articles+ search results

citizen science, Crowsnest Pass, highways, road ecology, transportation, web-based GIS, wildlife-vehicle collisions, Biology (General), QH301-705.5, Ecology, and QH540-549.5

Road Watch in the Pass is a citizen-science project that engages local citizens in reporting wildlife observations along a 44-km stretch of Highway 3 through Crowsnest Pass in southwestern Alberta, Canada. The numbers of wildlife vehicle collisions and a recent proposal to expand the highway have raised concerns from both human safety and wildlife conservation perspectives. Through the use of a web-based GIS, interested citizens can contribute information that will be instrumental in making final decisions concerning measures to mitigate the effects of highway expansion. Currently, 58 people have contributed over 713 observations to Road Watch. We performed a preliminary comparison of 11 months of Road Watch observations and wildlife mortality data for the same time period to demonstrate that the use of citizen science not only augments more conventional approaches, but also results in the emergence of new knowledge and insights. A Kappa index of agreement of 14% indicates poor agreement between the data sets, highlighting that wildlife successfully cross the highway in areas not identified by the wildlife mortality data. This has important implications for design and mitigation efforts for Highway 3 and other roadways.

Réseau social, Social network, Red social, Vie privée, Private life, Vida privada, Vie publique, Sciences exactes et technologie, Exact sciences and technology, Sciences et techniques communes, Sciences and techniques of general use, Sciences de l'information. Documentation, Information science. Documentation, Technologie de la communication et de l'information, Information and communication technologies, Technologies de l'information: supports, équipements, Information technologies: storage media, equipment, Applications (par exemple: numérisation,...), Applications (e.g. Digitizing,...), Ressources internet (portails, blogs, wikis,...), Internet resources (portals, blogs, wikis,...), Sciences de l'information et de la communication, Information and communication sciences, Applications, Ressources internet (portails, blogs, wikis,…), Internet resources (portals, blogs, wikis,…), Sciences de l'information communication, and Documentation

[ point de vue ] Les nouveaux médias numériques ontsensiblementmodifiél'acceptiontraditionnelledes concepts de vie privée et de vie publique. Née du développement des réseaux sociaux, cette rupture a généré de nouvelles « sphères publiques médiatées » au sein desquelles se déploie désormais une part de notre vie quotidienne. Une évolution de l'espace public qui appelle un accompagnement des jeunes, particulièrement présents et investis dans ces réseaux numériques.

Homme, Human, Hombre, Adolescent, Adolescente, Harcèlement moral, Psychological harassment, Acoso moral, Internet, Intimidation, Bullying, intimidación, Méthode mesure, Measurement method, Método medida, Méthodologie, Methodology, Metodología, Technologie information communication, Information communication technology, Nueva tecnología información comunicación, Victimisation, Victimization, Victimización, Cyberbullying, Measurement, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Psychopathologie. Psychiatrie, Psychopathology. Psychiatry, Techniques et méthodes, Techniques and methods, Méthodologie. Expérimentation, Methodology. Experimentation, Psychologie. Psychanalyse. Psychiatrie, Psychology. Psychoanalysis. Psychiatry, PSYCHOPATHOLOGIE. PSYCHIATRIE, Pediatrics, Pédiatrie, Psychology, psychopathology, psychiatry, and Psychologie, psychopathologie, psychiatrie

Purpose: To inform the scientific debate about bullying, including cyberbullying, measurement. Methods: Two split-form surveys were conducted online among 6―17-year-olds (n = 1,200 each) to inform recommendations for cyberbullying measurement. Results: Measures that use the word bully result in prevalence rates similar to each other, irrespective of whether a definition is included, whereas measures not using the word bully are similar to each other, irrespective of whether a definition is included. A behavioral list of bullying experiences without either a definition or the word bully results in higher prevalence rates and likely measures experiences that are beyond the definition of bullying. Follow-up questions querying differential power, repetition, and bullying over time were used to examine misclassification. The measure using a definition but not the word bully appeared to have the highest rate of false positives and, therefore, the highest rate of misclassification. Across two studies, an average of 25% reported being bullied at least monthly in person compared with an average of 10% bullied online, 7% via telephone (cell or landline), and 8% via text messaging. Conclusions: Measures of bullying among English-speaking individuals in the United States should include the word bully when possible. The definition may be a useful tool for researchers, but results suggest that it does not necessarily yield a more rigorous measure of bullying victimization. Directly measuring aspects of bullying (i.e., differential power, repetition, over time) reduces misclassification. To prevent double counting across domains, we suggest the following distinctions: mode (e.g., online, in-person), type (e.g., verbal, relational), and environment (e.g., school, home). We conceptualize cyberbullying as bullying communicated through the online mode.

Activisme, Activism, Féminisme, Feminism, Internet, Mouvement, Movement, Notes de terrain, Fieldnotes, Prostitution, Réseau, Network, Trafic, Traffic, Tráfico, Feminist STS, Internet studies, Network studies, Sex trafficking, Ethnologie, Ethnology, Structure et relations sociales, Social structure and social relations, Relations sociales. Relation interculturelles et interethniques. Identité collective, Social relations. Intercultural and interethnic relations. Collective identity, Amérique, America, Cognition, Social anthropology and ethnology, and Anthropologie sociale et ethnologie

In this essay, we offer field notes from our ongoing ethnographic research on sex trafficking in the United States. Recent efforts to regulate websites such as Craigslist and Backpage have illuminated activist concerns regarding the role of networked technologies in the trafficking of persons and images for the purposes of sexual exploitation. We frame our understanding of trafficking and technology through a network studies approach, by describing anti-trafficking as a counter-network to the sex trafficking it seeks to address. Drawing from the work of Annelise Riles and other scholars of feminist science and technology studies, we read the anti-trafficking network through the production of expert knowledge and the crafting of anti-trafficking techniques. By exploring anti-trafficking activists' understandings of technology, we situate the activities of anti-trafficking experts and law enforcement as efforts toward network stabilization.

