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Yu, F., Stål, P., Thornell, L.-E., and Larsson, L.
- Journal of Muscle Research & Cell Motility; Aug2002, Vol. 23 Issue 4, p317-326, 10p
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Striated craniofacial and limb muscles differ in their embryological origin, regulatory program during myogenesis, and innervation. In an attempt to explore the effects of these differences on the striated muscle phenotype in humans, the expression of myosin and myosin-associated thick filament proteins were studied at the single fiber level both in the human jaw-closing masseter muscle and in two limb muscles (biceps brachii and quadriceps femoris muscles). In the masseter, unique combinations of myosin heavy chain (MyHC) and myosin binding protein C (MyBP-C) isoforms were observed at the single fiber level. Compared to the limb muscles, the MyHC isoform expression was more complex in the masseter while the opposite was observed for MyBP-C. In limb muscles, a coordinated expression of three MyHC and three MyBP-C isoforms were observed, i.e., single fibers contained one or two MyHC isoforms, and up to three MyBP-C isoforms. Also, the relative content of the different MyBP-C isoforms correlated with the MyHC isoform expression. In the masseter, on the other hand, up to five different MyHC isoforms could be observed in the same fiber, but only one MyBP-C isoform was identified irrespective MyHC isoform expression. This MyBP-C isoform had a migration rate similar to the slow MyBP-C isoform in limb muscle fibers. In conclusion, a unique myofibrillar protein isoform expression was observed in the human masseter muscle fibers, suggesting significant differences in structural and functional properties between muscle fibers from human masseter and limb muscles. [ABSTRACT FROM AUTHOR]
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Stål, P., Marklund, S., Thornell, L.-E., De Paul, R., and Eriksson, P.-O.
- Cells Tissues Organs; 2003, Vol. 173 Issue 3, p147-161, 15p, 4 Black and White Photographs, 2 Diagrams, 5 Charts, 5 Graphs
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TONGUE, MORPHOLOGY, COMPARATIVE anatomy, MUSCLES, and MOUTH
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The muscle fibre composition of three human intrinsic tongue muscles, the longitudinalis, verticalis and transversus, was investigated in four anterior to posterior regions of the tongue using morphological and enzyme- and immunohistochemical techniques. All three muscles typically contained type I, IIA and IM/IIC fibres. Type I fibres expressed slow myosin heavy chain (MyHC), type II fibres fast MyHC, mainly fast A MyHC, whereas type IM/IIC coexpressed slow and fast MyHCs. Type II fibres were in the majority (60%), but regional differences in proportion and diameter of fibre types were obvious. The anterior region of the tongue contained a predominance of relatively small type II fibres (71%), in contrast to the posterior region which instead showed a majority of larger type I and type IM/IIC fibres (66%). In general, the fibre diameter was larger in the posterior region. This muscle fibre composition of the tongue differs from those of limb, orofacial and masticatory muscles, probably reflecting genotypic as well as phenotypic functional specialization in oral function. The predominance of type II fibres and the regional differences in fibre composition, together with intricate muscle structure, suggest generally fast and flexible actions in positioning and shaping the tongue, during vital tasks such as mastication, swallowing, respiration and speech.Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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Koona, P., Osisanya, E. O., Lajide, L., Jackai, L. E. N., and Tamo, M.
- Journal of Applied Entomology; Jun2003, Vol. 127 Issue 5, p293, 6p
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PLANT chemical defenses, VIGNA, and COREIDAE
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The effects of secondary metabolites in different Vigna species on the development of Clavigralla tomentosicollis were investigated in an artificial seed system using different fractions of crude pod extracts, while the orientation response of this pod-bug to volatile extracts was studied using a dual-choice olfactometer. Feeding on the neutral fraction extracts, in contrast to the basic and acidic fractions, resulted in significantly higher mortalities, longer total developmental time, and lower growth index of the insects in comparison with controls. All volatile extracts elicited an avoidance reaction by C. tomentosicollis, except the volatile from the susceptible genotype IT84S-2246 which generally attracted as many insects as controls. Extracts from wild Vigna species showed higher activity than those from their cultivated relatives. The present study which has established that most secondary metabolites in cowpea pods were localized in the neutral fraction of the crude extract, could facilitate experiments on the separation and characterization of the toxic factors involved. [ABSTRACT FROM AUTHOR]
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Koona, P., Osisanya, E. O., Jackai, Len, and Tonye, J.
