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Traveling wave structures for lossless ion manipulation (TW-SLIM) has proven a valuable tool for the separation and study of gas-phase ions. Unfortunately, many of the traditional components of TW-SLIM experiments manifest practical and financial barriers to the technique's broad implementation. To this end, a series of technological innovations and methodologies are presented which enable for simplified SLIM experimentation and more rapid TW-SLIM prototyping. In addition to the use of multiple independent board sets that comprise the present SLIM system, we introduce a low-cost, multifunctional traveling wave generator to produce TW within the TW-SLIM. This square-wave producing unit proved effective in realizing TW-SLIM separations compared to traditional approaches. Maintaining a focus on lowering barriers to implementation, the present set of experiments explores the use of on-board injection (OBI) methods, which offer potential alternatives to ion funnel traps. These OBI techniques proved feasible and the ability of this simplified TW-SLIM platform to enhance ion accumulation was established. Further experimentation regarding ion accumulation revealed a complexity to ion accumulation within TW-SLIM that has yet to be expounded upon. Lastly, the ability of the presented TW-SLIM platform to store ions for extended periods (1 s) without significant loss (<10%) was demonstrated. The aforementioned experiments clearly establish the efficacy of a simplified TW-SLIM platform which promises to expand adoption and experimentation of the technique.
(Copyright © 2022 Elsevier B.V. All rights reserved.)

Electromagnetic fields, Antennas (Electronics), Wireless sensor networks, and Rapid prototyping

Keywords: metallization; radio frequency performance; SLA reflector; three-dimensional printed Abstract A novel high precision and lightweight reflector antenna is proposed. The fabrication process of the reflector adopted Stereo Lithography Apparatus (SLA) printed and metallization. The proposed SLA Reflector (SLAR) antenna structure adopts three-dimensional-printed, which can design complex geometric shapes flexibly and rapid prototyping. That is a good substitute for the traditional method of millimeter wave reflector processing. In order to realize radio frequency (RF) characteristics perfectly, the metallization process of photosensitive resin was elaborated, which realized by first electroless nickel plating, then copper electroplating, and finally chromium electroplating on the protective layer. For verification, the designed reflector antenna was manufactured and measured. The reflectivity of SLAR was measured well by the bow method, which validates excellent fabrication accuracy and reliability. The gain and pattern were measured in the anechoic chamber. The results show that the proposed reflector antenna achieves the gain of 25dBi and the 3dB gain bandwidth of 43% over the full Ka-band. A good agreement can be observed between measurement and simulation. Biographical information: Liwei Guo received the B.E. degree in from the Guilin University of Electronic Technology, Guilin, China in 2006. She is currently pursuing the PhD degree in Guilin University of Electronic Technology, Guilin, China. Her current research interests include metasurfaces, millimeter-wave reflector antenna. Simin Li received the B.S. degree in wireless communication engineering from Nanjing University of Posts and Telecommunications, Nanjing, China, in 1984, and the M.S. and PhD degrees in electronics engineering from the University of Electronic Science and Technology of China, Chengdu, China, in 1989 and 2007, respectively. Dr. Li is currently the President and a Professor with Guangxi University of Science and Technology, Liuzhou, China. His current research interests include the design of electrically small antennas, antenna arrays for high-frequency communication systems, and wireless sensor networks. Xing Jiang received the Master's degree in electromagnetic field and microwave technology from Beijing Institute of Technology, Beijing, China, in 1986. Since 2000, she has been a Professor with the Guilin University of Electronic Technology, Guilin, China. She was sponsored by the National Natural Science Foundation of China and the Natural Science Foundation of Guangxi. Her research interests include smart communication system design, conformal antenna array, and bioelectromagnetics. Xin Liao received the B.E. degree from Chongqing University of Posts and Telecommunications, Chongqing, China, in 1990. He is currently a Lecturer with the Guilin University of Electronic Technology, Guilin, China. His research interests include Electromagnetic Compatibility and antenna measurement. Ying Zhang received the B.E. degree in Harbin Institute of Technology of optical instrument. Now she is a researcher at Beijing Simulation Center. Her research interest is the simulation of visible light/infrared guidance and control systems. Bin Shi is an associate researcher- in Beijing Simulation Center. Her research interest is the simulation of radio frequency target accuracy. Article Note: Funding information Guangxi Innovation Driven Development Special Fund Project, Grant/Award Number: GUIKEAA19254012; Innovation Project of Guangxi Graduate Education, Grant/Award Number: YCBZ2019051; National Natural Science Foundation of China, Grant/Award Numbers: 61761012, 61661011 Byline: Liwei Guo, Simin Li, Xing Jiang, Xin Liao, Ying Zhang, Bin Shi