Homme, Human, Hombre, Interaction sociale, Social interaction, Interacción social, Adolescent, Adolescente, Communication médiatisée ordinateur, Computer mediated communication, Communicación mediatizada computador, Comportement rendez vous, Dating behavior, Conducta cita, Messagerie instantanée, Instant messaging, Mensajería instantánea, Trouble du comportement social, Social behavior disorder, Trastorno comportamiento social, Violence, Violencia, Sciences exactes et technologie, Exact sciences and technology, Sciences appliquees, Applied sciences, Informatique, automatique theorique, systemes, Computer science, control theory, systems, Logiciel, Software, Systèmes informatiques et systèmes répartis. Interface utilisateur, Computer systems and distributed systems. User interface, Sciences biologiques et medicales, Biological and medical sciences, Sciences medicales, Medical sciences, Psychopathologie. Psychiatrie, Psychopathology. Psychiatry, Etude clinique de l'adulte et de l'adolescent, Adult and adolescent clinical studies, Troubles du comportement social. Comportement criminel. Délinquance, Social behavior disorders. Criminal behavior. Delinquency, Psychologie. Psychanalyse. Psychiatrie, Psychology. Psychoanalysis. Psychiatry, PSYCHOPATHOLOGIE. PSYCHIATRIE, Psychology, psychopathology, psychiatry, and Psychologie, psychopathologie, psychiatrie

Teen dating violence (TDV) is a serious form of youth violence that youth fairly commonly experience. Although youth extensively use computer-mediated communication (CMC), the epidemiology of CMC-based TDV is largely unknown. This study examined how perpetration of psychological TDV using CMC compares and relates to perpetration using longer-standing modes of communication (LSMC; e.g., face-to-face). Data from the national Growing up with Media study involving adolescents aged 14―19 collected from October 2010 to February 2011 and analyzed May 2012 are reported. Analyses focused on adolescents with a history of dating (n = 615). Forty-six percent of youth daters had perpetrated psychological TDV. Of those who perpetrated in the past 12 months, 58% used only LSMC, 17% used only CMC, and 24% used both. Use of both CMC and LSMC was more likely among perpetrators who used CMC than among perpetrators who used LSMC. In addition, communication mode and type of psychological TDV behavior were separately related to frequency of perpetration. Finally, history of sexual intercourse was the only characteristic that discriminated between youth who perpetrated using different communication modes. Results suggest that perpetration of psychological TDV using CMC is prevalent and is an extension of perpetration using LSMC. Prevention should focus on preventing perpetration of LSMC-based TDV as doing so would prevent LSMC as well as CMC-based TDV.

Sciences exactes et technologie, Exact sciences and technology, Sciences et techniques communes, Sciences and techniques of general use, Sciences de l'information. Documentation, Information science. Documentation, Sciences de l'information et des bibliothèques. Etude d'ensemble, Library and information science. General aspects, Bibliométrie. Scientométrie. Evaluation, Bibliometrics. Scientometrics. Evaluation, Sciences de l'information et de la communication, Information and communication sciences, Bibliométrie. Scientométrie, Bibliometrics. Scientometrics, Cognition, Documentation, Computer science, and Informatique

When information practices are understood to be shaped by social context, privilege and marginalization alternately affect not only access to, but also use of information resources. In the context of information, privilege, and community, politics of marginalization drive stigmatized groups to develop collective norms for locating, sharing, and hiding information. In this paper, we investigate the information practices of a subcultural community whose activities are both stigmatized and of uncertain legal status: the extreme body modification community. We use the construct of information poverty to analyze the experiences of 18 people who had obtained, were interested in obtaining, or had performed extreme body modification procedures. With a holistic understanding of how members of this community use information, we complicate information poverty by working through concepts of stigma and community norms. Our research contributes to human information behavior scholarship on marginalized groups and to Internet studies research on how communities negotiate collective norms of information sharing online.

Strategic Risk Reduction, Strategic Method, Defect Detection and Prevention, Risk Reduction Leverage, Ant Colony Optimization, Electronic computers. Computer science, and QA75.5-76.95

Risk Management is one of the key cares of any organization strategic management; proper benefit of risk management is finding risks and their solutions. In this article, we will suggest a new Strategic Risk Reduction technique for producing optimal risk reduction strategies; which reduce risk exposure for expected income by allowing several countermeasures per risk rather than one countermeasure as previous works did. Our Strategic Risk Reduction will be optimized using Ant Colony Optimization approach.

Communication. Mass media and P87-96

The phenomenon of “social media” has more to do with its cultural positioning than its technological affordances. Rooted in the broader “Web 2.0” landscape, social media helped engineers, entrepreneurs, and everyday people reimagine the role that technology could play in information dissemination, community development, and communication. While the technologies invoked by the phrase social media have a long history, what unfolded in the 2000s reconfigured socio-technical practices in significant ways. Reflecting on the brief history of social media, this essay argues for the need to better understand this phenomenon.

Geography. Anthropology. Recreation, Folklore, and GR1-950

Medicine

Background and objectives: In Kuwait, information regarding public knowledge and attitudes towards organ donation are scanty. This study aimed to evaluate public knowledge and attitude regarding organ donation and determine factors which predict them. Methods: This cross-sectional study was conducted among 630 participants recruited from 27 randomly selected public cooperative societies and private supermarkets in Kuwait. A self-administered questionnaire was used to collect data. Results: The prevalence rate of knowledge about organ donation was 68%, with a significantly higher rate among females than males (73% vs. 63%, respectively, p = 0.01). A composite score of knowledge was also higher among females than males (8.4 ± 5.8 vs. 6.8 ± 5.8, respectively, p = 0.001). In multivariate analysis, female gender (OR = 1.7; 95% CI =1.2, 2.4) and an educational level of bachelor’s degree or higher (OR = 2.6, 95% CI = 1.7, 3.9) were significant predictors of the knowledge. Among the barriers, more females than males mentioned about the fear of the operative procedures (p

