Byline: Sheng Yan, Sheng Yan, Shi-Yang Tang, Yuxing Li, Qianbin Zhao, Dan Yuan, Guolin Yun, Jun Zhang, Shiwu Zhang, Shiwu Zhang Keywords: Capillary microfluidics; Laser ablation; Rapid prototyping; Ur Abstract Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point-of-care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, maskless 3D prototyping for fabrication of capillary fluidic circuits using laser engraving. The capillary circuits can be fabricated in a short amount of time (<10 min) without the requirements of clean-room facilities and photomasks. The advanced capillary components (e.g., trigger valves, retention valves and retention bursting valves) were fabricated, enabling the sequential liquid delivery and sample-reagent mixing. With the integration of smartphone-based detection platform, the microfluidic device can quantify the urinary protein via a colorimetric analysis. By eliminating the bulky and expensive equipment, this smartphone-based detection platform is portable for on-site quantitative detection. Article Note: These authors contributed equally to this work. Additional corresponding author: Prof. Weihua Li E-mail: email@example.com Color Online: See the article online to view Figs. 1-5 in color. CAPTION(S): Supporting information
Journal of Medical Systems. May 2019, Vol. 43 Issue 5, p1, 9 p.
Time to market, Product development, Thermoplastics, Sleep apnea syndromes, and Home appliances
Obstructive Sleep apnea is a public health problem. This disease is associated with daytime sleepiness, increased motor vehicle accidents, heart failure and stroke. Treatment options include weight loss, positive airway pressure, pharyngeal and orthognatic surgery. However, selected patients have good response to oral appliances devices that intended to protrude and stabilize the mandible mechanically during the night in order to reduce the collapsibility of the upper airway. Selection of patients includes primary snoring, mild, moderate and positional apnea. The perfect mandibular advance device has not yet been designed. For these reasons, the objective of this paper is to present a new thermoadjustable chair-side oral appliance. Device integrates the best characteristics of custom made and boils and bite previous designs and minimizes inconveniences and possible side effects. The device is a titratable mandibular advancement appliance. It consists of two independent prefabricated trays adaptable to the shape of adult dental arch and linked to each other by a protrusion mechanism. Each tray contains a hard outer shell and a soft thermoplastic resin inner body. The position of the jaw can be adjusted by moving an aluminum rack into, or out from, the guide so the ratchet may get locked into a certain position ensuring the length of the mechanism. The protrusion mechanism is fixed to the splint using small rings that are articulated over a 't' button. Our prototype satisfies the requirements of an effective oral appliance, in terms of retention, comfort, safety and efficacy. It is easy to fit, durable, low cost, quickly titratable, not bulky and easy cleaning. Thermoplastic appliances are specially used like a predictor of treatment response in apnea patients. The device described is a cost-effective introduction to mandibular advancement technology. A qualified dentist or trained sleep doctor could mitigate dental side effects and reduce their incidence.
Obesity, Fitness & Wellness Week. April 18, 2020, 2735
Nova Southeastern University, Cancer -- Reports, Biological markers -- Reports, Biological markers -- Research, Physical fitness -- Research, Physical fitness -- Reports, Microfluidics -- Reports, and Microfluidics -- Research
2020 APR 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness Wellness Week -- Investigators publish new report on cancer biomarkers. According to news reporting originating from [...]