Colorimetry methods, Humans, Microfluidics, Paper, Printing, Three-Dimensional, Reproducibility of Results, Drinking Water analysis, and Nitrites

To ensure safe drinking water, it is necessary to have a simple method by which the probable pollutants are detected at the point of distribution. Nitrite contamination in water near agricultural locations could be an environmental concern due to its deleterious effects on the human population. The development of a frugal paper-based microfluidic sensor could be desirable to achieve the societal objective of providing safe drinking water. This work describes the development of a facile and cost-effective microfluidic paper-based sensor for quantitative estimation of nitrite in aquatic environments. A simple punching machine was used for fabrication and rapid prototyping of paper-based sensors without the need of any specialized equipment or patterning techniques. A reusable 3D printed platform served as the support for simultaneous testing of multiple samples. The nitrite estimation was carried out with smartphone-assisted digital image acquisition and colorimetric analysis. Under optimized experimental conditions, the variation in average grayscale intensity with concentration of nitrite was linear in the range from 0.1 to 10 ppm. The limits of detection and quantitation were 0.12 ppm and 0.35 ppm respectively. The reproducibility, expressed as relative standard deviation was 1.31%. The selectivity of nitrite detection method was determined by performing interference studies with commonly existing co-ions in water, such as bicarbonates, chloride and sulphate. The paper-based sensor was successfully applied for estimation of nitrite in actual water samples and showed high recoveries in the range of 83.5-109%. The results were in good agreement with those obtained using spectrophotometry. The developed paper-based sensor method, by virtue of its simplicity, ease of fabrication and use, could be readily extended for detection of multiple analytes in resource-limited settings.
(Copyright © 2022 Elsevier Inc. All rights reserved.)

Engineering regulatory parts for improved performance in genetic programs has played a pivotal role in the development of the synthetic biology cell programming toolbox. Here, we report the development of a novel high-throughput platform for regulatory part prototyping and analysis that leverages the advantages of engineered DNA libraries, cell-free protein synthesis (CFPS), high-throughput emulsion droplet microfluidics, standard flow sorting adapted to screen droplet reactions, and next-generation sequencing (NGS). With this integrated platform, we screened the activity of millions of genetic parts within hours, followed by NGS retrieval of the improved designs. This in vitro platform is particularly valuable for engineering regulatory parts of nonmodel organisms, where in vivo high-throughput screening methods are not readily available. The platform can be extended to multipart screening of complete genetic programs to optimize yield and stability.

Purpose: An automated algorithm for generating realizable MR gradient and shim coil layouts based on the boundary element method is presented here. The overall goal is to reduce postprocessing effort and thus enable for rapid prototyping of new coil designs. For a given surface mesh and target field, the algorithm generates a connected, non-overlapping wire path.
Methods: The proposed algorithm consists of several steps: Stream function optimization, two-dimensional surface projection, potential discretization, topological contour sorting, opening and interconnecting contours, and finally adding non-overlapping return paths. Several technical parameters such as current strength, inductance and field accuracy are assessed for quality control.
Results: The proposed method is successfully demonstrated in four different examples. All exemplary results demonstrate high accuracy with regard to reaching the respective target field. The optimal discretization for a given stream function is found by generating multiple layouts while varying the input parameter values.
Conclusion: The presented algorithm allows for a rapid generation of interconnected coil layouts with high flexibility and low discretization error. This enables to reduce the overall post-processing effort. The source code of this work is publicly available ( https://github.com/Philipp-MR/CoilGen).
(© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Background: Temporal hollowing is a common complication following the rotation of the temporalis muscle that leaves the patient with a cosmetic impairment. Several alloplastic materials have been used to reconstruct the donor site; however, these implants need meticulous adaptation to conform the periphery of the defect and restore the contour of the temporal area. The aim of this study was to assess the use of patient-specific polyetheretherketone (PEEK) temporal implants to prevent temporal hollowing following the use of full temporalis muscle flap for large maxillary defects reconstruction.
Methods: This was a prospective study conducted on eight patients with major maxillary defects indicating the need of reconstruction with full temporalis muscle flap or any lesion indicating major maxillary resection and immediate reconstruction with total temporalis muscle flap. For each patient, a patient-specific PEEK implant was fabricated using virtual planning and milled from PEEK blocks. In the surgical theater, the temporalis muscle was exposed, elevated, and transferred to the maxilla. After the temporalis muscle transfer, PEEK implants were fixed in place to prevent temporal hollowing.
Results: The surgical procedures were uneventful for all patients. The esthetic result was satisfactory with no post-operative complications except in one patient where seroma occurred after 2 weeks and resolved after serial aspiration.
Conclusion: Patient-specific PEEK implant appears to facilitate the surgical procedures eliminate several meticulous steps that are mainly based on the surgeon's experience.
Trial Registration: Clinical trials registration: NCT05240963 .
(© 2022. The Author(s).)