Medicine and Science

INTRODUCTION:Polyneuropathy is one of the most prevalent neurologic disorders. Although several studies explored the role of the neurological examination in polyneuropathy, they were mostly restricted to specific subgroups of patients and have not correlated examination findings with symptoms and electrophysiological results. OBJECTIVES:To explore the sensitivity and specificity of different neurological examination components in patients with diverse etiologies for polyneuropathy, find the most sensitive combination of examination components for polyneuropathy detection, and correlate examination findings with symptoms and electrophysiological results. METHODS:Patients with polyneuropathy attending the neuromuscular clinic from 01/2013 to 09/2015 were evaluated. Inclusion criteria included symptomatic polyneuropathy, which was confirmed by electrophysiological studies. 47 subjects with no symptoms or electrophysiological findings suggestive for polyneuropathy, served as controls. RESULTS:The total cohort included 312 polyneuropathy patients, with a mean age of 60±14 years. Abnormal examination was found in 95%, most commonly sensory findings (86%). The most common abnormal examination components were impaired ankle reflexes (74%), vibration (73%), and pinprick (72%) sensation. Combining ankle reflex examination with vibration or pinprick perception had the highest sensitivity, of 88%. The specificities of individual examination component were generally high, excluding ankle reflexes (62%), and vibration perception (77%). Abnormal examination findings were correlated with symptomatic weakness and worse electrophysiological parameters. CONCLUSION:The neurological examination is a valid, sensitive and specific tool for diagnosing polyneuropathy, and findings correlate with polyneuropathy severity. Ankle reflex examination combined with either vibration or pinprick sensory testing is the most sensitive combination for diagnosing polyneuropathy, and should be considered minimal essential components of the physical examination in patients with suspected polyneuropathy.

Biology (General) and QH301-705.5

Thioxoquinazolin-4(3H)-one, Anticancer activity, Antioxidant activity, Anticonvulsant activity, Molecular docking, Chemistry, and QD1-999

Abstract Background The quinazoline are an important class of medicinal compounds that possess a number of biological activities like anticancer, anticonvulsant and antioxidant etc. Results We evaluated the previously synthesized quinazoline derivatives 1–3 for their anticancer activities against three cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were found to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds had less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies were performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2, butyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking properties with the CDK2 as compared to the other two enzymes. Conclusions The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence of drug resistance, it is important to explore and develop more efficacious drugs.

Communication. Mass media and P87-96

While few studies examine the online privacy practices or attitudes of young people of low socio-economic status (SES), they are often at the most risk of and most susceptible to privacy violations. This participatory, collaborative study of 28 low-SES young adults in the New York City area investigates how they view online information sharing. Like most Americans, our participants viewed online privacy as an individual responsibility. We make two primary contributions. First, participants revealed extensive awareness of the risks of sharing information online, and many avoided social media, self-censored, or obfuscated their contributions as a result. Second, many participants had extensive experience with policing and physical surveillance and were aware they could not avoid such encounters through their own efforts. This window into structural discrimination provides an alternate frame to that of “individual responsibility” that educators and researchers can use to conceptualize how privacy is violated online. Framing online privacy violations as inevitable and widespread may not only help foster activist anger and strategic resistance but also avoid the victim-blaming narratives of some media literacy efforts. By examining the experiences of these young people, who are often left out of mainstream discussions about privacy, we hope to show how approaches to managing the interplay of on- and offline information flows are related to marginalized social and economic positions.

Affimer, antibody, assay, Medicine, Science, Biology (General), and QH301-705.5

Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many show excellent performance, although some are poorly characterised or have stability or batch variability issues, supporting the use of alternative binding proteins as complementary reagents for many applications. Here we report on the use of Affimer proteins as research reagents. We selected 12 diverse molecular targets for Affimer selection to exemplify their use in common molecular and cellular applications including the (a) selection against various target molecules; (b) modulation of protein function in vitro and in vivo; (c) labelling of tumour antigens in mouse models; and (d) use in affinity fluorescence and super-resolution microscopy. This work shows that Affimer proteins, as is the case for other alternative binding scaffolds, represent complementary affinity reagents to antibodies for various molecular and cell biology applications.

Medicine

BACKGROUND: Drug shortages are a serious and complex issue in any healthcare system. We conducted this study because the prevalence of drug shortages in Saudi Arabia is largely unknown, while there have been reports of shortages. OBJECTIVE: To explore the prevalence and characteristics of drug shortages as well as identify strategies to minimize their impact on patient care and safety in large hospitals. DESIGN: Questionnaire-based cross-sectional study. SETTING: Pharmacy departments in secondary and tertiary care hospitals in the city of Riyadh. SUBJECTS AND METHODS: Pharmacists in ten hospitals, categorized as Ministry of Health [MOH], MOH-affiliated medical cities, and non-MOH, were recruited using convenience sampling. The European Association of Hospital Pharmacists drug shortage questionnaire was administered to survey pharmacists about drug shortages in their hospitals. MAIN OUTCOME MEASURES: Percentages of drug class shortages, characteristics, and strategies to minimize impact on patient care and safety across each hospital sector. RESULTS: Of 200 pharmacists invited to participate, 120 pharmacists completed the questionnaire (60% response rate). Twenty-four percent were from MOH hospitals, 32% from MOH-affiliated medical cities, and 44% from non-MOH hospitals. A significantly higher percentage of pharmacists from MOH-affiliated medical cities (42.11%) reported encountering drug shortages on a daily basis compared to 13.79% and 15.09% of participants from MOH-hospitals and non-MOH hospitals, respectively (P=.001). The top three drug classes that ≥ 25% of participants reported having shortages of were cardiovascular, antineoplastic, and endocrine drugs. The two most common strategies that were reported to minimize the impact of drug shortages on patient care by more than 70% of participants were informing prescribers and recommending alternative drugs, and alerting hospital staff about the presence of drug shortages using new communication tools. CONCLUSIONS: The relatively high reported rates of drug shortages in some hospitals should encourage health policymakers to address this serious public health problem. LIMITATIONS: The generazibility of the study's findings were limited by the small sample size, convenience sampling technique, self-reported data, and the fact that only pharmacists were invited to participate.

