteins (talin, ezrin); and (4) decreased FAK ability to associate with PI 3-kinase. However, in Caco-2 cells, β1-mediated signaling failed to be activated downstream of FAK and PI 3-kinase at the level of Akt. Transfection studies show that NaBT treatment of Caco-2 cells promoted a significant activation of the NF-κB which was probably involved in the NaBT-induced apoptosis. Our results indicate that the prodifferentiating agent NaBT induced apoptosis of Caco-2 cells probably through NF-κB activation together with a defective β1 integrin-FAK-PI 3-kinase pathways signaling. J. Cell. Physiol. 197: 336347, 2003© 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

63. Firing Patterns of Type II Spiral Ganglion Neurons In Vitro. [2004]

  • Reid, Michael A., Flores-Otero, Jacqueline, and Davis, Robin L.
  • Journal of Neuroscience. 1/21/2004, Vol. 24 Issue 3, p733-742. 10p. 4 Color Photographs, 1 Black and White Photograph, 5 Graphs.
Subjects
NEURONS, ELECTROPHYSIOLOGY, SENSORY receptors, HAIR cells, and COCHLEA
Abstract
Type I and type II spiral ganglion neurons convey auditory information from the sensory receptors in the cochlea to the CNS. The numerous type I neurons have been extensively characterized, but the small population of type II neurons with their unmyelinated axons are undetectable with most recording methods. Despite the paucity of information about the type II neurons, it is clear that they must have a significant role in sound processing because they innervate the large number of outer hair cells that are critical for maintaining normal responses to stimuli. To elucidate the function of type II neurons, we have developed an approach for studying their electrophysiological features in vitro. Type II neurons obtained from postnatal day 6-7 mice displayed distinctly different firing properties than type I neurons. They showed slower accommodation, lower action potential thresholds, and more prolonged responses to depolarizing current injection than the type I neurons. These differences were most evident in neurons from the basal, high-frequency region of the cochlea. The basal type I neurons displayed uniformly fast firing features, whereas the basal type II neurons showed particularly slow accommodation and responses to depolarization. Interestingly, neurons from the apical, low-frequency region of the cochlea showed the opposite trend. These data suggest that the type I and type II neurons have specialized electrophysiological characteristics tailored to their different roles in auditory signal processing. In particular, the type II neuron properties are consistent with cells in other sensory systems that receive convergent synaptic input for high-sensitivity stimulus detection. [ABSTRACT FROM AUTHOR]

64. Evaluation of Urgotul plus K-Four compression for venous leg ulcers [2004]

  • Smith, Jacqueline, Hill, Jayne, Barrett, Simon, Hayes, Wendy, Kirby, Pamela, Walsh, Sally, Gittins, Eleri, Whitehurst, Fran, and Cooper, Robin
  • British Journal of Nursing; March 2004, Vol. 13 Issue: Supplement 1 pS20-S28, 9p
Abstract
In this non-comparative clinical evaluation, 36 subjects with venous leg ulcers, 85% of which were indolent or deteriorating, were treated with Urgotul® lipidocolloid wound dressing and the K-Four® multilayer compression bandaging system for 12 weeks or to healing — whichever occurred first. Results show that Urgotul® was an ideal dressing in combination with K-Four®, being easy to apply (98.7%) and remove (98.1%), and largely pain-free (95.6%) and non-adherent (99.7%). In a patient group of ‘hard-to-heal’ ulcers, 50% of the ulcers healed within the treatment period. Ulcers not healed after 12 weeks achieved almost 50% area reduction on average. The treatment combination proved safe, with only one of seven adverse events reported being probably related to the products used. This study supports the use of a combination of Urgotul® dressing and K-Four® compression to provide a ‘matched’ treatment for venous leg ulcers.

65. Removing GPS collar bias in habitat selection studies. [2004]

  • Frair, Jacqueline L., Nielsen, Scott E., Merrill, Evelyn H., Lele, Subhash R., Boyce, Mark S., Munro, Robin H. M., Stenhouse, Gordon B., and Beyer, Hawthorne L.
  • Journal of Applied Ecology. Apr2004, Vol. 41 Issue 2, p201-212. 12p.
Subjects
HABITAT selection, GLOBAL Positioning System, HABITATS, VEGETATION & climate, RADIO telemetry, and ANIMAL radio tracking
Abstract
Journal of Applied Ecology (2004) 41, 201–212 [ABSTRACT FROM AUTHOR]

66. Anxiety disorders and schizophrenia [2004]

  • Muller, Jacqueline E., Koen, Liezl, Seedat, Soraya, Emsley, Robin A., and Stein, Daniel J.
  • Current Psychiatry Reports. July, 2004, Vol. 6 Issue 4, p255, 7 p.

67. Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35 [2004]

  • Marazita, Mary L., Murray, Jeffrey C., Lidral, Andrew C., Arcos-Burgos, Mauricio, Cooper, Margaret E., Goldstein, Toby, Maher, Brion S., Daack-Hirsch, Sandra, Schultz, Rebecca, Mansilla, M. Adela, Field, L. Leigh, Liu, You-e, Prescott, Natalie, Malcolm, Sue, Winter, Robin, Ray, Ajit, Moreno, Lina, Valencia, Consuelo, Neiswanger, Katherine, Wyszynski, Diego F., Bailey-Wilson, Joan E., Albacha-Hejazi, Hasan, Beaty, Terri H., McIntosh, Iain, Hetmanski, Jacqueline B., Tuncbilek, Gokhan, Edwards, Matthew, Harkin, Louise, Scott, Rodney, and Roddick, Laurence G.
  • American Journal of Human Genetics. August 2004, Vol. 75 Issue 2, p161, 13 p.