Purpose: This study compared the dimensional changes between the computer-aided design and computer-aided manufacturing (CAD-CAM) milled complete denture bases (CDBs) and three-dimensional (3D) printed CDBs.
Materials and Methods: One maxillary completely edentulous stone model was fabricated with three reference points at the incisive papilla, right molar, and left molar areas marked as X, Y, and Z, respectively. It was scanned to produce a standard tessellation language (STL) file, which was imported to a metal milling machine software to produce the metal model. This metal model was used to fabricate 30 CDBs for analysis in this study. The CDBs were divided into three groups (n = 10 each) according to the fabrication method used as follows: Group 1, CAD-CAM milled CDBs; Group 2, 3D printed CDBs; and Group 3, conventional compression molded CDBs. The CDBs of all groups were scanned after fabrication, and the dimensional changes in each were evaluated by two methods. The first was the two-dimensional evaluation method that involved linear measurement of the distances between the reference points (X-Y, X-Z, and Y-Z) of the scanned reference cast and dentures. The second method was the 3D evaluation method that involved the superimposition of the STL files of the dentures on the STL file of the reference cast. Data were calculated and were statistically analyzed using one-way analysis of variance and Tukey's pairwise post hoc tests.
Results: There was a significant difference in the dimensional accuracy between the CAD-CAM milled, 3D printed, and conventional compression molded CDBs (P<0.05).
Conclusion: The dimensional accuracy of the CAD-CAM milling system in complete denture fabrication is superior to that of the compression molding and 3D printing systems. This article is protected by copyright. All rights reserved.
(This article is protected by copyright. All rights reserved.)

An electrochemical multi-scale model framework for the simulation of arbitrarily three-dimensional structured electrodes for lithium-ion batteries is presented. For the parameterisation, the electrodes are structured via laser ablation, and the model is fit to four different, experimentally electrochemically tested cells. The parameterised model is used to optimise the parameters of three different pattern designs, namely linear, gridwise, and pinhole geometries. The simulations are performed via a finite element implementation in two and three dimensions. The presented model is well suited to depict the experimental cells, and the virtual optimisation delivers optimal geometrical parameters for different C-rates based on the respective discharge capacities. These virtually optimised cells will help in the reduction of prototyping cost and speed up production process parameterisation.

Background: The rise of digital methods and computational tools has opened up the possibility of collecting and analyzing data from novel sources, such as discussions on social media. At the same time, these methods and tools introduce a dependence on technology, often resulting in a need for technical skills and expertise. Researchers from various disciplines engage in empirical bioethics research, and software development and similar skills are not usually part of their background. Therefore, researchers often depend on technical experts to develop and apply digital methods, which can create a bottleneck and hinder the broad use of digital methods in empirical bioethics research.
Objective: This study aimed to develop a research platform that would offer researchers the means to better leverage implemented digital methods, and that would simplify the process of developing new methods.
Methods: This study used a mixed methods approach to design and develop a research platform prototype. I combined established methods from user-centered design, rapid prototyping, and agile software development to iteratively develop the platform prototype. In collaboration with two other researchers, I tested and extended the platform prototype in situ by carrying out a study using the prototype.
Results: The resulting research platform prototype provides three digital methods, which are composed of functional components. This modular concept allows researchers to use existing methods for their own experiments and combine implemented components into new methods.
Conclusions: The platform prototype illustrates the potential of the modular concept and empowers researchers without advanced technical skills to carry out experiments using digital methods and develop new methods. However, more work is needed to bring the prototype to a production-ready state.
(©Manuel Schneider. Originally published in JMIR Formative Research (https://formative.jmir.org), 05.05.2022.)