General Works

Algorithms and data-driven technologies are increasingly being embraced by a variety of different sectors and institutions. This paper examines how algorithms and data-driven technologies, enacted by an organization like Facebook, can induce similarity across an industry. Using theories from organizational sociology and neoinstitutionalism, this paper traces the bureaucratic roots of Big Data and algorithms to examine the institutional dependencies that emerge and are mediated through data-driven and algorithmic logics. This type of analysis sheds light on how organizational contexts are embedded into algorithms, which can then become embedded within other organizational and individual practices. By investigating technical practices as organizational and bureaucratic, discussions about accountability and decision-making can be reframed.

creative thinking, innovation, action research, online activities, developmental learning, Special aspects of education, and LC8-6691

This essay describes one institution’s struggle to grow its EdD program by adding an equivalent online version of a successful face-to-face program. One of the challenges faced was that of creating a comparable experience for online students to share their ongoing action research, an activity that had long been part of the face-to-face version of the program. An innovative, all-day, virtual doctoral research conference was developed and implemented. We describe our creative rethinking of the original event, towards a new, successful, and fully-online redesigned event. Although the event continues to be refined, the inaugural event proved to be a successful solution to the challenge of transferring all components of a face-to-face program over to its online equivalent. Feedback from students who participated in the conference is shared, and recommendations for other EdD programs is offered.

pharmaceutical market, drugs, drug discovery, solid-phase peptide synthesis, Medicine, Pharmacy and materia medica, and RS1-441

2017 was an excellent year in terms of new drugs (chemical entities and biologics) approved by the FDA, with a total of 46. In turn, one of the highlights was the number of peptides (six) included in this list. Here, the six peptides are analyzed in terms of chemical structure, synthetic strategy used for their production, source, therapeutic use, and mode of action.

creativity, business, education, training, professional development, creative thinking, theories, arts, arts-based methods, innovation, Management. Industrial management, HD28-70, Business, and HF5001-6182

Creativity has become one of the most sought-after skills from graduates across business and industry. It is therefore imperative to infuse creativity training within business programs of study and professional development experiences, to remind people of their eternally curious and creative nature. The objective of this paper is to explore the literature around theories of creative potential and performance—including creative identity, creative mindset, and creative self-efficacy. We consider perspectives that reveal that creativity is a mindset predicated on beliefs and ways of thinking. Educational psychology literature and theories of creative self-belief illustrate how creative identity, mindset, and self-efficacy form the core of an individual’s belief system to think, act, and develop creatively in the world. This connects to the potential of arts-based methods as a means to infuse creative learning into business education. We illustrate how our findings can be put into practice by sharing an example of an art-based intervention that is currently in progress to develop creative capacity among students in an internationally known business program. We conclude with the idea that its incumbent upon business education, professional development, and training to incorporate methodologies that enhance creative capacity by initially eliminating or minimizing self-perceived limitations in people, such as fear, negative personal judgement, and chattering of the mind—and theories of creative self-belief provide a foundation that can undergird arts-based methods toward this goal.

Medicine

Objectives: This study aimed to determine the relationship between glycaemic control and carotid atherosclerotic disease among patients with acute ischaemic stroke (AIS). Methods: This retrospective cross-sectional study took place in the Neurology Department of King Fahad Hospital of University, Khobar, Saudi Arabia, from April to October 2017. Data were collected from the medical records of 244 patients with a diagnosis of AIS confirmed by computed tomography. Doppler ultrasounds of the carotid artery were performed to determine the presence of increased carotid intima media thickness (CIMT) and plaques. Results: Significantly higher mean glycated haemoglobin (HbA1c) levels were noted in cases with high CIMT values (P = 0.002), but not in cases with carotid plaques (P = 0.360). In addition, there was a significant association between diabetes mellitus (DM) and high CIMT (P = 0.045), but not with carotid plaques (P = 0.075). Finally, while dyslipidaemia and age were independently correlated with high CIMT values (P = 0.034 and 0.050 each). Conclusion: High HbA1c levels were associated with high CIMT values, but not with carotid plaques. Therefore, HbA1c levels may be useful as an indirect marker of the initial stages of carotid artery atherosclerosis. Keywords: Glycated Hemoglobin A1c; Diabetes Mellitus; Carotid Intima-Media Thickness; Atherosclerotic Plaque; Stroke.

college-age, female of childbearing age, isotretinoin, saudi arabia, Dermatology, and RL1-803

Background: The most effective treatment for severe acne is isotretinoin. However, it carries major side effects, such as teratogenicity, depression, and increased lipid profiles. It is advised to monitor the lipid profile and to use two forms of contraception during isotretinoin use. Although it is commonly prescribed, little data are available regarding patients' understanding of isotretinoin. Objectives: The aim of this study is to assess Saudi female college students' knowledge about isotretinoin use and side effects. Methods: Data were collected by a validated online questionnaire disseminated through social media, allowing the collection of information from students from different regions of the country. Results: The total number of responses was 622. The majority of respondents were 18–24 years old, single, and college students; all were female. About 48.6% (282) of the sample used isotretinoin. Most had good knowledge of isotretinoin side effects. Medical students were more knowledgeable than students of other majors, and users were more knowledgeable than nonusers. The most common side effect was dryness. Use among married females was 2.8%, the majority of whom were instructed by their physicians to use only one method of contraception. One respondent got pregnant while using the drug. Conclusion: College-aged females generally have good knowledge of isotretinoin and its side effects. However, awareness about proper contraceptive use while on the drug is lacking.

antiepileptic drugs, epilepsy, nonadherence, Neurosciences. Biological psychiatry. Neuropsychiatry, and RC321-571

Context: Medication nonadherence is a significant barrier in achieving seizure freedom in patients with epilepsy. There is a deficiency of data about the reasons for nonadherence in Saudi population. Aims: The aim of this study is to prove the existence of nonadherence to antiepileptic drugs (AEDs) in patients with epilepsy and identify the responsible factors. Setting and Design: This is a prospective, cross-sectional study carried in the Department of Neurology at King Fahd Hospital of the University affiliated with Imam Abdulrahman Bin Faisal University. Subjects and Methods: Patients of all ages diagnosed to have epilepsy as mentioned in their medical record and taking antiepileptic medications were interviewed using a questionnaire. Statistical Analysis Used: Statistical analysis was performed using IBM Statistical Package for the Social Sciences version 21 (IBM Corp., Armonk, NY, USA). Statistical significance was defined as two-tailed with a P ≤ 0.05. Results: Among 152 participants, 52.6% were male and 47.4% were female. Mean age of the patients was 28 ± 14.3 (mean ± standard deviation) years. Of 152 patients, 48.7% were found to be nonadherent to their AED therapy. The most commonly identified factor was forgetfulness. Nonadherence was significantly associated with poor seizure control (P = 0.002). Conclusion: Nonadherence to the AED is common among patients with epilepsy and affects seizure control adversely.

creative epistemologies, creative paradigms, creative thinking, creativity, creativity research, design, Social sciences (General), and H1-99