- Environmental Entomology; Jun2004, Vol. 33 Issue 3, p471-476, 6p, 2 Charts, 2 Graphs
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COWPEA, LEGUMES, DEFOLIATION, PLANT canopies, SEED disinfection, EFFECT of temperature on plants, and PHYSIOLOGICAL effects of temperature
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Pottedcowpea, Vigna unguiculata (L.) Walp., plants were used to determine the effects of defoliation and pod position relative to the leaf canopy on infestation and damage by the coreid pod-bugs Clavigralla tomentosicollis Stål and Anoplocnemis curvipes (F.). Temperature measurements were taken within and outside the canopy to determine whether there was a correlation to seed damage. Seed damage decreased significantly with increasing defoliation in plants infested with C. tomentosicollis; an inverse trend was observed with A. curvipes. Temperatures within the canopy increased as the number of leaves decreased. As observed in the defoliation experiment, C. tomentosicollis and A. curvipes reacted differently in a free-choice situation between pods located outside or within the canopy. Significantly higher numbers of C. tomentosicollis concealed themselves within the canopy, where they caused more severe damage to seeds, in comparison with numbers and damage outside the canopy. These trends were reversed for A. curvipes. There was a significant negative correlation between percentage of seed damage and temperature with C. tomentosicollis, and a significant positive correlation with A. curvipes, both in defoliated plants and those with pods distributed outside and within the canopy. Overall, plants with less dense canopy, and long peduncles holding pods outside the canopy showed some resistance to C. tomentosicollis, which is the most damaging pod bug on cowpea. Because such cowpea plants harbor fewer C. tomentosicollis, they are likely to suffer less overall damage from infestation by the complex of pod bugs that occur concurrently in cowpea fields. [ABSTRACT FROM AUTHOR]
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Jirström, K., Rydén, L., Anagnostaki, L., Nordenskjöld, B., Stål, O., Thorstenson, S., Chebil, G., Jönsson, P.-E., Fernö, M., and Landberg, G.
- Journal of Clinical Pathology; Nov2005, Vol. 58 Issue 11, p1135-1142, 8p, 6 Charts, 3 Graphs
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BREAST cancer, CANCER in women, CANCER treatment, THERAPEUTICS, TAMOXIFEN, TUMOR growth, and ESTROGEN
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Background: Subgroups of breast cancer that have an impaired response to endocrine treatment, despite hormone receptor positivily, are still poorly defined. Breast cancer can be subdivided according to standard pathological parameters including histological type, grade, and assessment of proliferation. These parameters are the net result of combinations of genetic alterations effecting tumour behaviour and could potentially reflect subtypes that respond differently to endocrine treatment. Aims: To investigate the usefulness of these parameters as predictors of the response to tamoxifen in premenopausal women with breast cancer. Materials/methods: Clinically established pathological parameters were assessed and related to the tamoxifen response in 500 available tumour specimens from 564 premenopausal patients with breast cancer randomised to either two years of tamoxifen or no treatment with 14 years of follow up. Proliferation was further evaluated by immunohistochemical Ki-67 expression. Results: Oestrogen receptor positive ductal carcinomas responded as expected to tamoxifen, whereas the difference in recurrence free survival between control and tamoxifen treated patients was less apparent in the relatively few lobular carcinomas. For histological grade, there was no obvious difference in treatment response between the groups. The relation between proliferation and tamoxifen response seemed to be more complex, with a clear response in tumours with high and low proliferation, whereas tumours with intermediate proliferation defined by Ki-67 responded more poorly. Conclusions: Clinically established pathology parameters seem to mirror the endocrine treatment response and could potentially be valuable in future treatment decisions for patients with breast cancer. [ABSTRACT FROM AUTHOR]
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de Greef, Tom F. A., Nieuwenhuizen, Marko M. L., Stals, Patrick J. M., Fitié, Carel F. C., Palmans, Anja R. A., Sijbesma, Rint P., and Meijer, E. W.
