Comina, German, Suska, Anke, Filippini, Daniel, Linköpings universitet, Institutionen för fysik, kemi och biologi, Linköpings universitet, Tekniska högskolan, and Linköpings universitet, Institutionen för fysik, kemi och biologi, Kemiska och optiska sensorsystem
Lab on a Chip. 14(16):2978-2982
Natural Sciences, Physical Sciences, Naturvetenskap, and Fysik
Versatile prototyping of 3D printed lab-on-a-chip devices, supporting different forms of sample delivery, transport, functionalization and readout, is demonstrated with a consumer grade printer, which centralizes all critical fabrication tasks. Devices cost 0.57US$ and are demonstrated in chemical sensing and micromixing examples, which exploit established principles from reference technologies.
Carlborg, Carl Fredrik, Haraldsson, Tommy, Öberg, Kim, Malkoch, Michael, van der Wijngaart, Wouter, KTH, Skolan för elektro- och systemteknik (EES), Mikrosystemteknik (Bytt namn 20121201), and KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi, Ytbehandlingsteknik
Lab on a Chip. 11(18):3136-3147
Natural Sciences, Chemical Sciences, Naturvetenskap, Kemi, LoC lab-on-chip OSTE thiol-enes microfluidics, TECHNOLOGY, and TEKNIKVETENSKAP
In this article we introduce a novel polymer platform based on off-stoichiometry thiol–enes (OSTEs), aiming to bridge the gap between research prototyping and commercial production of microfluidic devices. The polymers are based on the versatile UV-curable thiol–ene chemistry but takes advantage of off-stoichiometry ratios to enable important features for a prototyping system, such as one-step surface modifications, tuneable mechanical properties and leakage free sealing through direct UV-bonding. The platform exhibits many similarities with PDMS, such as rapid prototyping and uncomplicated processing but can at the same time mirror the mechanical and chemical properties of both PDMS as well as commercial grade thermoplastics. The OSTE-prepolymer can be cast using standard SU-8 on silicon masters and a table-top UV-lamp, the surface modifications are precisely grafted using a stencil mask and the bonding requires only a single UV-exposure. To illustrate the potential of the material we demonstrate key concepts important in microfluidic chip fabrication such as patterned surface modifications for hydrophobic stops, pneumatic valves using UV-lamination of stiff and rubbery materials as well as micromachining of chip-to-world connectors in the OSTE-materials.
Preechaburana, Pakorn, Filippini, Daniel, Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik, Linköpings universitet, Tekniska fakulteten, and Linköpings universitet, Tekniska högskolan
LAB ON A CHIP. 11(2):288-295
Engineering and Technology, Teknik och teknologier, TECHNOLOGY, and TEKNIKVETENSKAP
This article describes a method and platform for fast prototyping of monolithic 3D microstructures, capable of producing arbitrary positive, negative and suspended 3D geometries, as well as sealed spaces and aligned 3D geometries using standard photoresists and few fabrication steps. Here a microfabrication method employing a mask-less micro-projection lithography platform, which co-exists on a routine fluorescence microscope, has been refined to produce a variety of 3D microstructures with up to 5 mm spatial resolutions and 10 : 1 aspect ratios, as well as its integration within macroscopic areas of several millimetres with up to 30 mu m spatial resolutions.