Designerly ways of knowing have significant untapped potential to inform creativity research. In this article, I draw upon in-depth interviews with expert design scholars to examine this connection. Thematic analysis reveals how design offers potential lenses on creativity that are not often taken up in dominant psychological discourses around creativity. I situate this by framing the need for design-based knowledge within creativity literature. The findings reflect a view of creativity involving perception, intuition, and ability to re-see the world; creativity as an action-orientated phenomenon; and a focus on the ethics of creativity in an increasingly technology-empowered society. In exploring scholarly definitions of and views about creativity, there are insights on how design offers distinctive viewpoints for paradigms around creativity. Santrauka Dizaineriško pažinimo būdai turi reikšmingų nepanaudotų galimybių praturtinti kūrybiškumo tyrinėjimus. Siekdama išnagrinėti šį ryšį, straipsnyje remiuosi išsamiais interviu su dizaino srityje dirbančiais mokslininkais ekspertais. Teminė analizė atskleidžia, kaip dizainas kūrybiškumui suteikia galimybių, atveriančių jo perspektyvas, kurios nėra pasitelkiamos vyraujančiuose psichologijos diskursuose, susijusiuose su kūrybiškumu. Tam skiriu dėmesio, kūrybiškumui skirtoje literatūroje sukurdama dizainu grindžiamų žinių poreikį. Išvados atspindi kūrybiškumo vaizdą, apimantį suvokimą, intuiciją ir gebėjimą naujaip pažvelgti į pasaulį; kūrybiškumą kaip į veiksmą nukreiptą reiškinį ir į kūrybiškumo etiką visuomenėje, kurioje vis didesnių galių įgyja technologijos. Tyrinėjant mokslinius kūrybiškumo apibrėžimus ir nusistatymus jo atžvilgiu, kyla įžvalgų apie tai, kaip dizainas formuoja išskirtinius požiūrius į kūrybiškumo paradigmas. Reikšminiai žodžiai: kūrybinė epistemologija, kūrybinės paradigmos, kūrybinis mąstymas, kūrybiškumas, kūrybiškumo tyrinėjimai, dizainas, dizaineriški pažinimo būdai, etika, intuicija, suvokimas.

cerebral venous thrombosis, etiology, gender, risk factors, Neurosciences. Biological psychiatry. Neuropsychiatry, and RC321-571

Objective: Our study aims to evaluate the etiologic and clinical features of cerebral venous sinus thrombosis (CVST) in Saudi Arabia, and secondarily whether gender plays a role in CVST. Materials and Methods: Data were collected retrospectively from the stroke registry during the period from January 2008 to April 2018, and the patients with the diagnosis of CVST were identified, and data were analyzed for any gender-specific differences in clinical presentation and etiology of cerebral venous thrombosis. Results: There were 15 females while 11 males with a female:male ratio of 1.4:1. The mean age was 29.4± standard deviation 8.9 with the age range of 15–49. Headache was the most common and usually the first presenting symptoms present in 65% followed by hemiparesis and cranial nerve palsies. The first neurological examination was normal in 9/26 (34.6%) of the patients, while the common abnormality was cranial nerve palsies. Infections and trauma played an important part in risk factor analysis of our patient after the pregnancy- and hormone-related conditions. Some significant differences between the clinical presentation and risk factors among males and females were noted as age at presentation was higher in females while trauma and infections were common in male patients, although the involvement of the sinuses and response to treatment did not prove to be statistically significant. Conclusion: The results of this study were similar to the available literature with few differences. The relatively higher proportion of males in our study can be explained partly with more cases of traumatic CVST. Some important differences were noted between the risk factors and clinical presentation among genders. Large-scale prospective studies are needed to further clarify these differences.

dotatate, drugs, inotersen, Lutathera, oligonucleotides, Onpattro, patisiran, peptides, pharmaceutical market, Tegsedi, Medicine, Pharmacy and materia medica, and RS1-441

In 2018, the United States Food and Drug Administration (FDA) approved a total of 59 new drugs, three of them (5%) are TIDES (or also, -tides), two oligonucleotides and one peptide. Herein, the three TIDES approved are analyzed in terms of medical target, mode of action, chemical structure, and economics.

Forschungsdaten, Geisteswissenschaften, Forschungsdateninfrastruktur, Digital Humanities, and Technology

In bewusst enger Verzahnung von Fach- und Informationswissenschaft entwickelt und implementiert das INF-Projekt des an der Freien Universität Berlin angesiedelten Sonderforschungsbereichs 980 "Episteme in Bewegung: Wissenstransfers von der Alten Welt bis in die frühe Neuzeit" in der gegenwärtigen Förderphase unter dem Titel „Bücher auf Reisen. Informationstechnologische Erschließung von Wissensbewegungen in vormodernen Kulturen” zum einen ein zentrales Forschungsdatenrepositorium für den SFB und betreibt zum anderen gemeinsame Forschung und Entwicklung mit derzeit vier ausgewählten Teilprojekten. Der vorliegende Beitrag skizziert, wie die Kollaboration von Geisteswissenschaften, Computerphilologie und Informatik sowohl innerhalb des INF-Projekts als auch im Zusammenspiel mit den Pilotprojekten ausgestaltet wird, welche Herausforderungen bei gemeinsamer Forschung entstehen und welche Rolle das INF-Projekt eines großen geisteswissenschaftlichen Verbundes in den Nachhaltigkeitsüberlegungen der Heimatinstitution spielen kann.

COVID-19 epidemic, country lockdown, online learning, Malaysia, Electrical engineering. Electronics. Nuclear engineering, and TK1-9971

The COVID-19 pandemic has struck the world and forced countries to go into lockdown including education sector. Students have been staying in hostels or houses, unable to go to university campuses. This situation has left university administrators no choice, but to have an online learning channel. Malaysian universities in particular have gone through many challenges to bring their online learning system up and ready to resume education process. However, students have found themselves caught in this situation (pure online learning) with no plan or readiness. Literature reviews showed that students encountered some challenges that could not be easily resolved. This study explored the challenges encountered by students of a government-linked university. This university is one of the largest in Malaysia with over 10 campuses across the country. This study collected 284 valid answers. The findings show that respondents lacked full readiness in this situation physically, environmentally, and psychologically with some differences in perspectives according to their gender, age, and residing state. Respondents were concerned about the implications of lockdown on their performance. The findings of this study indicate that a sudden switch to a pure online alternative creates considerable challenges to students who have no plans to be physically apart from classes. The findings also indicate that the current blended learning process which uses online learning as a support mechanism for face-to-face learning has faced a considerable challenge to replace it, particularly with unprepared students.