Electrodes, Glucose, Gold chemistry, Hydrogen Peroxide, Silver, Electrochemical Techniques, and Microfluidics

We present a low-cost, accessible, and rapid fabrication process for electrochemical microfluidic sensors. This work leverages the accessibility of consumer-grade electronic craft cutters as the primary tool for patterning of sensor electrodes and microfluidic circuits, while commodity materials such as gold leaf, silver ink pen, double-sided tape, plastic transparency films, and fabric adhesives are used as its base structural materials. The device consists of three layers, the silver reference electrode layer at the top, the PET fluidic circuits in the middle and the gold sensing electrodes at the bottom. Separation of the silver reference electrode from the gold sensing electrodes reduces the possibility of cross-contamination during surface modification. A novel approach in mesoscale patterning of gold leaf electrodes can produce generic designs with dimensions as small as 250 μm. Silver electrodes with dimensions as small as 385 μm were drawn using a plotter and a silver ink pen, and fluid microchannels as small as 300 μm were fabricated using a sandwich of iron-on adhesives and PET. Device layers are then fused together using an office laminator. The integrated microfluidic electrochemical platform has electrode kinetics/performance of Δ Ep = 91.3 mV, Ipa / Ipc = 0.905, characterized by cyclic voltammetry using a standard ferrocyanide redox probe, and this was compared against a commercial screen-printed gold electrode (Δ Ep = 68.9 mV, Ipa / Ipc = 0.984). To validate the performance of the integrated microfluidic electrochemical platform, a catalytic hydrogen peroxide sensor and enzyme-coupled glucose biosensors were developed as demonstrators. Hydrogen peroxide quantitation achieves a limit of detection of 0.713 mM and sensitivity of 78.37 μA mM -1 cm -2 , while glucose has a limit of detection of 0.111 mM and sensitivity of 12.68 μA mM -1 cm -2 . This rapid process allows an iterative design-build-test cycle in under 2 hours. The upfront cost to set up the system is less than USD 520, with each device costing less than USD 0.12, making this manufacturing process suitable for low-resource laboratories or classroom settings.

Problem: Physicians are playing a growing role as clinician-innovators. Academic physicians are well-positioned to contribute to the medical device innovation process, and yet few medical school curricula provide students opportunities to learn the conceptual framework for clinical needs finding, needs screening, concept generation and iterative prototyping, and intellectual property management. This framework supports innovation and encourages the development valuable interdisciplinary communication skills and collaborative learning strategies.
Approach: Our university offers a novel 3-year-long medical student Longitudinal Interdisciplinary Elective in Biodesign (MSLIEB) that teaches medical device innovation in 4 stages: (1) seminars and small group work, (2) shared clinical experiences for needs finding, (3) concept generation and product development by serving as consultants for biomedical engineering capstone projects, and (4) reflection and mentorship. The MSLIEB objectives are to: create a longitudinal interdisciplinary peer mentorship relationship between undergraduate biomedical engineering students and medical students; and encourage codevelopment of professional identities in relation to medical device innovation.
Outcomes: The MSLIEB enrolled 5 entering cohorts from 2017-2021 with a total of 37 medical student participants. The first full entering cohort of 12 medical students produced 8 mentored biomedical engineering capstone projects, 7 of which were based on clinical needs statements derived from earlier in the elective. Medical student participants have coauthored poster and oral presentations, contributed to projects that won WolfieTank, a university-wide competition modeled after the television show Shark Tank, and participated in the filing of provisional patents. Students reflecting on the course reported a change in their attitude towards existing medical problems, felt better-equipped to collaboratively design solutions for clinical needs, and considered a potential career path in device design.
Next Steps: The MSLIEB will be scaled-up by recruiting additional faculty, broadening clinical opportunities to include the outpatient setting, and increasing medical student access to rapid prototyping equipment.