- Chemical Communications; Sep2008, Vol. 2008 Issue 36, p4306-4308, 3p
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ETHYLENE glycol, THERMODYNAMICS, HYDROGEN bonding, SUPRAMOLECULAR chemistry, SOLVENTS, and CHEMICAL reduction
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Substitution of hydrogen bond directed supramolecular assemblies with ethylene glycol chains leads to a reduction in the association constant in apolar solvents, where the reduction of the association constant is dependent on the length of the aliphatic spacer connecting the hydrogen bonds and the ethylene glycol chain. [ABSTRACT FROM AUTHOR]
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7. A global census of marine microbes [2010]
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Amaral- Zettler, L., Artigas, L.F., Baross, J., Loka Bharathi, P.A., Boetius, A., Chandramohan, D., Herndl, G., Kogure, K., Neal, P., Pedrós-Alió, C., Ramette, A., Schouten, S., Stal, L., Thessen, A., e Leeuw, J., Sogin, M., McIntyre, A.D., and Aquatic Microbiology (IBED, FNWI)
- Life in the world's oceans: diversity, distribution, and abundance. :223-246
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Edmundsson, D., Toolanen, G., Thornell, L‐E., and Stål, P.
- Scandinavian Journal of Medicine & Science in Sports; Dec2010, Vol. 20 Issue 6, p805-813, 9p, 2 Diagrams, 4 Charts, 1 Graph
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COMPARTMENT syndrome, FASCIAE surgery, THERAPEUTICS, ANALYSIS of variance, CAPILLARIES, CHI-squared test, COMPUTER software, EXERCISE, IMMUNOHISTOCHEMISTRY, LEG, LONGITUDINAL method, MICROCIRCULATION, MUSCLES, RESEARCH funding, STRIATED muscle, T-test (Statistics), DATA analysis, CASE-control method, ANALYTICAL chemistry, PATHOLOGY, and DONOR blood supply
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There is a paucity of data regarding the pathogenesis of chronic exertional compartment syndrome (CECS), its consequences for the muscles and the effects of treatment with fasciotomy. We analyzed biopsies from the tibialis anterior muscle, from nine patients, obtained during a decompressing fasciotomy and during follow-up 1 year later. Control biopsies were obtained from nine normal subjects. Muscle capillarity, fiber-type composition and fiber area were analyzed with enzyme- and immunohistochemistry and morphometry. At baseline, CECS patients had lower capillary density (273 vs 378 capillaries/mm, P=0.008), lower number of capillaries around muscle fibers (4.5 vs 5.7, P=0.004) and lower number of capillaries in relation to the muscle fiber area (1.1 vs 1.5, P=0.01) compared with normal controls. The fiber-type composition and fiber area did not differ, but focal signs of neuromuscular damage were observed in the CECS samples. At 1-year follow-up after fasciotomy, the fiber area and the number of fibers containing developmental myosin heavy chains were increased, but no enhancement of the capillary network was detected. Thus, morphologically, patients with CECS seemed to have reduced microcirculation capacity. Fasciotomy appeared to trigger a regenerative response in the muscle, however, without any increase in the capillary bed. [ABSTRACT FROM AUTHOR]
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Groenewald, Gerald
- Historia; Nov2011, Vol. 56 Issue 2, p203-206, 4p
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NAMIBIAN history and NONFICTION
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The article presents a book review of "Môrewind oor die Karasberge: ’n Kultuurhistoriese Verkenning van die Karasstreek van die Laat Negentiende Eeu," by E. L. P. Stals.