68. Positive end-expiratory pressure above lower inflection point minimizes influx of activated neutrophils into lung. [2004]

  • Monkman, Shelley L, Andersen, Chad C, Nahmias, Claude, Ghaffer, Hasan, Bourgeois, Jacqueline M, Roberts, Robin S, Schmidt, Barbara, and Kirpalani, Haresh M
  • Critical Care Medicine. Dec2004, Vol. 32 Issue 12, p2471-2475. 5p.
Abstract
Objectives: To compare the effects of low vs. high tidal volume (Vt) with three positive end-expiratory pressure (PEEP) strategies on activated neutrophil influx into the lung.Design: Prospective, randomized controlled animal study.Setting: Animal laboratory in a university hospital.Subjects: Newborn piglets.Interventions: Surfactant-depleted piglets were randomized in littermate pairs; to PEEP of either 0 (zero end-expiratory pressure [ZEEP]; n = 6), 8 cm H2O (PEEP 8; n = 5), or 1 cm H2O above the lower inflection point (LIP) (PEEP>LIP; n = 6). Within each pair piglets were randomized to a low VT (5-7 mL/kg) or high VT strategy (17-19 mL/kg). After 4 hrs of mechanical ventilation, 18-fluorodeoxyglucose (18FDG) was injected and positron emission tomography scanning was performed.Measurements and Main Results: VT and PEEP changes on influx constants of 18FDG were assessed by analysis of variance. A within-litter comparison of Vt was nonsignificant (p = .50). A between-litter comparison, ordered in linear trend rank, from ZEEP, to PEEP 8, to PEEP>LIP, showed a strong effect of PEEP on influx constant (p = .019).Conclusions: PEEP set above the LIP on the inspiratory limb of the pressure-volume curve affords a stronger lung protection than VT strategy. [ABSTRACT FROM AUTHOR]

69. THE PREVALENCE, CORRELATES, AND COSTS OF DEPRESSION IN PEOPLE LIVING WITH HIV/AIDS IN ONTARIO: IMPLICATIONS FOR SERVICE DIRECTIONS. [2005]

  • Williams, Peter, Narciso, Lea, Browne, Gina, Roberts, Jacqueline, Weir, Robin, and Gafni, Amiram
  • AIDS Education & Prevention. Apr2005, Vol. 17 Issue 2, p119-130. 12p. 6 Charts.
Subjects
MENTAL depression, QUALITY of life, PSYCHOLOGICAL adaptation, HIV-positive persons, AIDS patients, and SOCIAL services
Abstract
Examines the prevalence of depression, and its association with quality–of–life, coping strategies, social support, and use of health and social services among people living with HIV and AIDS in Ontario. Indication of the prevalence of depression; Increase of the use of crisis health care and related services among subjects; Improvement of the quality of life through expanding the capacity of medical workers to recognize and address depression.

70. Standards for hospital libraries 2002 with 2004 revisions. [2005]

  • Hassig, Robin Ackley, Balogh, Leeni, Bandy, Margaret, Doyle, Jacqueline Donaldson, Gluck, Jeannine Cyr, Lindner, Katherine Lois, Reich, Barbara, and Varner, Douglas
  • Journal of the Medical Library Association. Apr2005, Vol. 93 Issue 2, p282-283. 2p.
Subjects
BOOKS, LIBRARIES, INFORMATION science, HEALTH services administration, HEALTH of physicians, and MEDICAL care
Abstract
The article presents a special report on the book "Standards for Hospital Libraries 2002." The 2004 revisions of the book include an expansion of standard 6, which is a glossary definition of "library," and updates to the bibliography. The expanded standard 6 defines appropriate resources, technology, and services that must be provided. The updates to the bibliography include the latest edition of the Joint Commission on Accreditation of Healthcare Organizations Comprehensive Accreditation Manual for Hospitals, the Medical Library Association policy statement on the role of expert searching in health sciences libraries, and updates of some Website addresses. The librarian uses a variety of tools and techniques, both formal and informal, to assess the knowledge-based information needs of the hospital and medical staff. The needs assessment should address the timeliness of information services and document delivery. In response, resources and services are made available to meet those identified needs.

71. Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism [2005]

  • Woods, Kathryn S., Cundall, Maria, Crace, Jim, Rizotti, Karine, Mehta, Ameeta, Palmer, Rodger, Wong, Jacqueline, Chong, W.K., Al-Zyoud, Mahmoud, El-Ali, Maryam, Otonkoski, Timo, Martinez-Barbera, Juan-Pedro, Thomas, Paul Q., Robinson, Iain C., Lovell-Badge, Robin, Woodward, Karen J., and Dattani, Mehul T.
  • American Journal of Human Genetics. May 2005, Vol. 76 Issue 5, p833, 17 p.

72. Characteristics of People Living With HIV Who Use Community-Based Services in Ontario, Canada: Implications for Service Providers. [2005]

  • Williams, Peter, Narciso, Lea, Browne, Gina, Roberts, Jacqueline, Weir, Robin, and Gafni, Amiram
  • JANAC: Journal of the Association of Nurses in AIDS Care; Jul/Aug2005, Vol. 16 Issue 4, p50-63, 14p, 6 Charts
Abstract
Community-based AIDS service organizations (CBAOs) direct services to multiple-needs people living with HIV/AIDS who are less likely to use mainstream health promotion services. As people live longer with HIV, the potential to enhance quality of life increases, yet little is known about who uses CBAOs or how this use affects other health and social services. This study of people living with AIDS in Ontario, Canada (n = 297) examined the demographic and health-related characteristics of people with AIDS who do and do not use CBAOs and their patterns of mainstream service utilization. It found that users of CBAOs were significantly less healthy, less able to sustain normal activities, and more often depressed. They reported physical disabilities significantly more often. Their quality of life was also lower along certain dimensions. They were significantly poorer and more reliant on government income supports. They consumed significantly more nonhospital health and social services and had significantly higher out-of-pocket costs. These results suggest CBAOs are being accessed appropriately by those most vulnerable. In an effort to strengthen CBAO capacity to recognize and address depression and physical health problems prevalent among their clients, links to other mainstream health promotion and social services is recommended. [ABSTRACT FROM AUTHOR]

73. A high-density screen for linkage in multiple sclerosis: international multiple sclerosis genetics consortium * [2005]

  • Sawcer, Stephen, Ban, Maria, Maranian, Mel, Yeo, Tai Wai, Compston, Alastair, Kirby, Andrew, Daly, Mark J., De Jager, Philip L., Walsh, Emily, Lander, Eric S., Rioux, John D., Hafler, David A., Ivinson, Adrian, Rimmler, Jacqueline A., Gregory, Simon, Schmidt, Silke, Pericak-Vance, Margaret A., Akesson, Eva, Hillert, Jan, Datta, Pameli, Oturai, Annette, Ryder, Lars P., Harbo, Hanne F., Spurkland, Anne, Myhr, Kjell-Morten, Laaksonen, Mikko, Booth, David, Heard, Robert, Stewart, Graeme, Lincoln, Robin, Barcellos, Lisa F., Hauser, Stephen L., Oksenberg, Jorge R., Kenealy, Shannon J., and Haines, Jonathan L.
  • American Journal of Human Genetics. Sept 2005, Vol. 77 Issue 3, p454, 14 p.