Gamification in medical education involves integrating game principles-including mechanics, design, or experiences-into a learning context. Game-based approaches in higher education have been shown to improve student engagement, motivation, and performance when applied effectively. Many medical students report feeling overwhelmed by the complexity and content-heavy nature of anatomy, making it an ideal subject for gamification. In this project, we developed and designed an educational anatomy card game intended for medical students. Students in the inaugural cohort of the Certificate in Biomedical Visualization and Communication (BMVC) at the University of British Columbia teamed up with the Hackspace for Immersive Virtual Experiences (HIVE) and faculty advisors for their capstone project. The team collected survey responses from current medical students to determine desirable game features and dynamics, followed by several rounds of prototyping and piloting. The students also enlisted the help of a subject matter expert in game design. The final card game, entitled "Gut it Out", is appropriate for players possessing any level of anatomy knowledge, with optional mechanics designed for medical students. Gameplay involves players competing to build fully innervated and vascularized organs. Organ cards specify the number of blood vessel cards (arteries and veins) and nerve cards (somatic, sympathetic, and parasympathetic) required for completion. Additional clinical cards can be played to gain advantages or sabotage opponents. An optional gameplay component challenges players to name each blood vessel and nerve associated with the organs they have completed in exchange for double points. Aesthetics feature a high-contrast colour palette and bold, simple organ illustrations. The team developed multiple versions of the rules that are currently being play tested by medical students and anatomists. Future directions include incorporating an interactive augmented reality component to enrich the educational value of the organ cards and conducting a mixed methods study to assess the efficacy of the game as a study tool. "Gut it Out" applies gamification to anatomy education to create a fun and educational card game featuring accessible, fast-paced gameplay. This game was designed to complement and expand the current ecosystem of anatomy resources hosted by the HIVE.
(© FASEB.)

Humans, Oxides, Printing, Three-Dimensional, Radiography, Strontium, and Acquired Immunodeficiency Syndrome

The aim of this research was to assess a selection of radiopaque filler compounds for increasing radiopacity in a resin suitable for Polyjet multi-material 3D printing. A radiopaque resin has potential applications in medicine to produce patient-specific anatomical models with realistic radiological properties, training aids, and skin contacting components such as surgical or procedural guides that require visibility under fluoroscopy. The desirable filler would have a high level of radiopacity under ionising imaging modalities, such as X-ray, CT, fluoroscopy or angiography. Nine potential filler compounds were selected based on atomic number and handling risk: barium sulphate, bismuth oxide, zirconium oxide, strontium oxide, strontium fluoride, strontium carbonate, iodine, niobium oxide and tantalum oxide. The fillers were evaluated using selected criteria. A weighted material selection matrix was developed to prioritise and select a filler for future 3D printing on a multi-material 3D printer. Zirconium oxide was the highest scoring filler compound in the material selection matrix, scoring 4.4 out of a maximum of 5. MED610 TM resin doped with zirconium oxide was shown to be UV curable, and when cured is non-toxic, environmentally friendly, and has the ability to display antimicrobial properties. In terms of radiopacity, a sample with thickness 1.5 mm of MED610™ resin doped with 20 wt.% zirconium oxide produced X-ray radiopacity equivalent to 3 mm of aluminium. Zirconium oxide was selected using the material selection matrix. This radiopaque resin can be used to produce anatomical models with accurate radiological properties, training aids or skin contacting devices that require visibility under ionising imaging modalities. The 3D printing validation run successfully demonstrated that the material selection matrix prioritised a filler suitable for radiopaque multi-material 3D printing.

Rehabilitation of a post-exenterated orbital defect is a necessity, to restore a patient's esthetic appearance and help overcome the associated psychosocial stigma. An implant supported prosthesis enjoys a better patient acceptance due to its superior retention and stability. This clinical report highlights the challenges faced in planning, designing and placement of maxillofacial implants in the supra-orbital rim of an exenterated socket post-radiotherapy along with the management of the unexpected complications which developed subsequently. Administration of hyperbaric oxygen therapy, fabrication of a digitally designed surgical guide to ensure predictable implant placement, selection of surface treated implants for better biomechanical anchorage, and a gentler surgical technique for recovery of irradiated hard and soft tissues were measures undertaken during the treatment phase. An effort has been made to point-out the fact that despite the various approaches adopted in an irradiated patient, success of implant placement in such a situation remains a challenge.
(© 2022 Craniofacial Research Foundation. Published by Elsevier B.V. All rights reserved.)

