Messina, Christopher J., Gumbach, Eric S., and Diehl, Diane M.
LC-GC North America; Oct2007, Vol. 25 Issue 10, p1042-1049, 8p
SEROTONIN uptake inhibitors, PRESCRIPTION of drugs, ANTIDEPRESSANTS, PANIC disorders, LIQUID chromatography, CHROMATOGRAPHIC analysis, and SCIENTIFIC method
Paroxetine is a potent and selective serotonin (5-hydroxytryptamine) reuptake inhibitor. It is used in a prescribed drug substance to treat panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, posttraumatic stress disorder, renal-hepatic impairment, and depression (1). An ultrahigh-pressure liquid chromatography (UHPLC) method was developed to separate paroxetine from several of its related compounds using a systematic screening protocol that monitors combinations of selectivity factors including column chemistry, organic modifier, and pH. When the best combination of these factors was selected, the method was optimized by varying gradient slope and temperature. Validation was performed when final method conditions were selected. This method was demonstrated to be robust, sensitive, specific, accurate and reliable. [ABSTRACT FROM AUTHOR]
LC-GC North America; 2013 Corporate Capabilities, Vol. 30, p10-10, 1p
LIQUID chromatography-mass spectrometry
The article focuses on the product facilities and services provided by Advion Inc. It reports that Advion was established in the year 1993 based on techniques developed by Jack Henion, expert of liquid chromatography-mass spectrometry (LC-MS) at Cornell University in New York. It reports that Advion provide services to several fields in the market which include medicinal chemistry, organic synthetic chemistry and analytical chemistry.