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Carloni, E., Virla, E., Paradell, S., Carpane, P., Nome, C., Laguna, I., and Pecci, M. P. GimÉNez
- Journal of Economic Entomology; Dec2011, Vol. 104 Issue 6, p1793-1799, 7p
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EXITIANUS, CORN diseases, LEAFHOPPERS, and INSECTS
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"Corn stunt" caused by the mollicute Spiroplasma kunkelii (Whitcomb) is potentially one of the most severe diseases affecting the corn (Zea mays L.) crop in the Americas, and the leafhopper Dalbulus maidis (DeLong & Wolcott) is considered its most important vector. However, other insects seen quite frequently in corn crops might well be its vectors in Argentina. To identify any leafhoppers species other than D. maidis that can transmit S. kunkelii, transmission assays were conducted, using individuals of Exitianus obscurinervis (Stål) collected in field and reared under controlled conditions. S. kunkelii was transmitted to corn plants by E. obscurirwrvis. The pathogen was transmitted to seven of the 11 plants, which showed characteristic corn stunt symptoms, and the presence of the pathogen was confirmed by DAS-ELISA. The presence of S. kunkelii in the E. obscurinervis individuals used in transmission experiments was confirmed by polymerase chain reaction and electron microscopy. The current study shows the existence of a new experimental vector of S. kunkelii, the leafhopper E. obscurinervis, which acquired spiroplasmas from infected plants and inoculated it to healthy plants. [ABSTRACT FROM AUTHOR]
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Voss, B., Bolhuis, H., Fewer, D.P., Kopf, M., Möke, F., Haas, F., l-Shehawy, R., Hayes, P., Bergman, B., Sivonen, K., Dittmann, E., Scanlan, D.J., Hagemann, M., Stal, L.J., and Hess, W.R.
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Voß, B., Bolhuis, H., Fewer, D., Kopf, M., Möke, F., Haas, F., l-Shehawy, R., Hayes, P., Bergman, B., Sivonen, K., Dittmann, E., Scanlan, D.J., Hagemann, M., Stal, L.J., Hess, W.R., and Aquatic Microbiology (IBED, FNWI)
- PLoS ONE. 8(3)
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Huerta Martinez, E., Genabeek, van, B., Stals, P.J.M., Meijer, E.W., Palmans, A.R.A., Macromolecular and Organic Chemistry, and Macro-Organic Chemistry
- Macromolecular Rapid Communications. 35(15):1320-1325
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Florian, D. de, Grojean, C., Maltoni, F., Mariotti, C., Nikitenko, A., Pieri, M., Savard, P., Schumacher, M., Tanaka, R., Aggleton, R., Ahmad, M.A., Allanach, B., Anastasiou, C., Astill, W., Badger, S.A., Badziak, M., Baglio, J., Bagnaschi, E., Ballestrero, A., Banfi, A., Barducci, D., Beckingham, M., Becot, C., Bélanger, G., Bellm, J., Belyaev, N., Bernlochner, F. U., Beskidt, C., Biekötter, A., Bishara, Fady, Bizon, W., Bomark, N. E., Bonvini, Marco, Borowka, S., Bortolotto, V., Boselli, S., Botella, F. J., Boughezal, R., Branco, G. C., Brehmer, J., Brenner, L., Bressler, S., Brivio, I., Broggio, A., Brun, V.H., Buchalla, G., Burgard, C. D., Calandri, A., Caminada, L., Armadans, R. Caminal, Campanario, F., Campbell, J., Caola, Fabrizio, Calame, C. M. Carloni, Carrazza, Stefano, Carvalho, A., Casolino, M., Cata, O., Celis, A., Cerutti, Francesco, Chanon, N., Chen, M., Chen, X., Nejad, B. Chokoufé, Christensen, N., Ciuchini, M., Contino, R., Corbett, T., Costa, S.R., Curtin, D.M., Dall'Osso, M., David, A., Dawson, S.J., Blas, J. de, Boer, W. de, Manzano, P. de