Martínez-Reina, C. Marlon and Amado-González, C. Eliseo
Revista Cubana de Química. ene-abr2013, Vol. 25 Issue 1, p9-19. 11p. 3 Color Photographs.
POSTAGE stamps, NOBEL Prizes, NOBEL Prize in Chemistry, STAMP collecting, ANALYTICAL chemistry, ORGANIC chemistry awards, NATURAL products, BIOCHEMISTRY, and AWARDS
Nobel Prizes in Chemistry and Philately, Part II, is a review of the stamps issued in different countries to commemorate the Nobel Prizes in analytical chemistry, organic chemistry, natural products and biochemistry. [ABSTRACT FROM AUTHOR]
PHOTONS, PHYSICAL organic chemistry, PHOTOCHEMISTRY, SUPRAMOLECULAR chemistry, and NUCLEAR spin
This Perspective presents a review and survey of the science and philosophy of my research career over the past five decades at Columbia as a physical organic chemist and photochemist. I explore the role of paradigms, structure, and geometric thinking in my own cognitive and intellectual development. The Perspective describes my investigations of high energy content molecules in electronically excited states and the development of electronic spin and supramolecular photochemistry chemistry. Current research dealing with the nuclear spin chemistry of H2 incarcerated in buckyballs is illustrated. In the second part of this Perspective, I recount a personal role of the philosophy and history of science and the scientific communities' use of paradigms in their every day research and intellectual activities. Examples are given of the crucial role of geometry and structure in the rapid development of organic chemistry and physical organic chemistry over the past century. [ABSTRACT FROM AUTHOR]
Examines proposed partial least squares (PLS) multivariate statistical models for predicting concentration of hydrocarbon- and oxygen-containing functional groups for a calibration set of model homopolymers. Plasma-deposited films; Static secondary ion mass spectrometry (SIMS); PLS modeling; Preprocessing; Prediction of surface oxygen and hydrogen concentration.
COMPOSITION of water, POLYMERS, CATALYSTS, INORGANIC chemistry, and POWER resources
The article discusses research on how the light-induced splitting of water into oxygen and hydrogen generates storable polymers and chemical fuels that could be used to address the world's energy demands. Particular attention is also given to the use of inorganic materials as semiconductor catalysts for such splits.
SUSTAINABILITY, COVID-19 pandemic, SUSTAINABLE chemistry, UNDERGRADUATES, PHYSICAL constants, and CHEMICAL laboratories
In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. We may suggest strategies for dealing with them, or invite responses, or both. "Classroom" is equally a forum for raising broader issues and sharing personal experiences and viewpoints on matters related to teaching and learning science. Amidst the Covid-19 pandemic, we have planned a strategy for our institution which aims towards reuse and reduce principles of Green Chemistry. Organic preparations in the undergraduate curriculum can be utilized for other sister laboratory experiments such as recrystallization, determination of physical constants (m.pt) and detection of extra elements, detection of functional group and in qualitative analysis. The product of preparation can also be subjected to a second synthesis. This approach will reduce the amount of chemicals needed for carrying out experiments other than organic preparations. This paper illustrates a few organic preparations which can be reused for other companion laboratory exercises. This approach may set a model towards sustainability for other undergraduate laboratories. [ABSTRACT FROM AUTHOR]
Chalcones have been well examined in the extant literature and demonstrated antibacterial, antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the purported health benefits of chalcone and its derivatives, including molecular mechanisms of pharmacological activities, can be further explored. Therefore, this review aimed to describe the main characteristics of chalcone and its derivatives, including their method synthesis and pharmacotherapeutics applications with molecular mechanisms. The presence of the reactive α,β-unsaturated system in the chalcone's rings showed different potential pharmacological properties, including inhibitory activity on enzymes, anticancer, anti-inflammatory, antibacterial, antifungal, antimalarial, antiprotozoal, and anti-filarial activity. Changing the structure by adding substituent groups to the aromatic ring can increase potency, reduce toxicity, and broaden pharmacological action. This report also summarized the potential health benefits of chalcone derivatives, particularly antimicrobial activity. We found that several chalcone compounds can inhibit diverse targets of antibiotic-resistance development pathways; therefore, they overcome resistance, and bacteria become susceptible to antibacterial compounds. A few chalcone compounds were more active than conventional antibiotics, like vancomycin and tetracycline. On another note, a series of pyran-fused chalcones and trichalcones can block the NF-B signaling complement system implicated in inflammation, and several compounds demonstrated more potent lipoxygenase inhibition than NSAIDs, such as indomethacin. This report integrated discussion from the domains of medicinal chemistry, organic synthesis, and diverse pharmacological applications, particularly for the development of new anti-infective agents that could be a useful reference for pharmaceutical scientists. [ABSTRACT FROM AUTHOR]
Stini, Naya A., Gkizis, Petros L., and Kokotos, Christoforos G.
