El Sabbagh, Abdallah, Eleid, Mackram F., Matsumoto, Jane M., Anavekar, Nandan S., Al-Hijji, Mohammed A., Said, Sameh M., Nkomo, Vuyisile T., Holmes, David R., Rihal, Charanjit S., and Foley, Thomas A.
Catheterization and Cardiovascular Interventions. Dec 1, 2018, Vol. 92 Issue 7, E537, 13 p.
Heart valve diseases -- Care and treatment, Ablation (Surgery), Implants, Artificial, Prosthesis, Calcification, 3D printing, and CT imaging
Byline: Abdallah El Sabbagh,Mackram F. Eleid, Jane M. Matsumoto, Nandan S. Anavekar,Mohammed A. Al-Hijji, Sameh M. Said, Vuyisile T. Nkomo, David R. Holmes, Charanjit S. Rihal, Thomas A. Foley Keywords: 3D prototyping; 3D printing; mitral annular calcification Abstract Introduction Three-dimensional (3D) prototyping is a novel technology which can be used to plan and guide complex procedures such as transcatheter mitral valve replacement (TMVR). Methods Eight patients with severe mitral annular calcification (MAC) underwent TMVR. 3D digital models with digital balloon expandable valves were created from pre-procedure CT scans using dedicated software. Five models were printed. These models were used to assess prosthesis sizing, anchoring, expansion, paravalvular gaps, left ventricular outflow tract (LVOT) obstruction, and other potential procedure pitfalls. Results of 3D prototyping were then compared to post procedural imaging to determine how closely the achieved procedural result mirrored the 3D modeled result. Results 3D prototyping simulated LVOT obstruction in one patient who developed it and in another patient who underwent alcohol septal ablation prior to TMVR. Valve sizing correlated with actual placed valve size in six out of the eight patients and more than mild paravalvular leak (PVL) was simulated in two of the three patients who had it. Patients who had mismatch between their modeled valve size and post-procedural imaging were the ones that had anterior leaflet resection which could have altered valve sizing and PVL simulation. 3D printed model of one of the latter patients allowed modification of anterior leaflet to simulate surgical resection and was able to estimate the size and location of the PVL after inserting a valve stent into the physical model. Conclusion 3D prototyping in TMVR for severe MAC is feasible for simulating valve sizing, apposition, expansion, PVL, and LVOT obstruction. Article Note: Funding information None Supporting information: Additional Supporting Information may be found in the online version of this article Additional Supporting Information may be found online in the supporting information tab for this article. CAPTION(S): Supporting Information Vidoe 1 Supporting Information Vidoe 2
Ciocca, L., Mazzoni, S., Fantini, M., Persiani, F., Baldissara, P., Marchetti, C., and Scotti, R.
Medical & Biological Engineering & Computing. July 2012, Vol. 50 Issue 7, p743, 7 p.
Universities and colleges, Orthopedic surgery, Implants, Artificial, Prosthesis, Ablation (Surgery), Computer-aided design, Tumors, and Rapid prototyping
This paper describes a new protocol for mandibular reconstruction. Computer-aided design/computer-aided manufacturing (CAD/CAM) technology was used to manufacture custom-made cutting guides for tumor ablation and reconstructive plates to support fibula free flaps. CT scan data from a patient with an odontogenic keratocyst on the left mandibular ramus were elaborated to produce a virtual surgical plan of mandibular osteotomy in safe tissue for complete ramus resection. The CAD/CAM procedure was used to construct a customized surgical device composed of a cutting guide and a titanium reconstructive bone plate. The cutting guide allowed the surgeon to precisely transfer the virtual planned osteotomy into the surgical environment. The bone plate, including a custom-made anatomical condylar prosthesis, was designed using the outer surface of the healthy side of the mandible to obtain an ideal contour and avoid the bone deformities present on the side affected by the tumor. Operation time was reduced in the demolition and reconstruction phases. Functional and aesthetic outcomes allowed patients to immediately recover their usual appearance and functionality. This new protocol for mandibular reconstruction using CAD/CAM to construct custom-made guides and plates may represent a viable way to reproduce the patient's anatomical contour, give the surgeon better procedural control, and reduce operation time.
Compton, Laine R., Reschke, Brent, Friend, Jordan, Powell, Matthew, and Vertes, Akos
Rapid Communications in Mass Spectrometry. Jan 15, 2015, Vol. 29 Issue 1, p67, 7 p.
Mass spectrometry, Ablation (Surgery), and Measuring instruments
Byline: Laine R. Compton, Brent Reschke, Jordan Friend, Matthew Powell, Akos Vertes RATIONALE We introduce remote laser ablation electrospray ionization (LAESI), a novel, non-proximate ambient sampling technique. Remote LAESI allows additional analytical instrumentation to be incorporated during sample analysis. This work demonstrates the utility of remote LAESI and, when combined with optical microscopy, allows for the microscopy-guided sampling of biological tissues. METHODS Rapid prototyping using a 3D printer was applied to produce various ablation chamber geometries. A focused 5 ns, 2.94 A[micro]m laser pulse kept at 10 Hz ablated the sample within the chamber, remote to the mass spectrometer inlet. Ablated particulates were carried through a transfer tube by N.sub.2 gas, delivered to the electrospray plume and ionized. A long-distance microscope was used to capture images of tissues before, during and after ablation. RESULTS Optimized remote LAESI was found to have a 27% transport efficiency compared with conventional LAESI, sufficient for many applications. A comparable molecular coverage was obtained with remote LAESI for the analysis of plant tissue. Proof-of-principle experiments using a pansy flower and a maple leaf indicated the functionality of this approach for selecting domains of interest for analysis by optical microscopy and obtaining chemical information from those selected regions by remote LAESI-MS. CONCLUSIONS Remote LAESI is an ambient non-proximate sampling technique, proven to detect metabolites in biological tissues. When combined with optical microscopy, remote LAESI allows for the simultaneous acquisition of morphological and chemical information. This technique has important implications for histology, where chemical information for specific locations within a tissue is critical. Copyright [c] 2014 John Wiley & Sons, Ltd. CAPTION(S): Supporting info item