Castro, Degrande, C., Rueda-Delgado, L.M., Demartin, Federico, Denner, A., Micco, B. Di, Nardo, R. Di, Dittmaier, S., Dobado, A., Dorigo, T., Dreyer, F. A., Dührssen, M., Duhr, C., Dulat, F., cker, K., llis, K.A., llwanger, U., nglert, C., priu, D., Falkowski, A., Fayard, L., Feger, R., Ferrera, G., Ferroglia, A., Fidanza, N., Figy, T., Flechl, M., Fontes, J.D., Forte, Stefano, Francavilla, P., Franco, E, Frederix, R., Freitas, A., Freitas, F., Frensch, F., Frixione, S., Fuks, B., Furlan, E., Gadatsch, S., Gao, J., Gao, Y., Garzelli, M. V., Gehrmann, T., Gerosa, R., Ghezzi, M., Ghosh, D., Gieseke, S., Gillberg, D., Giudice, G. F., Glover, E. W. N., Goertz, F., Gonçalves, D., Gonzalez-Fraile, J., Gorbahn, M., Gori, S., Gottardo, C. A., Gouzevitch, Maxime, Govoni, P., Gray, D., Grazzini, M., Greiner, N., Greljo, A., Grigo, J., Gritsan, A. V., Gröber, R., Guindon, S., Haber, H. E., Han, C., Han, T.S., Harlander, R., Harrendorf, M. A., Hartanto, H. B., Hays, C., Heinemeyer, S., Heinrich, G., Herrero, M., Herzog, F., Hespel, B., Hirschi, V., Hoeche, S., Honeywell, S., Huber, S. J., Hugonie, C., Huston, Joey, Ilnicka, A., Isidori, G., Jäger, B., Jaquier, M., Jones, S. P., Juste, A., Kallweit, S., Kaluza, A., Kardos, A., Karlberg, A.T., Kassabov, Zahari, Kauer, N., Kazakov, D. I., Kerner, M., Kilian, W., Kling, M.F., Köneke, K., Kogler, R., Konoplich, R., Kortner, S., Kraml, S., Krause, C., Krauss, F., Krawczyk, P.M., Kulesza, Anna, Kuttimalai, S., Lane, R., Lazopoulos, A., Lee, W.G., Lenzi, P., Lewis, I. M., Li, Y., Liebler, S., van Lindert, E.J., Liu, X., Liu, Z., Llanes-Estrada, F. J., Logan, H. E., Lopez-Val, D., Low, I., Luisoni, G., Maierhöfer, P., Maina, E., Mansoulié, B., Mantler, H., Mantoani, M., Marini, A. C., Outschoorn, V. I. Martinez, Marzani, Simone, Marzocca, D., Massironi, A., Mawatari, K., Mazzitelli, J., McCarn, A., Mellado, B., Melnikov, K., Menari, S. B., Merlo, L., Meyer, C., Milenovic, P., Mimasu, K., Mishima, S., Mistlberger, B., Moch, S. O., Mohammadi, A., Monni, P. F., Montagna, G., Llácer, M. Moreno, Moretti, N., Moretti, S., Motyka, L., Mück, A., Mühlleitner, M., Munir, S., Musella, P., Nadolsky, Pavel, Napoletano, D., Nebot, M., Neu, C., Neubert, R.E.M., Nevzorov, R., Nicrosini, O., Nielsen, J., Nikolopoulos, K., No, J. M., O'Brien, C., Ohl, T., Oleari, C., Orimoto, T. J., Pagani, D., Pandini, C. E., Papaefstathiou, A., Papanastasiou, A. S., Passarino, G., Pecjak, B. D., Pelliccioni, M., Perez, J.G., Perrozzi, Luca, Petriello, F., Petrucciani, G., Pianori, E., Piccinini, F., Pierini, M., Pilkington, A., Plätzer, S., Plehn, T., Podskubka, R., Potter, C. T., Pozzorini, S., Prokofiev, K., Pukhov, A., Puljak, I., Queitsch-Maitland, M., Quevillon, J., Rathlev, D., Rauch, S.A.M., Re, E., Rebelo, M. N., Rebuzzi, D., Reina, L., Reuschle, C., Reuter, J., Riembau, M., Riva, F., Rizzi, A., Robens, T., Röntsch, R., Rojo, J., Romão, J. C., Rompotis, N., Roskes, J., Roth, R., Salam, Gavin