Dentistry and RK1-715

Background. Detachment of acrylic teeth from denture base material is a common complication in dentistry which accounts for 26–30% of repair cases. This study aimed to evaluate the effect of alumina-blasting, silane coupling agent, and thermal cycling on the shear bond strength of repaired teeth to denture base. Materials and Methods. Specimens (140) of repaired teeth to denture bases were fabricated and divided into 14 groups: 7 groups before thermal cycling and 7 groups after thermal cycling (n = 10). The groups were divided according to surface treatment into no treatment (control), treatment of the base (B), the tooth (T), or both (BT). Each group was further subdivided according to the surface treatment method into alumina-blasting or alumina-blasting and silane coupling agent. After treatment, acrylic discs and teeth were fixed in a jig, and the repair procedure was done. Half the specimens were thermally cycled. Shear bond strength was measured using a universal testing machine. ANOVA and Tukey HSD tests were performed at α = 0.05. Results. Surface treatment significantly improved the bond strength compared to the control group P

medical students, mental illness, mentally ill, stigma, and Medicine

Aim: The study aimed to measure the level of the stigma of medical students at King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh campus, towards mentally ill patients. Material and Methods: A cross-sectional survey was conducted in King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh. The data collection was started in July 2017 till March 2018. The students completed a self-administered questionnaire consisting of sociodemographic data and the Community Attitudes toward the Mentally Ill (CAMI) Scale. Results: The sample size was realized as 274 participants. There were no significant differences in all CAMI subscales for the different academic years except for Authoritarianism which showed a significant increase in the level of stigma (P-value = 0.04). Male gender, previous psychiatric treatment, and having a relative with psychiatric illness were associated with higher Authoritarianism and Social Restrictiveness scores and lower Benevolence and CMHI scores. Discussion: More stigma was observed among the 4th year students and it might be due to insufficient academic preparation as well as more exposure to psychiatric rotations. Conclusion: The results support the importance of implementing anti-stigma programs throughout the medical program to improve the healthcare provided to mentally ill patients.

Fe (III) chelators, Siderophores, Solid phase peptide synthesis, 1-Hydroxypyridine-2-one, Trifluoromethanesulfonic acid (TFMSA), and Science

afamelanotide, bremelanotide, dotatoc, drugs, 68ga-dotatoc, enfortumab vedotin, golodirsen, givosiran, polatuzumab vedotin, oligonucleotides, peptides, pharmaceutical market, Medicine, Pharmacy and materia medica, and RS1-441

2019 has been an excellent year in terms of peptides and oligonucleotides (TIDES) approved by the FDA. Despite the drop in the number of total drugs approved by the FDA in 2019 in comparison with 2018 (48 vs. 59), the total number of TIDES authorized increased (seven vs. three). Year after year, TIDES are increasingly present in therapy, as imaging agents, theragnostic and constituent moieties of other complex drugs, such as antibody drug conjugates. This means a consolidation of these kinds of drugs in the pharmaceutical arena, paving the way in the coming years for the approval of others for diverse medical indications. Here the TIDES approved in 2019 are analyzed in terms of chemical structure, medical target, mode of action, and adverse effects.

methicillin resistant Staphylococcus aureus (MRSA), methicillin susceptible Staphylococcus aureus (MSSA), nasal carriage, medical students, antibiotic susceptibility, and Medicine

Background: Healthcare workers (HCWs) and medical students can be asymptomatic carriers in transmitting methicillin resistant and susceptible Staphylococcus aureus (MRSA and MSSA). Studying epidemiological and antibiotic susceptibility data is necessary to limit the spread of infections, help with treatment and understand the transmission dynamics of MSSA and MRSA. Our study assessed the rate of MSSA and MRSA nasal carriage and its antibiogram among medical students in basic and clinical years at the University of Jordan. Methods: A total of 210 nasal swabs were randomly collected from participants. MSSA and MRSA were identified by culture, biochemical and other phenotypical analysis methods. Antibiotic susceptibility was determined by the disc diffusion method. Results: The nasal carriage of MSSA was 6.6% and 11.4% and that of MRSA was 1.9% and 2.8% among basic and clinical years, respectively. There was no significant difference for the nasal carriage of MSSA and MRSA among basic and clinical year students (p value ≥ 0.05). MSSA resistance ranged between 25% and 33% for trimethoprim-sulfamethoxazole, tetracycline and ciprofloxacin. For MRSA, the highest resistance was to trimethoprim-sulfamethoxazole and tetracycline (67% to 100%), followed by gentamicin and ciprofloxacin (33% to 67%), in all participants in the study. Conclusion: The difference in the carriage rates of MSSA and MRSA among basic and clinical students was statistically insignificant. The continuous awareness and implementation of infection control procedures and guided patient contact are recommended. The results might also suggest that healthcare workers could be victims in the cycle of MRSA nasal carriage, a theory that needs further study.

Medicine

Guillain-Barré syndrome (GBS) is a heterogeneous disorder with a diverse clinical presentation ranging from weakness of certain body regions to tetraparesis with autonomic dysfunction and respiratory failure. Paraparetic GBS is a variant of GBS which is characterised by weakness limited to the lower limbs only. It is crucial to identify such topographical presentations, as a delay in diagnosis can lead to delayed initiation of specific treatment, which can negatively impact the outcome. We report a 29-year-old female patient who presented to the King Fahd Hospital of the University, Al Khobar, Saudi Arabia, in 2017 with rapid onset asymmetrical weakness of lower extremities associated with bladder dysfunction during the immediate postpartum period. The weakness spared cranial nerves and arms and imaging studies of the spine was unremarkable. Cerebrospinal fluid investigations showed cyto-albuminologic dissociation and nerve conduction studies showed features of demyelination. The patient was diagnosed with a paraparetic variant of GBS and treated with intravenous immunoglobulin. She had almost recovered completely at the two–month follow-up. Keywords: Paraparesis; Guillain-Barré Syndrome; Demyelination; Postpartum Period; Case Report; Saudi Arabia.

