Chemical research -- Research, Chemical research -- Methods, Chemical research -- Chemical properties, Antibody-drug conjugates -- Research, Antibody-drug conjugates -- Chemical properties, Chemistry, Organic -- Chemical properties, Chemistry, Organic -- Methods, Chemistry, Organic -- Research, Drug discovery -- Research, and Drug discovery -- Methods
Abstract
Bioorthogonal chemistry, already a workhorse of drug discovery research, prepares for the leap into human testing. Bioorthogonal chemistry, already a workhorse of drug discovery research, prepares for the leap into human testing.
Organocatalysiscatalysis mediated by small chiral organic moleculesis a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic, two-electron-pair reactivity domains. Recently, organocatalysis has been successfully combined with photochemical reactivity to unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities. Here we describe the historical context, scientific reasoning and landmark discoveries that were essential in expanding the functions of organocatalysis to include one-electron-mediated chemistry and excited-state reactivity.
Barnard, Rachel A., Boothe, Jordan R., Salvatore, Joe, Emerson, Kelley, Boone, Allison, Sandler, Claire, and Coppola, Brian P.
Journal of College Science Teaching. March-April, 2018, Vol. 47 Issue 4, p21, 9 p.
Subjects
University of Michigan -- Curricula, Sciences education -- Methods, Peer-group tutoring of students -- Methods, and Chemistry, Organic -- Study and teaching
Abstract
An institutionalized program of peer-led study groups (PLSG) adds instructional power to our large-enrollment introductory organic chemistry courses. Concomitantly, there is a challenge to keep the instructional philosophy and subject matter coherent with the faculty expectations and goals across this diverse group of undergraduate instructors. Thus, to improve communication within the instructional workforce of our large organic chemistry course, we have installed a required course for all undergraduate PLSG facilitators and peer tutors hired by the Science Learning Center at the University of Michigan. This liaison course, taught by a graduate student instructor under the direction of the faculty course coordinator, focuses on enhancing subject matter clarity and stemming the flow of misinformation that has sometimes been reported in the PLSG sessions. We examined the perceived value of the liaison course, self-assessment of course content knowledge by the facilitators, and how enrollment in the course has shaped the experience of those leading a PLSG.
Murphy, John J., Bastida, David, Paria, Suva, Fagnoni, Maurizio, and Melchiorre, Paolo
Nature. April 14, 2016, Vol. 532 Issue 7598, p218, 5 p.
Subjects
Radicals (Chemistry) -- Analysis, Chemistry, Organic -- Analysis, and Carbon -- Chemical properties
Abstract
An important goal of modern organic chemistry is to develop new catalytic strategies for enantioselective carbon-carbon bond formation that can be used to generate quaternary stereogenic centres. Whereas considerable advances [...]
View/download PDF