74. Longitudinal Study of Inpatients Admitted to a General Activation Service: Variables That Predict Discharge to a Patient’s Discharge Goal Location. [2005]

  • Blackman-Weinberg, Carol, Crook, Joan, Roberts, Jacqueline, and Weir, Robin
  • Archives of Physical Medicine & Rehabilitation; Sep2005, Vol. 86 Issue 9, p1782-1787, 6p
Abstract
Abstract: Blackman-Weinberg C, Crook J, Roberts J, Weir R. Longitudinal study of inpatients admitted to a general activation service: variables that predict discharge to a patient’s discharge goal location. Objective: To determine which sociodemographic and clinical characteristics of patients admitted to a general activation service (GAS) are predictive of discharge to patients’ discharge goal locations (DGLs). Design: Prospective cohort study. Setting: Rehabilitation and complex continuing care hospital in southern Ontario, Canada. Participants: Patients admitted from January 2000 to December 2002 (N=154). Intervention: The GAS. Main Outcome Measure: Patients indicated on their service applications where they wanted to be discharged. This is termed the DGL. Results: Fifty-three percent of the sample were discharged to their DGLs. Ninety-eight percent of these patients were discharged by 9 months. Eighty-seven percent who were discharged to their DGLs were discharged to their own home. Predictors of being discharged to the DGL were better activities of daily living scores, good vision, and having sufficient help at home. Expert clinician opinion of the likelihood of each patient being discharged to his/her DGL, based on initial assessment, was also predictive of each patient’s eventual discharge to his/her DGL. Conclusions: The GAS has a 53% success rate in discharging patients to their DGLs. Variables have been identified that should be useful in predicting whether patients will be discharged to their DGLs. Our findings are meaningful and informative in determining future admission criteria for the service. [Copyright &y& Elsevier]

75. A Case of "Ifufunyane" A Xhosa Culture-Bound Syndrome [2005]

  • NIEHAUS, DANA J. H., STEIN, DAN J., KOEN, LIEZL, LOCHNER, CHRISTINE, MULLER, JACQUELINE E., MBANGA, N. IRENE, EMSLEY, ROBIN A., and GORMAN, JACK M.
  • Journal of Psychiatric Practice; November 2005, Vol. 11 Issue: 6 p411-413, 3p

76. Positive and negative symptoms in affected sib pairs with schizophrenia: Implications for genetic studies in an African Xhosa sample [2005]

  • Niehaus, Dana J.H., Koen, Liezl, Laurent, Claudine, Muller, Jacqueline, Deleuze, Jean-Francois, Mallet, Jacques, Seller, Cathlene, Jordaan, Esme, and Emsley, Robin
  • Schizophrenia Research. Nov2005, Vol. 79 Issue 2/3, p239-249. 11p.
Subjects
SCHIZOPHRENIA, PSYCHOSES, DELUSIONS, HALLUCINATIONS, DIAGNOSIS of schizophrenia, SIBLINGS, CHI-squared test, COMPARATIVE studies, DEMOGRAPHY, FACTOR analysis, FAMILY health, RESEARCH methodology, MEDICAL cooperation, PSYCHOLOGICAL tests, PSYCHOLOGY, RESEARCH, EVALUATION research, and SEVERITY of illness index
Abstract
Abstract: Careful phenotyping and the identification of subtypes of schizophrenia can contribute significantly to the success of genetic studies in schizophrenia. The phenomenology of schizophrenia in affected sib pairs has been well-described in Caucasian populations, however a paucity of data exists for African populations. This study therefore investigated symptom dimensions in a sizeable group of affected Xhosa sib pairs as a means of evaluating the role of shared familial factors in the psychosis of schizophrenia. Five hundred and thirteen participants were interviewed with the Diagnostic Interview for Genetic Studies (DIGS), which included the Schedules for the Assessment of Negative and Positive symptoms (SANS/SAPS). One hundred and four sib pairs were then extracted (N =208) for analysis of concordance for lifetime psychotic symptoms and an exploratory factor analysis of the SANS/SAPS. Concordance analysis of life-time symptoms indicated a significant concordance for olfactory hallucinations, persecutory delusions, jealousy, somatic, reference and control delusions as well as thought insertion and withdrawal. The factor analysis of the global scores of the SAPS and SANS revealed a five factor best-fit model and accounted for 92.5% of variance. The factors included a negative symptom factor, a positive symptom factor, a positive thought disorder and a bizarre behaviour component. The core symptomatology of schizophrenia in this sib pair sample was similar to that reported in Caucasian populations with the exception of higher rates of auditory hallucinations and delusions of persecution. In summary therefore; although the factor analysis only supported the concept of the universality of psychotic symptoms in schizophrenia, the concordance analysis of these symptoms did reveal hallucinations as well as delusions of control as possible candidates relevant for future research into genotype–phenotype relationships. [Copyright &y& Elsevier]

77. Community-Associated Methicillin-Resistant Staphylococcus aureusEpidemic Clone USA300 in Isolates from Florida and Washington [2006]

  • Roberts, Jill C., Krueger, Robin L., Peak, K. Kealy, Veguilla, William, Cannons, Andrew C., Amuso, Philip T., and Cattani, Jacqueline
  • Journal of Clinical Microbiology; January 2006, Vol. 44 Issue: 1 p225-226, 2p
Abstract
ABSTRACTWe examined 299 methicillin-resistant, community-associated Staphylococcus aureusisolates from Florida and Washington State for the presence of the USA300 epidemic clone. Pulsed-field gel electrophoresis demonstrated the epidemic clone in 43% of our S. aureusstrains and in isolates from both states. The majority of the USA300 isolates (88%) were from wound infections.

78. Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors [2006]

  • Smith, Leon, Piatnitski, Evgueni L., Kiselyov, Alexander S., Ouyang, Xiaohu, Chen, Xiaoling, Burdzovic-Wizemann, Sabina, Xu, Yongjiang, Wang, Ying, Rosler, Robin L., Patel, Sheetal N., Chiang, Hui-Hsien, Milligan, Daniel L., Columbus, John, Wong, Wai C., Doody, Jacqueline F., and Hadari, Yaron R.
  • Bioorganic & Medicinal Chemistry Letters. Mar2006, Vol. 16 Issue 6, p1643-1646. 4p.
Subjects
AZEPINES, HETEROCYCLIC compounds, EPIDERMAL growth factor, and PROTEIN-tyrosine kinase inhibitors
Abstract
Abstract: A novel class of pyrimido[4,5-b]-1,4-benzoxazepines is described as inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase. Two compounds display potent EGFR inhibitory activity of less than 1μM in cellular phosphorylation assays (IC50 0.47–0.69μM) and are highly selective against a small kinase panel. Such compounds demonstrate anti-EGFR activity within a class that is different from any known EGFR inhibitor scaffolds. They also provide a basis for the design of kinase inhibitors with the desired selectivity profile. [Copyright &y& Elsevier]

79. Health consequences of the September 11 World Trade Center attacks: a review. [2006]

  • Moline, Jacqueline, Herbert, Robin, and Nguyen, Ngoctram
  • Cancer Investigation. 2006, Vol. 24 Issue 3, p294-301. 8p.
Subjects
SEPTEMBER 11 Terrorist Attacks, 2001, PARTICLES, TOXINS, GLASS fibers, POLYCYCLIC aromatic hydrocarbons, DIOXINS, and PUBLIC health
Abstract
In the aftermath of the September 11 World Trade Center (WTC) attack, a large number of people sustained potential exposures to smoke, dust, particulate matter, and a variety of toxins, including asbestos, pulverized concrete, glass fibers, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated furans and dioxins. Additionally, many had exposure to psychological traumatogens. The most common effects seen to date are respiratory and mental health consequences. The long-term consequences of exposures are not yet known, and there remains concern about the potential for late-emerging diseases such as cancers. This article reviews WTC-related health effects, the spectrum of exposures and how they were documented, and discusses future preventive efforts. [ABSTRACT FROM AUTHOR]

80. Health promotion for frail older home care clients. [2006]

  • Markle-Reid, Maureen, Weir, Robin, Browne, Gina, Roberts, Jacqueline, Gafni, Amiram, and Henderson, Sandra
  • Journal of Advanced Nursing (Wiley-Blackwell). May2006, Vol. 54 Issue 3, p381-395. 15p. 2 Diagrams, 4 Charts.
Subjects
HEALTH promotion, NURSING, HOME care services, PREVENTIVE health services, and FRAIL elderly
Abstract
Aim. This paper reports a study evaluating the comparative effects and costs of a proactive nursing health promotion intervention in addition to usual home care for older people compared with usual home care services alone. Background. An ageing population, budget constraints and technological advances in many countries have increased the pressure on home care resources. The result is a shift in nursing services from health promotion to meet the more pressing need for postacute care. For frail older people with long-term needs, these changes combine to create a fragmented system of health service delivery, characterized by providing nursing on demand rather than proactively. Methods. A two-armed, single-blind, randomized controlled trial was carried out with older people ≥75 years and eligible for personal support services through a home care programme in Ontario, Canada. Participants were randomly allocated either to usual home care (control) or to a nursing (experimental) group. In addition to usual home care, the nursing group received a health assessment combined with regular home visits or telephone contacts, health education about management of illness, coordination of community services, and use of empowerment strategies to enhance independence. The data were collected in 2001–2002. Results. Of the 288 older people who were randomly allocated at baseline, 242 (84%) completed the study (120 nursing group; 122 control group). Proactively providing older people with nursing health promotion, compared with providing nursing services on-demand, resulted in better mental health functioning ( P = 0·009), a reduction in depression ( P = 0·009), and enhanced perceptions of social support ( P = 0·009) at no additional cost from a societal perspective. Conclusions. Home based nursing health promotion, proactively provided to frail older people with chronic health needs, enhances quality of life while not increasing the overall costs of health care. The results underscore the need to re-invest in nursing services for health promotion for older clients receiving home care. [ABSTRACT FROM AUTHOR]

81. ATTITUDES OF THE ELDERLY TOWARD PHYSICAL ACTIVITY AND EXERCISE. ADAPTATION OF THE OLDER PERSON'S ATTITUDES TOWARD PHYSICAL ACTIVITY AND EXERCISE QUESTIONNAIRE IN SPAIN. [2006]

  • Pappous, Athanasios, Cruz, Francisco, De Leseleuc, Eric, Marcellini, Anne, Recours, Robin, and Schmidt, Jacqueline
  • Studies in Physical Culture & Tourism; 2006, Vol. 13 Issue 1, p69-77, 9p
Subjects
PHYSICAL fitness, OLDER people, EXERCISE, and ATTITUDE (Psychology)
Abstract
In Spain today, few studies have been carried out to provide sufficient information regarding the attitudes of older persons toward physical activity and exercise. The present study was designed to remedy this deficiency by adapting and validating the Older Person's Attitudes Toward Physical Activity and Exercise Questionnaire. Firstly, a panel of experts offered first hand evidence in support of the content validity of the Spanish adaptation of the questionnaire. Evidence regarding the viability of the instrument was obtained through a test-retest pilot study and with the use of internal consistency method. In line with theoretical expectations, respondents who reported more positive attitudes toward physical activity showed better adherence rates. Finally, recommendations for future replications are discussed, considering the fact that the data on predictive validity of the instrument was obtained only at correlational level. [ABSTRACT FROM AUTHOR]

82. Corrigendum to “Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors” [Bioorg. Med. Chem. Lett. 16 (2006) 1643–1646] [2006]

  • Smith, Leon, Piatnitski, Evgueni L., Kiselyov, Alexander S., Ouyang, Xiaohu, Chen, Xiaoling, Burdzovic-Wizemann, Sabina, Xu, Yongjiang, Pan, Weitao, Chen, Xin, Wang, Ying, Rosler, Robin L., Patel, Sheetal N., Chiang, Hui-Hsien, Milligan, Daniel L., Columbus, John, Wong, Wai C., Doody, Jacqueline F., and Hadari, Yaron R.
  • Bioorganic & Medicinal Chemistry Letters. Jul2006, Vol. 16 Issue 14, p3869-3869. 1p.

83. Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase [2006]

  • Smith, Leon, Wong, Wai C., Kiselyov, Alexander S., Burdzovic-Wizemann, Sabina, Mao, Yunyu, Xu, Yongjiang, Duncton, Matthew A.J., Kim, Ki, Piatnitski, Evgueni L., Doody, Jacqueline F., Wang, Ying, Rosler, Robin L., Milligan, Daniel, Columbus, John, Balagtas, Chris, Lee, Sui Ping, Konovalov, Andrey, and Hadari, Yaron R.
  • Bioorganic & Medicinal Chemistry Letters. Oct2006, Vol. 16 Issue 19, p5102-5106. 5p.
Subjects
DIAZEPINES, EPIDERMAL growth factor, CYTOKINES, and PROTEIN-tyrosine kinases
Abstract
Abstract: Novel tricyclic derivatives containing an oxazepine, thiazepine, or diazepine ring were studied for their EGFR tyrosine kinase inhibitory activity. While the oxazepines were in general more potent than thiazepines, the diazepines displayed somewhat different structure–activity relationships. Moreover, the diazepines, in contrast to the oxazepines, showed appreciable inhibitory activity against the KDR tyrosine kinase. Furthermore, both oxazepines and diazepines demonstrated significant ability to inhibit autophosphorylation of EGFR in DiFi cells (generally, IC50 values in the single-digit micromolar to submicromolar range). [Copyright &y& Elsevier]

84. Lessons Learned Combining N-of-1 Trials to Assess Fibromyalgia Therapies [2006]

  • ZUCKER, DEBORAH, RUTHAZER, ROBIN, SCHMID, CHRISTOPHER, FEUER, JACQUELINE, FISCHER, PETER, KIEVAL, RAPHAEL, MOGAVERO, NICOLA, RAPOPORT, RONALD, SELKER, HARRY, STOTSKY, SHARON, WINSTON, EILEEN, and GOLDENBERG, DON
  • Journal of Rheumatology; October 2006, Vol. 33 Issue: 10 p2069-2077, 9p
Abstract
OBJECTIVE: Applying population research to individual treatment requires understanding the connections between patient-specific characteristics, population-based studies, and treatment responses. Conducting practice-based research using individual-focused (N-of-1) trials may aid this process. We combined N-of-1 trials to compare fibromyalgia therapies and to assess the feasibility and outcomes of this approach for practice-based effectiveness research. METHODS: Community- and center-based rheumatologists enrolled patients with fibromyalgia syndrome in randomized, double-blind, multi-crossover, N-of-1 trials comparing amitriptyline and the combination amitriptyline and fluoxetine. Fibromyalgia Impact Questionnaire outcomes were used for the individuals' treatment and combined across patients for sample-based analyses. Outcomes were compared with results from more standard trial designs. RESULTS: Eight rheumatologists enrolled 58 patients in N-of-1 trials. Most physicians and patients had not previously participated in clinical trials. Using several analytic methods, the pooled results showed a better outcome score (mean difference: –6.1 ± 2.0 to –8.0 ± 3.7 points) in patients taking combination therapy. These population results are similar to published outcomes from a more traditional crossover trial. Neither practice type nor patient characteristics were significantly associated with the observed treatment-effect variation. Most participants, irrespective of selected treatment, felt their individual N-of-1 trials were helpful. CONCLUSION: Implementation of the combined N-of-1 methodology is feasible in rheumatology practices and results confirm greater fibromyalgia improvement with combination therapy. This research approach broadens participation, although our trials' specifics likely influenced enrollment eligibility. In addition to individual benefits, combining N-of-1 trial data provides population research benefits. This patient-focused approach should be further explored to bridge research and practice.

85. The Effectiveness and Efficiency of Home-Based Nursing Health Promotion for Older People: A Review of the Literature. [2006]

  • Markle-Reid, Maureen, Browne, Gina, Weir, Robin, Gafni, Amiram, Roberts, Jacqueline, and Henderson, Sandra R.
  • Medical Care Research & Review. Oct2006, Vol. 63 Issue 5, p531-569. 39p. 2 Diagrams, 3 Charts.
Subjects
COMMUNITY health nurses, HEALTH promotion, HOME care of older people, HOME care services, and COMMUNITY health services
Abstract
Despite the large potential role that community nurses have in providing individualized health promotion to older people, there is a lack of consensus in the literature regarding this role's effectiveness and efficiency. This article presents a literature review and synthesis of 12 randomized controlled trials selected from 344 published studies on preventive home visitation programs for older people. The findings suggest that a diversity of home visiting interventions carried out by nurses can favorably affect health and functional status, mortality rates, use of hospitalization and nursing homes, and costs. Further research is needed that focuses on the outcomes of quality of life, mental health, social support, caregiver burden, the acceptability of intervention, and specific subgroups of clients who benefit most. Findings also indicate the need for a theoretical foundation, increased emphasis on health-promotion strategies, and more research using a more complete economic evaluation to establish efficiency. [ABSTRACT FROM AUTHOR]

86. The world trade center disaster and the health of workers: five-year assessment of a unique medical screening program [2006]

  • Herbert, Robin, Moline, Jacqueline, Skloot, Gwen, Metzger, Kristina, Baron, Sherry, Luft, Benjamin, Markowitz, Steven, Udasin, Iris, Harrison, Denise, Stein, Diane, Todd, Andrew, Enright, Paul, Stellman, Jeanne Mager, Landrigan, Philip J., and Levin, Stephen M.
  • Environmental Health Perspectives. Dec 2006, Vol. 114 Issue 12, p1853, 6 p.

87. WTC five-year assessment: Herbert et al. respond [2007]

  • Herbert, Robin, Skloot, Gwen, Metzger, Kristina, Landrigan, Philip J., Moline, Jacqueline, Stein, Diane, Todd, Andrew, Levin, Stephen M., Baron, Sherry, and Udasin, Iris
  • Environmental Health Perspectives. Feb 2007, Vol. 115 Issue 2, pA72, 2 p.

88. Genetic and environmental influences on prereading skills and early reading and spelling development in the United States, Australia, and Scandinavia [2007]

  • Samuelsson, Stefan, Olson, Richard, Wadsworth, Sally, Corley, Robin, DeFries, John C., Willcutt, Erik, Hulslander, Jacqueline, and Byrne, Brian
  • Reading and Writing. Feb, 2007, Vol. 20 Issue 1, p51, 25 p.

89. Longitudinal twin study of early literacy development: Preschool through Grade 1 [2007]

  • Byrne, Brian, Samuelsson, Stefan, Wadsworth, Sally, Hulslander, Jacqueline, Corley, Robin, DeFries, John C., Quain, Peter, Willcutt, Erik G., and Olson, Richard K.
  • Reading and Writing. Feb, 2007, Vol. 20 Issue 1, p77, 26 p.