Hyperviscosity syndrome, Colour vision, Systemic disease, Hematologic malignancy, Leukemia, Ophthalmology, and RE1-994

Purpose: To report a case of subjective intermittent loss of bilateral colour vision and episodic white-out vision in a patient with undiagnosed chronic myeloid leukemia (CML). Observations: A patient initially diagnosed with diabetic retinopathy presented with a chief complaint of subjective intermittent loss of colour vision in both eyes, as well as intermittent bilateral white-out vision. These symptoms previously went uninvestigated until a thorough history revealed concurrent constitutional symptoms including recent night sweats and fevers. Closer fundus examination revealed that the lesions previously thought to be diabetic retinal hemorrhages were Roth spots. Conclusions: and Importance: An unusual chief complaint of colour vision loss and multiple Roth spots in the context of chronic night sweats and fevers prompted further workup. A CBC with differential revealed a markedly increased WBC count and the patient was diagnosed with CML. Cytoreduction therapy led to complete resolution of the patient's visual symptoms and a return to normal WBC count at the most recent follow up appointment. We report, to our knowledge, the only case of colour vision loss as the initial presenting symptom of CML in the current literature, and reiterate the importance of a thorough history, neuro-ophthalmic examination and relevant investigations in patients with unusual visual symptoms, including intermittent loss of colour vision. In this case, we speculate that hyperviscosity syndrome secondary to CML was the cause of this patient's peculiar visual disturbance.

angiotensin, tonicity, transporters, virus, thrombosis, hypertension, Biology (General), and QH301-705.5

COVID-19 symptoms, including hypokalemia, hypoalbuminemia, ageusia, neurological dysfunctions, D-dimer production, and multi-organ microthrombosis reach beyond effects attributed to impaired angiotensin-converting enzyme 2 (ACE2) signaling and elevated concentrations of angiotensin II (Ang II). Although both SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) and SARS-CoV-2 utilize ACE2 for host entry, distinct COVID-19 pathogenesis coincides with the acquisition of a new sequence, which is homologous to the furin cleavage site of the human epithelial Na+ channel (ENaC). This review provides a comprehensive summary of the role of ACE2 in the assembly of Na+-dependent transporters of glucose, imino and neutral amino acids, as well as the functions of ENaC. Data support an osmotic adaptation mechanism in which osmotic and hemostatic instability induced by Ang II-activated ENaC is counterbalanced by an influx of organic osmolytes and Na+ through the ACE2 complex. We propose a paradigm for the two-site attack of SARS-CoV-2 leading to ENaC hyperactivation and inactivation of the ACE2 complex, which collapses cell osmolality and leads to rupture and/or necrotic death of swollen pulmonary, endothelial, and cardiac cells, thrombosis in infected and non-infected tissues, and aberrant sensory and neurological perception in COVID-19 patients. This dual mechanism employed by SARS-CoV-2 calls for combinatorial treatment strategies to address and prevent severe complications of COVID-19.

architectural heritage, historicist reconstruction, cultural continuity, environmental sustainability, energy efficiency, Environmental effects of industries and plants, TD194-195, Renewable energy sources, TJ807-830, Environmental sciences, and GE1-350

Although attempts for formulating sustainable approaches in heritage management have been ongoing since the 1980s, sustainability dimensions in the context of ‘reconstruction’ have remained an unexplored research area. By investigating the case of the ruined Khaz’al Diwan in Kuwait, an architectural heritage site in the United Nations Educational, Scientific and Cultural Organization (UNESCO) World Heritage (WH) Tentative List, we explore and compare the roles of the ‘cultural continuity’ and ‘environmental protection’ pillars of sustainability in reconstruction planning. By employing rapid ethnographic surveying and case study methods, we first investigate the approach to ‘cultural continuity’ from the State’s stance and through local community perceptions. Albeit with nuances, the surveying revealed a preference for historicist reconstruction. However, the Khaz’al Diwan, like most of the heritage structures in the Gulf region, was originally constructed with coral stone, which is now protected under environmental laws. How feasible is the use of replacement materials in terms of sustainability perspectives that is also acceptable from heritage perspectives? Considering the high cooling loads required in this climatic region, we prioritized the energy performance of the construction materials of the external walls and the roof. Computer simulations based on scenarios testing same-type and replacement construction materials revealed how the latter could be considered as an alternative in a historicist reconstruction. The discussion revolves around the environmental and cultural parameters that are instrumental in reconstruction planning. This ultimately highlights how reconstruction policies must be shaped to redefine the role and scope of material authenticity to accommodate the local environmental and cultural realities in the wider Gulf region and Middle Eastern context.

Polycystic ovary syndrome, Binge eating disorder, Health related quality of life, Depression disorder, Riyadh, Biology (General), and QH301-705.5

Background & objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinal disorder, and the greatest cause of infertility in women. Despite availability of individual data on impact of multiple endocrinal, reproductive and even metabolic factors in PCOS individuals, the data on the co-existence of BED and depression in PCOS patients with its relationship on the quality of life in Saudi Arabian females is not found. Hence this study is aimed to elucidate the implication of PCOS on eating behaviour, induction of depression and general health quality in Saudi Arabian population of Riyadh. Materials and methods: This is a cross-sectional study carried out in multiple health facilities of Riyadh from January to March 2019. The study samples (494) were recruited by convenience sampling and administered validated questionnaire by trained research participants. The data obtained was analysed by binary logistic regression using SPSS-IBM 25. Results: Of the total 494 women participated in the study, 23.48% (116) were PCOS individuals. The odds of developing abnormal health related quality of (HRQ) in patients with PCOS was significantly (P = 0.000, OR = 3.472) high when compared to non-PCOS participants. The odds of showing high binge eating disorder (BED, P = 0.007, OR = 2.856) and depression (P = 0.000, OR = 2.497) scores in PCOS participants were significantly more than patients who were not having PCOS. Out of the three parameters studied, abnormal health related quality of life possessed a higher influence of PCOS compared to depression and abnormal eating behavior. Interpretation & conclusion: In conclusion, the present study shows that women with PCOS are at a significant risk for depressive disorders, disorganized eating behavior and impaired quality of life. Therefore, necessary care and screening is required to minimize the impact of PCOS on already burdened individuals.

