Byline: Mohamed Farid Shehab, Nabila Mohammed Abdel Hamid, Nevien Abdullatif Askar, Ahmed Mokhtar Elmardenly Keywords: CAD-CAM, electron beam melting; immediate mandibular reconstruction; patient-specific titanium mesh; rapid prototyping Abstract Background Immediate mandibular reconstruction was performed using a patient-specific titanium mesh tray fabricated by electron beam melting (EBM) /rapid prototyping techniques. Methods Patient-specific titanium trays were virtually designed and fabricated using EBM technology/rapid prototyping for patients requiring mandibular resection and immediate reconstruction using an iliac crest bone graft. Dental implants were placed in the grafted sites and the patients received prosthetic rehabilitation with a follow-up of one year. Clinical data, postoperative bone formation and complications were evaluated. Results A symmetric appearance of facial contours was achieved. The titanium tray incorporated the particulate iliac crest bone graft that provided significant bone formation (mean 18.97 [+ or -] 1.45 mm) and predictable results. Stability of the dental implants was achieved. Conclusion The patient-specific titanium meshes and immediate particulate autogenous bone graft showed satisfactory clinical and surgical results in improving patients' quality of life and decreasing the overall treatment time with adequate functional rehabilitation.
Dorozynski, Przemyslaw, Jamroz, Witold, Wegiarz, Wladyslaw P., Kulinowski, Wojciech, Zaborowski, Mateusz, and Kulinowski, Piotr
Dissolution Technologies. Nov 2018, Vol. 25 Issue 4, p48, 6 p.
3D printing and Testing equipment
INTRODUCTION The number of studies concerning application of three dimensional (3D) printing techniques in pharmaceutical technology has grown continuously since 2005, but the main interest in application of these techniques [...] Purpose of the research was to assess feasibility of fused deposition techniques (3D printing) for development of analytical equipment dedicated for specific dosage forms and for nonstandard applications. Dissolution profiles as well as 3D magnetic resonance imaging (MRI) of the buccal tablets during hydration in dissolution medium were analyzed. The principal result of the study was the first working example of rapid 3D prototyping of dedicated, MRI-compatible dissolution equipment for mucoadhesive buccal tablets. Rapid prototyping techniques were found to be a fast, inexpensive way to develop a dedicated dissolution testing setup. KEYWORDS: additive manufacturing, 3D printing, solid free-form fabrication, buccal bioadhesive tablets, 3D ultrashort echo time magnetic resonance imaging (3D UTE MRI), pharmaceutical dissolution testing equipment