3D printing -- Case studies, Engineering schools -- Case studies, Labor market -- Case studies, and Mechanical engineering -- Case studies

Keywords: 3D digitizing; design skills; hands-on activities; redesign; reverse engineering Abstract Today's job market is seeking engineers with competencies to design innovative solutions that meet sophisticated customer needs. Engineering education is then challenged to equip future engineers with holistic engineering design skills, especially functional ones. A powerful means to strengthen these skills is the use of reverse-engineering-based activities, which consist of examining, extracting information, and redesigning existing products. However, most current education endeavours, based on reverse engineering, consist only of practicing simple teardowns that have circumscribed impact on the acquisition of skills. Therefore, there is a need for more elaborated authentic hands-on activities to gain a broad set of design skills. This study addresses this gap by the development of a concept of wide-ranging engineering activities that start with the study of an existing product and ends with an improved redesigned three-dimensional (3D) printed product. This concept of activities was developed to strengthen a conventional course on product design. Thus, a tailored comprehensive redesign process is proposed first, and expanded as a concept of a set of experiential activities, with associated measures for skills acquisition. This concept encompasses teardown, 3D digitizing and rapid prototyping, and aims mainly at facilitating the understanding of components' functionalities, the numerical reconstruction by 3D digitizing, the mechanical modelling and engineering analysis of parts and finally the 3D printing of the redesign output. To understand, experience, and weigh up the relevance of the proposed concept of activities, a preliminary implementation, and a case study are illustrated. Particularly, the relevance of the concept is demonstrated through the assessment of the activities' measures. In short, this study provides educators with an authentic education tool that leverages on a broader reverse engineering vision to boost the job's sought-after design skills. Byline: Mohammed Akerdad, Ahmed Aboutajeddine, Mohammed Elmajdoubi

Program errors -- Analysis, Executives -- Analysis, Computer science -- Analysis, Business, and Computers and office automation industries

Keywords Concolic testing; Virtual prototyping; SystemC; RISC-V; Internet of things Abstract Constrained Internet of Things (IoT) devices with limited computing resource are increasingly employed in security critical areas. Therefore, it is important for the firmware of these devices to be tested sufficiently. On non-constrained conventional devices, dynamic testing techniques (e.g. fuzzing, symbolic execution, or concolic testing) are successfully utilized to discover critical bugs in tested software. Unfortunately, the diverse ecosystem and the dependence on low-level details of a wide range of peripherals makes it difficult to use these techniques in the IoT context. In order to address these challenges, we present SymEx-VP an open source emulation-based approach for concolic testing of IoT firmware. SymEx-VP is a virtual prototype for RISC-V hardware platforms and allows concolic testing of RISC-V machine code. To support a wide range of different peripherals, SymEx-VP utilizes SystemC, a hardware modeling language for C++. By employing a SystemC extension mechanism, SymEx-VP can inject concolic inputs into the emulated firmware through the memory-mapped I/O peripheral interface of existing SystemC peripheral models. This allows us to support different operating systems and libraries used in the IoT with minimal integration effort. We provide an extensive description of SymEx-VP, illustrate peripheral modeling and firmware testing using it by example, and perform tests with four operating systems to demonstrate the advantages of our OS-agnostic firmware testing method. Author Affiliation: (a) Institute of Computer Science, University of Bremen, Bremen, Germany (b) Cyber-Physical Systems, DFKI GmbH, Bremen, Germany * Corresponding author. Article History: Received 21 December 2021; Revised 25 February 2022; Accepted 2 March 2022 (footnote) The code (and data) in this article has been certified as Reproducible by Code Ocean: (https://codeocean.com/). More information on the Reproducibility Badge Initiative is available at https://www.elsevier.com/physical-sciences-and-engineering/computer-science/journals. (footnote)[white star] This work was supported in part by the German Federal Ministry of Education and Research (BMBF) within the poject Scale4Edge under contract no. 16ME0127 and within the project VerSys under contract no. 01IW19001. Byline: Sören Tempel [tempel@uni-bremen.de] (a,*), Vladimir Herdt [vherdt@uni-bremen.de] (a,b), Rolf Drechsler [drechsler@uni-bremen.de] (a,b)

Curriculum, Humans, Physical Education and Training, Schools, Educational Personnel, and Students

School-based programs may be more effective when an array of stakeholders, including users, are involved during the relevant stages of program co-creation-specifically during key development stages such as design, implementation and evaluation. How such programs can be operationally co-created and tested is less known and is therefore the purpose of this article. Two sequential co-design phases underpin this study. First, a co-design session with 20 health and physical education (HPE) teachers focussed on reviewing, testing and critically discussing initial prototype online modules for an alcohol education program. Teacher insights were assessed and incorporated, and the updated online modules were tested with secondary school students (n = 120) capturing their experience in a classroom setting. Insights from each group were analysed using thematic analysis. Teachers and students serve important roles in program co-creation. Teachers remain an underutilized stakeholder group whom are however critical in delivering important insights to enhance educational program design. Teachers demanded more relevance to the national curriculum, further alignment with curriculum assessment standards, and age appropriate content. Student feedback focussed largely on realistic content, personalization and gamification elements. This study represents an application of the seven-step co-design process and advances understanding of the 'fuzzy back-end' of the process, namely reflecting on feasibility of integrating teacher and student feedback and ideas. More specifically, how these key-yet distinct-stakeholder groups can be involved, and the merits of their involvement are discussed.
(© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