Theory and practice of education and LB5-3640

age of acquisition, bilingualism, english as a second language, perception of speech in noise, signal-to-noise ratio, snr loss, Otorhinolaryngology, RF1-547, Industrial medicine. Industrial hygiene, and RC963-969

Background: Previous studies have highlighted that bilingual listeners have a deficit in speech perception in their second language compared with monolingual listeners in noisy listening environments. This deficit may give rise to educational and occupational implications for bilingual speakers who are studying or working in non-native language environments in poor acoustic conditions. Objectives: To compare the speech perception performance of monolingual English speakers and English as a second language (ESL) bilinguals within environments with various levels of background noise and to examine whether bilinguals with an early age of second language acquisition would perform better than those with a late age of acquisition. Study sample: Two groups of adult listeners with normal hearing participated: monolingual British English listeners (N = 15) and bilingual Arabic listeners for whom English was their second language and who were proficient in English (N = 15). The quick speech-in-noise (QuickSIN) test was used to assess signal-to-noise ratio (SNR) loss and SNR-50 for both groups. Results: The QuickSIN test results indicated that bilingual Arabic listeners with normal hearing displayed a mild SNR loss comparable to that observed for a person with hearing loss, indicating a higher SNR needed for this population to achieve a comparable level of comprehension to their monolingual English peers. Conclusion: Results highlight the importance of measuring SNR loss to obtain accurate diagnosis and potential rehabilitative information that is not available from audiogram studies.

Children, Intensive care, SARS-CoV-2, Mortality, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, and RA1-1270

Background: Characteristics of critical Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) infection in children is not well understood. This study described the clinical characteristics of children admitted to intensive care units (ICU) and explored factors associated with the need for invasive ventilation or mortality. Methods: A multicenter, retrospective, cohort study was conducted over eight medical centers, including all patients younger than 18 years of age and admitted to the ICU due to a direct consequence of coronavirus disease 2019 (COVID-19). Patients who were admitted to the ICU for any alternate reason and tested positive for SARS-CoV-2 by screening test, and patients who were admitted due to multi-inflammatory syndrome in children, were excluded. Demographic, laboratory, imaging, and clinical data were collected. Descriptive statistics were used to compare survivors and non-survivors. Fine and Gray’s hazard model was used to estimate the association between clinical variables and ICU death. Results: During the study period, 25 pediatric COVID-19 patients received care in the ICUs. The median age was 2.78 years (IQR 0.21–8.51), and 60% were male. Only three patients were reported to be previously healthy at admission. Nine (36%) patients required invasive mechanical ventilation, including two were on extracorporeal membrane oxygenation. Four (16%) patients died during ICU care. In univariate analysis, the presence of comorbidity (HR 0.0001; 95%CI 0.00001–0.00016), platelets count (HR 0.99; 95% CI 0.98–0.99), elevated procalcitonin (HR 1.05; 95%CI 1.016–1.09), and circulatory compromise (HR 16.34; 95%CI 1.99–134.35), all at the time of ICU admission, were associated with in-ICU mortality. Conclusion: Our findings suggest that children admitted to the ICU with SARS-CoV-2 infection, generally, have a favorable outcome. Low platelets count, elevated procalcitonin, presence of comorbidity, and shock at the time of ICU admission were associated with death. This study may shed more light on the disease dynamics of critical pediatric COVID-19.

belantamab mafodotin-blmf, 64Cu-DOTATATE, drugs, FDA, 68Ga-PSMA-11, lumasiran, Medicine, Pharmacy and materia medica, and RS1-441

2020 has been an extremely difficult and challenging year as a result of the coronavirus disease 2019 (COVID-19) pandemic and one in which most efforts have been channeled into tackling the global health crisis. The US Food and Drug Administration (FDA) has approved 53 new drug entities, six of which fall in the peptides and oligonucleotides (TIDES) category. The number of authorizations for these kinds of drugs has been similar to that of previous years, thereby reflecting the consolidation of the TIDES market. Here, the TIDES approved in 2020 are analyzed in terms of chemical structure, medical target, mode of action, and adverse effects.

citizen science, urban ecology, biodiversity, amphibian, conservation planning, urbanization, Biology (General), and QH301-705.5

As cities adopt mandates to protect, maintain and restore urban biodiversity, the need for urban ecology studies grows. Species-specific information on the effects of urbanization is often a limiting factor in designing and implementing effective biodiversity strategies. In suburban and exurban areas, amphibians play an important social-ecological role between people and their environment and contribute to ecosystem health. Amphibians are vulnerable to threats and imbalances in the aquatic and terrestrial environment due to a biphasic lifestyle, making them excellent indicators of local environmental health. We developed a citizen science program to systematically monitor amphibians in a large city in Alberta, Canada, where 90% of pre-settlement wetlands have been removed and human activities continue to degrade, alter, and/or fragment remaining amphibian habitats. We demonstrate successes and challenges of using publicly collected data in biodiversity monitoring. Through amphibian monitoring, we show how a citizen science program improved ecological knowledge, engaged the public in urban biodiversity monitoring and improved urban design and planning for biodiversity. We outline lessons learned to inform citizen science program design, including the importance of early engagement of decision makers, quality control assessment, assessing tensions in program design for data and public engagement goals, and incorporating conservation messaging into programming.

digital health (eHealth), evidence-based & research methodology, pediatrics - children, health system - organization and administration, mobile application (app), Medicine, Public aspects of medicine, RA1-1270, Electronic computers. Computer science, and QA75.5-76.95

Embedding digital technologies in healthcare has the potential to streamline and personalize medical care. However, healthcare systems are often fragmented, and therefore achieving a truly integrated digital health program can be challenging. To promote a streamlined, evidence-based approach to implementing digital health solutions in a healthcare system, the Murdoch Children's Research Institute (MCRI) established the Digital Health Translation and Implementation Program (DHTI) bringing together clinicians, researchers and digital health experts. From the program commencement, frontline clinical innovators have collaborated with DHTI team members to develop and implement digital solutions to address pain-points in the healthcare system. Throughout this program, important lessons have been learnt relating to the development, evaluation and implementation of digital solutions in the healthcare system. This paper explores these lessons and makes recommendations for the successful implementation of digital health solutions in healthcare systems under five main categories: (1) design and usability, (2) stakeholder engagement and uptake, (3) project management and resourcing, (4) process and implementation, and (5) evaluation. Recommendations suggested here are designed to support future healthcare-based digital health programs to maximize the impact digital solutions can have on the healthcare system and patients.