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SEROTONIN uptake inhibitors, DRUG prescribing, ANTIDEPRESSANTS, PANIC disorders, LIQUID chromatography, CHROMATOGRAPHIC analysis, and SCIENTIFIC method

Paroxetine is a potent and selective serotonin (5-hydroxytryptamine) reuptake inhibitor. It is used in a prescribed drug substance to treat panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, posttraumatic stress disorder, renal-hepatic impairment, and depression (1). An ultrahigh-pressure liquid chromatography (UHPLC) method was developed to separate paroxetine from several of its related compounds using a systematic screening protocol that monitors combinations of selectivity factors including column chemistry, organic modifier, and pH. When the best combination of these factors was selected, the method was optimized by varying gradient slope and temperature. Validation was performed when final method conditions were selected. This method was demonstrated to be robust, sensitive, specific, accurate and reliable. [ABSTRACT FROM AUTHOR]

LIQUID chromatography-mass spectrometry

The article focuses on the product facilities and services provided by Advion Inc. It reports that Advion was established in the year 1993 based on techniques developed by Jack Henion, expert of liquid chromatography-mass spectrometry (LC-MS) at Cornell University in New York. It reports that Advion provide services to several fields in the market which include medicinal chemistry, organic synthetic chemistry and analytical chemistry.

EXTRACTION (Chemistry), TECHNICAL chemistry, ORGANIC chemistry, CHEMICAL models, CHEMICAL processes, and ANALYTICAL chemistry

The article offers information on formal and informal training opportunities that may be available to educate all chemists in the fundamentals of these necessary laboratory skills. It mentions that analytical chemistry textbooks provide an overview, at best, of the practice of extraction; and also mentions about Liquid–liquid extraction (LLE), including proper use of separatory funnels, is found in organic chemistry laboratory manuals.

LIFE sciences, SAMPLE preparation (Chemistry), SOLID phase extraction, and ORGANIC chemistry

The article presents the short profile of Biotage, a global company offering innovative and effective solutions for separation and sample preparation within organic and analytical chemistry. Topics discussed include information on focus to reduce the impact of product activities on the environment; acquisition of Horizon Technology by Biotage to strengthened the company's product portfolio; and product offerings involving manual and automated extractors.

FUNCTIONAL groups, ORGANIC chemistry, ELECTROSTATICS, MOLECULES, and ORGANIC compounds

When electrostatic effects are superimposed on hydrophilic interactions, specific functional groups can be selected (when the column has the opposite charge) Or de-selected (when the column has the same charge). This can be exploited to isolate compounds, such as phosphopeptides, or to diminish the role of basic groups in solutes to enhance the selectivity for the rest of the molecule. [ABSTRACT FROM AUTHOR]

ACETONITRILE, STATIONARY phase (Chromatography), ORGANIC chemistry, HYDROPHOBIC surfaces, and LIQUID chromatography

The article discusses the topics on dealing with acetonitrile such as shorter column with smaller particles, reduction of the column internal diameter, and changing the type or amount of stationary phase. It notes that the current trend in higher throughput liquid chromatography (LC) is the use of smaller particles packed into shorter columns. It points out that changing the internal diameter of the column can reduce solvent consumption.

INDUCTIVELY coupled plasma mass spectrometry, LIQUID chromatography, LIFE sciences, MOLECULES, ORGANIC compounds, and ORGANIC chemistry

Emerging as a complementary analytical tool to liquid chromatography-mass spectrometry (LC-MS), LC-inductively coupled plasma-mass spectrometry (LC-ICP-MS) brings added value to the determination of inorganic element containing molecules of biological importance with its high selectivity, superior sensitivity, and nearly matrix-effect free determination. This article discusses the important roles LC-ICP-MS speciation analysis can play in meeting exploratory analytical challenges in the life sciences. Two promising capabilities of LC-ICP-MS that have the potential to broaden its applications in the life sciences but have not been investigated intensively and widely appreciated are emphasized: element-selective screening and species-independent quantification of organic compounds that contain one or more inorganic element, either naturally present in the compounds or intentionally introduced as an ICP-MS tag, such as P, S, Br, I, Si, Se, As, and metals. [ABSTRACT FROM AUTHOR]

ISOELECTRIC focusing, ELECTROPHORESIS, ORGANIC chemistry, QUALITATIVE chemical analysis, ELECTROCHEMISTRY, PHASE partition, MASS spectrometry, and PROTEOMICS

Discusses the articulation of the use of capillary isoelectric focusing (CIEF) with mass spectrometry as a multidimensional separation technique for proteomic studies. Importance of identifying proteins involved in a disease state and elucidation of their structure and function; Dimensions of the classical approach gel electrophoresis; Methods of performing CIEF.

ORGANIC chemistry and CHROMATOGRAPHIC analysis

The article provides information on North Carolina based organization Biotage, which provides separation and synthesis technology services in organic chemistry and analytical chemistry, and talks of flash chromatography, protein precipitation, and filtration.