90. Letters. [2007]

  • Fisher, Trevor, Karp, Jacqueline, Addington, Jim, Arrand, Peter, Cowley, George, Green, Colin, Hamel, Noel, Clark, Roy, Wendt, Robin, Sturgeon, Nicola, Reed, Jamie, Burns-Cox, Chris, and McKenna, Peter
  • New Statesman. 5/21/2007, Vol. 136 Issue 4845, p6-7. 2p. 1 Illustration.
Subjects
LETTERS to the editor
Abstract
Several letters to the editor are presented in response to articles in previous issues including an editorial, a column by John Pilger concerning Robert F. Kennedy and Gordon Brown and the article "Inside Track" by Philip Gould. All of these items appeared in the May 14, 2007 issue.

91. Clinical features of the DOK7 neuromuscular junction synaptopathy. [2007]

  • Jacqueline Palace, Daniel Lashley, John Newsom-Davis, Judy Cossins, Susan Maxwell, Robin Kennett, Sandeep Jayawant, Yuji Yamanashi, and David Beeson
  • Brain: A Journal of Neurology. Jun2007, Vol. 130 Issue 6, p1507-1507. 1p.
Subjects
NEUROMUSCULAR diseases, HUMAN chromosome abnormality diagnosis, GENETIC mutation, and GENETIC testing
Abstract
Mutations in DOK7 have recently been shown to underlie a recessive congenital myasthenic syndrome (CMS) associated with small simplified neuromuscular junctions (‘synaptopathy’) but normal acetylcholine receptor and acetylcholinesterase function. We identified DOK7 mutations in 27 patients from 24 kinships. Mutation 1124_1127dupTGCC was common, present in 20 out of 24 kinships. All patients were found to have at least one allele with a frameshift mutation in DOK7 exon 7, suggesting that loss of function(s) associated with the C-terminal region of Dok-7 underlies this disorder. In 15 patients, we were able to study the clinical features in detail. Clinical onset was usually characterized by difficulty in walking developing after normal motor milestones. Proximal muscles were usually more affected than distal, leading to a ‘limb-girdle’ pattern of weakness; although ptosis was often present from an early age, eye movements were rarely involved. Patients did not show long-term benefit from anticholinesterase medication and sometimes worsened, and where tried responded to ephedrine. The phenotype can be distinguished from ‘limb-girdle’ myasthenia associated with tubular aggregates, where DOK7 mutations were not detected and patients respond to anticholinesterase treatments. CMS due to DOK7 mutations are common within our UK cohort and is likely to be under-diagnosed; recognition of the phenotype will help clinical diagnosis, targeted genetic screening and appropriate management. [ABSTRACT FROM AUTHOR]

92. Genome-wide association study identifies novel breast cancer susceptibility loci [2007]

  • Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D. P., Thompson, Deborah, Ballinger, Dennis G., Struewing, Jeffery P., Morrison, Jonathan, Field, Helen, Luben, Robert, Wareham, Nicholas, Ahmed, Shahana, Healey, Catherine S., Bowman, Richard, Luccarini, Craig, Conroy, Don, Shah, Mitul, Munday, Hannah, Jordan, Clare, Perkins, Barbara, West, Judy, Redman, Karen, Driver, Kristy, Meyer, Kerstin B., Haiman, Christopher A., Kolonel, Laurence K., Henderson, Brian E., Le Marchand, Loic, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Eccles, Diana, Evans, D. Gareth, Peto, Julian, Fletcher, Olivia, Johnson, Nichola, Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Chenevix-Trench, Georgia, Bojesen, Stig E., Nordestgaard, Borge G., Axelsson, Christen K., Garcia-Closas, Montserrat, Brinton, Louise, Chanock, Stephen, Lissowska, Jolanta, Peplonska, Beata, Nevanlinna, Heli, Fagerholm, Rainer, Eerola, Hannaleena, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Cox, David G., Hall, Per, Wedren, Sara, Liu, Jianjun, Low, Yen-Ling, Bogdanova, Natalia, Schurmann, Peter, Dork, Thilo, Tollenaar, Rob A. E. M., Jacobi, Catharina E., Devilee, Peter, Klijn, Jan G. M., Sigurdson, Alice J., Doody, Michele M., Alexander, Bruce H., Zhang, Jinghui, Cox, Angela, Brock, Ian W., MacPherson, Gordon, Reed, Malcolm W. R., Couch, Fergus J., Goode, Ellen L., Olson, Janet E., Meijers-Heijboer, Hanne, van den Ouweland, Ans, Uitterlinden, Andre, Rivadeneira, Fernando, Milne, Roger L., Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Hopper, John L., McCredie, Margaret, Southey, Melissa, Giles, Graham G., Schroen, Chris, Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, kConFab, Aghmesheh, Morteza, Amor, David, Andrews, Lesley, Antill, Yoland, Armes, Jane, Armitage, Shane, Arnold, Leanne, Balleine, Rosemary, Begley, Glenn, Beilby, John, Bennett, Ian, Bennett, Barbara, Berry, Geoffrey, Blackburn, Anneke, Brennan, Meagan, Brown, Melissa, Buckley, Michael, Burke, Jo, Butow, Phyllis, Byron, Keith, Callen, David, Campbell, Ian, Clarke, Christine, Colley, Alison, Cotton, Dick, Cui, Jisheng, Culling, Bronwyn, Cummings, Margaret, Dawson, Sarah-Jane, Dixon, Joanne, Dobrovic, Alexander, Dudding, Tracy, Edkins, Ted, Eisenbruch, Maurice, Farshid, Gelareh, Fawcett, Susan, Field, Michael, Firgaira, Frank, Fleming, Jean, Forbes, John, Friedlander, Michael, Gaff, Clara, Gardner, Mac, Gattas, Mike, George, Peter, Giles, Graham, Gill, Grantley, Goldblatt, Jack, Greening, Sian, Grist, Scott, Haan, Eric, Harris, Marion, Hart, Stewart, Hayward, Nick, Hopper, John, Humphrey, Evelyn, Jenkins, Mark, Jones, Alison, Kefford, Rick, Kirk, Judy, Kollias, James, Kovalenko, Sergey, Lakhani, Sunil, Leary, Jennifer, Lim, Jacqueline, Lindeman, Geoff, Lipton, Lara, Lobb, Liz, Maclurcan, Mariette, Mann, Graham, Marsh, Deborah, McKay, Michael, Anne McLachlan, Sue, Meiser, Bettina, Milne, Roger, Mitchell, Gillian, Newman, Beth, O'Loughlin, Imelda, Osborne, Richard, Peters, Lester, Phillips, Kelly, Price, Melanie, Reeve, Jeanne, Reeve, Tony, Richards, Robert, Rinehart, Gina, Robinson, Bridget, Rudzki, Barney, Salisbury, Elizabeth, Sambrook, Joe, Saunders, Christobel, Scott, Clare, Scott, Elizabeth, Scott, Rodney, Seshadri, Ram, Shelling, Andrew, Spurdle, Amanda, Suthers, Graeme, Taylor, Donna, Tennant, Christopher, Thorne, Heather, Townshend, Sharron, Tucker, Kathy, Tyler, Janet, Venter, Deon, Visvader, Jane, Walpole, Ian, Ward, Robin, Waring, Paul, Warner, Bev, Warren, Graham, Watson, Elizabeth, Williams, Rachael, Wilson, Judy, Winship, Ingrid, Young, Mary Ann, AOCS Management Group, Bowtell, David, Green, Adele, deFazio, Anna, Gertig, Dorota, Webb, Penny, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Hartikainen, Jaana, Day, Nicholas E., Cox, David R., and Ponder, Bruce A. J.
  • Nature. June 28, 2007, Vol. 447 Issue 7148, p1087, 7 p.

93. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [2007]

  • Adewumi, Oluseun, Aflatoonian, Behrouz, Ahrlund-Richter, Lars, Amit, Michal, Andrews, Peter W, Beighton, Gemma, Bello, Paul A, Benvenisty, Nissim, Berry, Lorraine S, Bevan, Simon, Blum, Barak, Brooking, Justin, Chen, Kevin G, Choo, Andre B H, Churchill, Gary A, Corbel, Marie, Damjanov, Ivan, Draper, Jon S, Dvorak, Petr, Emanuelsson, Katarina, Fleck, Roland A, Ford, Angela, Gertow, Karin, Gertsenstein, Marina, Gokhale, Paul J, Hamilton, Rebecca S, Hampl, Ales, Healy, Lyn E, Hovatta, Outi, Hyllner, Johan, Imreh, Marta P, Itskovitz-Eldor, Joseph, Jackson, Jamie, Johnson, Jacqueline L, Jones, Mark, Kee, Kehkooi, King, Benjamin L, Knowles, Barbara B, Lako, Majlinda, Lebrin, Franck, Mallon, Barbara S, Manning, Daisy, Mayshar, Yoav, Mckay, Ronald D G, Michalska, Anna E, Mikkola, Milla, Mileikovsky, Masha, Minger, Stephen L, Moore, Harry D, Mummery, Christine L, Nagy, Andras, Nakatsuji, Norio, O'Brien, Carmel M, Oh, Steve K W, Olsson, Cia, Otonkoski, Timo, Park, Kye-Yoon, Passier, Robert, Patel, Hema, Patel, Minal, Pedersen, Roger, Pera, Martin F, Piekarczyk, Marian S, Pera, Renee A Reijo, Reubinoff, Benjamin E, Robins, Allan J, Rossant, Janet, Rugg-Gunn, Peter, Schulz, Thomas C, Semb, Henrik, Sherrer, Eric S, Siemen, Henrike, Stacey, Glyn N, Stojkovic, Miodrag, Suemori, Hirofumi, Szatkiewicz, Jin, Turetsky, Tikva, Tuuri, Timo, van den Brink, Steineke, Vintersten, Kristina, Vuoristo, Sanna, Ward, Dorien, Weaver, Thomas A, Young, Lesley A, and Zhang, Weidong
  • Nature Biotechnology. July 2007, Vol. 25 Issue 7, p803, 14 p.

94. Developmental changes in object control skills as a result of motor intervention in disadvantaged preschoolers. [2007]

  • Robinson, Leah E., Goodway, Jacqueline D., Dunn, Robin, Johnson, Erica, and Devins, Lori
  • Journal of Sport & Exercise Psychology. Jul2007 Supplement, Vol. 29, pS42-S43. 2p.
Subjects
HEALTH of poor children, MOTOR ability in children, PHYSIOLOGICAL control systems, LOCOMOTOR control, AFRICAN American children, MOTOR ability -- Research, SOCIOECONOMIC factors, and PHYSIOLOGY
Abstract
Children from poor, urban, and disadvantaged environments often demonstrate poor motor skill competence in both object control (OC) and locomotor skills (Goodway & Rudisill, 1996; Hamilton et al., 1999). This study examined the motor skill competence of disadvantaged, African American preschoolers. Further, it investigated the effects of a 9-week OC intervention on OC competence. Two instructional approaches were compared: low autonomy (LA) consisting of direct-instruction and a mastery motivational climate (MMC). Participants were randomly assigned to a LA (n = 36), MMC (n = 38), or comparison (no motor intervention) group (n = 39). The LA and MMC groups participated in 18 30-min OC sessions and the comparison group participated in the same amount of unstructured recess. All children were pre-and posttested on the OC subscale of the TGMD-2 (Ulrich, 2001). Preintervention OC competence was low based on percentile ranks (LA = 23%, MMC = 20%, comparison = 20%). A 3 (Group) x 2 (Sex) ANOVA on pre-OC scores revealed no significant group differences (p = .90) or Group x Sex interaction (p = .60). However, a significant sex main effect was found with boys having greater OC competence than girls, F(1, 107) = 29.34, p < .001. A 3 (Group) x 2 Time x 2 (Sex) ANOVA with repeated measures revealed a significant Group x Time interaction, F(2, 107) = 210.97, p < .001, indicating the OC intervention was effective. Post hoc Tukey HSD analysis reported the LA (p ≤ = < .001) and MMC (p ≤ = < .001) groups had significantly better OC competence than the Comparison group from pre- to postintervention. There was no difference between the LA and MMC groups (p = .88). A nonsignificant Group x Time x Sex interaction (p = .94) showed that there were no sex differences within groups from pre- to postintervention. Clearly, disadvantaged preschoolers had low OC competence and needed motor intervention. When instruction was provided by either LA or MMC, preschool children improved their OC skills. [ABSTRACT FROM AUTHOR]

95. Reducing Fall Risk for Frail Older Home-Care Clients Using a Multifactorial and Interdisciplinary Team Approach [2007]

  • Markle-Reid, Maureen, Henderson, Sandra, Hecimovich, Catherine, Baxter, Pamela, Anderson, Malcolm, Browne, Gina, Weir, Robin, Gafni, Amiram, and Roberts, Jacqueline
  • Journal of Patient Safety; September 2007, Vol. 3 Issue: 3 p149-157, 9p
Abstract
This article describes the background and design of a study that is currently in progress. The objective of the study is to evaluate the 6-month effects and costs of a multifactorial and interdisciplinary team approach to fall prevention compared with usual home care for frail older people at risk for falls. The barriers and facilitators to implementing an interdisciplinary team approach in home care will also be discussed.

96. Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding. [2007]

  • Lianghua Bin, Thorburn, Jacqueline, Thomas, Lance R., Clark, Peter E., Humphreys, Robin, and Thorburn, Andrew
  • Journal of Biological Chemistry. 9/21/2007, Vol. 282 Issue 38, p28189-28194. 6p.
Subjects
CYTOKINES, CELLULAR immunity, APOPTOSIS, CELL death, GENETIC mutation, and LIGANDS (Biochemistry)
Abstract
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a cytokine that preferentially induces apoptosis in tumor cells compared with normal cells through two receptors (DR4 and DR5). Somatic mutations in these receptors have been found in different kinds of cancer; however, it is poorly under- stood how the mutations affect signaling. We found that point mutations (L334F, E326K, E338K, and K386N) that were identified in human tumors result in the DR5 receptor losing its ability to form a functional death-inducing signaling complex and induce apoptosis. The mutant receptors also have a ‘dominant negative’ effect whereby they inhibit the ability of TRAIL to induce apoptosis through functional DR4 receptors. This dominant negative mechanism is achieved through competition for TRAIL binding as shown by experiments where the ability of the mutant DR5 receptor to bind with the ligand was abolished, thus restoring TRAIL signaling through DR4. The inhibitory effect on signaling through the wild-type DR4 protein can be overcome if the inhibitory mechanism is bypassed by using a DR4-agonistic antibody that is not subject to this competition. This study provides a molecular basis for the use of specific therapeutic agonists of TRAIL receptors in people whose tumors harbor somatic DR5 mutations. [ABSTRACT FROM AUTHOR]

97. African-Caribbean cancer consortium for the study of viral, genetic and environmental cancer risk factors [2007]

  • Ragin, Camille C., Taioli, Emanuela, McFarlane-Anderson, Norma, Avery, Gordon, Bennett, Franklyn, Bovell-Benjamin, Adelia, Thompson, Angela Brown, Carrington, Agatha, Campbell-Everett, Lydia, Ford, Jacqueline, Hennis, Anselm, Jackson, Maria, Lake, Sandra, Leske, M Cristina, Magai, Carol, Nemesure, Barbara, Neugut, Alfred, Odedina, Folakemi, Okobia, Michael, Patrick, Alan, Plummer, Wallis Best, Reams, R Renee, Roberts, Robin, Scott-Hastings, Sharaneen, Sharma, Sangita, Wheeler, Victor, Wu, Suh-Yuh, and Bunker, Clareann
  • Infectious Agents and Cancer. Sept 24, 2007, Vol. 2, 17

98. The New University of Colorado Medical School Curriculum: A Pediatric Perspective. [2007]

  • Deterding, Robin R., Wong, Shale, Faries, Glenn, Glover, Jacqueline J., Garrington, Timothy P., Wang, Michael, Anderson, Marsha S., and Krugman, Richard D.
  • Journal of Pediatrics; Nov2007, Vol. 151 Issue 5, pS32-S36, 0p
Abstract
The University of Colorado School of Medicine has developed an innovative 4-year undergraduate curriculum. As a strong advocate for education and curriculum reform, Dr M. Douglas Jones Jr. created an environment for pediatrics to flourish in this new curriculum. Pediatric content has increased in all years of the curriculum, and pediatric faculty have had greater opportunities to teach and seek career development in medical education. In this report, we review the process that led to curriculum reform, provide an overview of the new curriculum design, and highlight examples of the positive impact this process has had on education in pediatrics. We hope that sharing our experience, may benefit others in medical education. [Copyright &y& Elsevier]

99. Bacteriocin producers from traditional food products. [2007]

  • Diop, Michel Bakar, Dubois-Dauphin, Robin, Tine, Emmanuel, Ngom, Abib, Destain, Jacqueline, and Thonart, Philippe
  • Biotechnologie, Agronomie, Societe et Environnement; 2007, Vol. 11 Issue 4, p275-281, 7p, 1 Black and White Photograph, 6 Charts, 1 Graph
Subjects
BACTERIOCINS, FERMENTED foods, LACTOCOCCUS lactis, ENTEROCOCCUS, and NUCLEOTIDE sequence
Abstract
Copyright of Biotechnologie, Agronomie, Societe et Environnement is the property of Les Presses Agronomiques de Gembloux and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

100. Reciprocal Regulation of Presynaptic and Postsynaptic Proteins in Bipolar Spiral Ganglion Neurons by Neurotrophins. [2007]

  • Flores-Otero, Jacqueline, Hui Zhong Xue, and Davis, Robin L.
  • Journal of Neuroscience. 12/19/2007, Vol. 27 Issue 51, p14023-14034. 12p. 1 Color Photograph, 1 Chart, 5 Graphs.
Subjects
PROTEINS, NEURONS, SENSE organs, AUDITORY pathways, SENSORY receptors, and COCHLEA
Abstract
A unifying principle of sensory system organization is feature extraction by modality-specific neuronal maps in which arrays of neurons show systematically varied response properties and receptive fields. Only beginning to be understood, however, are the mechanisms by which these graded systems are established. In the peripheral auditory system, we have shown previously that the intrinsic firing features of spiral ganglion neurons are influenced by brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). We now show that is but a part of a coordinated package of neurotrophin actions that also includes effects on presynaptic and postsynaptic proteins, thus encompassing the input, transmission, and output functions of the spiral ganglion neurons. Using immunocytochemical methods, we determined that proteins targeted to opposite ends of the neuron were organized and regulated in a reciprocal manner. AMPA receptor subunits GluR2 and GluR3 were enriched in base neurons compared with their apex counterparts. This distribution pattern was enhanced by exposure to BDNF but reduced by NT-3. SNAP-25 and synaptophysin were distributed and regulated in the mirror image: enriched in the apex, enhanced by NT-3 and reduced by BDNF. Moreover, we used a novel coculture to identify potential endogenous sources of neurotrophins by showing that sensory receptors from different cochlear regions were capable of altering presynaptic and postsynaptic protein levels in these neurons. From these studies, we suggest that BDNF and NT-3, which are systematically distributed in complementary gradients, are responsible for orchestrating a comprehensive set of electrophysiological specializations along the frequency contour of the cochlea. [ABSTRACT FROM AUTHOR]

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