The nanophotonic engineering of light-matter interactions has profoundly changed research behind the design and fabrication of optical materials and devices. Metasurfaces-arrays of subwavelength nanostructures that interact resonantly with electromagnetic radiation-have emerged as an integral nanophotonic platform for a new generation of ultrathin lenses, displays, polarizers and other devices. Their success hinges on advances in lithography and nanofabrication in recent decades. While existing nanolithography techniques are suitable for basic research and prototyping, issues of cost, throughput, scalability, and substrate compatibility may preclude their use for many metasurface applications. Patterning via spontaneous self-assembly of block copolymer thin films offers an enticing alternative for nanophotonic manufacturing that is rapid, inexpensive, and applicable to large areas and diverse substrates. This review discusses the advantages and disadvantages of block copolymer-based nanopatterning and highlights recent progress in their use for broadband antireflection, surface enhanced Raman spectroscopy, and other nanophotonic applications. Recent advances in diversification of self-assembled block copolymer nanopatterns and improved processes for enhanced scalability of self-assembled nanopatterning using block copolymers are also discussed, with a spotlight on directions for future research that would enable a wider array of nanophotonic applications.
(© 2022 US Government.)

Microwave undulators (MUs) have great potential to be an alternative solution to permanent magnet undulators in a free electron laser (FEL) when shorter undulator periods are required. In this paper, the factors that affect the choice of the high-power drive sources were studied via a Ka-band cavity-type MU with a corrugated waveguide proposed for the CompactLight X-ray FEL. They include the technology of the high-power vacuum electronic devices, the quality factor of the MU cavity that was demonstrated by prototyping a short section of the MU structure, and the beam dynamic study of the electrons' trajectories inside the MU. It showed that at high beam energy, a high-power oscillator is feasible to be used as the drive source. At low beam energy, the maximum transverse drift distance becomes larger therefore an amplifier has to be used to minimize the drift distance of the electrons by controlling the injection phase.
(© 2022. The Author(s).)

Adolescent, Adult, Anti-Retroviral Agents therapeutic use, Continuity of Patient Care, Humans, Mozambique, Pilot Projects, Public Health, HIV Infections drug therapy, and Medication Adherence

Adolescents and young people represent a growing proportion of people living with HIV (AYAHIV), and there is an urgent need to design, implement, and test interventions that retain AYAHIV in care. Using a human-centered design (HCD) approach, we codesigned CombinADO, an intervention to promote HIV viral suppression and improve antiretroviral therapy (ART) adherence and retention in care among AYAHIV in Nampula, Mozambique. The HCD process involves formative design research with AYAHIV, health care providers, parents/caretakers, and experts in adolescent HIV; synthesis of findings to generate action-oriented insights; ideation and prototyping of intervention components; and a pilot study to assess feasibility, acceptability, and uptake of intervention components.CombinADO promotes ART adherence and retention in care by fostering peer connectedness and belonging, providing accessible medical knowledge, demystifying and destigmatizing HIV, and cultivating a sense of hope among AYAHIV. Successful prototypes included a media campaign to reduce HIV stigma and increase medical literacy; a toolkit to help providers communicate and address the unique needs of AYAHIV clients; peer-support groups to improve medical literacy, empower youth, and provide positive role models for people living with HIV; support groups for parents/caregivers; and discreet pill containers to promote adherence outside the home. In the next phase, the effectiveness of CombinaADO on retention in care, ART adherence, and viral suppression will be evaluated using a cluster-randomized control trial.We demonstrate the utility of using HCD to cocreate a multicomponent intervention to retain AYAHIV in care. We also discuss how the HCD methodology enriches participatory methods and community engagement. This is then illustrated by the youth-driven intervention development of CombinADO by fostering youth empowerment, addressing power imbalances between youth and adult stakeholders, and ensuring that language and content remain adolescent friendly.
(© Mukherjee et al.)