MASS spectrometry, INDUCTIVELY coupled plasma mass spectrometry, CHROMATOGRAPHIC analysis, SPECTRUM analysis, ORGANIC acids, CARBON compounds, AMINES, and ORGANIC chemistry

The article focuses on the application of ion chromatography-mass spectrometry (IC-MS) and ion chromatograph-inductively coupled plasma mass spectrometry (IC-ICP-MS) in analyzing potentially harmful compounds. It notes that ion chromatography has been used in analyzing low-molecular organic compounds including amines, anionic and cationic substances. A study that determines bromate, perchlorate, and organic acids by IC-MS is presented.

MASS spectrometry, ORGANIC chemistry, and CONFERENCES & conventions

A calendar of organic chemistry events from September 2, 2015 to December 11, 2015 is presented which includes the Saudi Lab Expo in Riyadh, Saudi Arabia, the Mass Spec 2015 in Biopolis, Singapore and the International Symposium on Applied Chemistry in Bandung, Indonesia.

ORGANIC acids, POLARITY (Chemistry), PHASE rule & equilibrium, CHROMATOGRAPHIC analysis, and ORGANIC chemistry

The challenging retention of polar organic acids in reversed phase conditions is accomplished using a unique multi-mode stationary phase. Retention characteristics are compared with a standard ODS stationary phase highlighting the value of additional selectivities in development of methods for organic acids. [ABSTRACT FROM AUTHOR]

LITERARY excerpts, SOLID phase extraction, EXTRACTION techniques, EXTRACTION (Chemistry), CHEMICAL equilibrium, and ORGANIC chemistry

Several excerpts related to six discrete stages of solid-phase extraction (SPE) including sample pretreatment, conditioning, equilibration, sample loading, washing, and elution are presented.

METHANOL, EXTRACTION (Chemistry), VOLATILE organic compounds, ORGANIC chemistry, ORGANIC compounds, and CARBON compounds

The article focuses on the application of Atomx, a concentrator/multimatrix autosampler, developed by Teledyne Tekmar Co. for the analysis of elevated volatile organic compound (VOC) concentrations in soils. It notes that Atomix provides shorter sample pathway, improves temperature uniformity, and decreases caryover. A reproducibility study was conducted to demonstrate the precision and accuracy of the methanol extraction option on the Atomx.

NITROGEN, HELIUM, ORGANIC compounds, VOLATILE organic compounds, CARBON compounds, and ORGANIC chemistry

The article focuses on the application of nitrogen as an alternative replacement for helium for analysis of Volatile Organic Compounds (VOC) with the use of purge-and-trap (P&T) method. It notes that using nitrogen as purge gas will have a significant reduction on the costs of operation for VOC method. Nitrogen is inert, affordable, and abundant compared to helium.

AUTOMATION, EXTRACTION apparatus, CHEMICAL engineering equipment, PERSISTENT pollutants, ORGANIC compounds, ORGANIC chemistry, and WASTE products

The article focuses on the automated extraction to compounds such as the polychlorinated dioxins/furans PCDD/Fs, DLPCBs, BDEs, and PCNs in real fish and biota matrices. It notes that Persistent Organic Pollutants (POPs) are organic compounds from the anthropogenic class, are linked to have an adverse effect on human health and the environment. The clean-up automation help lowering the possibility of any health hazards and the automated extraction provides a less labor-intensive.

BIODIESEL fuels, SUPERCRITICAL fluid chromatography, ORGANIC compounds, FATTY acids, CHROMATOGRAPHIC analysis, CARBON compounds, and ORGANIC chemistry

The article presents an analysis of the separation of organic compounds for biodiesel using supercritical fluid chromatography (SFC). These organic compounds include free fatty acids (FFAs), fatty acid methyl esters (FAMEs), and glycerol that can be separated by using SFC within 3.5 minutes. Furthermore, SFC provides a facile means for biodiesel process monitoring and quality control.

VOLATILE organic compounds, CONTAMINATION of drinking water, ORGANIC compounds, and ORGANIC chemistry

The article offers information about a study which aims to determine techniques for reducing purge-and-trap (P&T) cycle times in volatile organic compounds (VOC) system . The technique was first implemented at the U.S. Environmental Protection Agency (USEPA) research laboratory in Cincinnati, Ohio. Meanwhile, USEPA uses several equipment from OI Analytical to update Method 524.2 for the Determination of Volatile Organic Compounds in Drinking Water.

ORGANIC compounds, DRINKING water, FRESH water, ORGANIC chemistry, CARBON compounds, and WATER

A turn-key Productivity Solution for the GC-MS analysis of semivolatile organics in drinking water streamlines method validation and instrument integration. This comprehensive approach ensures easy compliance with method criteria and provides optimal instrument performance. [ABSTRACT FROM AUTHOR]

SCIENTIFIC apparatus & instruments, VOLATILE organic compounds, ORGANIC chemistry, and CARBON compounds

The article evaluates O.I. Analytical's model 4660 Eclipse purge-and-trap sample concentrator which is designed for volatile organic compound analysis.