Green Chemistry; 9/7/2022, Vol. 24 Issue 17, p6435-6449, 15p
ORGANIC solvents, PEPTIDES, POISONS, FIELD research, RESEARCH teams, ORGANIC synthesis, and SOLVENTS
Dihydrolevoclucosenone (Cyrene is its market name) is a biomass-derived solvent that can be produced in only two steps from biomass, while being biodegradable, non-mutagenic and non-toxic. Its "green" profile combined with its physical properties makes Cyrene a plausible substitute for a number of widely used toxic organic solvents. The first attempt to assess Cyrene as a solvent dates back to 2014 and since then, numerous research groups have opted for this promising alternative. Cyrene has successfully been employed as a solvent in materials chemistry, peptide chemistry, organic synthesis and many more research fields, which are going to be discussed in the context of this review. [ABSTRACT FROM AUTHOR]
Chemistry - A European Journal; 1/26/2021, Vol. 27 Issue 6, p1865-1869, 5p
SUSTAINABLE chemistry, ORGANIC synthesis, CHEMICAL engineering, CHEMICAL processes, INORGANIC chemistry, AMMONIUM sulfate, and METHACRYLATES
Keywords: green chemistry; industrial chemistry; organic synthesis; synthetic methods EN green chemistry industrial chemistry organic synthesis synthetic methods 1865 1869 5 01/29/21 20210126 NES 210126 B Making industry greener b : Many principles for the economic production of organic bulk chemicals, the syntheses of which have potentially the highest environmental impact, currently overlap with principles of green chemistry. For about 93 % of the 250 million tons organic chemicals produced annually by oxidation, oxygen is used as the oxidant, in most cases in combination with catalysts to achieve appropriate selectivities. I Addressed Principles of Green Chemistry: Prevent Waste, Atom Economy, Reduce Derivatives, Catalysis vs. Getting Greener: Propylene Oxide O SB 2 sb is not always the most efficient oxidant, as shown in the different synthetic routes to valuable propylene oxide (Scheme 4). The chlorohydrin process uses chlorine and produces CaCl SB 2 sb as the by-product and is therefore not that green. This would allow the entry into a circular economy.[18, 19] Certain initiatives involving large chemical producers were recently started to introduce a circular economy based on chemcycling in order to replace the current linear use of feedstocks. Greener alternatives should also be as economic as possible. [Extracted from the article]
Efficient conversion of light from short wavelengths to longer wavelengths using color conversion layers (CCLs) underpins the successful operation of numerous contemporary display and lighting technologies. Inorganic quantum dots, based on CdSe or InP, for example, have received much attention in this context, however, suffer from instability and toxic cadmium or phosphine chemistry. Organic nanoparticles (NPs), though less often studied, are capable of very competitive performance, including outstanding stability and water-processability. Surfactants, which are critical in stabilizing many types of nano-structures, have not yet been used extensively in organic NPs. Here we show the utility of surfactants in the synthesis and processing of organic NPs by thoroughly characterizing the effect of ionic and non-ionic surfactants on the properties of fluorescent organic NPs. Using this information, we identify surfactant processing conditions that result in nearly 100 % conversion of organic fluorophores into sub-micrometer particles, or nano-dots, with outstanding performance as CCLs. Such water dispersions are environmentally benign and efficiently convert light. They can be used for a range of fluorophores covering a full spectral gamut, with excellent color purity, including full-width at half-maximum (FWHM) values as low as 21 nm. Compared to inorganic (InP) reference CCLs, the organic nano-dot based CCLs show superior color conversion efficiency and substantially improved long-term stability. Compared to inorganic nanoparticles, organic nanoparticles aren't as well understood. Here the authors explore the use of surfactants to prepare organic semiconductor nanoparticles with outstanding photophysical properties. [ABSTRACT FROM AUTHOR]
CATALYSIS, ORGANIC chemistry, FLOW chemistry, and METAL catalysts
Fine chemical industry, flow chemistry, organic process, single-atom catalysis Keywords: fine chemical industry; flow chemistry; organic process; single-atom catalysis EN fine chemical industry flow chemistry organic process single-atom catalysis 1 1 1 11/11/22 20221108 NES 221108 B The Cover Feature b shows a flow reactor employing a single-atom catalyst schematically represented. Cover Feature: Continuous Flow Single-Atom Catalysis: A Viable Organic Process Technology?. [Extracted from the article]
During the COVID-19 pandemic, various drug candidates have been developed, molnupiravir (MK-4482 and EIDD-2801), which is a new orally anti-viral agent under development for the treatment of COVID-19, is under study in the final stage of the clinical trial. Molnupiravir enhances the replication of viral RNA mutations in animals and humans. Due to the high demand for the synthesis of this drug, it was essential to develop an efficient and suitable synthetic pathway from raw material. In this study, molecular docking analysis on molnupiravir is examined also, the mechanism of action (MOA) and the recent synthetic pathway is reported. This review will be helpful to different disciplines such as medicinal chemistry, organic chemistry, biochemistry, and pharmacology. [ABSTRACT FROM AUTHOR]
A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology. [ABSTRACT FROM AUTHOR]