P., Salerno, R., Sampaio, M. O. P., Santos, R., Sanz-Nebot, V., Sanz-Cillero, J. J., Sargsyan, H., Sarica, U., Schichtel, P., Schlenk, J., Schmidt, T., Schmitt, C., Schönherr, M., Schubert, U., Schulze, M., Sekula, S. J., Sekulla, M., Shabalina, E., Shao, H. -S., Shelton, J., Shepherd-Themistocleous, C. H., Shim, S. Y., Siegert, F., Signer, A., Da Silva, J.P., Silvestrini, L., Sjodahl, M., Slavich, P., Slawinska, M., Soffi, L., Spannowsky, M., Speckner, C., Sperka, D. M., Spira, M., Stål, O., Staub, F., Stebel, T., Stefaniak, T., Steinhauser, M., Stewart, I. W., Strassler, M. J., Streicher, J., Strom, D. M., Su, S., Sun, X., Tackmann, F. J., Tackmann, K., Teixeira, A. M., Lima, R. Teixeira de, Theeuwes, V., Thorne, R., Tommasini, D., Torrielli, P., Tosi, M., Tramontano, F., Trócsányi, Z., Trott, M., Tsinikos, I., Ubiali, Maria, Vanlaer, P., Verkerke, W., Vicini, A., Viliani, L., Vryonidou, E., Wackeroth, D., Wagner, C. E. M., Wang, J., Wayand, S., Weiglein, G., Weiss, C., Wiesemann, M., Williams, C., Winter, J., Winterbottom, D., Wolf, R., Xiao, S.M., Yang, L. L., Yohay, R., Yuen, S. P. Y., Zanderighi, G., Zaro, M., Zeppenfeld, D., Ziegler, R., Zirke, T., Zupan, J., and (Astro)-Particles Physics
- arXiv.
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Aigner, B. L., Herbert, D. A., Dively, G. P., Venugopal, D., Whalen, J., Cissel, B., Kuhar, T. P., Brewster, C. C., Hogue, J. W., and Seymore, E.
- Journal of Economic Entomology; Dec2016, Vol. 109 Issue 6, p2586-2589, 4p
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SOYBEAN diseases & pests, BROWN marmorated stink bug, and STINKBUGS
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Sampling soybean fields for the brown marmorated stink bug, Halyomorpha halys Stål (Hemiptera: Pentatomidae), can be challenging. Both adults and nymphs have a "startle response" and drop to the ground with even the slightest disturbance. This behavior could reduce the effectiveness of the traditional sweep net and ground cloth sampling methods. In 2013 and 2014, in Virginia, Delaware, and Maryland, we evaluated a visual plant inspection method that consisted of counting the number of brown marmorated stink bug nymphs and adults seen on soybean plants in a 2-min inspection period while walking carefully between two rows. After a 30-min interval, which allowed the stink bugs to reposition in the canopy, the area was resampled using 15 sweeps with a 38-cm-diameter sweep net. In total, 76 soybean fields and 2,042 paired comparisons were used to determine a strong linear relationship between sampling methods (y = 0.984x + 0.4359, R2 = 0.6934, where y = brown marmorated stink bugs/2-min visual count and x = brown marmorated stink bugs/15 sweeps). An average visual count of 5.4 brown marmorated stink bugs in 2 min was estimated as being equivalent to the current economic threshold of 5 stink bugs per 15 sweeps. Visual inspection appears to be an effective method for assessing brown marmorated stink bug populations in soybeans. [ABSTRACT FROM AUTHOR]
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Koch, Robert L., Pezzini, Daniela T., Michel, Andrew P., and Hunt, Thomas E.