Byline: Fabian Guba, Umit Tastan, Katrin Gugeler, Melanie Buntrock, Tobias Rommel, Dirk Ziegenbalg Keywords: Photochemistry; 3D Printing; Process intensification; Rapid prototyping; Reaction engineering Abstract This contribution gives an overview of the general aspects of photochemical reaction engineering, discusses these aspects in the context of rapid prototyping and evaluates the constraints of current additive manufacturing technologies. Subsequently, possible approaches to utilize the benefits of rapid prototyping for process intensification of photochemical reactions are described. Furthermore, the advantageous application of rapid prototyping is demonstrated with the help of four examples. CAPTION(S): Supplementary Information
Lee, Yujin, Kim, Byeongyeon, Oh, Insung, and Choi, Sungyoung
Small. Dec 27, 2018, Vol. 14 Issue 52, n/a
Byline: Yujin Lee, eongyeon Kim, Insung Oh,Sungyoung Choi Keywords: microfluidics; modular blocks; on-demand prototyping; open-source sharing; optofluidics Abstract Rapid prototyping of microfluidic devices has advanced greatly, along with the development of 3D printing and micromachining technologies. However, peripheral systems for microfluidics still rely on conventional equipment, such as bench-top microscopy and syringe pumps, which limit system modification and further improvements. Herein, optofluidic modular blocks are presented as discrete elements to modularize peripheral optical and fluidic systems and are used for on-demand and open-source prototyping of whole microfluidic systems. Each modular block is fabricated by embedding optical or fluidic devices into the corresponding 3D-printed housing. The self-interlocking structure of the modular blocks enables easy assembly and reconfiguration of the blocks in an intuitive manner, while also providing precise optical and fluidic alignment between the blocks. With the library of standardized modular blocks developed here, how the blocks can be easily assembled to build whole microfluidic systems for blood compatibility testing, droplet microfluidics, and cell migration assays is demonstrated. Based on the simplicity of assembling the optofluidic blocks, the prototyping platform can be easily used for open-source sharing of digital design files, assembly and operation instructions, and block specifications, thereby making it easy for nonexperts to implement microfluidic ideas as physical systems. CAPTION(S): Supplementary
El Sabbagh, Abdallah, Eleid, Mackram F., Matsumoto, Jane M., Anavekar, Nandan S., Al-Hijji, Mohammed A., Said, Sameh M., Nkomo, Vuyisile T., Holmes, David R., Rihal, Charanjit S., and Foley, Thomas A.
Catheterization and Cardiovascular Interventions. Dec 1, 2018, Vol. 92 Issue 7, E537, 13 p.
Heart valve diseases -- Care and treatment, Ablation (Surgery), Implants, Artificial, Prosthesis, Calcification, 3D printing, and CT imaging
Byline: Abdallah El Sabbagh,Mackram F. Eleid, Jane M. Matsumoto, Nandan S. Anavekar,Mohammed A. Al-Hijji, Sameh M. Said, Vuyisile T. Nkomo, David R. Holmes, Charanjit S. Rihal, Thomas A. Foley Keywords: 3D prototyping; 3D printing; mitral annular calcification Abstract Introduction Three-dimensional (3D) prototyping is a novel technology which can be used to plan and guide complex procedures such as transcatheter mitral valve replacement (TMVR). Methods Eight patients with severe mitral annular calcification (MAC) underwent TMVR. 3D digital models with digital balloon expandable valves were created from pre-procedure CT scans using dedicated software. Five models were printed. These models were used to assess prosthesis sizing, anchoring, expansion, paravalvular gaps, left ventricular outflow tract (LVOT) obstruction, and other potential procedure pitfalls. Results of 3D prototyping were then compared to post procedural imaging to determine how closely the achieved procedural result mirrored the 3D modeled result. Results 3D prototyping simulated LVOT obstruction in one patient who developed it and in another patient who underwent alcohol septal ablation prior to TMVR. Valve sizing correlated with actual placed valve size in six out of the eight patients and more than mild paravalvular leak (PVL) was simulated in two of the three patients who had it. Patients who had mismatch between their modeled valve size and post-procedural imaging were the ones that had anterior leaflet resection which could have altered valve sizing and PVL simulation. 3D printed model of one of the latter patients allowed modification of anterior leaflet to simulate surgical resection and was able to estimate the size and location of the PVL after inserting a valve stent into the physical model. Conclusion 3D prototyping in TMVR for severe MAC is feasible for simulating valve sizing, apposition, expansion, PVL, and LVOT obstruction. Article Note: Funding information None Supporting information: Additional Supporting Information may be found in the online version of this article Additional Supporting Information may be found online in the supporting information tab for this article. CAPTION(S): Supporting Information Vidoe 1 Supporting Information Vidoe 2
Angewandte Chemie International Edition. August 20, 2018, Vol. 57 Issue 34, p11074, 4 p.
Laboratories -- Equipment and supplies and Laboratory equipment
Byline: Pawel L. Urban Keywords: instrumentation; open-source electronics; prototyping Abstract Open-source electronics and programming can augment chemical and biomedical research. Currently, chemists can choose from a broad range of low-cost universal electronic modules (microcontroller boards and single-board computers) and use them to assemble working prototypes of scientific tools to address specific experimental problems and to support daily research work. The learning time can be as short as a few hours, and the required budget is often as low as 50 USD. Prototyping instruments using low-cost electronic modules gives chemists enormous flexibility to design and construct customized instrumentation, which can reduce the delays caused by limited access to high-end commercial platforms. Supporting information: Additional Supporting Information may be found in the online version of this article As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. CAPTION(S): Supplementary