- Journal of Integrated Pest Management; 2017, Vol. 8 Issue 1, p1-14, 14p
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BROWN marmorated stink bug, PODISUS, and INSECT pest control
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Stink bugs (Hemiptera: Heteroptera: Pentatomidae) are an emerging threat to soybean and corn production in the midwestern United States. An invasive species, the brown marmorated stink bug, Halyomorpha halys (Stål), is spreading through the region. However, little is known about the complex of stink bug species associated with corn and soybean in the midwestern United States. In this region, particularly in the more northern states, stink bugs have historically caused only infrequent impacts to these crops. To prepare growers and agricultural professionals to contend with this new threat, we provide a review of stink bugs associated with soybean and corn in the midwestern United States. Descriptions and images of common stink bug species are provided as a diagnostic aid. The biologies and impacts of stink bugs to crops are discussed, with particular attention to differences among species. Based primarily on information from southern states, scouting, thresholds, and insecticide-based management of these pests are discussed. It is hoped that this review will provide stakeholders sufficient information for management of these pests, until more region-specific research can be performed on stink bugs in soybean and corn in the midwestern United States. [ABSTRACT FROM AUTHOR]
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den Heijer, Casper D. J., Hoebe, Christian J. P. A., van Liere, Geneviève A. F. S., van Bergen, Jan E. A. M., Cals, Jochen W. L., Stals, Frans S., and Dukers-Muijrers, Nicole H. T. M.
- BMC Infectious Diseases; 4/20/2017, Vol. 17, p1-10, 10p, 1 Diagram, 3 Charts, 1 Graph
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NEISSERIA gonorrhoeae, SEXUALLY transmitted diseases, ANTIBIOTICS, CHLAMYDIA trachomatis, GYNECOLOGISTS, DIAGNOSIS, CHLAMYDIA infection diagnosis, GENITOURINARY disease diagnosis, GONORRHEA diagnosis, CLINICS, GENITOURINARY diseases, GONORRHEA, DISEASES in men, NEISSERIA, PHARYNGEAL diseases, PHYSICIANS, GENERAL practitioners, CROSS-sectional method, and RECTAL diseases
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Background: Gonorrhoea, caused by Neisseria gonorrhoeae (NG), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and is frequently asymptomatic, which shows the essential role of NG test practice. In this study we wanted to compare NG diagnostic testing procedures between different STI care providers serving a defined geographic Dutch region (280,000 inhabitants).Methods: Data on laboratory testing and diagnosis of urogenital and extragenital (i.e. anorectal and oropharyngeal) NG were retrieved from general practitioners (GPs), an STI clinic, and gynaecologists (2006-2010). Per provider, we assessed their contribution regarding the total number of tests performed and type of populations tested, the proportion of NG positives re-tested (3-12 months after treatment) and test-of-cure (TOC, within 3 months post treatment).Results: Overall, 17,702 NG tests (48.7% STI clinic, 38.2% GPs, 13.1% gynaecologists) were performed during 15,458 patient visits. From this total number of tests, 2257 (12.7%) were extragenital, of which 99.4% were performed by the STI clinic. Men were mostly tested at the STI clinic (71%) and women by their GP (43%). NG positivity per visit was 1.6%; GP 1.9% (n = 111), STI clinic 1.7% (n = 131) and gynaecology 0.2% (n = 5). NG positivity was associated with Chlamydia trachomatis positivity (OR: 2.06, 95% confidence interval: 1.46-2.92). Per anatomical location, the proportion of NG positives re-tested were: urogenital 20.3% (n = 36), anorectal 43.6% (n = 17) and oropharyngeal 57.1% (n = 20). NG positivity among re-tests was 16.9%. Proportions of NG positives with TOC by anatomical location were: urogenital 10.2% (n = 18), anorectal 17.9% (n = 7) and oropharyngeal 17.1% (n = 6).Conclusions: To achieve best practice in relation to NG testing, we recommend that: 1) GPs test at extragenital sites, especially men who have sex with men (MSM), 2) all care providers consider re-testing 3 to 12 months after NG diagnosis and 3) TOC is performed following oropharyngeal NG diagnosis in settings which provide services to higher-risk men and women (such as STI clinics). [ABSTRACT FROM AUTHOR]
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en Heijer, Casper D. J., Hoebe, Christian J. P. A., van Liere, Genevieve A. F. S., van Bergen, Jan E. A. M., Cals, Jochen W. L., Stals, Frans S., Dukers-Muijrers, Nicole H. T. M., Promovendi PHPC, Med Microbiol, Infect Dis & Infect Prev, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Family Medicine, and RS: CAPHRI - R5 - Optimising Patient Care
- BMC Infectious Diseases. 17
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Arhrib, A., Hernandez-Sanchez, J., Mahmoudi, F., Santos, R., Akeroyd, A., Moretti, S., Yagyu, K., Yildirim, E., Khater, W., Krawczyk, M., Najjari, S., Sokołowska, D., Osland, P., Purmohammadi, M., Pruna, G., Sharma, P., Stål, O., Aoki, M., Basso, L., and Ginzburg, I.
- European Physical Journal C -- Particles & Fields; May2017, Vol. 77 Issue 5, p1-33, 33p
- Subjects
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HIGGS bosons, SCALAR field theory, SUPERSYMMETRY, STANDARD model (Nuclear physics), DARK matter, and MATHEMATICAL models
- Abstract
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The goal of this report is to summarize the current situation and discuss possible search strategies for charged scalars, in non-supersymmetric extensions of the Standard Model at the LHC. Such scalars appear in Multi-Higgs-Doublet models, in particular in the popular Two-Higgs-Doublet model, allowing for charged and additional neutral Higgs bosons. These models have the attractive property that electroweak precision observables are automatically in agreement with the Standard Model at the tree level. For the most popular version of this framework, Model II, a discovery of a charged Higgs boson remains challenging, since the parameter space is becoming very constrained, and the QCD background is very high. We also briefly comment on models with dark matter which constrain the corresponding charged scalars that occur in these models. The stakes of a possible discovery of an extended scalar sector are very high, and these searches should be pursued in all conceivable channels, at the LHC and at future colliders. [ABSTRACT FROM AUTHOR]
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Woudt, Sjoukje H. S., e Greeff, Sabine C., Schoffelen, Annelot F., Vlek, Anne L. M., Bonten, Marc J. M., Cohen Stuart, J. W. T., Weersink, A. J. L., Vandenbroucke-Grauls, C. M. J. E., Visser, C. E., van Ogtrop, M. L., Kaersenhout, D. J., Scholing, M., van Hees, B. C., van Keulen, P. H. J., Kluytmans, J. A. J. W., Kraan, E. M., Mattsson, E. E., Sebens, F. W., e Jong, E., Frénay, H. M. E., Maraha, B., van Griethuysen, A. J., Silvis, W., Demeulemeester, A., Wintermans, B. B., van Trijp, M., Ott, A., Arends, J. P., Kampinga, G. A., Veenendaal, D., Hol, C., e Brauwer, E. I. G. B., Stals, F. S., Bakker, L. J., Dorigo-Zetsma, J. W., Ridwan, B., van Zeijl, J. H., Bernards, A. T., rkens-Hulshof, S., e Jongh, B. M., Vlaminckx, B. J. M., Nabuurs-Franssen, M. H., Kuipers, S., Diederen, B. M. W., Melles, D. C., van Rijn, M., Dinant, S., Pontesilli, O., e Man, P., Vaessen, N., Leversteijn-van Hall, M. A., van Elzakker, E. P. M., Muller, A. E., Renders, N. H., van Dam, D. W., Buiting, A. G. M., Vlek, A. L. M., Deege, M. P. D., Frakking, F. N. J., Overdevest, I. T. M. A., Bosboom, R. W., Trienekens, T., Voorn, G. P., Ruijs, G. J. H. M., Wolfhagen, M. J. H. M., Alblas, J., Altorf-van der Kuil, W., Blijboom, L., Groenendijk, S., van Heereveld, J., Hertroys, R., Monen, J. C., Notermans, D. W., Reuland, E. A., van Triest, M. I., Wielders, C. C. H., Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, and AII - Infectious diseases
- Clinical infectious diseases. 66(11):1651-1657
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